University of Michigan  Department of Psychiatry

 Comprehensive Depression Center

Michigan Neuroscience Institute 

CURRICULUM VITAE

 Education and Training

            August 1975-May 1978   B.S., University of Puerto Rico

                                                         Major:  Biology, Magna Cum Laude

            July 1978-June 1982        M.D., University of Puerto Rico School of Medicine

            July 1982-June 1984        Psychiatry Residency:  PGY 1 and 2

                                                         University of Michigan Hospital, Ann Arbor, Michigan

            July 1984-June 1986        Psychiatry Residency:  PGY 3 and 4

                                                         University of Iowa Hospitals and Clinics, Iowa City, Iowa

            July 1985-June 1986        Genetics Fellowship, Department of Psychiatry,

                                                         University of Iowa Hospitals and Clinics, Iowa City, Iowa

            August 1986-June 1990   Research Fellow, Mental Health Research Institute

                                                         University of Michigan, Ann Arbor, Michigan

Certification and Licensure

            1981-83                            National Board Part I, II and III                                                       

            1984                                 Iowa Medical License #24228 (expired 7/1986)

            1987                                 Michigan Medical License #4301050784

            1991                                 Board Certified, American Board of Psychiatry and

                                                         Neurology, Certificate #34724

Academic, Administrative, and Clinical Appointments

July 1990-June 1993        Lecturer, University of Michigan Department of Psychiatry

            July 1990-June 1997        Research Investigator, Mental Health Research Institute

            July 1994-June 2001        Assistant Professor, Department of Psychiatry

            July 1994-Present            Staff Physician Michigan Medicine

July 1998-April 2013       Assistant Research Scientist, Molecular and Behavioral Neuroscience Institute

            July 2001-June 2020        Associate Professor with Tenure, Department of Psychiatry

            June 2004-July 2006        Co-director Treatment Resistant Depression Consultation Clinic

May 2013-June 2020       Associate Research Scientist, Molecular and Behavioral Neuroscience Institute

July 2020-Present            Associate Professor Emeritus (Active), Department of Psychiatry

July 2020-Present            Associate Research Scientist Emeritus (Active), Michigan Neuroscience Institute

July 2018-2024               Co-director Perinatal and Reproductive Psychiatry Clinic 

Honors and Awards

1987                           Individual National Research Service Award             

1989                          Robert Wood Johnson Minority Medical Faculty Development Program     

            1993                          American Suicide Foundation Psychiatric Research                                                               Development Award

            1994                          NARSAD Young Investigator Award

            1995                         NIMH Scientist Development Award

            1997                         Society of Biological Psychiatry A.E. Bennett Research  Award

            2004                         Kenneth J. Povish Service Award for service to migrant workers.

            2009                         St. Camillus Award, Lansing Guild Catholic Medical Association.

            2024                          Teacher of the Year, Dept. of Psychiatry Adult Residency Program

Membership in Professional Societies

American Society of Clinical Psychopharmacology

American College of Clinical Pharmacology

American Association for the Advancement of Science

American College of Lifestyle Medicine

North American Society for Psychosocial Obstetrics & Gynecology

National Boards and Peer-Review Service

  American Psychiatric Association Research Council (2000)

NIMH Board of Scientific Counselors (2000-2006)

Research Protocol Reviewer for the Intramural Program at NIMH (2000-2006)

National Scientific Advisory Board Depression and Bipolar Support Alliance (2003-2011)

The Translational Research Primate Network (Judy Cameron, P.I.) (2005-2010)

NIH Special Emphasis Panel, ZRG1 IFCN-L Learning and Memory (2006)

NIMH Special Emphasis Panel Pathway to Independence Award  (K99/R00, K22) (2006-2008)

NIH Neuroendocrinology, Neuroimmunology and Behavior Study Section (2006-2011)

Special Emphasis Panel RFA TW-13-002: Epigenetic, Social, Behavioral and Environmental Interactions (2014)

NIH Biobehavioral Regulation, Learning and Ethology (BRLE) study section (2018)

The Wellcome Trust Grant Adhoc Reviewer (July 2022)

NIH Biobehavioral Mechanisms of Emotion, Stress and Health (MESH) study section (2023)

Journal Reviewer for: Archives of General Psychiatry, Brain Research, Neuropsychopharmacology, Biological Psychiatry, Psychoneuroendocrinology, PNAS, American Journal of Psychiatry, Molecular Psychiatry.

Teaching and Mentoring Activities

            Co-director of the Neuroscience Core for Psychiatric Residents. (1996-2006).                           Lecturer for the Psychiatry Residency Core Curriculum (PGY 2) (1989-present).

            Lecturer on Depression for the Medical Student (MS 3) clerkship series (1992-2000).

            Long term case clinical supervisor for psychiatric residents, (1993-present).

            Psychiatric resident supervision in the Mood Disorders Clinic (1993-2000).

Lecturer and lab supervisor for the King-Chávez-Parks Summer Program of The University of Michigan Office of Minority Affairs (1990-1993).

Basic science research one to one supervision of undergraduate students during Fall, Spring and Summer sessions (work study and course study-1990-2020).

            Mentor of undergraduate students for the University of Michigan Undergraduate           Opportunity Research Program (1993-2012).

            Mentor of undergraduate students for the University of Michigan Summer Opportunity                         Research Program (1993-2012).

            Mentor and co-mentor for Neuroscience Program graduate students (1997-2014).

            Facilitator for the simulated psychiatric interview for M3 students (1998-2014).

Staffing and teaching of psychiatric residents, psychology and social work trainees in the Ambulatory Psychiatry Services (2001-present).

Co-mentor of K awards for Dr. Brian J Mickey, Dr. Leslie Swanson, and Dr. Brendon Watson (2014-2020)

Clinical Activities

            Attending psychiatrist at the U of M Depression Clinic (1988-2000)

            Attending psychiatrist (weekend coverage) at the Inpatient Psychiatry Unit (1988-2020)

            Attending psychiatrist at Psychiatric Emergency Services (7 times/year, 1988-present)

            Clinical supervision of psychiatric residents and fellows (1988-present)

            Clinical supervision of NPs, and non-medical mental health trainees (2000-present)

      Co-director, Treatment-Resistant Depression Consultation Clinic (2004-2006)

            Attending psychiatrist Women's Mental Health and Infants Program (2005-2011)

           Attending Perinatal and Reproductive Psychiatric Clinic (2011-present)

Membership in Dissertation and Thesis Committees

            Carrie Ann Zimmer, MD, Ph.D. Neuroscience (2000). Chair and Mentor.

            Debra Beth Speert, Ph.D. Neuroscience (2003). Committee Member

                Casandra M. Cartagena, M.S. Cellular and Molecular Biology (2003).   Chair and Mentor.                                 

            Sarah M. Clinton, Ph.D. Neuroscience (2004). Committee Member

            Helena T. Mueller, Ph.D. Neuroscience (2004). Committee Member

            Amy E. Steffek, Ph.D. Neuroscience (2004). Co-Chair and Mentor

            Javier A. Perez, Ph.D. Neuroscience (2008). Committee Member

            Deborah E. Bauer, Ph.D. Neuroscience (2010). Committee Member

            Lawrence Own, Ph.D. Neuroscience (2012). Committee Member

            Noel B. Ramsey, M.S. Clinical Research Administration (2015). Mentor

            Joshua A. Azevedo, Ph.D. Neuroscience (2016). Committee Member                                               

Committees and Advisory Boards

Departmental and Medical School

1991                           Committee to Increase Recruitment of Women and Minorities in the Department of Psychiatry, University of Michigan Medical School

1998-1999                                 Internal Review Committee Department of Psychiatry

2000-2020                  Appointments and Promotions Committee

2000-2016                  Rachel Upjohn Fellowship Committee

2007                           Dean’s Internal Review Committee Dept. of Psychiatry

2012-2015                  University Committee on Use and Care of Animals

2018                           Interim Chair Appointments and Promotions Committee

2019-present              University of Michigan Medical School Institutional Review Board  (IRBMED)

2020                           Post Covid-10 Mental Health Toolkit Task Force

2021-present              Dr. Michael Louis Smith Scholar Award and Colloquium Selection Committee

Regional

1989-1992                  Multicultural Mental Health Education and Training Committee of the Michigan Dept. of Mental Health

National                          

1996                           Invited Workshop Participant: Raising the Profile of Substance Abuse and Alcoholism Research. The Institute of Medicine, Washington, D.C.

2000-2001                   American Psychiatric Association Research Council

2005                            National Institute of Mental Health Search Committee for the Director of the Intramural Mood and Anxiety Disorders Program

2000-2006                   Board of Scientific Counselors, National Institute of Mental Health

2008-2009                   External Advisory Board for the University of Alabama at  Birmingham Comprehensive Neuroscience Center

2003-2011                   Depression and Bipolar Support Alliance Advisory Board

Consulting Positions

2002                             Arena Pharmaceutical Consultant

2005                             Eli Lilly Multicultural Advisory Board

2008                             External Advisory Board University of Alabama at Birmingham Comprehensive Neuroscience Center

Community and Volunteer Service

1992-2020                  Local Coordinator and volunteer for the Manchester Migrant Ministry, Diocese of Lansing

2010-2019                   Office of Multicultural Evangelization Advisory Board, Diocese of Lansing

2012                            Operation Rice Bowl Advisory Committee Member

2009-2021                   Hispanic Men’s Conference Organizing Committee, Archdiocese of Detroit

Grant Support History

Identification of Biomarkers for Stress Vulnerability and Resilience

Navy-DoD-US (Role: Co-PI) to Stanley Watson Jr, Cortney Turner, Michael Uhler, Huda Akil, Juan Lopez     

 $2,447,681    2019‐ 2025

Sleep-Disordered Breathing and PAP in Perinatal Depression

NIH-DHHS-US (Role: Co-Mentor)

to Leslie Swanson, Renee Shellhaas, Juan Lopez, Louise O'Brien, Ronald Chervin, Mark Chames

$ 813,250    2015‐2020

Identification of Biomarkers for Stress Vulnerability and Resilience

Navy-DoD-US (Role: Co-Principal Investigator)

to Stanley Watson Jr, Cortney Turner, Srijan Sen, Huda Akil, Juan Lopez

$1,619,667   2015‐2018

Tranylcypromine Inactivation of LSD1 as a Possible Treatment for Sickle Cell Disease

NIH-DHHS-US (Role: Co-Principal Investigator)

to James Engel, Juan Lopez

$418,295        2012‐2013

Identification of Biomarkers for Stress Vulnerability and Resilience

Navy-DoD-US (Role: Co-Principal Investigator)

to Michael Uhler, Cortney Turner, Juan Lopez, Stanley Watson Jr, Huda Akil

$1,438,294    2012‐2015

Maternal Behavior and Effects of Paternal Affiliation in 5-HT1a Overexpressing Mice

NIH-DHHS-US (Role: Principal Investigator)

to Juan Lopez, Paresh Patel

$413,430       2009‐2011

MR:GR Balance in Depression

NIH-DHHS-US (Role: Principal Investigator)

to Juan Lopez ,Audrey Seasholtz, Lisa Seyfried, Huda Akil

$1,537,276     2009‐2014

DST and Suicide Prediction

NIH-DHHS-US (Role: Co-Investigator)

to Juan Lopez, John Greden

$553,050      2002‐2005

Molecular Elements, Neurocircuits and Mental Illness

NIH-DHHS-US (Role: Co-Investigator)

to Stanley Watson, Robert Koeppe, Audrey Seasholtz, Delia Vazquez, Huda Akil, Juan Lopez, Fan Meng

$6,595,223     2001‐2007

Stress Regulation of 5HT Receptors and The HPA Axis

NIH-DHHS-US (Role: Principal Investigator)

to Juan Lopez, Delia Vazquez

$1,539,233 2001‐2007

MRNA Regulation in Depression: Candidate and Array Studies

CMMS-DHHS-US-SubK sourced funding through University of California - Irv

to Margit Burmeister, Paresh Patel, Stanley Watson Jr, Juan Lopez, Audrey Seasholtz, Huda Akil

$1,101,616      1999‐2004

Gene Arrays as a Tool to Explore Brain Stress Mechanisms

NSF-US (Role: Principal Investigator)

to Juan Lopez

$40,000    1999‐2001

Genes Regulated by Antidepressants

Pritzker Foundation (Role: Principal Investigator)

to Juan Lopez

$51,750       1999‐2008

Chronic Unpredictable Stress, Ovarian Steroids and Brain Serotonergic Systems

Pritzker Foundation (Role: Principal Investigator)

to Juan Lopez

$27,254      1999‐2001

Serotonin System and HPA Axis Interactions in Monkey Brain

NIH-DHHS-US (Role: Principal Investigator)

to Juan Lopez, Stanley Watson Jr

$35,000  1998‐2000

A Double-Bind Placebo Controlled Trial of Estrogen Augmentation of Fluoxetine in Pre-menopausal Women with Major Depression

Pritzker Foundation (Role: Co-Investigator)

to Juan Lopez, Elizabeth Young

$208,296  1998‐2002

Molecular Elements, Neurocircuits and Mental Illness

NIH-DHHS-US (Role: Co-Investigator)

to Kirk Frey, Juan Lopez, Delia Vazquez, Stanley Watson Jr, Huda Akil

$4,184,523  1996‐2001

Serotonin and HPA Axis Interactions in Suicide Brains

NIH-DHHS-US (Role: Principal Investigator)

to Juan Lopez

$645,656  1995‐2001

Neurotransmitter Control of the Pituitary POMC System

NIMH Fellowship Training Grant

to Juan Lopez

$60,000  1988‐1988

Selected Visiting Professorships, Seminars, and Invited Presentations

1.  The hypothalamic-pituitary-adrenal axis:  Birth, Life and Death.  Psychiatry Department Grand Rounds, Ann Arbor, Michigan.  April 16, 1990.

2.  Regulation of the Serotonin 1A Receptor.  Post-Baccalaureate Pre-Medical Fellowship Program, University of Michigan, February 19, 1993.

3.  Steroid and Antidepressant Regulation of the 5HT1A System in the Hippocampus:  Implications for the Pathophysiology and Treatment of Anxiety and Depressive Disorders.  Department of Psychiatry Preclinical-Clinical Neuroscience Seminar Series.  January 7, 1994.

4.  Brain Banks and Brain Research in Mental Illness.  Invited Speaker for the Detroit Chapter of the National Alliance for the Mentally Ill.  April 25, 1994.

5.  Strategies for the Study of the Disinhibition of Hypothalamo-Pituitary-Adrenal Axis in Affective Disorders.  Symposium at the CINP International Congress.  Washington D.C., June 29, 1994.

6.  Advances in Office Psychiatry III:  Mood and Anxiety Disorders.  University of Michigan CME Course.  Mackinac Island, Michigan.  July 8-10, 1994.

7.  Mood Disorders:  Diagnosis and Psychobiology.  Advances in Psychiatry for Practicing and General Psychiatrists (CME Course).  Ann Arbor, Michigan.  November 14, 1994.

8.  Recent  Research Advances in Depression.  Invited Speaker for the Oakland County Depressive and Manic Depressive Association.  Livonia, Michigan.  November 28, 1994.

9.  The Relationship Between Stress and Depression.  North Oakland Medical Center, Dept. of Psychiatry Grand Rounds.  Pontiac, Michigan.  March 24, 1995.

10.  Brain Circuits and Antidepressant Action.  Michigan Alliance for the Mentally Ill Meeting.  Novi, Michigan.  May 6, 1995.

11.  Stress and the Neurobiology of Depression.  School of Nursing, University of Michigan.  Ann Arbor, Michigan.  February 28, 1996.

12.  Advances in Office Psychiatry V:  Mood and Anxiety Disorders.  University of Michigan CME Course.  Mackinac Island, Michigan.  July 18-20, 1996.

13. Advances in Dysthymic and Atypical Depressions.  Invited Lecture Sponsored by Eli Lilly.  Sands Hotel, San Juan, Puerto Rico.  April 19, 1996.

14.  CRF in Mood and Anxiety Disorders.  Symposium Chairperson and Discussant.  Society of Biological Psychiatry Annual Meeting.  May 17, 1997.

15.  Stress Hormones and the Brain.  Invited speaker for the Dearborn Alliance for the Mentally Ill.  October 5th, 1997.

16.  The Neurobiology of Stress, Implications for the Treatment of Depression.  Mental Health Grand Rounds, Dallas V.A. Medical Center, Dallas Tx. March 19, 1998.

17.  The Relationship Between Stress, Mood, and Antidepressant Treatment.  Psychiatry Grand Rounds, Henry Ford Health System, October 15, 1998.

18.  Depression, Serotonin, and the Neurobiology of Stress.  Psychiatry Grand Rounds, Michigan State University, Kalamazoo Center for Medical Studies.  December 8, 1998.

19.  The Neurobiology of Suicide. Symposium at the Winter Brain Research Conference, Breckenridge, Colorado. January 25, 2000.

20.  Genes Array Analysis as a Tool to Study Mechanisms of Antidepressant Action. Symposium at the American College of Neuropsychopharmacology Annual Meeting, San Juan. December 12, 2000.

21.  Neurobiological Mechanisms of Treatment Resistance: The Role of Stress. Symposium on Contemporary Approaches to Resistant Depression, at the American Psychiatric Association  Annual Meeting, New Orleans. May 5, 2001.

22.  Sexually Dimorphic Effect of Stress on Learning and Memory. Workshop at the Society of Biological Psychiatry Annual Convention, Philadelphia. May 17, 2002.

23.  Stress and the Developing Organism: From Animal Models to Psychopathology. Symposium at the Society of Biological Psychiatry Annual Convention, Philadelphia. May 17, 2002.

24.  Stress, Serotonin, and Development. Invited Lecture at the Glucocorticoid Network Meeting, San Juan, P.R. February 2002.

25.  Mineralocorticoid Receptors in Brain: Role in Stress and Related Disorders. Symposium at the International Society of Psychoneuroendocrinology Annual Meeting, New York. September 8, 2003.

26.  Stress and the Neurobiology of Mood. Grand Rounds, St. Joseph Mercy Hospital, Ann Arbor, Michigan. March 2004.

27.  Stress, Serotonin, and Depression: Implications for Treatment. Invited Lecture at the Center for Forensic Psychiatry. Ann Arbor, Michigan. November 19, 2004.

28.  Treatment Resistant Depression is Treatable. Invited Public Lecture at the Washtenaw County Alliance for the Mentally Ill. Ann Arbor, Michigan. March 14, 2005.

29.  Of Mice and Women: The Effect of Stress and Risk for Depression in the Mother-Infant Dyad . Invited Seminar at The Center for Neurobehavioral Development. University of Minnesota. July 28, 2006.

30.  Depression and Medical Illness: The Role of Stress. Invited Grand Rounds Presentation at the St. Joseph Regional Medical Center, South Bend, Indiana. October, 2007.

31.  The Neurobiology of Depression. University of Michigan Department of Neurology  Seminar. April 14th, 2009.

32.   The Neurobiology of Stress. Invited Symposium at the Michigan State Medical Society Annual Meeting. Troy, MI. October 22nd, 2010.

33.  The Neurobiology of Stress and Medical Illness. Invited Grand Rounds Presentation at St. Mary’s Mercy Hospital, Livonia, MI. April 22, 2011.

34.  Glucocorticoid and Mineralocorticoid Receptor Balance in Health and Disease. University of Michigan Pediatric Endocrinology Seminar. February 28th, 2012.

35.  The Mood/Food Connection: How Nutrition Impacts Mental Health. Bright Nights Community Forum, Plymouth, MI, March 6th, 2013

36.  Worsening Anxiety and Physical Symptoms after Switching to an SSRI. Evidence Based Medicine Seminar, Rachel Upjohn Building, April 25th, 2013

37.  Electroconvulsive Therapy for Adolescents and Adults: An Update. Depression Center Colloquium Series, Rachel Upjohn Building, April 25th, 2014

38.  Pharmacological Treatment of Perimenopausal Mood Disorders. Evidence Based Medicine Seminar University of Michigan Department of Psychiatry. January 28th, 2016

39.  Medication Options for Pregnant and Post-partum Depressed Females. VA Hospital Grand Rounds, March 15th, 2016.

40.  Treatment Resistant Depression. Advanced Psychopharmacology for Psychiatrists. (On-line lecture). November 2, 2016.

41.  El Hombre en la Familia, (The Role of the Hispanic Man in his Family). Keynote Address at the 8th Annual Hispanic Men’s Conference. Detroit, MI. March 19, 2017

42.  The Neurobiology of Depression. Keynote Address at the University of Michigan GIDAS Research Conference on Genes and Depression.  May 27, 2017.

43.  Psychiatric Disorders in the Peripartum Period. Invited Lecture at the University of Michigan Medical School. July 13, 2018.

44.  Mood Supporting Supplements and Complementary Treatments in Pregnancy. 27th Annual Primary Health Care of Woman Conference. Ann Arbor, MI. December 6, 2019.

45.  Personality, Stress and Psychiatric Disorders. Two Day Seminar on Human Formation at St. Luis Center. Chelsea, MI. March 4th-5th, 2020

46.  Focus on Fathers: Paternal Depression and Anxiety in the Perinatal Period. Michigan Childcare Collaborative Perinatal Educational Presentation. (Webinar). June 8, 2020.

47.  Complementary and Alternative Medicine Therapies for Perinatal Depression and Anxiety. Michigan Childcare Collaborative Perinatal Educational Presentation. (Webinar). September 14, 2020

48.  Your Brain on Hormones: Exploring Research on a Neuroendocrine Target for Depression. Discussant (Tova Berg, presenter)  V.A. Hospital Grand Rounds, Ann Arbor, MI. November 27, 2020.

49.  Mood Supporting Supplements and “Integrative” Treatments for Depression. Summer Grand Rounds, Ann Arbor, MI August 2022.

50.  Medical Management of Depression and Bipolar and Other Treatment Options. 7th Annual Kevin’s Song Symposium on Suicide. Plymouth, MI. January 26, 2023.

51.  Depression Risk and Cortisol Regulation During Pregnancy: Implications for the Mother and Infant. Invited Grand Rounds Presentation at University of Illinois Chicago Dept of Psychiatry, Chicago, IL. November 29, 2023.

52.  Depression Risk and Perinatal Dysregulation of the HPA Axis: Clinical Implications. Maternal Fetal Medicine Grand Rounds Christus Children, San Antonio, TX. April 11, 2024.

Bibliography

Scientific Publications

1.  Jaeckle RS and López JF:  Corticotropin releasing hormone:  Clinical endocrinology and implications for Cushing's disease and endogenous depression.  Psychiatric Medicine, Vol. 3(2):111-134, 1986.

2.  Kathol RG, Meller WM, Jaeckle RS and López JF:  Stable adrenocorticotropin-stimulated 11-b-hydroxylase activity but loss of age-related changes in patients with hypercortisolemia.  Biol Psychiatry, 22:1243-1252, 1987.

3.  Meller WM, Kathol RG, Jaeckle RS and López JF:  Stimulation of the pituitary-adrenal axis with arginine vasopressin in patients with depression.  J Psych Research, 21(3):269-277, 1987.

4.  Jaeckle RS, Kathol RG, López JF, Meller WM, Krummel SF:  Enhanced adrenal sensitivity to exogenous ACTH1-24 stimulation in major depression:  Relationship to dexamethasone suppression test results.  Arch Gen Psychiatry, 44:233-240, 1987.

5.  López JF, Kathol RG, Jaeckle RS and Meller WM:  The HPA response to insulin hypoglycemia in depression.  Biol Psychiatry, 22:153-166, 1987.

6.  Watson SJ, López JF, Young EA, Vale W, Rivier J and Akil H:  Effects of low dose oCRH in humans:  Endocrine relationships and b-endorphin/b-lipotropin response.  J Clin Endocrinol & Metab, 66(1):10-15, 1988.

7.  Meller WM, Kathol RG, Jaeckle RS, Grambsch P and López JF:  HPA axis abnormalities in depressed patients with normal response to the DST.  Am J Psych, 145(3):318-324, 1988.

8.  Kathol RG, Jaeckle RS, López JF and Meller WM:  Pathophysiology of HPA axis abnormalities in patients with major depression:  An update.  Am J Psych, 146(3):311-317, 1989.

9.   Meller WM, Kathol RG, Jaeckle RS, Grambsch P and López JF: Dr. Meller and Associates Reply. Am J Psych (Ltr), 146(4):570, 1989

10.  Jaeckle RS, Kathol RG, Krummel SJ, Meller WM and López JF:  Adrenal gland in major depression:  Enhanced capacity or enhanced sensitivity?  Arch Gen Psych (Ltr), 45:965-966, 1989.

11.  Kathol RG, Jaeckle RS, López JF and Meller WM:  Consistent reduction of ACTH responses to stimulation with CRH, vasopressin and hypoglycaemia in patients with major depression.  British J Psych 155:468-478 (1989).

12.  Gehris TL, Kathol RG, Meller WH, López JF and Jaeckle RS. Multiple steroid hormone levels in depressed patients and normal controls before and after exogenous ACTH.  Psychoneuroendocrinology 16:481-497, 1991.

13.  López JF, Palkovits M, Arato M, Mansour A, Akil H, and Watson SJ.  Localization and Quantification of Proopiomelanocortin mRNA, Glucocorticoid Receptor mRNA and Corticotropin Releasing Hormone Receptors in Human Pituitaries.  Neuroendocrinology 56:491-501, 1992.

14.  Vázquez DM, Morano MI, López JF, Watson SJ and Akil H:  Short term adrenalectomy increases glucocorticoid and mineralocorticoid receptor mRNA in selective areas of the developing hippocampus.  Mol Cel Neurosci 4:455-471, 1993.

15.  Chalmers D., López JF, Akil H and Watson SJ.  Molecular aspects of the stress axis and serotonergic function in Depression:  Clinical Neuroscience 1:122-128, 1993.

16.  López JF, Chalmers DT, Vázquez DM, Akil H and Watson SJ.  Corticosteroid regulation of serotonin 1A receptor mRNA and binding in the hippocampus.  Neuropsychopharmacology 9:84S, 1993.

17.  López JF, Chalmers D, Vázquez DM, Akil H and Watson SJ.   Serotonin transporter mRNA in the rat brain is regulated by classical antidepressants:  Biological Psychiatry 35:287-290, 1994.

18.  Chalmers DT, López JF, Vázquez DM, Akil H and Watson SJ:   Regulation of hippocampal 5HT1A receptor gene expression by dexamethasone.  Neuropsychopharmacology 10:215-222, 1994.

19.  López JF, Vázquez DM, Akil H and Watson SJ:   Effect of imipramine and swim stress on the hypothalamic-pituitary-adrenal axis.  Endocrine Journal 2:723-728, 1994.

20.  Liberzon I, Chalmers DT, Mansour A, López JF, Watson SJ and Young EA.  Glucocorticoid regulation of hippocampal oxytocin receptors.  Brain Research 650:317-322, 1995.

21.  McLaughlin DP, Little KY, López JF and Watson SJ:  Expression of serotonin transporter mRNA in human brainstem raphe nuclei.  Neuropsychopharmacology 15:523-529, 1996.

22.  Young EA, López JF, Weingberg-Murphy V, Watson SJ and Akil H:  Normal pituitary response to metyrapone in the morning in depressed patients:  Implications for circadian regulation of CRH secretion.  Biological Psychiatry 41:1149-1155, 1997.

23.  Little KY, McLaughlin DP, Rank J, Gilmore J, López JF and Watson SJ:  Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide.  Biological Psychiatry 41:1156-1164, 1997.

24.  López JF, Vázquez DM, Chalmers DT, Akil H and Watson SJ:  Regulation of 5-HT receptors and the Hypothalamic-Pituitary-Adrenal axis:  Implications for the neurobiology of suicide.  Ann NY Acad Sci 836:106-134, 1997.

25. Vázquez DM, Watson SJ and López JF: Hypothalamic-Pituitary-Adrenal Axis and the Termination of the Stress Response: Alterations in Children with Psychosocial Growth Failure. Pediatric Research 43:87, 1998.

26.  López JF, Chalmers DT, Little KY and Watson SJ :  Regulation of 5-HT1A receptor, Glucocorticoid and Mineralocorticoid receptor in rat and human hippocampus:  Implications for the Neurobiology of Depression.  Biological Psychiatry 43:547-573, 1998.

27.  Vázquez DM, López JF, Morano MI, Kwak SP, Watson SJ and Akil, H: Alpha, Beta and Gamma mineralocorticoid receptor mRNA splice variants:  Differential expression and rapid regulation in the developing hippocampus.  Endocrinology 139:3165-3177, 1998.

28. Young EA, López JF, Weingberg-Murphy V, Watson SJ and Akil H:  The role of mineralocorticoid receptors in HPA axis regulation in humans.  J Clin Endocrinol & Metab 83:3339-3345, 1998.

29. Liberzon I, López JF, Flagel SB, Vázquez DM and Young EA:  Differential regulation of hippocampal glucocorticoid receptors and negative feedback: Relevance to post-traumatic stress disorder.  Journal of  Neuroendocrinology 11:11-17, 1999.

30.  López JF, Liberzon I, Vázquez DM,Young EA and Watson SJ:  Serotonin 1a receptor mRNA regulation in the hippocampus after acute stress.  Biological Psychiatry 45:943-947, 1999.

31. López JF, Akil H and Watson SJ: Neural circuits mediating stress. Biological Psychiatry 46:1461-1471, 1999.

32.   Vázquez DM, López JF, Watson SJ and Levine S: Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat. Brain Research 855:76-82, 2000.

33.  Young EA, López JF, Weinberg V, Watson SJ and Akil H: Hormonal evidence for altered responsiveness to social stress in major depression. Neuropsychopharmacology 23:411-418, 2000.

34.  Braham T, López JF, Zimmer CA, Nash A and Vázquez DM: The effect of prenatal dexamethasone treatment on the HPA axis and hippocampal function in the male and female rat. Am J Physiology 279:1899-1909, 2000.

35.  Patel PD, López JF, Lyons DM, Burke S, Wallace M and Schatzberg  AF: Glucocortioid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psych Research 34:383-392, 2000.

36.  Vázquez DM, Eskandari R, Zimmer CA, Levine S and López JF: Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abuse. Psychoneuroendocrinology 27:245-272, 2002.

37.    Stearns V, Ullmer L, López JF, Isaacs C, Hayes DF:  Hot Flashes: New Prospects for an Old Problem. Lancet. 360:1851-61, 2002.

38.  Altemus M, Young E, Luine VN, Wood GE, Lopez JF: Sexually dimorphic effects of stress on learning and memory. Biological Psychiatry 51:93S, 2002

39.  Young EA. López JF. Murphy-Weinberg V. Watson SJ. Akil H. Mineralocorticoid receptor function in major depression. Archives of General Psychiatry. 60:24-8, 2003.

40.  Vázquez DM, Eskandari R, Phelka A and López JF:  The impact of chronic intermittent saline injections and maternal deprivation on brain corticotropin releasing hormone (CRH) circuits: Selective regulation of CRH receptor-2 by desipramine treatment Neuropsychopharmacology. 28:898-909, 2003.

41.  Evans SJ, Choudry PV, Vawter MP, Li J, Meador-Woodruff JH, L López JF, Burke SM, Thompson RG, Myers RM, Jones EG, Bunney WM, Watson SJ. Akil  H.  DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles. Neurobiology of Disease 14:240-250, 2003

42.  López -Figueroa AL, Norton CS, López -Figueroa MO, Burke S, Meador-Woodruff JH, L López JF, Watson SJ.  Serotonin 5-HT1a, 5-HT1b, and 5-HT2a receptor mRNA expression in subjects with Major Depression, Bipolar Disorder and Schizophrenia. Biological Psychiatry 55:225-233, 2004.

43.  Li JZ. Vawter MP. Walsh DM. Tomita H. Evans SJ. Choudary PV. López JF. Avelar A. Shokoohi V. Chung T. Mesarwi O. Jones EG. Watson SJ. Akil H. Bunney WE Jr. Myers RM. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Human Molecular Genetics. 13:609-16, 2004.

44.  Vawter MP. Evans S. Choudary P. Tomita H. Meador-Woodruff J. Molnar M. Li J. López JF. Myers R. Cox D. Watson SJ. Akil H. Jones EG. Bunney WE. Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology. 29:373-84, 2004.

45.  Young EA, Altemus MA, López JF, Kocsis JH, Schatzberg AF, deBattista C. Zubieta J-K: HPA Activation in Major Depression and Response to Fluoxetine: A Pilot Study.  Psychoneuroendocrinology. 29:1198-1204, 2004.

46.  Evans SJ, Choudry PV, Vawter MP, Li J, Meador-Woodruff JH, L López JF, Burke SM, Thompson RG, Myers RM, Jones EG, Bunney WM, Watson SJ. Akil  H.  Dysregulation of the fibroblast growth factor system in major depression. Proceedings of the National Academy of Sciences. 101: 15506-15511, 2004.

47.  López JF: Stress and Antidepressant Modulation of the Limbic HPA Axis. In Neuroimmune Mechanisms and Chronic Fatigue Syndrome. NIH Publication No. 04-5497, 2005

48.   Vazquez DM, Bailey C, Dent GW, Okimoto DK, Steffek A, López JF. Levine S. Brain corticotropin-releasing hormone (CRH) circuits in the developing rat: effect of maternal deprivation.  Brain Research. 1121:83-94, 2006.

49.  Armitage R, Flynn H, Hoffman R, Vazquez DM, López JF, Marcus S. Early Developmental Changes in Sleep in Infants: The Impact of Maternal Depression. SLEEP. 32: 693-696, 2009.

50.  Marcus S, López JF, McDonough S, MacKenzie MJ, Flynn H, Neal CR Jr.,  Gahagan S, Volling B,   Kaciroti N, and Vazquez DM  Depressive Symptoms During Pregnancy: Impact on Neuroendocrine and Neonatal Outcome.  Infant Behav Dev. 34:26-34, 2011.

51.  Williams RA and López JF. Influence of paroxetine and cognitive/behavioral strategies in neurocardiogenic syncope and depression. Open Journal of Psychiatry 1:79-87, 2011.

52.  Vazquez DM, Neal CR, Patel PD, Kaciaroti N, López JF. Regulation of corticoid and serotonin receptor brain system following early life exposure of glucocorticoids: Long term implications for the neurobiology of mood.  Psychoneuroendocrinology 37:421-437, 2012.

53.  Sexton MB, Flynn H, Lancaster C, Marcus S, McDonough S, Volling B, López JF, Kaciroti N, Vazquez DM.  Predictors of Recovery from Prenatal Depressive Symptoms from Pregnancy through Postpartum. J Women’s Health 21: 43-49, 2012.

54.  Lindell SG, Yuan Q, Zhou Z, Goldman D, Higley JD, Thompson RC, López JF, Suomi SJ, Barr CS. The serotonin transporter gene is a substrate for age and stress dependent epigenetic regulation in rhesus. Development and Psychopathology 24:1391-400, 2012.

55.  Berman D, Campbell E, López J, Vasquez D, Marcus S, Treadwell S. Maternal depression and impaired fetal growth. Am J Obstet Gynecol 206:S359, 818, 2012.

56.  Berman D, Campbell E, Treadwell S, Vasquez D, López J, Marcus S Antenatal depression, altered maternal and neonatal neuroendocrine profiles, and fetal growth patterns. Am J Obstet Gynecol 206:S359,812, 2012.

57.  Yuan Q, Zhou Z, Lindell SG, Higley JD, Ferguson B, Thompson RC, López JF, Suomi SJ, Baghal B, Baker M, Mash DC, Barr CS, Goldman D. The rhesus macaque is three times as diverse but more closely equivalent in "damaging" coding variation as compared to the human. BMC Genetics 13:52, 2012.

58.  Novick D, Allbaugh L, Zhao Z, Henshaw E, Vazquez DM., López J, Armitage R, Flynn H, Women’s Mental Health and Infants Program.  Representativeness of obstetric patients for depression-related research findings from the Women's Mental Health and Infants Program (WMHIP) integrated dataset.  Arch Women Ment Health. 17:97-105,2014.

59.  Thomason E, Volling BL, Flynn HA, McDonough SC, Marcus SM, Lopez JF, Vazquez DM. Parenting stress and depressive symptoms in postpartum mothers: bidirectional or unidirectional effects? Infant Behav Dev. 37:406-415, 2014.

60.  Baker MB, Lindell SG, Driscoll CA, Zhou Z, Yuan Q, Schwandt ML, Miller-Crews I, Simpson EA, Paukner A, Razayar M, Lopez JF, Thompson RC, Goldman D, Higley JD, Suomi SJ, Barr CS. Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques. Proc Natl Acad Sci U S A. 114:11769-11774. 2017.

61.  Menke RA, Swanson L, Erickson NL, Reglan G, Thompson S, Bullard KH, Rosenblum K, Lopez JF, Muzik M. Childhood adversity and sleep are associated with symptom severity in perinatal women presenting for psychiatric care. Arch Women Mental Health. 22:457-465, 2019.

62.  Turner CA, Khalil H, Murphy-Weinberg V, Hagenauer MH, Gates L, Tang Y, Weinberg L, Grysko R, Floran-Garduno L, Dokas T, Samaniego C, Zhao Z, Fang Y, Sen Sr S, Lopez JF, Watson Jr SJ, Akil H. The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress. Proc Natl Acad Sci U S A. 120: e2305779120, 2023.

63.  Pacilio R, Lopez JF, Parikh SV, Patel PD, Geller J. Safe ketamine use and pregnancy: A nationwide survey and retrospective review of informed consent, counseling, and testing practices. The Journal of Clinical Psychiatry 85:24m15293, 2024.

Submitted Papers

1. Vazquez DM, McDonough S, Marcus S, Flynn H, Neal CR Jr, Volling B, Kaciroti N, Lopez JF. Hypothalamic-Pituitary-Adrenal function in pregnant women at risk for depression. (submitted).

2.  Swanson L, Chervin RD, Lopez JF, Zollars J, Raglan GB, Shelgikar AV, Mooney AJ, Kelley DuBuc K, de Sibour T, O’Brien LM. Positive Airway Pressure for Prenatal Sleep-Disordered Breathing Reduces Cortisol, but Not Depressive or Sleep Symptoms: A Randomized-Controlled Trial. (submitted).

3. Bader LR, Volling BR, Safyer P, Tengelitsc E, Huth-Bocks A, Hiltz C, Gonzalez R, Tan L, Lopez JF and Vazquez DM. Trajectories of Mother and Infant Cortisol Reactivity Related to Security of the Mother-Infant Attachment Relationship at 14-Month. (submitted)

Electronic Publications

1.     López JF:  Stress, serotonin receptors and the neurobiology of depression.  Cyberounds www.cyberounds.com, 1999.

2.     López JF: The neurobiology of depression. The Doctor Will See You Now  www.thedoctorwillseeyounow.com/articles/ behavior, 2000.

Book Chapter Publications

1.   Watson SJ, Kelsey JE, López JF and Akil H:  Neuropeptide biology:  Basic and clinical lessons from the opioids.  In APA Annual Review, Vol. 4, Chapter 6, 1985.

2.   López JF, Young EA, Herman JP, Akil H and Watson SJ:  The Regulatory Biology of the HPA Axis:  An Integrative Approach.  In CNS Peptide Mechanisms in Stress and Depression, S. Risch ed.  American Psychiatric Press, Inc. 1991, pp. 1-52.

3.   Greden JF and López JF:  Treatment of Major Depression.  In Current Psychiatric Therapy II, D. Dunner ed.  American Psychiatric Press, Inc. 1997.

4.   Vázquez DM and López JF:  Developmental Neuroendocrinology. In The Handbook of Child and Adolescent Psychiatry, Basic Psychiatric Science and Treatment. Joseph D. Noshpitz, Editor-in-Chief;  Norman E. Alessi, Joseph T. Coyle, Saul Isaac Harrison and Spencer ETH, editors;  John Wiley & Sons, Inc.  Vol 6: 3-31. 1998.

5.   Mansour A, Meador-Woodruff JH, López JF and Watson SJ:  Biochemical Anatomy:  Insights Into the Cell Biology and Pharmacology of the Dopamine and Serotonin Systems in the Brain.  In Textbook of Psychopharmacology.  American Psychiatric Press, Inc. 1998.

6.  Charney DS, Barlow DH, Botteron K, Cohen JD, Goldman D, Gur RE, Lin K-M, López JF, Meador-Woodrruff JH, Moldin SO, Nestler EJ, Watson SJ and Zalcman SJ.  Neuroscience Research Agenda to Guide Development of a Pathophysiologically Based Classification System. In A Research Agenda for DSM-V. David J Kupfer, Michael B. First, and Darrel A. Reiger, editors.  American Psychiatric Press, Inc. 2002.

7.  López JF, Neal CR, Meador-Woodruff JH: Methods of Postmortem Investigation of Human Brain. In Neurobiology of Mental Illness (2nd edition). DS Charney and E Nestler editors. Oxford University Press, 2004.

Research Interests

The Neurobiology of Mood Disorders.  The Effects of Stress on the Serotonin System and the HPA axis. The long-term consequences of early life stress. Peripartum Mood Disorders.  

Clinical Interests

Reproductive and Perinatal Psychiatry. Mood Disorders. Treatment-refractory Depression.

Complementary and Alternative Treatments for Mood Disorders.