Trial was an American post-punk band formed by Desmond Shea and John Borruso in Berkeley, California in 1982. In addition to Shea (bass) and Borruso (vocals), the initial lineup included Jason Ellish (drums) and Rob Noxious (guitar). Trial's raw sound and brooding, often political lyrics aligned them with a handful of local bands collectively described as "peace punk," including Crucifix, PLH (Peace, Love & Happiness), Treason, Atrocity, Sleeping Dogs, and A State of Mind, among others.[1] Trial's performances, recordings, and printed materials frequently addressed themes of human rights, non-violence, and nuclear disarmament.[2]

In 1984 Trial moved towards self-produced, immersive events at non-music venues such as warehouses and art spaces. One-off compositions, 16mm film loops, and slide projections marked this phase, with events like Trial of the Subconscious at San Francisco's Co-Lab[5] and Non-Fiction Reality Effect at New Langton Arts. The band's stark, mid-tempo, garage sound grew gradually darker and more atmospheric, introducing elements of industrial and experimental music.[6] The period saw personnel changes as well, with Shea moving to guitar, Cyrnai[7] joining on bass, and Christopher Douglas replacing Ellish on drums. The resultant songs defined Trial's later years and were documented in their full-length album, Moments of Collapse.


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Trial, with Humon's band Rhythm & Noise, toured the US from 1986 to 1987, supporting both Moments of Collapse and Rhythm & Noise's recent Chasms Accord LP. Trial's tour lineup featured bassist Andrew Bosch of PLH. On their return Trial disbanded after recording a final demonstration cassette, The Fragmentary, in early 1987.

Shortly afterwards, bassist Brian Redman was killed in a moped accident. The band took two years off before returning to play Rainfest in Seattle, The Rumble in Chicago, East Coast Tsunami Fest in Pennsylvania, a surprise show in New York City, and Sound and Fury Fest in Santa Barbara, California. They went on tour throughout Europe for thirty shows in late 2011.

Methods:  This pilot randomized controlled trial focused on elderly women with SO. The study group underwent progressive elastic band resistance training for 12 weeks (3 times per week). The control group received only a 40-minute lesson about the exercise concept. Dual-energy X-ray absorptiometry was performed before and after intervention to evaluate body composition. Mann-Whitney U and Wilcoxon signed rank tests were used to analyze the differences within and between these groups.

Conclusions:  Our study demonstrated that progressive elastic band resistance exercise can reduce fat mass and increase BMD in elderly women with SO, and that this exercise program is feasible for this demographic. Additional studies with larger sample sizes and longer intervention periods should be conducted.

Current therapy for preventing the first variceal bleed includes beta-blocker and variceal band ligation (VBL). VBL has lower bleeding rates, with no differences in survival, whereas beta-blocker therapy can be limited by side effects. Carvedilol, a non-cardioselective vasodilating beta-blocker, is more effective in reducing portal pressure than propranolol; however, there have been no clinical studies assessing the efficacy of carvedilol in primary prophylaxis. The goal of this study was to compare carvedilol and VBL for the prevention of the first variceal bleed in a randomized controlled multicenter trial. One hundred fifty-two cirrhotic patients from five different centers with grade II or larger esophageal varices were randomized to either carvedilol 12.5 mg once daily or VBL performed every 2 weeks until eradication using a multibander device. Seventy-seven patients were randomized to carvedilol and 75 to VBL. Baseline characteristics did not differ between the groups (alcoholic liver disease, 73%; median Child-Pugh score, 8; median age, 54 years; median follow-up, 20 months). On intention-to-treat analysis, carvedilol had lower rates of the first variceal bleed (10% versus 23%; relative hazard 0.41; 95% confidence interval 0.19-0.96 [P = 0.04]), with no significant differences in overall mortality (35% versus 37%, P = 0.71), and bleeding-related mortality (3% versus 1%, P = 0.26). Six patients in the VBL group bled as a result of banding ulcers. Per-protocol analysis revealed no significant differences in the outcomes.

If you accidentally started your free trial for Apple Music and you don't want to use the trial just yet, you'll need to reach out to Apple Support directly to see if they're able to cancel it for you. They're best-equipped to take a closer look and provide some additional guidance. This link will help you get started: Contact - Official Apple Support

That all depends on which offer you choose. (1) Students can choose the Apple Music Student Plan at $5.99 per month. (2) An individual monthly subscription is just$10.99 per month after your free trial. (3) The Apple Music Family Plan, which allows you to share your account with up to five people and gives each member a personal account, is just$16.99 per month. (4) The Apple Music Individual Plan and the Apple Music Family Plan are also included in Apple One, which bundles up to five other Apple services into a single monthly subscription. Apple One plans start at$19.95 per month.

Verbal Assault was one of the pioneering hardcore bands to come of the East Coast during the movement's first wave in the early '80s. Touring extensively through North America later in the decade, the group's final performance came in 1991, but not before leaving a recorded legacy behind that has influenced countless acts for decades now.

I asked Christopher if there were any songwriting and/or sonic aspects about the previous Verbal Assault records/recordings that the band wanted to avoid before going into the Trial sessions. "For me, the time around Trial is when VA really became a band. To that end, we definitely wanted the songs to have a bigger sound and feel than the stuff that we did before (The Masses tape and Learn EP). We thought that our songwriting had gotten better, and we wanted the production for Trial to reflect that."

Baseline characteristics will be presented by trial arm. All trial outcomes will be reported descriptively by group (as randomized and as analyzed) at all time points at which they were collected. Continuous data will be summarized as means, standard deviations, medians and ranges, whereas data on further procedures and complications will be summarized as frequencies and percentages. Outcomes will be illustrated graphically over time where appropriate, including confidence intervals.

The primary economic outcome will be the additional cost per quality-adjusted life year (QALY) gained by undergoing tension suture repair using an intention-to-treat approach. Costs and health outcome data for the economic analysis will be collected prospectively during the trial at baseline, four, 12, and 18 months (and 24 months for those participants that reach this timepoint during the trial).

Health care resource use will be presented for both arms in terms of mean value, standard deviation and mean difference (with 95% CI) between the groups. The cost of each type of surgery and related complications will be essential for the analysis. Hence, an accurate record of procedures at hospital level (e.g. centres in the trial) will be put in place in order to record per patient information (e.g. surgical procedures, complications related to the procedures, other medical complications). Costs relating to surgical procedures will be micro-estimated based on time in theatre, staff time, consumables and devices, and nights in hospital after the procedure. Unit costs will be derived from established national costing sources such as NHS Reference Costs and PSSRU Unit costs of health and social care. Unit costs will be multiplied by resource use to obtain a total cost for each patient. QALYs will be estimated by means of the EQ-5D as recommended by the NICE appraisal guidance.33 Patients will complete the EQ-5D-5L,34 and descriptive statistics will be summarized by trial arm for each time point.35

Data from the internal pilot phase will be used by the DMC and TSC to check the assumptions about the feasibility of the trial and its continuation, particularly concerning recruitment assumptions. These data will also contribute to the final analyses.

The PI or delegated clinician will record an assessment of causality (to trial treatment). Once received, causality and expectedness will be confirmed by the chief investigator. SAEs that are deemed to be unexpected and related to the trial will be notified to the Research Ethics Committee (REC) and sponsor within 15 days. Follow-up reports a month later will be reviewed by the chief investigator to ensure that adequate action has been taken and progress made.

All records will be kept in locked locations. All consent forms will be secured safely in a separate compartment of a locked cabinet. Clinical information will not be released without written permission, except as necessary for monitoring by the trial monitors.

The executive summary and copy of the trial report will be sent to NICE and other relevant bodies, including Clinical Commissioning Groups, so that the study findings can inform their deliberations and be translated into clinical practice nationally. We will also work with the relevant National Clinical Director in the DoH to help ensure the findings of the trial are considered when implementing policy and will work with the SACs to incorporate the findings into the training curriculum for clinicians who will undertake treatment of olecranon fractures. The British Elbow and Shoulder Society have adopted the trial for inclusion in their research portfolio which will facilitate dissemination of findings to relevant stakeholders. A number of dissemination channels will be used to inform clinicians, patients and the public about the results of the study. be457b7860

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