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Carnitine orotate complex (Godex) improved mitochondrial function. (A) Hepatic oxidative phosphorylation (OXPHOS) enzyme activity, (B) transmission electron microscope images of liver mitochondria (15,000) (C) proteins expression in mitochondrial metabolism in the liver (D) mitochondrial contents in C57BL/6J mice during 8 weeks of normal-fat diet (ND) or high-fat diet (HFD) feeding. HFD mice were subdivided into vehicle-treated (HFD), Godex 500 mg/kg/body weight (B.W.) (HFD+G500), and Godex 2,000 mg/kg/B.W. (HFD+G2000) groups. Scale bar: 40 m. To correct for mitochondrial volume, all OXPHOS enzyme activities were normalized by the activity of citrate synthase. Data are presented as meanstandard deviation (n=10). (E) mitoTracker staining intensity in HepG2 cells after treatment with 800 M palmitic acid (PA) with 150 g/mL Godex for 24 hours (400). (F) proteins expression in mitochondrial metabolism in HepG2 cells after treatment with 150 g/mL Godex for 24 hours. -Actin was used as the loading control for normalization. Data are presented as meanstandard deviation (n=10). SIRT1, sirtuin 1; PGC1, peroxisome proliferator-activated receptor-gamma coactivator 1; NRF1, nuclear respiratory factor 1; mtCOX1, mitochondrial cytochrome c oxidase subunit 1; HPRT, hypoxanthine phosphoribosyltransferase. a,b,c,dValues within groups indicate significant difference at P

Muoio et al. [10] showed that muscle-specific ablation of CrAT caused systemic glucose intolerance by inhibition of PDH, and blunted the normal postprandial rise in glucose oxidation; however, carnitine treatment, which increases tissue acetylcarnitine efflux, could stimulate the PDH complex in muscle [10,48]. It was previously suggested that CrAT could regulate mitochondrial acetyl-CoA/CoA balance and PDH activity [10,49]. Acetyl-CoA is a critical intracellular metabolite poised to regulate many cellular processes, including transcription, post-translational modifications, and metabolism [50]. G2000 group showed an increase in PDH activity through modulation of CrAT activity and the acetyl-Co/CoA ratio in the liver. Moreover, G2000 group showed a significant increase in PDH activity through modulation of the acetyl-Co/CoA ratio via increased CrAT activity in the skeletal muscle. Significant reduction of plasma lactate level, after the supply of Godex, suggests the activation of PDH, which could increases the oxidation of glucose and OXPHOS from mitochondria. Furthermore, Godex could increase glucose uptake by controlling the expression of membrane GLUT4 in myotubes, which were reversed by blocking CrAT expression.

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Typically I put the Godox X1 trigger on camera, then use a hotshoe optical slave to fire the YN 560 T trigger. Or I can stack the YN trigger on top of the Godox trigger. Either way I have control of all flashes within reach. Stacking units feels awkward to me, but could be handy outdoors or in setups where the slave cannot "see" the main flash.

Yes, you can stack triggers, because the YN-622 transceivers have a full TTL passthrough hotshoe (the Godox X1T does not, btw). If you use a YN-622 on top of the camera to control your 622s, and an X1T or XPro on top of the 622 to control the Godox Witstro strobe, then you can get both systems to work together.

This will be substantially more of a PITA, though, than using a YN-622-TX, especially if you aren't shooting Canon. The YN-622 controls aren't nearly as nice as those of the YN-622-TX (which has no passthrough hotshoe), and I believe you only have camera menu control over the 622 wireless functions if you're using a Canon DIGIC 4 (or later) body.

The Yongnuo YN-622 tranceivers and commander also allows perfect off-camera control of non-brand flash units, such Olympus flash speedlights to work on and off Nikon camera bodies, and fire together with numerous Nikon flashes at the same time - with full remote control via the YN-622n-tx in the hotshoe, or a YN-622n in the hotshoe, or via a TTL cable connected to YN-622N.

There is NO way you are going to get "perfect" and "full remote control" of an off-camera non-Nikon iTTL speedlight using the YN-622-n gear. The YN-622 triggers are only available in Nikon or Canon versions and require the camera, speedlights and all trigger units to be that same flavor to have TLL/HSS/remote manual power control. Add an Olympus speedlight to the mix and at best case you will only be able to fire it.

The AD200 and AD600 don't have flash feet. They are studio strobes. The only way to get TTL, HSS, or remote power control through them is via their built-in radio receivers. Any external add-on receiver (e.g., a YN-622) cabled to them will be manual-only, regardless of whether or not the trigger can communicate TTL/HSS with its hotshoe, because they're not using the hotshoe, they're using the sync port. And that only has the sync (fire) signal, as it only has two connections: sync and ground. With 3.5/2.5mm phone plugs/jacks, tip is sync and ring is ground. With PC, center pin is sync, and outer pin is ground.

The flash + & - exposure of the SB800 in TTL can of course still be adjusted remotely by direct control of the camera or on-camera Yongnuo (which relays directly to the off-camera SB800 as if it were planted on the camera). Any exposure adjustment on the Olympus, if needed, can also be done using camera controls of aperture/shutter/ISO, or by simply spinning the wheels on the back of the FL50 fitted to the flash grip/bracket.

A third way to use both flashes off camera, is to slide the Nikon speedlight into one Yongnuo YN622n hotshoe placed completely off-camera, and the Olympus flash in a second YN622n hotshoe placed off-camera, and then simply control both flashes units via a Yongnuo YN622N-tx fitted in the hotshoe of the Nikon body.

If you only have two Yongnuo YN622n but want to fire three mixed flashes remotely from the camera, for example a Nikon SB910, an SB800 and an Olympus FL50R/Panasonic FL500 together. Simply place a Nikon & Panasonic flash off-camera on seperate YN622n hotshoes, and set the SB800 to SU4. Then all three flash units will fire off-camera simultaneously at your controlled settings.

then I stand corrected. I assumed based upon your description that TTL auto flash exposure and remote manual power control were part of the deal. Glad you have a way to use different brands of flash gear together.

Or wirelessly fire two Nikon & Olympus flashes at the same time using the Panasonic camera, or visa-versa using Nikon bodies. Doing this, I have unlimited options, and can combine Auto, TTL and Manual control of the light, without the need to carry many extra flashes for each camera system. 2351a5e196