Download Beta Profiles
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AirPods beta firmware for Apple Developer Program members enables development of features on iOS and macOS for AirPods. This program also enables debugging of issues by Apple with on-in log collection. This release includes improvements to Automatic Switching and various bug and stability fixes.
-Secretase complexes are involved in the generation of amyloid- (A) in the brain. Therefore, -secretase has been proposed as a potential therapeutic target in Alzheimer disease (AD). Targeting -secretase activity in AD requires the pharmacological dissociation of the processing of physiological relevant substrates and the generation of "toxic" A. Previous reports suggest the differential targeting of -secretase complexes, based on their subunit composition, as a valid strategy. However, little is known about the biochemical properties of the different complexes, and key questions regarding their A product profiles should be first addressed. Here, we expressed, purified, and analyzed, under the same conditions, the endopeptidase and carboxypeptidase-like activities of the four -secretase complexes present in humans. We find that the nature of the catalytic subunit in the complex affects both activities. Interestingly, PSEN2 complexes discriminate between the A40 and A38 production lines, indicating that A generation in one or the other pathway can be dissociated. In contrast, the APH1 subunit mainly affects the carboxypeptidase-like activity, with APH1B complexes favoring the generation of longer A peptides. In addition, we determined that expression of a single human -secretase complex in cell lines retains the intrinsic attributes of the protease while present in the membrane, providing validation for the in vitro studies. In conclusion, our data show that each -secretase complex produces a characteristic A signature. The qualitative and quantitative differences between different -secretase complexes could be used to advance drug development in AD and other disorders.
Starting in iOS 16.4, registered developers will have an option to enable developer betas directly in Settings. Apple is automatically enabling this setting for devices with beta profiles installed, assuming that the device is logged into iCloud with the same Apple ID used to enroll in the Apple Developer Program.
Apple uses device profiles for multiple reasons. One is mobile device management profiles, that organizations can use to remotely configure devices. Another, is authorization for beta downloads from Apple servers.
Beta profiles, including for the developer beta of iOS 16.4, have been made available on the Internet by individuals other than Apple. Presumably, this change has been made to stifle that distribution.
blockquoteBeginning with iOS & iPadOS 16.4 beta, members of the Apple Developer Program will see a new option to enable developer betas directly from Software Update in Settings. This new option will be automatically enabled on devices already enrolled in the program that update to the latest beta release. Your iPhone or iPad must be signed in with the same Apple ID you used to enroll in the Apple Developer Program in order to see this option in Settings. In future iOS and iPadOS releases, this new setting will be the way to enable developer betas and configuration profiles will no longer grant access.
Apple released the first beta of iOS 16.4 on Thursday, just a bit over three weeks after the public release of iOS 16.3. New emoji have already been discovered, as have changes to Podcasts, web app push notifications in iOS Safari, and more.
Thanks for the question Thomas (internalnote.com). In short, yes. We're working on a new apps panel for the Customer Profile Page now, and it will be flexible. We will release the new apps panel before the page moves out of open beta. The team working on this are just getting started, so I can't comment on a release date yet.
Hi Brett,
It's not about editing so much as being able to immediately first see any important notes, or custom fields, such as a VIP field. It's also extremely common and needed to be able to see the language.
In the new version, all of these things have been removed from the default view. I also see no way to return to the ticket you clicked through from. Will this be possible in the final version? Will there be any flexibility in allowing us to choose what shows in Customer Details vs what is in "More Information"?
Will this impact what admins can see for agent profiles as well as end-user profiles?
No. The new experience is for viewing your customer (end user) profiles only. If you navigate to the profile page of a Team Member (agent, admin or account owner), then the existing User Profile Page will be shown.
There have been a number of questions about whether profiles for cameras such as the D90 and D300 were supposed to appear in the Camera Calibration panel. Did anyone get any answer to this? I was unable to find an answer on Adobe site.
One more quirk when deleting the beta profiles: any image which was using a beta profile seems to look the same as when using the new released profiles, but the calibration tab no longer shows the profile name (with or without the term beta in it).
What does happen with all the photos which has one of the beta profiles attached?
I like to switch them to the new profiles before removing the beta ones. Is there a way to filter all of these photos by a filter or something like this.
For me, they migrated over to the released profiles automatically. However, as I mentioned in my blog, there may have been changes to the profiles between beta and release. Since my work flow applies camera calibration first, all my images could have some unexpected results by getting ride of beta profiles. So I would try both the beta and release profiles on the same image and make sure the results appear to be the same.
So far I have not seen any differences in my work so I deleted the beta profiles. It would have been nice to have a list of those profiles that changed between beta and release, but using the above procedure worked well for me.
FF preference selected is 'download updates but let me install them' but really there is no choice. It installs and next opening of FF it is automatically installed. I already changed about:config preference for update channel to 'release' but FF merrily kept on with beta channel updates.
iPadOS 14 developer beta 1 is aimed at advanced users and software developers, but technically speaking anyone who enrolls in the Apple Developer program is able to access the iPadOS 14 beta profile, along with the same profiles for macOS Big Sur beta, iOS 14 beta, tvOS 14 beta, and watchOS 7 beta. Casual users who are interested in beta testing ipadOS should instead wait a few weeks for the public beta program to become available to everyone.
While this is obviously aimed at developers and those in the Apple Developer program, theoretically anyone who obtains one can install an iPadOS 14 beta profile onto an eligible iPad and install it onto their device. Despite being a technical possibility, doing so is not recommended, and for more casual users a better approach is to wait for the iPadOS 14 public beta to begin in July.
Private beta sites aren't really private, in that anybody can join via Area 51. But they've always been "mostly private"; they don't show up in users' network profiles, the hamburger list, the list of all sites, or migration options (for moderators). They're there, but the paths to them are limited.
When I've been a user on private betas I've been frustrated that I didn't have convenient access from the rest of the network, so this might well be intentional. On the other hand, private betas still don't show up on the list of all sites, so maybe it wasn't intended.
APIs under the /beta version in Microsoft Graph are subject to change. Use of these APIs in production applications is not supported. To determine whether an API is available in v1.0, use the _______ selector.
Microsoft Graph SDKs use the v1.0 version of the API by default, and do not support all the types, properties, and APIs available in the beta version. For details about accessing the beta API with the SDK, see Use the Microsoft Graph SDKs with the beta API. 5376163bf9
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