Louis-Felix Nothias

Louis-Felix Nothias, PhD

Louis Felix Nothias has a PhD degree in organic and analytical chemistry (2015), applied to the study of antiviral secondary metabolites from Euphorbia plants found in Corsica (France). Co-mentored by the Pr. Jean Costa (University of Corsica), and the Dr. Marc Litaudon (University Paris-Saclay, France), he has been trained in bioassay-guided fractionation, isolation, structural elucidation by NMR, and metabolite profiling by tandem mass spectrometry and molecular networking.

He joined the Prof. Pieter Dorrestein lab (UC San Diego) as a post-doctoral researcher in March 2016, where he performs mass spectrometry-based metabolomics, and bioinformatics data analysis. Since its arrival, he contributed to the development of new methods, such as 3D-molecular cartography (collaboration Dorrestein-Alexandrov at EMBL, Heidelberg), or feature-based molecular networking, as well as generated multiple public spectral libraries available on GNPS (NIH natural products, pesticides). Currently, he is participating to a research project on the molecular cartography of skin psoriasis, and lead a study on the influence of biotic factors and abiotic factors on plant metabolome and microbiome, such as endophyte or pesticides (MSCA fellow). Louis Felix has a strong interest in application of machine learning based-tools for the annotation of tandem mass spectrometry data (collaboration Dorrestein-Boecker at University of Jena, Germany), especially its integration with molecular networking on GNPS.