The Spectrum TV App is a FREE mobile app that allows Spectrum TV customers to stream live TV and On Demand content on a smartphone, tablet or smart TV, Apple TV, Xumo TV (also known as Xclass TV), Xumo Stream Box, Roku, Xbox One or Google Chromecast. The app lets you stream Spectrum TV at home or on-the-go. You can also program your DVR, browse the channel guide, set parental controls and search for content with the Spectrum TV App.

For kinase inhibitors, intracellular target selectivity is fundamental to pharmacological mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymatic inhibition, such approaches can fail to accurately predict engagement in cells. Here we report the application of an energy transfer technique that enabled the first broad-spectrum, equilibrium-based approach to quantitatively profile target occupancy and compound affinity in live cells. Using this method, we performed a selectivity profiling for clinically relevant kinase inhibitors against 178 full-length kinases, and a mechanistic interrogation of the potency offsets observed between cellular and biochemical analysis. For the multikinase inhibitor crizotinib, our approach accurately predicted cellular potency and revealed improved target selectivity compared with biochemical measurements. Due to cellular ATP, a number of putative crizotinib targets are unexpectedly disengaged in live cells at a clinically relevant drug dose.


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Hey folks,

When tuning a live sound system, do any of you use a spectrum analyzer? I am trying to determine a quantifiable way to tune a large scale sound system for live DJ events. I downloaded an SA app on my phone (well aware that the mic on my phone is likely far from accurate enough) just to toy with how the sound profile changes based on location.

I'd like to get into understanding how to EQ a system with objective measurable results. Some other questions: What should the spectrum look like in a 'perfect' system? Flat across the board? Scooped? multiple peaks?

The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products. The latter is a class of organisms developed exclusively for pharmaceutical application. In this Perspective, we discuss what lessons have been learned from working with traditional probiotics, explore the kinds of organisms that are likely to be used as novel microbial therapeutics, discuss the regulatory framework required, and propose how scientists may meet this challenge.

Unbelievable that in this day and age, we cannot pause, rewind, FF live tv using Xumo/Spectrum App. We received our Xumo devices this week, hooked them up, thought they were great, until I wanted to go to the bathroom and tried to pause what I was watching. Nope, cannot do that. We are back to our cable boxes. However, I might keep the Xumo devices, since they are inexpensive, for streaming and in the hopes that they figure out how to add pausing live TV.

In order to rewind live TV there needs to be something recording and storing content as it is watched. Even traditional cable needs a DVR to do this, and we do offer a Cloud DVR service which can grant those capabilities through the Spectrum TV app.

At this time no device that has access to use the Spectrum TV app has the ability to pause/rewind/fast forward live TV. That is only an ability of the physical DVR boxes we offer. There is no information as to if or when this function will be available on the app.

I'm sorry, we do have Cloud DVR service that will allow you to start an in-progress recording and then view that recording with rewind/fast forward up until live. I will be happy to forward your feedback about this feature without the DVR.

We just received our xumo and started spectrum streaming. We cloudDVR the national news every evening. It appears that we cannot fast forward through the commercials and unwanted stories with the xumo but our Roku will do it. What am I missing???.

At this time pause/rewind/fast forward on live TV is not available on any device using the Spectrum TV app. This feature is solely available on the physical DVR boxes. I can definitely forward that feedback up for you as well.

Xumo is a rolling train wreck. Constantly get error messages either channel or program we are watching live is unavailable, recordings are unavailable while in midstream (same error message as with channels), switches channels to some random one, shuts off, unable to preview while fast forwarding, cannot page up or down, cannot get to what you want to watch via guide (must input channel number while not in guide), & finally, remote that works only when it wants to. Had tech replace line to the house & now on to the 2nd box. Nothing has helped!

I'd like to clarify some things regarding pausing live TV. Even with traditional cable TV service pausing was only ever possible with a DVR or VCR actively recording what you are watching to a harddrive in the DVR or cassette in the VCR. It is only Live TV when at the very latest moment available in the broadcast, so you can never really pause live only switch between live and a recording.

Our tv's currently have a spectrum cable box for live tv, and a roku for emby. We use the tv remote to switch between hdmi ports. I'd like to just watch live tv via emby if possible. I'm planning to ditch the roku, and just use a mini pc either running emby theater or kodi w/ emby. Currently checking out kodi, it's interesting, but training the family on a new interface will just create more tension, so just using emby theater is preferred right now.

I do not recommend self install. It's worth the cost to put spectrum on the hook for the installation which probably requires a a tuning adapter and all the proper set up on their end. Plan on at least 4 hours with the tech if you get one who knows what they are doing.

I just spent an hour at my local Spectrum store. Their computers suck, the tech tried to order one, it wouldn't let him. The manager tried for 30 minutes, it wouldn't let him. He tried to order inventory for his store, wouldn't let him. He tried to schedule a tech, and have the tech bring a card, wouldn't let him. He called around to the other local spectrum stores, nobody had one.

Figures, I just checked, good 'ole FedEx says they made a delivery attempt, which is a lie, I've been here all day, it's raining. Maybe they forgot to knock. So, maybe tomorrow. I doubt it. Probably have to wait until Monday, and tape a note on the door "hey fedex dude please knock or just leave the package"

RTSPECT is a free program for displaying a real time waveform and spectrum display of an audio signal. With RTSPECT you can monitor the waveform and spectral shape of sounds being played into the computer's microphone or line input ports. RTSPECT can display one or two-channel audio signals.

Running Channels on two different Nvidia Shield Android boxes. Cable is Spectrum digital through a pair of HD-DVR HDHomeRun CableCard boxes. if I'm watching live tv, after a while the video lags waay behind the audio and the frame rate drops more and more as time goes on. The buffer automatically increases, similar to if I had paused livetv, but the audio is usually current. The fix is to click right on the d-pad till everything catches up. This happens on both Shield boxes and is a daily occurrence.

One thing I noticed is that the drift starts when a local Spectrum commercial block comes on. I'm not sure what Spectrum is doing when they insert their commercials, but whatever it is, it makes Channels get confused, and the lag begins. If I leave live TV on all day the video can be hours behind the audio.

Built as a Bokeh server application, with periodic callbacks handling the 1) spectrum data generation or live data 2) Scikit-learn calls to train with the new data available and 3) Look for changes to the interactive slider UI which changes the moving window or memory size of the radio data to put into scikit-learn.

Hey folks


Bit of an odd one but I happen to use Vegas (18 Pro) to edit podcasts - yup I know, but as a multitrack audio editor it just works great!


I was wondering though if there was a plugin of some kind, maybe a VST or something that I can have on my channels so as Im editing I can see the spectrum of frequencies as the tracks play. A bit like the Loudness Meters window I can have activated or the video histogram (but essentially for audio).

In Tibetan tradition, there is an image of the hungry ghost, a figure of the imaginal realms with a large, distended belly and tiny mouth. No matter how much food (experience) is consumed, there is a deep ache and longing for more. Regardless of how much is taken in, the ghost retains an insatiable hunger. Because this one is not able to digest, make use of, or enjoy what is given, a primordial hole is left behind that can never seem to be filled. One invitation, as this image appears in our own lives, is to slow way down and send awareness and compas- sion directly into the hole, infusing it with presence and warmth, and finally tend to what is already here, not what is missing and might come one day in the future by way of further procurement. 2351a5e196

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