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基本資料
姓名：
翁意欣
電子信箱：
連絡電話/傳真：
TEL: 03-3281200#5237
服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
林口長庚紀念醫院/神經內科部/動作障礙科/科主任
林口長庚紀念醫院/神經內科部/動作障礙科/副教授
長庚大學/醫學院/醫學系/副教授
機構地址：
333 桃園市龜山區復興街5號
個人網站：
研究領域：
巴金森氏症、神經影像學、轉殖基因小鼠
個人簡歷
Dr. Weng was the attending neurologist (1998-2006), Assistant Professor (2006-2013) and Associate Professor (2013-) of the Department of Neurology at Chang Gung Memorial Hospital and University, Taiwan. She is the director of Department of Neurology, Branch of Movement Disorders, Chang Gung Memorial Hospital and University since 2017. Her research interests are in neuroimaging of movement disorders, especially in PET and SPECT imaging. She also carries out extensive research into the pathogenic mechanisms and mouse models of Parkinson's disease.
發表論文或著作等
A. 期刊論文
1. Yi-Hsin Weng†, Chu-Yu Chen†, Kun-Jun Lin, Ying-Ling Chen, Tu-Hsueh Yeh, Ing-Tsung Hsiao, Ing-Jou Chen, Chin-Song Lu, Hung-Li Wang*. (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental Neurology. 2016 January; 275(1) :104-115. (SCI)
2. Chin-Song Lu+, Shu-Hang Ng+, Yi-Hsin Weng, Jur-Shan Cheng, Wey-Yil Lin, Yau-Yau Wai, Yao-Liang Chen, Jiun-Jie Wang*. Alterations of diffusion tensor MRI parameters in the brains of patients with Parkinson's disease compared with normal brains: possible diagnostic use. European Radiology. Epub 2016 March 5; 2016 November; 26(11):3978-3988. (SCI)
3. Ching-Chi Chiu+, Tu-Hsueh Yeh+, Szu-Chia Lai, Yi-Hsin Weng, Yin-Cheng Huang, Yi-Chuan Cheng, Rou-Shayn Chen, Ying-Zu Huang, June Hung, Chiung-Chu Chen, Wey-Yil Lin, Hsiu-Chen Chang, Yu-Jie Chen, Chao-Lang Chen, Hsin-Yi Chen, Yan-Wei Lin, Yah-Huei Wu Chou, Hung-Li Wang*, Chin-Song Lu*. Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease. Oncotarget. 2016 August; 7(34):54215-54227.
4. Ching-Chi Chiu+, Tu-Hsueh Yeh+, Chin-Song Lu, Yin-Cheng Huang, Yi-Chuan Cheng, Ying-Zu Huang, Yi-Hsin Weng, Yu-Chuan Liu, Szu-Chia Lai, Ying-Ling Chen, Yu-Jie Chen, Chao-Lang Chen, Hsin-Yi Chen, Yan-Wei Lin, Hung-Li Wang*. PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway. Oncotarget. 2017 Oct 3; 8(45):79046-79060.
5. Chin-Man Wang, Wann-Yun Shieh, Yi-Hsin Weng, Yi-Hsuan Hsu, Yih-Ru Wu*. Non-invasive assessment determine the swallowing and respiration dysfunction in early Parkinson's disease. Parkinsonism & Related Disorders. 2017 Sep;42:22-27.(SCI)
6. Yi‐Ying Lin, Rou‐Shayn Chen*, Chin‐Song Lu, Ying‐Zu Huang, Yi‐Hsin Weng, Tu‐Hsueh Yeh, Wey‐Yil Lin, June Hung. Sleep disturbances in Taiwanese patients with Parkinson's disease. Brain and Behavior. 2017 Oct; 7(10):e00806. (SCI)
7. Hsiu-Chen Chang*, Chin-Song Lu*, Wei-Da Chiou, Chiung-Chu Chen, Yi-Hsin Weng, Ya-Ju Chang. An 8-Week Low-Intensity Progressive Cycling Training Improves Motor Functions in Patients with Early-Stage Parkinson's Disease. Journal of Clinical Neurology. 2018 Apr; 14(2):225-233. (SCI)
8. Ying‐Zu Huang*, Rou‐Shayn Chen, Po-Yu Fong, John C. Rothwell, Wen Li Chuang, Yi-Hsin Weng, Wey‐Yil Lin, Chin‐Song Lu. Inter-cortical modulation from premotor to motor plasticity. The Journal of Physiology. 2018 Sep; 596(17):4207-4217. (SCI)
9. Hsu Jung Lung, Yi-Hsin Weng, Ming Ching Wen, Ing Tsung Hsiao, Kun Ju Lin*. Quantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis. Scientific Reports. 2018 Oct 30; 8(1):16027. (SCI)
10. Ching-Chi Chiu, Chin-Song Lu, Yi-Hsin Weng, Ying-Ling Chen, Ying-Zu Huang, Rou-Shayn Chen, Yi-Chuan Cheng, Yin-Cheng Huang, Yu-Chuan Liu, Szu-Chia Lai,Kun-Jun Lin, Yan-Wei Lin, Yu-Jie Chen, Chao-Lang Chen, Tu-Hsueh Yeh*, Hung-Li Wang*. PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Molecular Neurobiology. 2019 June; 56(6):3835-3853. (SCI)
11. Wey-Yil Lin1, Ming-Shyan Lin1,Yi-Hsin Weng, Tu-Hsueh Yeh,Yu-Sheng Lin,Po-Yu Fong, Yih-Ru Wu, Chin-Song Lu, Rou-Shayn Chen,Ying-Zu Huang*.
Association of Antiviral Therapy with Risk of Parkinson Disease in Patients with Chronic Hepatitis C Virus Infection. JAMA Neurology. 2019 Sep; 76(9):1019-1027. (SCI)
12. Ching-Chi Chiua1, Hung-Li Wanga1, Yi-Hsin Weng, Rou-Shayn Chen, Chiung-Mei Chen, Tu-Hsueh Yeh, Chin-Song Lu, Yu-Jie Chen, Yu-Chuan Liu, Ying-Zu Huang*, Kuo-Hsuan Chang**. Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations. Stem Cell Research. 2019 Oct; 40:101552. (SCI)
13. Hung-Li Wang, Chin-Song Lu, Tu-Hsueh Yeh, Yu-Ming Shen, Yi-Hsin Weng, Ying-Zu Huang, Rou-Shayn Chen, Yu-Chuan Liu, Yi-Chuan Cheng, Hsiu-Chen Chang, Ying-Ling Chen, Yu-Jie Chen, Yan-Wei Lin, Chia-Chen Hsu, Huang-Li Lin, Chi-Han Chiu, Ching-Chi Chiu*. Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson’s Disease. Journal of Clinical Neurology. 2019 Oct; 15(4):488-495. (SCI)
14. Yi-Ai Raua1, Shi-Ming Wang1, Jacques-Donald Tournier, Sung-Han Lin, Chin-Song Lu, Yi-Hsin Weng, Yao-Liang Chen, Shu-Hang Ng, Shao-Wen Yu, Yi-Ming Wu, Chih-Chien Tsai, Jiun-Jie Wang*. A longitudinal fixel-based analysis of white matter alterations in patients with Parkinson's disease. NeuroImage-Clinical. 2019 Nov; 24:102098. (SCI)
15. Ching-Chi Chiu, Tu-Hsueh Yeh, Rou-Shayn Chen, Hua-Chien Chen, Ying-Zu Huang, Yi-Hsin Weng, Yi-Chuan Cheng, Yu-Chuan Liu, Ann-Joy Cheng, Ya-Ching Lu, Yu-Jie Chen, Yan-Wei Lin, Chia-Chen Hsu, Ying-Ling Chen, Chin-Song Lu, Hung-Li Wang*. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Frontiers in Cellular Neuroscience. 2019 Sep; 13:399. (SCI)
16. Chang Hsiu-Chen, Chen Chiung-Chu, Liaw Jiunn-Woei, Chiou Wei-Da, Weng Yi-Hsin, Chang Ya-Ju1, Lu Chin-Song1*. The effects of dual-task in patients with Parkinson’s disease performing cognitive-motor paradigms. Journal of Clinical Neuroscience. 2020 Feb; 72: 72-78. (SCI)
17. Chih-Chien Tsai+, Yu-Chun Lin+, Shu-Hang Ng+, Yao-Liang Chen, Jur-Shan Cheng, Chin-Song Lu, Yi-Hsin Weng, Sung-Han Lin, Po-Yuan Chen, Yi-MingWu, Jiun-JieWang* . A Method for the Prediction of Clinical Outcome Using Diffusion Magnetic Resonance Imaging: Application on Parkinson's Disease. Journal of Clinical Medicine. 2020 Feb 28; 9(3):647. (SCI)
18. Yu-Chuan Liu 1, Hung-Li Wang 1, Ying-Zu Huang , Yi-Hsin Weng , Rou-Shayn Chen, Wen-Chung Tsai , Tu-Hsueh Yeh , Chin-Song Lu , Ying-Ling Chen , Yan-Wei Lin, Yu-Jie Chen, Chia-Chen Hsu, Chi-Han Chiu , Ching-Chi Chiu*. Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models. Biochemical Pharmacology. 2020 May; 175:113919. (SCI)
19. Yi-Chieh Chen, Ying-Zu Huang, Yi-Hsin Weng, Chiung-Chu Chen, June Hung, Yi-Ying Lin, Wey-Yil Lin, Rou‐Shayn Chen*. Nonmotor symptoms of 820 Taiwanese patients with Parkinson's disease: an exploratory-comparative study. Journal of Neurology. 2020 May; 267(5):1499-1507. (SCI)
20. Hsiu-Chen Chang, Chiung-Chu Chen , Yi-Hsin Weng, Wei-Da Chiou, Ya-Ju Chang, Chin-Song Lu*. The efficacy of cognitive-cycling dual-task training in patients with early-stage Parkinson's disease: A pilot study. NeuroRehabilitation. 2020 Dec 22; 47(4):415-426. (SCI)
21. Jung-Lung Hsu1, Shih-Hsin Chen1, Ing-Tsung Hsiao, Chin-Song Lu,Tzu-Chen Yen, Nobuyuki Okamura, Kun-Ju Lin*,Yi-Hsin Weng*. 18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty. Scientific Reports. 2020 Nov 10; 10(1):19410. (SCI)
22. Ching-Chi Chiu1, Yi-Hsin Weng1, Ying-Zu Huang, Rou-Shayn Chen, Yu-Chuan Liu, Tu-Hsueh Yeh, Chin-Song Lu, Yan-Wei Lin, Yu-Jie Chen, Chia-Chen Hsu, Chi-Han Chiu, Yu-Ting Wang, Wan-Shia Chen, Shu-Yu Liu, Hung-Li Wang*. (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death & Disease. 2020 Nov 30; 11(11):1018. (SCI)
23. Demy J.S. Kuipers*, Wim Mandemakers*, Chin-Song Lu, Simone Olgiati, Guido J. Breedveld, Christina Fevga, Vera Tadic, Miryam Carecchio, Bradley Osterman, Lena Sagi-Dain, Yah-Huei Wu-Chou, Chiung C. Chen, Hsiu-Chen Chang, Shey-Lin Wu, Tu-Hsueh Yeh, Yi-Hsin Weng, Antonio E. Elia, Celeste Panteghini, Nicolas Marotta, Martje G. Pauly, Andrea A. Kühn, Jens Volkmann, Baiba Lace, Inge A. Meijer, Krishna Kandaswamy, Marialuisa Quadri, Barbara Garavaglia, Katja Lohmann, Peter Bauer, Niccolò E. Mencacci, Steven J. Lubbe, Christine Klein, Aida M. Bertoli-Avella, Vincenzo Bonifati#. EIF2AK2 missense variants associated with early-onset generalized dystonia. Annals of Neurology. 2021 Mar; 89(3):485-497. (SCI)
24. Thanh-Thao Nguyen†, Jur-Shan Cheng†, Yao-Liang Chen†, Yu-Chun Lin, Chih-Chien Tsai, Chin-Song Lu, Yi-Hsin Weng, Yi-Ming Wu, Ngoc-Thanh Hoang, Jiun-Jie Wang*. Fixel-based analysis of white matter degeneration in patients with Progressive Supranuclear Palsy or Multiple System Atrophy, as compared to Parkinson’s Disease. Frontiers in Aging Neuroscience. 2021 March 16 online publication. (SCI)
B. 研討會論文
1. Poster: Differential diagnosis of parkinson’s disease and parkinson plus syndrome by 18F-FP-(+)-DTBZ PET imaging. Yi-Hsin Weng, Kun-Ju Lin, Ing-Tsung Hsiao, Wey-Yil Lin, Chia-Ju Hsieh, Chin-Song Lu, Tzu-Chen Yen, Shiaw-Pyng Wey.
The 12th International Conference on Alzheimer’s and Parkinson’s Diseases. Nice,France.(AD/PD 2015).
2. Poster: Screening for the presence of FMRI premutation alleles in patients with various movement disorders in Taiwan. Hsiu-Chen Chang, Yah-Huei Wu-Chou, Yi-Hsin Weng, Chiung-Chu Chen,Tu-Hsueh Yeh, Szu-Chia Lai, Chia-Ling Huang, Rou-Shayn Chen, Ying-Zu Huang, June Hung, Wey-Yil Lin, TM Ko, YY Chang, CH Huang, Chin-Song Lu.
The 12th International Conference on Alzheimer’s and Parkinson’s Diseases. Nice,France.(AD/PD 2015).
3. Poster: Unproportional degeneration of nigrostriatal and mesolimbic system in Parkinson’s Disease Patients with Impulse Control Disorders. Po-Yu Fong, Yi-Hsin Weng, Ing-Tsung Hsiao, Kun-Ju Lin, Chia-Ju Hsieh, Wey-Yil Lin, Tzu-Chen Yen, Kuan-yi Wu, Shiaw-Pyng Wey, Chin-Song Lu.
The 2nd Taiwan International Congress of Parkinson's Disease and Movement Disorders.Taipei,Taiwan.(TIC-PDMD 2015).
4. Poster: The degeneration of dopaminergic system in LRRK2 G2385R patients is distinct from idiopathic Parkinson’s disease patients- evidences from 18F-FP-DTBZ PET imaging. Yi-Hsin Weng, Kun-Ju Lin, Wey-Yil Lin, Ing-Tsung Hsiao, Chia-Ju Hsieh, Chin-Song Lu, Tzu-Chen Yen, Mei-Ping Kung, Shiaw-Pyng Wey.
The 1st International Taiwanese Congress of Neurology.Taipei,Taiwan. (ITCN 2015)
5. Poster: From mouse models to patients: Development of a novel 18F-DTBZ PET imaging as a biomarker to monitor neurodegeneration of PARK6 and PARK8 parkinsonism. Chin-Song Lu, Yi-Hsin Weng, Hung-Li Wang, Tu-Hsueh Yeh, Kun-Ju Lin, Wey-Yil Lin, Ing-Tsung Hsiao, Chia-Ju Hsieh, Tzu-Chen Yen, Mei-Ping Kung, Shiaw-Pyng Wey.
2015年科技部生科司「轉譯醫學專案研究計畫」成果發表暨學術交流研討會
6. Poster: Investigating molecular pathogenic mechanisms of PARK6 using knockin mouse model. Tu-Hsueh Yeh, Hsiun-Chen Lin, Chu-Yu Chen, Yi-Ping Cheng, Yi-Hsin Weng, Chin-Song Lu, Hung-Li Wang.
2015年科技部生科司「轉譯醫學專案研究計畫」成果發表暨學術交流研討會
7. Poster: Metabolomic profiling in patients with different stages of Parkinson's disease. Yi-Hsin Weng, Mei-Ling Cheng, Ming-Shi Shiao, Chin-Song Lu.
The 13th International Conference on Alzheimer’s and Parkinson’s Diseases. Vienna, Austria. (AD/PD 2017).
8. Poster: Differential diagnosis of parkinson's disease and atypical parkinsonism by positron emission tomography imaging with 18F-FP-(+)-DTBZ. Yi-Hsin Weng, Wey-Yil Lin, Kun-Ju Lin, Ing-Tsung Hsiao, Chia-Ju Hsieh, Chin-Song Lu, Tzu-Chen Yen, Shiaw-Pyng Wey.
Advances in Alzheimer's and Parkinson's Therapies an AAT-AD/PD Focus
Meeting. Torino,Italy. (AAT-AD/PD 2018).
9. Poster: [18F] THK5351 PET imaging in patients with corticobasal syndrome. Yu-Chieh Kuo, Kun Ju Lin, Ing-Tsung Hsiao, Tzu-Chen Yen, Chin-Song Lu, Shiaw-Pyng Wey, Yi-Hsin Weng*.
4th Taiwan International Congress of Parkinson's Disease and Movement Disorders. Taipei,Taiwan. (2018 TIC-PDMD).
專利
完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
學歷
中山醫學院 Taiwan 醫學系 學士 1986/09至1993/06
長庚大學 Taiwan 臨床醫學研究所臨床醫學組 博士 2007/09至2017/01
現職
林口長庚醫院 神經內科系 動作障礙科 副教授級主治醫師 2013/07~ 迄今
長庚大學 醫學院 醫學系 副教授 2014/08~ 迄今
經歷
林口長庚醫院 神經內科系 動作障礙科 助理教授級主治醫 2006/07至2013/06
林口長庚醫院 神經內科 主治醫師 1998/07至2006/06
林口長庚醫院 神經內科 Fellow 1997/07至1998/06
林口長庚醫院 神經內科 Resident Physician 1993/07至1997/06
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