Department of Molecular Microbiology

We study Actinobacteria (Streptomyces, Mycobacteria), focusing on:

• chromosome organization during the cell cycle, including the roles of topoisomerases, nucleoid-associated proteins, and condensins.

• chromosome replication and its regulation by chromosome topology.

• mechanisms of chromosome segregation, particularly the role of the ParAB system.

• coordination of the cell cycle, including the synchronization of chromosome segregation with cell division and cell elongation.

• regulation of gene expression, emphasizing the influence of chromosome topology and transcriptional regulators.

• morphogenesis and apical cell growth.

• antibiotic biosynthesis and the activation of silent biosynthetic pathways.