So I was looking through the thread of people's favourite kairo games and thought I'd give pocket stables another try because I just never got into it and wanted to mix things up, and I am just godawful at that game. Seriously. I've looked online for strategies and everyone's just like "this is how i bred the ultimate horse" I can't even GET to the breeding stage.

To encourage visitors, you're asked to train horses to win races; the more you win, the more money you have to spruce up your stables. There are various facilities you can use to increase the stats of your chosen steeds, and you can hire jockeys to automatically set them on a given training regime. You can spend a bit extra on specialist exercises for an instant boost to dexterity or stamina, for example, but the speed stat is the only one you really need to keep an eye on.


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In other words, all you have to show for your efforts is a larger and prettier set of stables, while your horses become little more than a commodity. Combine that with the ruinously low difficulty level and Pocket Stables feels hollow and cynical. Kairosoft's traditionally cutesy trappings aren't enough to save this one from the knacker's yard.

Hey there, fellow gamers! Buckle up because I've got a wild ride for you! Introducing Pocket Stables, the game that puts you in the saddle as the ultimate ranch manager. Get ready to gallop toward greatness and train your racehorses to compete for that elusive Triple Crown! Yeehaw!


In this adrenaline-pumping extravaganza, you'll be running the show at your very own ranch. From feeding and grooming your majestic steeds to expanding your facilities, it's your job to turn your stable into the talk of the town. And trust me, I've seen some stables, but with your expertise, this one's gonna be legendary!


Get the hooves tapping by honing your horses' skills and giving them the training they need to reach their full potential. Speed? Check. Stamina? Check. Charisma? Well, we won't be entering any beauty pageants, but hey, we can work with that too!


But hold onto your saddles, folks - it's race time! Step into the virtual jockey seat and guide your trusty steed through exhilarating tracks and nail-biting competitions. You'll be pushing those reins to the limit, strategizing when to make that epic sprint to the finish line. It's all about timing, baby!


And let's not forget about the Triple Crown. This is the big leagues, my friends, where only the best of the best can claw their way to victory. So, saddle up, grab yourself a lucky horseshoe, and get ready to make history!


Get ready to immerse yourself in a horse racing adventure like no other. With addictive gameplay, stunning visuals, and more horse puns than you can shake a crop at, Pocket Stables is sure to keep you horsing around for hours.


So what're you waiting for? Gather your digital jockeys, roll up those sleeves, and let's transform that humble ranch into a legendary stable where dreams go to gallop, and champions are born! Giddy up, my friends!

With a significant number of beneficiaries facing the donut hole choosing to forgo medications altogether rather than switch to a generic (or pay out of pocket for the branded version), pharma finds itself struggling not only to maintain brand loyalty, but also to convince affected beneficiaries of the importance of sticking with treatment.

‘No, sir—not a moment—for he was saying this very minute,’ answered the domestic, ‘he had them in his pocket, and the key of Miss Mary's room along with them; he took it from Flora Guy, the maid, scarce a quarter of an hour ago.’ ‘Then all is right,’ said Blarden, while the momentary blackness of suspicion passed from his face, ‘the girl's in some hole or corner of this lumbering old barrack, but here comes Chancey himself, what's all the fuss about—who's in the upper room—the—the boudoir, eh?’ he continued, addressing the barrister, who was sneaking downstairs with a candle in his hand, and looking unusually sallow.

‘Ay, dear me, to be sure I have, except the one that I gave to little Bat there, to let you in this minute. I have the three other keys; dear me—dear me—what could ail me?’ And so saying, Chancey slapped the skirt of his coat slightly so as to make them jingle in his pocket.

‘Get horses—horses all,’ shouted he, ‘to the stables—by Jove, it was they we met on the road—the two girls—quick to the stables—whoever catches them shall have his hat full of crowns.’

With the fall season completed, horse sales were in full swing and dozens of stables were bustling with activity as I drove around looking for a place to park. The sun was just starting to crest the horizon and there was an unmistakable serenity present as I made my way to the famous grandstands where scenes from the movies Seabiscuit and Secretariat were filmed. Having been at the fall meet two years prior with thousands of other fans, it was stunningly silent. Beautifully silent. Slowly that began to change as a handful of horses made their way to the track to do some breezing.

In my mind\u2019s eye I could see my grandpa\u2014the way I remember him looking\u2014laughing with his brothers while standing along the rail, beer in hand with a Daily Racing Form in his back pocket. It\u2019s a sight I never actually got to see in my own lifetime, but the vision of them was so real to me it was as if the sound of each breezing thoroughbred had pumped life through their veins. Call it romanticism or nostalgia, but the surrealness of it all had a profound effect on me that beautiful autumn morning. I found myself in wonderful spirits with little doubt as to why they had been lifted.

I have some serious doubts about the validaty of the experimental design.

The authors investigate the binding mode of Rubromycin to HIV-RT. In the introduction it is already mentioned that they also inhibit telomerase. Furthermore these compounds inhibit other polymerases.(Mizushina, et al 2000) The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin. 


These compounds were found to be direct DNA substrate competitors or interact with DNA. These proteins do not have an NNRTI binding side, but all of them have a DNA interacting surface ... It is unclear on what ground the authors have decided that these compounds would bind to the NNRTI pocket in HIV-RT. This should at least be added to the manuscript. 

As a remark. The insensitivity towards certain resistance mutations can also be explained by binding to a different binding site. 


Furthermore the compounds do not exhibit any similarity with previous inhibitors. In fact the overall shape of the compounds is very different from Rilpivirine. Please indicate why the Rilpivirine structure was choosen and not one of the many other HIV-RT inhibitors complexes. As this pocket is very flexibile it addapts to the ligand. Therefore, in the case the compounds truly would work by binding to the pocket it is important to select the correct conformation of the binding receptor, as this will influence the docking results. 

It would have been better to choose different receptor conformations and dock in all of them instead of just one conformation, analyse these results before continuing the results.

The authors have not shown that they have produced stables simulations (no run-away ligands , stable RMSD during the simulation)


The authors have performed MM/PBSA simulations, this produces a binding affinity which should correlate with the inhibitory portency (IC50 or Ki) in case of a correct simulation. There is no such figure in the manuscript. 


And all results depend on hypothesis that these compounds act by binding into the NNRTI pocket which remains unvalidated. ff782bc1db

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