Visiting Scientist

Department of Pharmacology

University of California, San Diego

9500 Gilman Drive

La Jolla, CA 92093-0601

For deliveries, add: BSB Room 4080

Phone: (858)-534-8903

Email: vmouchlis@ucsd.edu

Home Town: Nicosia, Cyprus

Education

Ph.D., Rational Design and Synthesis of Phospholipase A2 Inhibitors, University of Athens, Greece (2007-10)

M.Sc., Organic Synthesis and its Applications in the Chemical Industry, University of Athens, Greece (2005-07)

B.Sc., Chemistry, University of Athens, Greece (2001-05)

Publications

Mouchlis, V. D.; Mavromoustakos, T. M.; Kokotos, G., Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor. J. Comput.-Aided Mol. Des. 2010, 24, 107-15. PMID: 20130961

Mouchlis, V. D.; Mavromoustakos, T. M.; Kokotos, G., Molecular docking and 3D-QSAR CoMFA studies on indole inhibitors of GIIA secreted phospholipase A₂. J. Chem. Inf. Model. 2010, 50, 1589-1601. PMID: 20795712

Tzoupis, H.; Leonis, G.; Durdagi, S.; Mouchlis, V.; Mavromoustakos, T.; Papadopoulos, M. G., Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson-Boltzmann surface area calculations. J. Comput.-Aided Mol. Des. 2011, 25, 959-976. PMID: 21969102

Mouchlis, V. D.; Magrioti, V.; Barbayianni, E.; Cermak, N.; Oslund, R. C.; Mavromoustakos, T. M.; Gelb, M. H.; Kokotos, G., Inhibition of secreted phospholipases A₂ by 2-oxoamides based on alpha-amino acids: Synthesis, in vitro evaluation and molecular docking calculations. Bioorg. Med. Chem. 2011, 19, 735-743. PMID: 21216150

Mouchlis, V. D.; Barbayianni, E.; Mavromoustakos, T. M.; Kokotos, G., The application of rational design on phospholipase A₂ inhibitors. Curr. Med. Chem. 2011, 18, 2566-2582. PMID: 21568891

Mouchlis, V. D.; Michopoulou, V.; Constantinou-Kokotou, V.; Mavromoustakos, T.; Dennis, E. A.; Kokotos, G., Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A₂ determined by molecular docking combined with molecular dynamics. J. Chem. Inf. Model. 2012, 52, 243-254. PMID: 22196172

Mouchlis, V. D.; Melagraki, G.; Mavromoustakos, T.; Kollias, G.; Afantitis, A., Molecular modeling on pyrimidine-urea inhibitors of TNF-α production: an integrated approach using a combination of molecular docking, classification techniques, and 3D-QSAR CoMSIA. J. Chem. Inf. Model. 2012, 52, 711-723. PMID: 22360289

Zhang, L.; Sedykh, A.; Tripathi, A.; Zhu, H.; Afantitis, A.; Mouchlis, V. D.; Melagraki, G.; Rusyn, I.; Tropsha, A., Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Toxicol. Appl. Pharmacol. 2013, 272, 67-76. PMC3775906

Bucher, D.; Hsu, Y. H.; Mouchlis, V. D.; Dennis, E. A.; McCammon, J. A., Insertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations. PLoS Comput. Biol. 2013, 9, e1003156. PMC3723492

Mouchlis, V. D.; Bucher, D.; McCammon, J. A.; Dennis, E. A., Membranes serve as allosteric activators of phospholipase A₂, enabling it to extract, bind, and hydrolyze phospholipid substrates. PNAS 2015, 112, E516-E525. PMC4330758

Mouchlis, V. D.; Limnios, D.; Kokotou, M. G.; Barbayianni, E.; Kokotos, G.; McCammon, J. A.; Dennis, E. A., Development of potent and selective inhibitors for group VIA calcium-independent phospholipase A₂ guided by molecular dynamics and structure-activity relationships. J. Med. Chem. 2016, 59, 4403-4414. PMC4946799

Mouchlis, V. D.; Morisseau, C.; Hammock, B. D.; Li, S.; McCammon, J. A.; Dennis, E. A., Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A₂. Bioorg. Med. Chem. 2016, 24, 4801-4811. PMC5053890

Antonopoulou, G.; Magrioti, V.; Kokotou, M. G.; Nikolaou, A.; Barbayianni, E.; Mouchlis, V. D.; Dennis, E. A.; Kokotos, G., 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A₂ with reduced lipophilicity. Bioorg. Med. Chem. 2016, 24, 4544-4554. PMC5014611

Mouchlis, V. D.; Dennis, E. A., Membrane and inhibitor interactions of intracellular phospholipases A₂. Adv. Biol. Regul. 2016, 61, 17-24. PMC4884535

Smyrniotou, A.; Kokotou, M. G.; Mouchlis, V. D.; Barbayianni, E.; Kokotos, G.; Dennis, E. A.; Constantinou-Kokotou, V., 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A₂ inhibitors. Bioorg. Med. Chem. 2017, 25, 926-940. PMC5291822

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