Clinical Nucleic Acid Research

Overview

The Clinical Nucleic Acid Research Lab focuses on genomics-driven biomarker discovery using integrated multi-omics approaches, including transcriptomics, single-cell and spatial transcriptomics, and circulating nucleic acid profiling.

Our research integrates cellular, spatial, and circulating molecular layers to define disease mechanisms and identify clinically relevant biomarkers.

Current Projects (selected)

• Integrated circulating nucleic acid profiling and spatial transcriptomics for disease mechanism discovery [SNUH Research Track II / NRF]

• Spatial transcriptomics for vessel pathogenesis mechanism study [SNU Medical School Grant / NRF]

• Integrated single-cell multi-omics (snATAC/GEX) and circulating nucleic acid profiling for biomarker discovery and disease monitoring [KHIDI]

• Integrated bulk RNA-seq and spatial transcriptomics for disease mechanism discovery [SNUH Research Track II /NRF]

• Development of subcellular-resolution spatial multi-omics to investigate post-transcriptional regulatory mechanisms [SNUH/NRF]

Ongoing projects include single-cell analysis, high-definition spatial transcriptomics, bulk RNA-seq, and targeted panel sequencing

Funding

Our research is supported by the National Research Foundation of Korea (NRF), Korea Health Industry Development Institute (KHIDI), Seoul National University Hospital (SNUH) Research Fund and SNU College of Medicine.