Lorcaserin
Lorcaserin hydrochloride 1431697-94-7.MOVThe lorcaserin works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction.Many antidepressant drugs work by preventing the reuptake of serotonin and keeping brain receptors bathed in the chemical.
Intake of food is controlled by satiety center, located in ventromedial nucleus of hypothalamus and hunger center present in lateral hypothalamus.Various inputs from higher centers and gastrointestinal tracts converge in arcuate nucleus, where two types of neurons controlling food intake is present.
Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus.Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetiteIn therapeutic doses lorcaserin acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin also acts on 5-HT 2B and 5-HT 2A receptors.According to clinical trial data submitted by Arena to the FDA, nearly half of dieters without Type 2 diabetes who used the medication lost at least 5% of their starting weight — or an average of 12 lbs. — over a year, compared with 23% of those taking a placebo. For best results, dieters are advised to use the medication together with a healthy diet and exercise program. The approved labeling for Belviq also recommends that people discontinue the drug if they fail to lose 5% of their body weight after 12 weeks; longer treatment is unlikely to lead to meaningful weight loss.Researchers at Arena say their drug is designed to seek out only the serotonin receptors that affect appetite.
How effective is Lorcaserin
Lorcaserin, used in combination with diet and exercise, results in modest weight loss of about 12.9 lb (5.8 kg) compared with 5.6 lb (2.5 kg) with placebo.3 On average, about 47% of patients will lose at least 5% of their body weight (about 11.1 lb [5 kg]) compared with 23% of patients receiving placebo (number needed to treat [NNT] = 4).1–3 About 22% of patients will lose at least 10% of their body weight vs. 9% of patients receiving placebo (NNT = 7). This weight loss is maintained, on average, for two years. Weight loss occurs early, and those who do not lose 5% of their body weight in the first three months are unlikely to achieve 5% loss by 52 weeks. Weight loss also occurs in patients with type 2 diabetes who are not taking insulin, although not to the same extent.4 Stopping lorcaserin after one year results in an average weight gain that is within 2.2 lb (1 kg) of baseline.1–3 There is no research on the effect of lorcaserin on mortality, incidence of diabetes, or other patient-oriented outcomes. Study shows,about half the dieters who took lorcaserin for a year in the study lost at least 5% of their body weight, compared to 20% of dieters who took a placebo pill. About one in five lorcaserin users lost 10% or more of their body weight, compared to one out of 14 placebo users.
Lorcaserin benefits
Obesity is developing into a pandemic in countries like the USA, the UK and India.1–3 The WHO projects that by 2015, about 700 million adults will be clinically obese.4 Obesity is a major public health problem, beyond the disability directly related to excessive adiposity, and it also increases the risk of several chronic diseases such as hypertension, sleep apnoea, diabetes, coronary artery disease and cancer. Clearly, obesity is a serious threat, imposing a vast economic burden on the healthcare system.
Obesity is the second most common preventable cause of death, second only to tobacco use.6 Evidence suggests that weight reduction substantially lowers the risk of related comorbidities and fosters their therapeutic management.7 ,8 Although bariatric surgery has emerged as the most clinically effective strategy for decreasing body weight for people with morbid obesity (body mass index (BMI) ≥40) or for those who cannot be managed otherwise,9 it is a very invasive procedure with significant risks.10 ,11 At this juncture, behavioural therapy, lifestyle modification and pharmacotherapy remain the mainstays of treatment. The most appealing solution for the public in general would be a “weight loss drug”. There are many kinds of weight loss drug, such as sibutramine,orlistat,cetilistat…etc. Lorcaserin is one of the popular use weight loss drug.
Lorcaserin powder All about the fat loss drug.pdfLorcaserin is a selective 5-HT2C receptor agonist that is thought to decrease food intake through the central POMC system. Lorcaserin benefits:
(1).Lorcaserin is used together with diet and exercise to treat obesity.
(2).Lorcaserin is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
(3).Lorcaserin will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure).
Lorcaserin HCL Powder To Maximize Your Energy
Lorcaserin benefits
Obesity is developing into a pandemic in countries like the USA, the UK and India.1–3 The WHO projects that by 2015, about 700 million adults will be clinically obese.4 Obesity is a major public health problem, beyond the disability directly related to excessive adiposity, and it also increases the risk of several chronic diseases such as hypertension, sleep apnoea, diabetes, coronary artery disease and cancer. Clearly, obesity is a serious threat, imposing a vast economic burden on the healthcare system.
Obesity is the second most common preventable cause of death, second only to tobacco use.6 Evidence suggests that weight reduction substantially lowers the risk of related comorbidities and fosters their therapeutic management.7 ,8 Although bariatric surgery has emerged as the most clinically effective strategy for decreasing body weight for people with morbid obesity (body mass index (BMI) ≥40) or for those who cannot be managed otherwise,9 it is a very invasive procedure with significant risks.10 ,11 At this juncture, behavioural therapy, lifestyle modification and pharmacotherapy remain the mainstays of treatment. The most appealing solution for the public in general would be a “weight loss drug”. There are many kinds of weight loss drug, such as sibutramine,orlistat,cetilistat…etc. Lorcaserin is one of the popular use weight loss drug.
Lorcaserin is a selective 5-HT2C receptor agonist that is thought to decrease food intake through the central POMC system. Lorcaserin benefits:
(1).Lorcaserin is used together with diet and exercise to treat obesity.
(2).Lorcaserin is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
(3).Lorcaserin will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure).
Who can use lorcaserin?
The FDA-approved Belviq assists with weight loss among obese and overweight individuals. You may be eligible to try lorcaserin if:You have a BMI over 30
Your BMI is 27 or above, but you struggle with at least one obesity related disease
To maintain weight loss long-term, you’ll have to make permanent changes to your diet and exercise habits. Like all weight loss medications, lorcaserin powder is only recommended under the supervision of your obesity medicine doctor.
Lorcaserin Suppliers & Factory
Our company has Lorcaserin powder and six Lorcaserin intermediates powder on sale
1. Lorcaserin hydrochloride is compound , which can be obtained （R）Lorcaserin hydrochloride , It can be regarded as the marketed Lorcaserin hydrochloride intermediate,
2. Lorcaserin hydrochloride hemihydrate is a drug substance approved by the US FDA for marketing. trade name is Belviq.
3. （R）Lorcaserin hydrochloride is the resolution product of Lorcaserin hydrochloride.
4. Lorcaserin is the base of Lorcaserin hydrochloride casserin.
5. 8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-3-benzazepine is the base of product Lorcaserin hydrochloride.
6. 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride is intermediate in the process of Lorcaserin hydrochloride.
What is the information I should know before I take lorcaserin?
You should not use lorcaserin if you are allergic to it.
Do not use lorcaserin if you are pregnant. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Tell your doctor right away if you become pregnant during treatment.
You’d better not take lorcaserin if you have diabetes, congestive heart failure, a heart valve disorder, sickle cell anemia, leukemia or myeloma, kidney or liver disease, or a physical deformity of the penis (such as Peyronie’s disease)
It is not known whether lorcaserin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Lorcaserin is not approved for use by anyone younger than 18 years old.
What should I know after I take lorcaserin?
Store lorcaserin at room temperature between 59°F to 86°F (15°C TO 30°C).
Keep this and all medicines out of the reach of children.
Lorcaserin powder is a controlled substance (CIV). Keep lorcaserin in a safe place to protect it from theft.
Lorcaserin Manufacturers & Suppliers
Lorcaserin Powder Bulk
All Quality Lorcaserin Suppliers
JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED. founded in 2007, is a technological enterprise company involved in the research,development and marketing of pharmaceutical raw materials.The company’s mianly products: Lorcaserin, intermediates of Lorcaserin, orlistat，Sesamol,tadalafil and intermediates of tadalafil, etc.
Our factory has comprehensive detection equipment, 60 sets of HPLC, 20 sets of gas chromatographs, LCMS, ELSD, ultraviolet and visible spectrometers, freeze driers and other advanced instruments. It has passed ISO14001, ISO9000 and DMF certification through mergers and acquisitions, and has a total quality management system.
Contact Us:
JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED
No.27 Keyuan Street, Economic Development District,
Shanghe County, Jinan City, Shandong Province
Ph: +86（1368）236 6549
Email: info@cmoapi.com
www.cmoapi.com/our-products/lorcaserin/
Lorcaserin Manufacturer Factory
Lorcaserin Manufacturers & Suppliers
Lorcaserin Suppliers & Factory