Gosia Murawska, Ph.D.
Postdoctoral Researcher
Department of Pharmacology
University of California, San Diego
9500 Gilman Drive
La Jolla, CA 92093-0601
For deliveries, add: BSB Room 4080
Phone:
Background
Gosia received her Bachelor's degree from the University of Warsaw, Poland. She then joined the Stratingh Institute from the University of Groningen, Netherlands, for her Master's degree and completed her thesis in the group of Prof. Dr. Ben L. Feringa. She then did a 6 month internship at Novartis Institutes for BioMedical Research and worked as an RA at Berkeley, California. She graduated Cum Laude from University of Basel in 2021. Gosia won several grants along her journey.
Research Experience
2021- present: Postdoc in the group of Prof. Edward Dennis in the field of lipidomics.
2017-2021: PhD student in the area of chemical protein silencing.
2016-2017: Research Assistant at Lawrence Berkeley National Laboratory, Joint BioEnergy Institute Feedstocks Division at Berkeley, California, US under the supervision of Dr. Jenny Mortimer.
Project: Investigating the role of lipid glycosylation in cell wall biosynthesis.
2016: 6 month internship in organic chemistry at the Novartis Institutes for Biomedical Research under the supervision of Dr. Siem Veenstra.
Project: Synthesis of drug precursor and enzyme inhibitors.
2013: 3 month internship at the University of Groningen, NL under the supervision of Dr. W. Szymanski, Prof. D. Janssen.
Project: Process optimization for a haloalkane dehalogenase-catalyzed kinetic resolution of racemic haloamides.
Education
Ph.D., Cum Laude, in Chemical Biology, Department of Chemistry, University of Basel, Switzerland.
Supervisor: Prof. Dennis Gillingham
Project: Study and exploitation of the direct DNA repair protein O6-Methylguanine Methyltransferase - MGMT
Master’s Degree in Organic Chemistry, Stratingh Institute, University of Groningen, The Netherlands.
Supervisor: Prof. Dr. Sir Ben L. Feringa
Project: Synthesis of overcrowded alkene switch for modification of peptides; Synthesis of a photoswitchable AT-hook useful for photocontrolling DNA peptide binding interactions.
Bachelor’s Degree in Chemistry, University of Warsaw, Poland
Project: Isolation and characterization of humic acids of natural and chemical origin.
Grants
2020: Swiss National Science Fundation SNSF, Mobility in project, Basel, Switzerland (8250 CHF)
2015: Backer Fundation Scholarship, Groningen, Netherlands (2000 €)
2015: Marco Polo Scholarship, Groningen, The Netherlands (1200 €)
2015: Groninger Universiteits Fonds Scholarship, Groningen, The Netherlands (400 €)
2014: Fundusz Stypendialny KIK, Warsaw, Poland (470 €)
Publications
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron
ACS Chem Biol, 2022, https://pubs.acs.org/doi/10.1021/acschembio.1c00771
Plants with altered sphingolipid glycosylation have increased resistance to biotrophic but not necrotrophic pathogens
B. Jing, T. Ishikawa, N. Soltis, N. Inada, Y. Liang, Gosia M. Murawska, L. Fang, F. Anderbehan, V. Pidatala, X. Yu, E. Baidoo, M. Kawai-Yamada, D. Kliebenstein, D. Loque, P. Dupree, J. Mortimer, Plant Direct, 2021, 5, e00309. doi:10.1002/pld3.309
Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading
D. Yan, S. R. Yadav, A. Paterlini, W. Nicolas, J. Pettit, L. Brocard, I. Belevich, M. Grison, A. Vatén, L. Karami, S. el-Shawk, J.-Y. Lee, Gosia M. Murawska, J. Mortimer, M. Knoblauch, E. Jokitalo, J. Markham, E. Bayer and Y. Helariutta
Nat. Plants 2019, 5, 604─615. doi:10.1038/s41477-019-0429-5
Comparative Study of Photoswitchable Zinc‐Finger Domain and AT‐Hook Motif for Light‐Controlled Peptide–DNA Binding
Gosia M. Murawska, C. Poloni, N. A. Simeth, W. Szymanski and B. L. Feringa
Chem. Eur. J. 2019, 25, 4965─4973. doi:10.1002/chem.201900090
GONST2 transports GDP-Mannose for sphingolipid glycosylation in the Golgi apparatus of Arabidopsis
B. Jing, T. Ishikawa, N. Soltis, N. Inada, Y. Liang, Gosia M. Murawska, F. Andeberhan, R. Pidatala, X. Yu, E. Baidoo, M. Kawai-Yamada, D. Loque, D. J. Kliebenstein, P. Dupree and J. C. Mortimer
bioRxiv 2018. doi:10.1101/346775
Loss of inositol phosphorylceramide sphingolipid mannosylation induces plant immune responses and reduces cellulose content in Arabidopsis
L. Fang, T. Ishikawa, E. A. Rennie, Gosia M. Murawska, J. Lao, J. Van, A. YL Tsai, E. E. K. Baidoo, J. Xu, J. D. Keasling, M. Kawai-Yamada, T. Demura, H. V. Scheller and J. C. Mortimer
The Plant Cell 2016. doi:10.1105/tpc.16.00186
Computational Library Design for Increasing Haloalkane Dehalogenase Stability
R. J. Floor, H. J. Wijma, D. I. Colpa, A. Ramos-Silva, P. A. Jekel, W. Szymanski, B. L. Feringa, S. J. Marrink and D. B. Janssen
ChemBioChem 2014, 15, 1660─1672. doi:10.1002/cbic.201402128
(Acknowledged for HPLC method development)