INFORMS Workshop on Data Science 2025, hosted by INFORMS College on Artificial Intelligence, is a premier research conference dedicated to developing novel data science theories, algorithms, and methods to solve challenging problems in business and society. The conference provides a venue for innovative data science studies that solve business and societal problems from the lens of data mining and machine learning, ranging from marketing and finance problems to health care, cybersecurity, and social network problems. Studies on theoretical and methodological foundations of data science, such as optimization for machine learning and new algorithms for data mining, are also welcome.