RNA-Mediated Feedback Control of Transcriptional Condensates
Keywords
1. Regulation: The process of controlling or directing according to rule, principle, or law.
2. Biological processes: The processes vital for a living organism to live.
3. Mechanisms: A system of parts working together in a machine; a piece of machinery.
4. Feedback control: A process in which information about the past or the present influences the same phenomenon in the present or future.
5. Transcription: The process by which the information in a strand of DNA is copied into a new molecule of messenger RNA (mRNA).
6. Cellular process: Processes that are carried out at the cellular level.
7. RNA: Ribonucleic acid, a molecule that plays an essential role in the synthesis of proteins.
8. Transcriptional control: The means by which cells regulate the conversion of DNA into RNA.
9. Non-equilibrium feedback control: A feedback control mechanism that does not reach a state of equilibrium.
10. Condensates: A form of matter which exists in dense phase.
11. Electrostatic interactions: Interactions between electrically charged particles.
12. In vitro experiments: Experiments conducted with microorganisms, cells, or biological molecules outside their normal biological context.
13. In vivo experiments: Experiments conducted on whole, living organisms or cells.
14. Elongation: The process of lengthening something.
Summary
Regulation of biological processes, fundamental cellular processes, and transcriptional regulation were studied, feedback control mechanisms and electrostatic interactions were incorporated, and non-equilibrium feedback control mechanisms were modeled, with RNA playing a crucial role in transcriptional control as evidenced by in vitro and in vivo experiments, ultimately suggesting that transcribed RNAs initially stimulate but then arrest the process.