Download Transporter Season 2

The series follows the events and concept of the film trilogy, continuing the adventures of Frank Martin, a professional freelance courier driver for hire who will deliver anything, anywhere for the right price, and lives by three "unbreakable" rules, which he frequently breaks. Chris Vance takes over the role of Frank from Jason Statham and was joined in season 1 by Andrea Osvrt as his office manager Carla Valeri, Charly Hbner as mechanic Dieter Hausmann and Franois Berland, the only returning actor from the film series, reprising his role as Inspector Tarconi.[8] The second season added Violante Placido as Caterina "Cat" Boldieu, his new booking agent. Unlike Carla, who did not return for the second season, Cat usually joins Frank on his adventures.[9]

In UK, the show started on 12 July 2015 on Channel 5. In the United States, TNT announced in January 2014 that it had picked up Transporter: The Series,[4] and began airing the show with back-to-back episodes on Saturday, 18 October 2014. TNT's sister network through Time Warner, Cinemax was previously due to air the series, but at the Television Critics Association 2013 Summer Press Tour confirmed that they would end their involvement with the series without showing it after all.[2] The premiere of season #2 aired on 29 November 2014 on TNT, which immediately followed the completion of the airing of season #1 the week before.[citation needed]

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Confusingly, RTL in Germany, M6 in France and TNT in the U.S., have all aired the first-season episodes in different orders, as compared to those shown by HBO/SE1 in Canada and Channel 5 in the UK, which have been shown sequentially, as detailed below:

Context: It is a common experience in temperate zones that individuals feel happier and more energetic on bright and sunny days and many experience a decline in mood and energy during the dark winter season. Brain serotonin is involved in the regulation of physiologic functions, such as mating, feeding, energy balance, and sleep. Although these behaviors and serotonin-related conditions show a clear seasonal pattern in humans, the molecular background of seasonal changes in serotonin function is entirely unknown. The serotonin transporter is a key element in regulating intensity and spread of the serotonin signal.

Objectives: To detect seasonal variations in serotonin transporter binding in the living human brain and to detect correlations between serotonin transporter binding and duration of daily sunshine.

Design: Regional serotonin transporter binding potential values, an index of serotonin transporter density, were assessed from December 1, 1999, to December 9, 2003, in a consecutive sample of healthy volunteers. Binding potential values were related to meteorologic data.

Results: Serotonin transporter binding potential values were significantly higher in all investigated brain regions in individuals investigated in the fall and winter compared with those investigated in the spring and summer (P = .01 to .001). Moreover, binding potential values showed negative correlations with average duration of daily sunshine in all brain regions (rho = -0.21 to -0.39; P = .05 to

Conclusions: Serotonin transporter binding potential values vary throughout the year with the seasons. Since higher serotonin transporter density is associated with lower synaptic serotonin levels, regulation of serotonin transporter density by season is a previously undescribed physiologic mechanism that has the potential to explain seasonal changes in normal and pathologic behaviors.

Cross-sectional neuroimaging studies in non-depressed individuals have demonstrated an inverse relationship between daylight minutes and cerebral serotonin transporter; this relationship is modified by serotonin-transporter-linked polymorphic region short allele carrier status. We here present data from the first longitudinal investigation of seasonal serotonin transporter fluctuations in both patients with seasonal affective disorder and in healthy individuals. Eighty (11)C-DASB positron emission tomography scans were conducted to quantify cerebral serotonin transporter binding; 23 healthy controls with low seasonality scores and 17 patients diagnosed with seasonal affective disorder were scanned in both summer and winter to investigate differences in cerebral serotonin transporter binding across groups and across seasons. The two groups had similar cerebral serotonin transporter binding in the summer but in their symptomatic phase during winter, patients with seasonal affective disorder had higher serotonin transporter than the healthy control subjects (P = 0.01). Compared to the healthy controls, patients with seasonal affective disorder changed their serotonin transporter significantly less between summer and winter (P < 0.001). Further, the change in serotonin transporter was sex- (P = 0.02) and genotype- (P = 0.04) dependent. In the patients with seasonal affective disorder, the seasonal change in serotonin transporter binding was positively associated with change in depressive symptom severity, as indexed by Hamilton Rating Scale for Depression - Seasonal Affective Disorder version scores (P = 0.01). Our findings suggest that the development of depressive symptoms in winter is associated with a failure to downregulate serotonin transporter levels appropriately during exposure to the environmental stress of winter, especially in individuals with high predisposition to affective disorders.media-1vid110.1093/brain/aww043_video_abstractaww043_video_abstract.

Heterotrophic microbes in the Southern Ocean are challenged by the double constraint of low concentrations of organic carbon (C) and iron (Fe). These essential elements are tightly coupled in cellular processes; however, the prokaryotic requirements of C and Fe under varying environmental settings remain poorly studied. Here, we used a combination of metatranscriptomics and metaproteomics to identify prokaryotic membrane transporters for organic substrates and Fe in naturally iron-fertilized and high-nutrient, low-chlorophyll waters of the Southern Ocean during spring and late summer.

Pronounced differences in membrane transporter profiles between seasons were observed at both sites, both at the transcript and protein level. When specific compound classes were considered, the two approaches revealed different patterns. At the transcript level, seasonal patterns were only observed for subsets of genes belonging to each transporter category. At the protein level, membrane transporters of organic compounds were relatively more abundant in spring as compared to summer, while the opposite pattern was observed for Fe transporters. These observations suggest an enhanced requirement for organic C in early spring and for Fe in late summer. Mapping transcripts and proteins to 50 metagenomic-assembled genomes revealed distinct taxon-specific seasonal differences pointing to potentially opportunistic clades, such as Pseudomonadales and Nitrincolaceae, and groups with a more restricted repertoire of expressed transporters, such as Alphaproteobacteria and Flavobacteriaceae.

The combined investigations of C and Fe membrane transporters suggest seasonal changes in the microbial requirements of these elements under different productivity regimes. The taxon-specific acquisition strategies of different forms of C and Fe illustrate how diverse microbes could shape transcript and protein expression profiles at the community level at different seasons. Our results on the C- and Fe-related metabolic capabilities of microbial taxa provide new insights into their potential role in the cycling of C and Fe under varying nutrient regimes in the Southern Ocean.

Heterotrophic prokaryotes consume roughly half of primary production and thereby influence the flux of carbon through the marine food web. The transformation of phytoplankton-derived organic matter by prokaryotes shapes the amount and quality of dissolved organic matter (DOM) that can accumulate in surface waters on a seasonal time scale and eventually be exported to depth via overturning circulation [1,2,3].

The concentration and composition of a variety of individual compounds that make up the pool of DOM determine its overall bioavailability and thus the quantity of carbon (C) that can be transformed over different time scales [4]. This process is regulated by inorganic nutrients essential for microbial metabolism. Nitrogen and phosphorus are the primary growth-limiting factors for heterotrophic prokaryotes in different regions of the oligotrophic ocean [1], and these nutrients might lead to seasonal accumulation of DOM in surface waters [2, 5]. In the Southern Ocean, where these macronutrients persist at high concentrations throughout the seasons, the trace element iron (Fe) is a limiting or co-limiting factor for prokaryotic growth [5,6,7]. These previous observations from experimental studies provide, however, restricted information on the temporal and spatial variability of the requirements of Fe by Southern Ocean prokaryotes.

Marine DOM is composed of diverse substrates of varying bioavailability. The complexity of organic compounds contained in DOM has become more accessible through advances in analytical methods [6, 7]. Concurrently, the chemical characterization and quantification of numerous siderophores have provided novel insights into Fe biogeochemistry [8]. However, organic substrate and Fe-uptake strategies of diverse prokaryotic taxa are still poorly understood. Expression profiles of microbial transporter genes can be used as an indicator to describe patterns of organic matter uptake and to link these to taxonomy [9,10,11]. Metaproteomic studies have revealed that a wide range of organic molecules participate in the microbial DOM flux [12,13,14]. Metatranscriptomics provided insights into the microbial uptake of a suite of highly labile organic substrates, including nitrogen-containing compounds such as taurine [15] and one-carbon compounds such as methanol [16], fatty acids [15], and sulfonates [17]. In a similar manner, the use of different forms of inorganic and organically bound Fe by diverse prokaryotes was illustrated [18,19,20]. However, combined investigations of C and Fe transporters under changing resource supply remain scarce [21, 22]. e24fc04721