Although it is generally assumed that brain damage predominantly affects only the function of the damaged region, here we show that focal damage to critical locations causes disruption of network organization throughout the brain. Using resting state fMRI, we assessed whole-brain network structure in patients with focal brain lesions. Only damage to those brain regions important for communication between subnetworks (e.g., "connectors")--but not to those brain regions important for communication within sub-networks (e.g., "hubs")--led to decreases in modularity, a measure of the integrity of network organization. Critically, this network dysfunction extended into the structurally intact hemisphere. Thus, focal brain damage can have a widespread, nonlocal impact on brain network organization when there is damage to regions important for the communication between networks. These findings fundamentally revise our understanding of the remote effects of focal brain damage and may explain numerous puzzling cases of functional deficits that are observed following brain injury.

Critical Access Hospitals (CAHs) are located in 45 states across the U.S. and the Flex Monitoring team tracks and regularly updates CAH locations. This page contains a list of CAHs with the most current data. These data are based on CMS reports, augmented by information provided by state Flex Coordinators and data collected by the North Carolina Rural Health Research Program on hospital closures. Historical CAH data from 2004 to the present is also available. Only states that have CAHs are available to select in the state dropdown list below.


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Floods affected more than 2 billion people worldwide from 1998 to 2017 and their occurrence is expected to increase due to climate warming, population growth and rapid urbanization. Recent approaches for understanding the resilience of transportation networks when facing floods mostly use the framework of percolation but we show here on a realistic high-resolution flood simulation that it is inadequate. Indeed, the giant connected component is not relevant and instead, we propose to partition the road network in terms of accessibility of local towns and define new measures that characterize the impact of the flooding event. Our analysis allows to identify cities that will be pivotal during the flooding by providing to a large number of individuals critical services such as hospitalization services, food supply, etc. This approach is particularly relevant for practical risk management and will help decision makers for allocating resources in space and time.

- If you dealt enough internal damage to destroy the body part, or all critical locations are destroyed, the body part is considered destroyed. Excess damage flows to the next body part (left arm -> left torso). Does this damage target torso-armor, or does it go straight for internal structure?

In November of 2020, the Department streamlined the process of determining if a practice is in an area of critical need (ACN). In May 2022, new Determinations were issued which replaced the November 2020 Determination. An updated Determination was issued on August 10, 2022, which replaces all prior Determinations. This new Determination identifies the ACNs in Florida to be in primary care and mental health Health Professional Shortage Areas (HPSA), Volunteer Health Care Provider Program participant locations, or in a free clinic, if the free clinic is not located in a HPSA. The Determinations keeps language that allows physicians with an active ACN license to maintain that license until it is due for renewal, even if the location where the physician practices loses its HPSA designation.

In mathematics, a critical point is the argument of a function where the function derivative is zero (or undefined, as specified below).The value of the function at a critical point is a critical value.[1]

More specifically, when dealing with functions of a real variable, a critical point, also known as a stationary point, is a point in the domain of the function where the function derivative is equal to zero (or where the function is not differentiable).[2] Similarly, when dealing with complex variables, a critical point is a point in the function's domain where its derivative is equal to zero (or the function is not not holomorphic).[3][4] Likewise, for a function of several real variables, a critical point is a value in its domain where the gradient norm is equal to zero (or undefined).[5]

It follows from these definitions that a differentiable function f (x) has a critical point x0 with critical value y0, if and only if (x0, y0) is a critical point of its graph for the projection parallel to the x-axis, with the same critical value y0. If f is not differentiable at x0 due to the tangent becoming parallel to the y-axis, then x0 is again a critical point of f, but now (x0, y0) is a critical point of its graph for the projection parallel to y-axis.

Critical points play an important role in the study of plane curves defined by implicit equations, in particular for sketching them and determining their topology. The notion of critical point that is used in this section, may seem different from that of previous section. In fact it is the specialization to a simple case of the general notion of critical point given below.

A multiple root of the discriminant correspond either to several critical points or inflection asymptotes sharing the same critical value, or to a critical point which is also an inflection point, or to a singular point.

For a function of several real variables, a point P (that is a set of values for the input variables, which is viewed as a point in R n {\displaystyle \mathbb {R} ^{n}} ) is critical if it is a point where the gradient is zero or undefined.[5] The critical values are the values of the function at the critical points.

A critical point (where the function is differentiable) may be either a local maximum, a local minimum or a saddle point. If the function is at least twice continuously differentiable the different cases may be distinguished by considering the eigenvalues of the Hessian matrix of second derivatives.

A critical point at which the Hessian matrix is nonsingular is said to be nondegenerate, and the signs of the eigenvalues of the Hessian determine the local behavior of the function. In the case of a function of a single variable, the Hessian is simply the second derivative, viewed as a 11-matrix, which is nonsingular if and only if it is not zero. In this case, a non-degenerate critical point is a local maximum or a local minimum, depending on the sign of the second derivative, which is positive for a local minimum and negative for a local maximum. If the second derivative is null, the critical point is generally an inflection point, but may also be an undulation point, which may be a local minimum or a local maximum.

For a function of n variables, the number of negative eigenvalues of the Hessian matrix at a critical point is called the index of the critical point. A non-degenerate critical point is a local maximum if and only if the index is n, or, equivalently, if the Hessian matrix is negative definite; it is a local minimum if the index is zero, or, equivalently, if the Hessian matrix is positive definite. For the other values of the index, a non-degenerate critical point is a saddle point, that is a point which is a maximum in some directions and a minimum in others.

By Fermat's theorem, all local maxima and minima of a continuous function occur at critical points. Therefore, to find the local maxima and minima of a differentiable function, it suffices, theoretically, to compute the zeros of the gradient and the eigenvalues of the Hessian matrix at these zeros. This requires the solution of a system of equations, which can be a difficult task. The usual numerical algorithms are much more efficient for finding local extrema, but cannot certify that all extrema have been found.In particular, in global optimization, these methods cannot certify that the output is really the global optimum.

When the function to minimize is a multivariate polynomial, the critical points and the critical values are solutions of a system of polynomial equations, and modern algorithms for solving such systems provide competitive certified methods for finding the global minimum.

Some authors[7] give a slightly different definition: a critical point of f is a point of R m {\displaystyle \mathbb {R} ^{m}} where the rank of the Jacobian matrix of f is less than n. With this convention, all points are critical when m < n.

The link between critical points and topology already appears at a lower level of abstraction. For example, let V {\displaystyle V} be a sub-manifold of R n , {\displaystyle \mathbb {R} ^{n},} and P be a point outside V . {\displaystyle V.} The square of the distance to P of a point of V {\displaystyle V} is a differential map such that each connected component of V {\displaystyle V} contains at least a critical point, where the distance is minimal. It follows that the number of connected components of V {\displaystyle V} is bounded above by the number of critical points.

Implement and maintain risk-informed countermeasures, and policies protecting people, borders, structures, materials, products, and systems associated with key operational activities and critical infrastructure sectors. 17dc91bb1f

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