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The novel concerns the efforts of retired police officer, Luke Fitzwilliam, to discover the identity of a serial killer, active in the village of Wychwood under Ashe. He learns that the series of deaths were mistaken for accidents by the locals, while the nobleman Lord Whitfield mysteriously attributes most of them to divine justice.

Luke believes Ellsworthy to be the killer because of his mental instability. Seeing Ellsworthy return home with blood on his hands adds to this image. Later on in that day, Luke and Miss Waynflete witness Whitfield arguing with his chauffeur, Rivers, who had taken Whitfield's Rolls-Royce for a joyride. Luke finds Rivers dead, hit by a decorative stone. Luke and Bridget realise that they are in love with each other, and Bridget tells Gordon of her decision to break off her engagement with him. Speaking to Luke, Gordon makes an odd statement. He claims that God kills people that do him harm, dispensing divine justice upon wrongdoers. Whitfield mentions that Mrs Horton had argued with him, Tommy Pierce did mocking impressions of him, Harry Carter shouted at him while drunk, Amy Gibbs was impertinent to him, Humbleby disagreed with him on the village water supply, and Rivers used his car without permission and then spoke disrespectfully to him; and all of them died soon afterwards. Whitfield predicts that Luke and Bridget, having wronged him, will soon meet their fates too.

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Luke changes his mind about who is responsible for the deaths, considering Whitfield as the murderer. He consults Miss Waynflete, who confirms his suspicions, and tells him of how she knew he was insane: when they were younger, Waynflete and Whitfield had been engaged to be married. But one evening, Whitfield killed the bird that she kept as a pet, with the appearance that he enjoyed doing it, and she says she ended their engagement.

Luke and Bridget decide that Bridget will leave Whitfield's estate to stay at Honoria Waynflete's house. Luke collects their luggage and prepares to leave, while Bridget and Honoria take a walk in the woods. Honoria reveals herself to be the murderer. During her engagement to Whitfield, Honoria had killed her own pet bird after it bit her, which prompted Gordon to abandon the engagement. She vowed revenge on Gordon, and decided to set him up for crimes he did not commit. She encouraged him in the belief that God exacted immediate retribution from those who disrespected him.

Honoria had poisoned the tea for Lydia Horton, while encouraging others to believe the problem was in the grapes sent by Whitfield. Honoria killed Amy by swapping the bottles around in the night and locking the door from the outside using pincers. She killed Carter by pushing him off the bridge on the day he had a row with Whitfield, and she likewise pushed Tommy Pierce out of the window while he was working. Whitfield had been the one to assign Tommy to this job.

Honoria had seen that Lavinia Pinkerton realised she was the killer and that Humbleby would be her next victim. Honoria had followed Lavinia into London and then pushed her in front of a passing car. Honoria framed Whitfield by telling a witness that she saw the registration number of Whitfield's Rolls-Royce. After inviting Humbleby round to her house, she cut his hand with scissors. She then applied a dressing to the wound, a dressing with pus seeping from her cat's ear; Humbleby dies a few days later from blood infection. After witnessing Rivers being sacked, Honoria hits him with a sandbag and caves his skull in with the stone pineapple.

Honoria drugs Bridget's tea and takes her into the woods, where the two of them begin talking. Bridget has not drunk the tea (though Honoria doesn't know that) and is ready for what comes. Honoria reveals a knife covered in Whitfield's fingerprints, and informs Bridget that she will kill her and leave the knife at the scene. Further, Honoria arranges for Whitfield to be seen walking alone through the area where Bridget's body will be. Instead, Bridget fights with Honoria. Luke realises that Honoria is the murderer and rescues Bridget. Bridget and Luke leave the village to live together as a married couple.

The Times Literary Supplement of 10 June 1939 published a review of the book by Maurice Percy Ashley, together with And Death Came Too by Richard Hull which began "A week in which new novels by Mr Hull and Mrs Christie appear should be a red letter week for connoisseurs of detective fiction. One must, however, reluctantly confess that neither of them is fully up to standard."

After considering in isolation And Death Came Too, Ashley turned his attention to Murder Is Easy and started, "Mrs Christie has abandoned M. Hercule Poirot in her new novel, but it must be confessed that his understudy, Luke Fitzwilliam, a retired policeman from the Mayang States is singularly lacking in 'little grey matter.' Poirot may have recently become, with advancing years, a trifle staid, but absence makes the heart grow fonder of him." After outlining the basics of the plot and the romantic interests of the main character, Mr Ashley concluded, "He (Luke) is less effective a detective than as a lover, which is not surprising since neither he nor the reader is provided with any clear clues pointing to the fantastically successful murderer. The love interest scarcely compensates for the paucity of detection and the characters verge on caricature; nor is Fitzwilliam able to recapture vividly enough the circumstances of the earlier murders."[4]

In The New York Times Book Review for 24 September 1939, Kay Irvin said the book was "one of Agatha Christie's best mystery novels, a story fascinating in its plot, clever and lively in its characters and brilliant in its technique." She concluded, "The story's interest is unflagging, and the end brings excitement as well as surprise."[5]

William Blunt in The Observer of 4 June 1939 raised a question regarding Christie's abilities to write non-crime fiction, which demonstrates that her pen name identity of Mary Westmacott was not yet public knowledge: "I should hate to have to state on oath which I thought was Agatha Christie's best story, but I do think I can say that this is well up in the first six. The humour and humanity of its detail raise a question which only one person can give an answer. Agatha Christie has grown accustomed to working her embroidery on a background of black. Could she, or could she not, leave death and detection out, and embroider as well on green? I believe she is one of the few detective novelists who could. If she would let herself try, just for fun. I believe it would be very good fun for other people, too."[6]

A 2009 adaptation,[12] with the inclusion of Miss Marple (played by Julia McKenzie), was included in the fourth series of Agatha Christie's Marple; it deviated significantly from the novel by removing some of the characters in it, while adding new ones and changing those left in. New subplots were introduced, and the murderer's motive was changed:

A novel alcohol-based antiseptic and a novel water-based antiseptic lotion, both with a synergistic combination of antimicrobial ingredients containing 0.2% benzethonium chloride, were evaluated using the standard time-kill method against 25 FDA-specified challenge microorganisms. The purpose of the testing was to determine whether a non-alcohol product could have equivalent rapid and broad-spectrum kill to a traditional alcohol sanitizer. Both the alcohol- and water-based products showed rapid and broad-spectrum antimicrobial activity. The average 15-s kill was 99.999% of the challenge organism for the alcohol-based antiseptic and 99.971% for the water-based antiseptic. The alcohol-based product demonstrated 100% of peak efficacy (60s) within the first 15s, whereas the water-based product showed 99.97%. The novel alcohol-based antiseptic reduced concentrations of 100% of organisms by 99.999%, whereas the water-based antiseptic lotion showed the same reduction for 96% of organisms. A novel water-based antiseptic product demonstrated equivalent rapid, broad-spectrum antimicrobial activity to an alcohol-based sanitizer and provided additional benefits of reduced irritation, persistent effect, and greater efficacy against common viruses. The combination of rapid, broad-spectrum immediate kill and persistent efficacy against pathogens may have significant clinical benefit in limiting the spread of disease.

Ticks are hematophageous arthropods that transmit a wide spectrum of pathogens to human and animals. The ability of an acaricidal product to kill ticks quickly provides an important added benefit, especially as protecting dogs from tick bites remains the best preventive measure against tick-borne diseases. The speed of kill of afoxolaner in a novel soft chewable formulation (NexGardTM) against induced infestations with Ixodes ricinus adult ticks was evaluated during a full-month negative controlled and blinded study following a single oral administration.

12 healthy beagle dogs were included and randomly allocated to 2 groups of six dogs each. One Group was a negative control while the other group was treated with an oral formulation of afoxolaner on Day 0. Tick infestations with 40 (5) female and 10 male adult unfed I. ricinus were performed on Days -1, 7, 14, 21 and 28. To evaluate immediate efficacy, the number of live ticks were thumb counted at 12 and 24 hours post treatment. To evaluate the persistent speed of kill following further infestations, ticks were thumb counted 12 and 24 hours post infestations. Ticks were removed 24 hours post treatment or infestation.

This study demonstrated that besides the excellent acaricidal efficacy of afoxolaner after single oral administration, the product has a rapid speed of kill against one of the most important European tick species and controlled the weekly re-infestations for 28 days post treatment.

The objective of the present study was to assess immediate efficacy of this novel oral formulation of afoxolaner (NexGardTM, Merial) against an existing I. ricinus tick infestation and its persistent preventive speed of kill against subsequent infestations with I. ricinus ticks within the first hours post- treatment or subsequent re-infestation. e24fc04721