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Two precursor lesions for testicular germ cell tumors type II, germ cell neoplasia in situ (GCNIS) and microinvasive germ cell tumor (MGCT) (Figure 1b) [5,6], and seminoma (SE) also express an OSKM panel, with SOX17 as substitute for SOX2. In SE, SOX17 stimulates genes that inhibit differentiation [7] but allows SE to be transformed into embryonal carcinoma (EC) [8]. EC is the undifferentiated nonseminomatous (NST) subtype of testicular germ cell tumors type II. The transformation includes a shift from a highly expressed SOX17 in SE to a highly expressed SOX2 in EC and a shift from the OSKM to the OSLN panel [9]. The iPSC panels are driver genes in the tumorigenesis of testicular germ cell tumors type II.

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Nvidia today released the latest 545.84 version of their Game Ready GeForce graphics driver, bringing along a useful quality-of life update to RTX 20-series GPU users in the form of Video Super Resolution (VSR) support. Besides that GeForce family support extension, the new driver also brings about support for DLSS 3-based frame generation for both Naraka: Bladepoint and the already-released, chaotic, bloody fest that is Warhammer: Vermintide 2.

The highlight of this driver in terms of how impactful it will be for the majority of users relates to Nvidia's VSR support. The technology, which aims to improve image quality of stream-compressed videos, now works for even older, lower-resolution content at the mere flick of a driver toggle.

While not directly related to the TensorRT announcement, the AI-acceleration engine that's responsible for an about 70% speedup in AI-related workloads, the added support for AI-based video quality increase does show that Nvidia is still finding more uses for AI and its Tensor cores, even on GPUs that are two product generations old now.

The new VSR 1.5 tech provides even greater clarity and resolution improvements, while also expanding support for RTX 20-series users. It will also improve the quality of video that doesn't need to be upscaled, meaning if you watch a 1080p video on a 1080p monitor, or even 4K content on a 4K monitor. The tech is so good that Microsoft built a version of it straight into the Edge browser.

Almost two years ago to the day, I sponsored a Green Taxi Law requiring San Francisco cab companies to lower their greenhouse gas emissions 20 percent below 1990 levels by 2012. When I announced this goal many said it was unattainable.

We thought it was not only possible, but necessary to reduce our dependence on fossil fuels, clean our air and accelerate a new green economy.

I am pleased to announce that we are well on our way to exceeding this goal. The city's taxi fleet as of this morning is comprised of 55 percent alternative fuel vehicles, including hybrids and compressed natural gas vehicles. These fuel-efficient vehicles have reduced gas consumption by 2.9 million gallons per year and lowered greenhouse gas emissions by 35,000 tons annually. That's the equivalent of taking 4,700 passenger cars off the road.

And its good news for cab drivers too. Even though lower-emission cabs cost a little more to take out for a shift ($104.50 per 10 hour shift instead of $96.50 for a gas vehicle), cab drivers like them because they save money.

Driving a gasoline-powered cab for one shift, about 135 miles, costs a driver anywhere from $28 to $35 in fuel, while filling up a hybrid costs about half that around $15 per shift. The economics behind our environmental decision has made the transition to a green taxi fleet that much easier.

Cab companies also appreciate the operational benefits of alternative-fuel vehicles. San Francisco's hills are hard on taxis, the brakes in particular, and the hybrids save time and money on brake repair. For example, the brakes on a gasoline-powered Crown Victoria have to be changed every 7,000- 8,000 miles -- about once a month -- while the brakes on a hybrid can go about 50,000 miles and only have to be changed every six to eight months.

To make the transition to cleaner vehicles easier, San Francisco developed a grant program to encourage cab companies to purchase alternative-fuel vehicles. We provide Clean Air Taxi Grant incentives of $2,000 per vehicle on a first-come, first-served basis.

In 2004, San Francisco taxi industry leaders Yellow Cab and Luxor Cab were the first cab companies in the United States to adopt hybrid vehicles. Without their innovation and participation, the city's clean taxi policy might have faced more obstacles, or even failed.

In San Francisco, our stakeholders have worked together successfully and have proven that aggressive action is possible at the local level to make major reductions in carbon emissions. Our continued collaboration will help us meet our next goal -- the nation's first 100 percent green taxi fleet.

Snowmaking shortcuts Nature's process. There's no evaporation phase. Rather, water is forced through a specialized nozzle or "gun" where it collides with highly pressurized air. The compressed air shatters the stream of water into minute particles and launches them into the atmosphere where they freeze and fall to the ground. ff782bc1db