Alexander Andreyev, Ph.D.
Project Scientist
9500 Gilman Drive
La Jolla, CA 92093-0601
Phone: (858) 822-5850
Fax: (858) 534 - 7390
email: andreyev@ucsd.edu
arrived: March 2005
Home Town: Moscow, Russia
Education
M.Sc. (with high distinction), Chemistry, Moscow State University, 1981. Thesis: Chemical determinism in genetic code: correlation of chemical parameters of amino acids and their anticodon nucleotides
Ph.D. Biochemistry, Moscow State University, 1988. Dissertation: ATP/ADP antiporter is involved in fatty acid-induced uncoupling of oxidative phosphorylation in skeletal muscle mitochondria
Current research topics
Subcellular localization of lipids in macrophages
Macrophage production of novel oxylipins (derivatives of eicosapentaenoic, docosahexaenoic and adrenic acid)
Regulation of oxilipin production, mitochondrial function and oxidative stress in stimulated macrophages on the protein expression level
Publications
L.S. Iaguzhinskii, A. Andreev. Genetic code. The correlation between codon structural elements and the chemical properties of amino acids. Nauchnye Dokl. Vyss. Shkoly Biol. Nauki [Biological Sciences], 1982, (7), 21-24.
A. Andreev, L.S. Iaguzhinskii. Unambiguous correspondence and complementarity of the chemical properties of amino acids and anticodons of the genetic code. Nauchnye Dokl. Vyss. Shkoly Biol. Nauki. [Biological Sciences], 1986, (11),16-25.
A.Yu. Andreev, E.N. Mokhova, V.P. Skulachev, N.I. Volkov. Carboxyatractylate and adenosinediphosphate reduce an uncoupling effect of palmitic acid on skeletal muscle mitochondria. Biologicheskie membrany [Biological membranes], 1987, 4, 474-478.
A.Yu. Andreyev, T.O. Bondareva, V.I. Dedukhova, E.N. Mokhova, V.P. Skulachev, N.I. Volkov. Carboxyatractylate inhibits the uncoupling effect of free fatty acids. FEBS Lett., 1988, 226, 265-269.
A. Andreev, L.S. Iaguzhinskii. The conformity of chemical parameters of amino acids and anticodons in the genetic code. Zhurnal evolyutsionnoi biokhimii i fiziologii [J. of evolutionary biochemistry and physiology], 1988, 24, 121-128.
L.S. Iaguzhinskii, A. Andreev. Chemical determinism of the genetic code: correlation of steric parameters of amino acids and anticodons. Zhurnal evolyutsionnoi biokhimii i fiziologii [J. of evolutionary biochemistry and physiology], 1988, 24, 746-757.
A.Yu. Andreyev, T.O. Bondareva, V.I. Dedukhova, E.N. Mokhova, V.P. Skulachev, L.M. Tzofina, T.V. Vygodina. The ATP/ADP antiporter is involved in the uncoupling effect of fatty acids. In: Anion Carriers of Mitochondrial Membranes (Azzy et al. eds.), Springer-Verlag, Heidelberg, 1988.
A.Yu. Andreyev, T.O. Bondareva, V.I. Dedukhova, E.N. Mokhova, V.P. Skulachev, L.M. Tzofina, N.I. Volkov, T.V. Vygodina. The ATP/ADP antiporter is involved in the uncoupling effect of fatty acids. Eur.J.Biochem., 1989, 187, 585-592.
A.Yu. Andreev, V.I. Dedukhova, E.N. Mokhova. Uncoupling of oxidative phosphorylation in liver and skeletal muscle mitochondria by fatty acid in incubation medium of different ion composition. Biologicheskie membrany [Biological membranes], 1990, 7, 480-485.
A.Yu. Andreyev, V.P. Skulachev, I.M. Tikhonova. Palmitic acid interaction with the ATP/ADP antiporter reconstituted into proteoliposomes. Biochemistry (Moscow), 1994, 59, 3-9.
I.M. Tikhonova, A.Yu. Andreyev, Yu.N. Antonenko, A.D. Kaulen, A.Yu. Komrakov, V.P. Skulachev. Ion permeability induced in artificial membranes after bovine heart ATP/ADP antiporter incorporation. Biologicheskie membrany [Biological membranes], 1994, 11, 620-630.
I.M. Tikhonova, A.Yu. Andreyev, Yu.N. Antonenko, A.D. Kaulen, A.Yu. Komrakov, V.P. Skulachev. Ion permeability induced in artificial membranes by the ATP/ADP antiporter. FEBS Letters, 1994, 337, 231-234.
A.Yu. Andreyev, L.M. Mikhaylova, A.A. Starkov. Resealing of permeability transition pore by cyclosporin A: role of Mg , adenine nucleotides and the conformation of ATP/ADP-antiporter. Biochemistry (Moscow), 1994, 59, 1589-1597.
A.Yu. Andreyev, L.M. Mikhaylova, A.A. Starkov, Yu.E. Kushnareva. Ca2+ loading modulates potencies of cyclosporin A, Mg and ADP to recouple permeabilized rat liver mitochondria. Biochem. and Mol. Biol. Intern., 1994, 34, 367-373.
Yu.E. Kushnareva, L.M. Mikhaylova, A.Yu. Andreyev. Low concentrations of cyclosporin A reseal permeability transition pore in inner mitochondrial membrane in absence of additional effectors. Biochemistry (Moscow), 1995, 60, 1510-1519.
L.M. Mikhaylova, Yu.E. Kushnareva, A.Yu. Andreyev. Inhibitors of ADP/ATP antiporter induce two Ca-dependent uncoupling pathways in rat liver mitochondria. Biochemistry (Moscow), 1996, 61, 905-910.
N.S. Gavrilova, L.A. Gavrilov, G.N. Evdokushkina, V.G. Semenova, A.L. Gavrilova, N.N. Evdokushkina, Y.E. Kushnareva, V.N. Kroutko, A.Yu. Andreyev. Evolution, mutations and human longevity: the study on European royal and noble families. Human Biology, 1998, 70, 799-804.
A.Y. Andreyev, B.Fahy, G.Fiskum. Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition. FEBS Lett., 1998, 439, 373-376.
A. Andreyev, G.Fiskum. Calcium induced release of mitochondrial cytochrme c by different mechanisms selective for brain versus liver. Cell Death and Differentiation, 1999, 6, 825-832.
G. Fiskum, A.J. Kowaltowksi, A.Y. Andreyev, Y.E. Kushnareva, A.A. Starkov. Apoptosis-related activities measured with isolated mitochondria and digitonin-permeabilized cells. Methods Enzymol., 2000, 322, 222-34.
K. Johnson, A. Jung, A. Murphy, A. Andreyev, J. Dykens, R. Terkeltaub. Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum., 2000, 43,1560-70.
Y. Kushnareva, A.N. Murphy, A. Andreyev. Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J., 2002, 368, 545-53.
M. Jazayeri, A. Andreyev, Y. Will, M. Ward, C.M. Anderson, W. Clevenger. Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype. J. Biol. Chem., 2003, 278, 9823-30.
A.Yu. Andreyev, Y. E. Kushnareva, A.A. Starkov. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Moscow), 2005, 70, 200-214. /REVIEW
Y. E. Kushnareva, S.E. Wiley, M.W. Ward, A.Y. Andreyev, and A.N. Murphy. Excitotoxic injury to mitochondria isolated from cultured neurons. J. Biol. Chem., 2005, 280, 28894-902.
J. Lee, C.-H. Kim, D.K. Simon, L. Aminova, A.Y. Andreyev, Y.E. Kushnareva, A.N. Murphy, B.E. Lonze, K.-S. Kim, D. Ginty, R.J. Ferrante, H. Ryu, and R. R. Ratan. Mitochondrial Cyclic AMP Response Element-Binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J. Biol. Chem., 2005, 280, 40398-40401.
R. Yamaguchi, A.Y. Andreyev, A.N. Murphy, G.A. Perkins, M.H. Ellisman, and D.D. Newmeyer. Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity. Cell Death and Differentiation, 2007, 14, 616-624.
R. Harkewicz, E. Fahy, A. Andreyev, and E.A. Dennis. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. J. Biol. Chem., 2007, 282, 2899-2910.