E.O. received grants from Chugai Pharmaceutical Co., Ltd., and received lecture fee from Chugai Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd., Eli Lilly, Bayer Japan, Yakult Honsha Co., Ltd., Merck Serono, and Takeda Pharmaceutical Co., Ltd. Y.E. received honoraria from Chugai Pharmaceutical Co., Ltd. T.Y. reports grants and received lecture fee from Chugai, Takeda, and Taiho and grants from Pfizer, Merck Serono, Astra Zeneca, Yakult Honsha, Bristol Myers Squibb, Daiichi-Sankyo, Gilead Sciences, Huya Biosciences, Bayer, and Sysmex. H.U. reports grants from Taiho Pharm., Chugai Pharm., Takeda Pharm., and Yakult. K.M. received grants from Chugai, MSD, Daiichi Sankyo, Shionogi, Kyowa Hakko Kirin, Gilead Sciences, Sanofi, Pfizer and Merck Serono, and personal fees from Taiho, Takeda, Bayer, and Eli Lilly. T.T. received lecture fees from Chugai Pharmaceutical Co., Ltd., Takeda Pharm,Sanofi, Taiho Pharm, Merck Serono, and Yakult Honsha. T.F. received grants from Astellas Pharma Inc., Otsuka Pharmaceutical Co., Sanofi, Taiho Pharmaceutical, Takeda Pharmaceutical Co., Chugai Pharmaceutical Co., Eli Lilly Japan K.K., and Yakult Honsha Co. K.Y. received grants and personal fees from Chugai Pharm. Co., Ltd., Merck Serono Co., Ltd., and Yakult Honsha Co., Ltd., grants from Kyowa Hakko Kirin, grants and personal fees from Nippon Kayaku Co., Ltd. during the conduct of the study, grants and personal fees from Johnson & Johnson K.K., Taiho Pharm. Co., Ltd., Daiichi Sankyo Co., Ltd., Tsumura, Takeda Pharmaceutical Co., Ltd., Asahi Kasei, Eisai, Sanofi, Eli Lilly Japan K.K., Covidient Japan, Novartis Pharma, EA Pharma Co., Ltd. and Ono Pharm. Co., Ltd, grants from Toyama Chemical, Abbott Japan, Otsuka Pharma Co., Ltd., Toray Medical Co., Ltd, KCI, Astellas, Sumitomo Dainippon Pharma, and Bristol Myers Japan and personal fees from Olympus, Terumo, Denka, MSD K.K., Bayer Yakuhin, Ltd., and Intuitive Surgical. M.U. received grants from Chugai, Yakult Honsha, and Takeda and received personal fees from Merck Serono, Chugai, Yakult Honsha, and Takeda during the conduct of the study, grants from Taiho, Novartis, Asahi Kasei, Asteras, Toyama Chem, and Pfizer and personal fees from Taiho, Novatis, Asahi Kasei, Pfizer, Teijin Pharm, Eisai, Daiichi Sankyo, Johnson & Johnson, Boston Scientific, Covidien/Medtronic, Nobelpharma, Ono Pharmaceutical, and Mylan. I.H. reports grants and personal fees from Taiho Pharma, Chugai Pharma, Daiichi-Sankyo Pharma, Yakult-Honsha Pharma, Lilly, Takeda Pharma, and Ono Pharma. N.T. received grants from Taiho Pharmaceutical Co. and Chugai Pharmaceutical Co., outside the submitted work. K.S. received honoraria from Chugai Pharm, Taiho, Takeda, Merck Serono, Yakult Honsha, Bristol-Meyers Japan, Bayer Yakuhin, and Eli Lilly Co. and received grants from Chugai, Taiho and Takeda. Y.M. received grants from Chugai Pharmaceutical Co., Ltd., Yakult Honsha Co., Ltd., and Merck Serono Co. Ltd. during the conduct of the study and grants from Taiho Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd., Eli Lilly Japan K.K., Otsuka Pharmaceutical Co., Ltd., DAIICHI SANKYO COMPANY, LIMITED., Pfizer Japan Inc., Astellas Pharma Inc., Sumitomo Dainippon Pharma Co., Ltd., Eisai Co., Ltd., Shionogi & Co., Ltd., and Novartis Pharma K.K. The other authors declare no competing interests.


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