Abstract: We estimate the returns from varieties of agglomeration for new manufacturing firms. Within each industry, we leverage marginal variation across similarly highly agglomerated counties that the industry operates in, highlighting differences in rates of horizontal and vertical agglomeration. The former identifies geographies with greater co-location of own-industry or peer establishments, and the latter identifies geographies with greater co-location of industry suppliers. Drawing from the population of US manufacturing firms founded between 2012 – 2015 and tracing their performance activity over their first five years of operations, we report differential results for firms operating in horizontally agglomerated counties relative to firms operating in vertically agglomerated counties. We document persistent trends that the appropriability from horizontal agglomeration increases sales by approximately 14 percent for new manufacturing firms. This trend is amplified for ventures located proximate to large, headquartered anchor firms. We report differential performance returns from horizontal agglomeration in manufacturing industries with greater upstream activity, whereas we document contrasting performance benefits for vertical agglomeration for industries operating at later stages of production. Lastly, new manufacturing firms positioned in an outlying manner to the dominant form of their industry’s agglomeration report disproportionately greater performance benefits. Our results support the theory that regional and industrial characteristics mediate the exact type of market failures (i.e., transaction costs, information asymmetries, and frictions in network formation) that influence the appropriability of agglomeration assets. This study offers several contributions by providing a framework to understand variation in agglomeration, disentangling the strategic returns from various features of agglomeration, and quantifying the returns from agglomeration on firm performance.