Woodroof starts selling the drugs in Dallas on the street, at gay nightclubs, and at discotheque bars. He reluctantly sets up a partnership with Rayon since she can bring in more customers. The pair establish the Dallas Buyers Club, charging $400 per month for membership and giving away the drugs to members, in order to circumvent the laws that made it illegal to sell the drugs. The club is extremely popular, and Woodroof gradually begins to respect Rayon as a friend. When Woodroof is hospitalized for a heart attack caused by an overdose of recently acquired interferon from Japan, Dr. Sevard learns of the club and its alternative drugs and is angry that the buyers club is interfering with his trial. The FDA confiscates the interferon and threatens to have Woodroof arrested. Dr. Saks agrees that there are benefits to clubs for HIV drugs, but feels powerless to change anything. The process the FDA uses to research, test, and approve drugs is considered flawed and part of the problem for people suffering from AIDS. At that time, the United States and the FDA were particularly conservative by international standards in testing and approving anti-AIDS drugs and were hostile to imported drugs to the point they were made contraband.[4] Dr. Saks and Woodroof begin a friendship.

The FDA gets a warrant to raid the buyers club but can do nothing but fine Woodroof. The FDA changes its regulations in 1987, making any unapproved drug illegal. With the club strapped for cash, Rayon begs her father for money and tells Woodroof that she has sold her life insurance policy to raise money. Woodroof travels to Mexico to get more peptide T. Upon his return, he finds that Rayon has died in the hospital and is extremely upset by her death. Dr. Saks is asked to resign when the hospital discovers she had been sending patients to the buyers club, but she refuses and insists they will have to fire her instead.


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After Rayon's death, Woodroof begins to show more compassion toward gay, lesbian, and transgender members of the club, and making money becomes less of a concern; his priority becomes providing the drugs. Peptide T gets increasingly challenging to acquire. Woodruff files a lawsuit against the FDA in late 1987, seeking the legal right to take the protein, which has been confirmed as nontoxic, but is still not FDA-approved. The judge is sympathetic toward him and admonishes the FDA, but lacks the power to do anything. The FDA later allows Woodroof to take peptide T for personal use. He dies of AIDS in 1992, seven years later than his doctors initially had predicted.

The characters of Rayon and Dr. Eve Saks were fictional; the writers had interviewed transgender AIDS patients, activists, and doctors for the film and combined these stories to create the two composite supporting roles.[97] However, Woodroof did lose all his friends after they found out he was HIV-positive. In his interviews with Borten, Woodroof implied that this, along with interactions with gay people living with AIDS through the buyers club, led to a rethinking of his apparent anti-gay sentiments and changed his views on gay people. Other people who knew him said that he did not harbor anti-gay sentiments; the real Woodroof was openly bisexual and assumed he had contracted HIV from sexual encounters with men.[98][99] Also, while a rodeo enthusiast, he never rode any bulls himself.[100] Although the film shows Woodroof diagnosed in 1985, he told Borten that a doctor had informed him he might have had the disease well before that; Woodroof believed that he may have been infected in 1981, something that was briefly alluded to in a flashback in the film.[19]

The treatments that Woodroof did promote were less-effective at best, or at worst, dangerous. According to Staley, Woodroof became a proponent of Peptide T, a treatment which "never panned out. It's a useless therapy, and it never got approved, and nobody uses it today, but the film implies that it helped him."[105] DDC, also promoted by Woodroof, did prove to be an effective antiviral treatment, but it also proved to have worse side effects than AZT, with the potential to cause irreversible nerve damage in some cases. As a result, it was only used by doctors for a relatively short time.[105] A third treatment promoted by Woodroof, called Compound Q (Trichosanthin), was specifically linked to two deaths during trials, and therefore, was not used by doctors thereafter. Most "buyers clubs" stopped providing it as well, but Woodroof continued to dispense it, part of the reason for Woodroof's conflict with the FDA.[105]

Over the next year, (1986) Woodroof begins selling the drugs on the street and at gay nightclubs. He comes back into contact with Rayon, with whom he reluctantly sets up business since she can bring many more customers. The pair establish the "Dallas Buyers Club", charging $400 per month for membership, and it becomes extremely popular. He gradually begins to respect Rayon and think of her as a friend. When Woodroof has a heart attack caused by a recently acquired dose of interferon, Sevard learns of the club and the alternative medication. He is angry that it is interrupting his trial, while the FDA confiscates the interferon and threatens to have Woodroof arrested. Saks agrees that there are benefits to AIDS medicine buyers clubs (of which there are several around the country) but feels powerless to change anything. The processes that the FDA uses to research, test and approve drugs are seen as flawed and a part of the problem for AIDS patients. Saks and Woodroof strike up a friendship.

As time passes, Woodroof shows compassion towards gay, lesbian, and transgender members of the club and making money becomes less of a concern; his priority is provision of the drugs. Peptide T gets increasingly difficult to acquire, and in 1987 he files a lawsuit against the FDA. He seeks the legal right to take the protein, which has been confirmed as non-toxic but is still not approved. The judge is compassionate toward him and admonishes the FDA, but lacks the power to do anything. As the film ends, on-screen text reveals that the FDA later allowed Woodroof to take peptide T for personal use and that he died of AIDS in 1992, seven years later than his doctors initially predicted. e24fc04721

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