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According to the sheet music published at MusicNotes, "Toxic" is composed in the key of C minor, with a tempo of 143 beats per minute. Spears's vocal range spans from the low note of F3 to the high note of G5.[19] Lyrically, "Toxic" talks about being addicted to a lover.[20] Spears refers to her addiction in the lyrics and sings lines such as "Too high / Can't come down / Losing my head / Spinning round and round" in a falsetto. A reviewer from Popdust called the verse "The most representative lyric of the song's delirious, disorienting charm."[17][21] "Toxic" ends with an outro in which Spears sings the lines, "Intoxicate me now / With your lovin' now / I think I'm ready now."[21] Nick Southall of Stylus Magazine said the lyrics made Spears sound afraid of sex.[22]

"Toxic" received acclaim. Heather Richels of The Paly Voice complimented its hook and catchiness while deeming it the most appealing song on In the Zone.[23] While reviewing The Onyx Hotel Tour, Pamela Sitt of The Seattle Times called it the album's strongest single.[24] Eric Olsen of Today stated the song could be the biggest hit off of its parent album while calling it "powerfully addicting."[25] Caryn Ganz of Spin commented, "Spears hits pay dirt on 'Toxic'".[14] Christy Lemire of Associated Press stated it was one of Spears' greatest hits and deemed it "insanely catchy", remarking that the chorus alone "makes you want to forgive the Alias wannabe video that accompanies the song."[26] Stephen Thomas Erlewine of Allmusic called it along with "Showdown", "irresistible ear candy in what is surely Britney's most ambitious, adventurous album to date".[27] In a separate review of Spears' greatest hits album Greatest Hits: My Prerogative (2004), Erlewine selected it as one of the "track picks" and described it as "a delirious, intoxicating rush".[28] Jeffrey Epstein of Out compared the innovative sound of "Toxic" to Madonna's "Vogue".[29]

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"The great pop song of this century. The ultimate Britney Spears classic. A taste of a poison paradise. "Toxic" is all that and more, summing up Britney at her best and brashest. Swedish studio wizards Bloodshy and Avant prove that they're the producers who understand her better than anyone. "Toxic" is a swirl of spaced-out glam-disco kicks, spy-movie strings, surf-guitar twang, a beat that should wear a warning, and Britney's distinctive slithery drawl. She doesn't just take "a sip from the devil's cup," she guzzles that bitch and crushes the cup on her forehead, slipping under the addictive spell of music itself, the one vice she'll never give up. Intoxicate her now? She's ready now."

In the 2005 episode "The End of the World" of the TV show Doctor Who, the character of Cassandra unveils an ancient jukebox that reproduced "Toxic" as an example of "a traditional ballad" from about 5 billion years prior.[166] NME stated that the inclusion of the song marked its cultural impact.[101] In the 2007 film Knocked Up, the song is played when Seth Rogen and Paul Rudd are driving to Las Vegas. Director Judd Apatow explained that he initially tried to use "Toxic" in the 2005 film The 40-Year-Old Virgin in the scene where Leslie Mann is drunk driving.[167] "Toxic" was also featured in the 2010 film You Again.[168] A string arrangement of "Toxic" was featured in the 2020 American thriller film Promising Young Woman, with film score producer Anthony Willis saying that "'Toxic' is one of the greatest pop songs of the [2000s]. It's such a fantastic track and has such an evocative lyric. And so if you hear that riff and you hear that tune, you're imagining the word 'toxic,' but you're not actually hearing it."[169] "Toxic" is featured on British soap opera Emmerdale in July 2021 when Meena Jutla (Paige Sandhu) dances to the song after she murders Leanna Cavanagh (Mimi Slinger).[170] "Toxic" was remixed with Elvis Presley's "Viva Las Vegas" for Baz Luhrmann's Elvis and he planned on releasing it in late 2022.[171][172] It came out on January 6, 2023, as "Toxic Las Vegas", a remix created by Jamieson Shaw.[173][174] "Toxic" was featured on Just Dance 2023 Edition, using the original version of the song instead of The Hit Crew's cover that was used in Just Dance 2 previously.[relevant?]

Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.[1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large. Sometimes the word is more or less synonymous with poisoning in everyday usage.

A central concept of toxicology is that the effects of a toxicant are dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints.[2]

Disease-causing microorganisms and parasites are toxic in a broad sense but are generally called pathogens rather than toxicants. The biological toxicity of pathogens can be difficult to measure because the threshold dose may be a single organism. Theoretically one virus, bacterium or worm can reproduce to cause a serious infection. If a host has an intact immune system, the inherent toxicity of the organism is balanced by the host's response; the effective toxicity is then a combination. In some cases, e.g. cholera toxin, the disease is chiefly caused by a nonliving substance secreted by the organism, rather than the organism itself. Such nonliving biological toxicants are generally called toxins if produced by a microorganism, plant, or fungus, and venoms if produced by an animal.

Physical toxicants are substances that, due to their physical nature, interfere with biological processes. Examples include coal dust, asbestos fibres or finely divided silicon dioxide, all of which can ultimately be fatal if inhaled. Corrosive chemicals possess physical toxicity because they destroy tissues, but are not directly poisonous unless they interfere directly with biological activity. Water can act as a physical toxicant if taken in extremely high doses because the concentration of vital ions decreases dramatically with too much water in the body. Asphyxiant gases can be considered physical toxicants because they act by displacing oxygen in the environment but they are inert, not chemically toxic gases.

Behavioral toxicity refers to the undesirable effects of essentially therapeutic levels of medication clinically indicated for a given disorder (DiMascio, Soltys and Shader, 1970). These undesirable effects include anticholinergic effects, alpha-adrenergic blockade, and dopaminergic effects, among others. [4]

Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). Because individuals typically have different levels of response to the same dose of a toxic substance, a population-level measure of toxicity is often used which relates the probabilities of an outcome for a given individual in a population. One such measure is the LD50. When such data does not exist, estimates are made by comparison to known similar toxic things, or to similar exposures in similar organisms. Then, "safety factors" are added to account for uncertainties in data and evaluation processes. For example, if a dose of a toxic substance is safe for a laboratory rat, one might assume that one-tenth that dose would be safe for a human, allowing a safety factor of 10 to allow for interspecies differences between two mammals; if the data are from fish, one might use a factor of 100 to account for the greater difference between two chordate classes (fish and mammals). Similarly, an extra protection factor may be used for individuals believed to be more susceptible to toxic effects such as in pregnancy or with certain diseases. Or, a newly synthesized and previously unstudied chemical that is believed to be very similar in effect to another compound could be assigned an additional protection factor of 10 to account for possible differences in effects that are probably much smaller. This approach is very approximate, but such protection factors are deliberately very conservative, and the method has been found to be useful in a deep variety of applications.

Assessing all aspects of the toxicity of cancer-causing agents involves additional issues, since it is not certain if there is a minimal effective dose for carcinogens, or whether the risk is just too small to see. In addition, it is possible that a single cell transformed into a cancer cell is all it takes to develop the full effect (the "one hit" theory).

It is more difficult to determine the toxicity of chemical mixtures than a pure chemical because each component displays its own toxicity, and components may interact to produce enhanced or diminished effects. Common mixtures include gasoline, cigarette smoke, and industrial waste. Even more complex are situations with more than one type of toxic entity, such as the discharge from a malfunctioning sewage treatment plant, with both chemical and biological agents.

The preclinical toxicity testing on various biological systems reveals the species-, organ- and dose-specific toxic effects of an investigational product. The toxicity of substances can be observed by (a) studying the accidental exposures to a substance (b) in vitro studies using cells/ cell lines (c) in vivo exposure on experimental animals. Toxicity tests are mostly used to examine specific adverse events or specific endpoints such as cancer, cardiotoxicity, and skin/eye irritation. Toxicity testing also helps calculate the No Observed Adverse Effect Level (NOAEL) dose and is helpful for clinical studies.[5] e24fc04721