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Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool in analysis of protein function, but its use as a therapeutic modality has been limited by inefficient or impractical delivery systems. We have used siRNA incorporated into the neutral liposome 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) for efficient in vivo siRNA delivery. In nude mice bearing i.p. ovarian tumors, nonsilencing siRNA tagged with the fluorochrome Alexa 555 was encapsulated into DOPC liposomes and shown to be taken up by the tumor as well as many major organs. Furthermore, DOPC-encapsulated siRNA targeting the oncoprotein EphA2 was highly effective in reducing in vivo EphA2 expression 48 hours after a single dose as measured by both Western blot and immunohistochemistry. Therapy experiments in an orthotopic mouse model of ovarian cancer were initiated 1 week after injection of either HeyA8 or SKOV3ip1 cell lines. Three weeks of treatment with EphA2-targeting siRNA-DOPC (150 microg/kg twice weekly) reduced tumor growth when compared with a nonsilencing siRNA (SKOV3ip1: 0.35 versus 0.70 g; P = 0.020; HeyA8: 0.98 versus 1.51 g; P = 0.16). When EphA2-targeting siRNA-DOPC was combined with paclitaxel, tumor growth was dramatically reduced compared with treatment with paclitaxel and a nonsilencing siRNA (SKOV3ip1: 0.04 versus 0.22 g; P < 0.001; HeyA8: 0.21 versus 0.84 g; P = 0.0027). These studies show the feasibility of siRNA as a clinically applicable therapeutic modality.

In August, the vivo counselling team in Gulu, Uganda participated in a two-day training course facilitated by Wibke Angelike, a trainer and mediator of non-violent conflict resolution working for the German Civil Peace Service in cooperation with the Justice and Peace Department of the Gulu Archdiocese. Lesen Sie weiter: Understanding and Overcoming Conflicts

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In August, the vivo counselling team in Gulu, Uganda participated in a two-day training course facilitated by Wibke Angelike, a trainer and mediator of non-violent conflict resolution working for the German Civil Peace Service in cooperation with the Justice and Peace Department of the Gulu Archdiocese. Continue reading: Understanding and Overcoming Conflicts

The IVT team also manages the radiation facility and performs irradiation services needed for in vitro and in vivo experiments, including hematopoietic stem-cell transplantations.

For more information, contact IVT manager Tony Sinn at alsinn@iupui.edu or 317-274-8811.

The core is funded, in part, by grants and contracts of the investigators who utilize the facility. Due to the variety of in vivo models and drug regimens requested, the specific costs of a study will be calculated once the study design is finalized.

In vivo testing, especially in clinical trials, is a vital aspect of medical research in general. In vivo studies provide valuable information regarding the effects of a particular substance or disease progression in a whole, living organism.

Welcome to the Stanford Center for Innovation in In vivo Imaging (SCi3), the primary small animal and translational imaging shared resource serving our diverse, multi-disciplinary research community.

Individual Entry: Travel and stay arrangements for the student and 1 parent/guardian/teacher will be made by Team vivo Ignite. Group Entry: Travel and stay arrangements for the group and only 1 parent/guardian/teacher will be made by Team vivo Ignite

Once you have submitted the entry, you will need to keep innovating, adding elements and working on the prototype to enter the Grand Finale. To know more about the next steps and key milestones of the programme, please visit www.vivoignite.com.

When a study is performed in vivo, it can include things like performing experiments in an animal model, or in a clinical trial in the case of humans. In this case, the work is taking place inside a living organism.

In vivo, very few sperm actually go on to potentially fertilize the egg. In fact, selection of specific sperm populations is mediated in the fallopian tube. During IVF, sperm selection can only be partially mimicked.

However, the dynamics of selection within the fallopian tube as well as the qualities of the sperm populations selected in vivo is an area of increased study. Researchers hope that findings will better inform sperm selection for IVF.

The two terms are essentially opposites of each other. But can you remember which is which? One way to do this is to note that in vivo sounds like words referring to life, such as live, viable, or vivacious. ff782bc1db