陳瓊珠

基本資料

姓名：
陳瓊珠

電子信箱：

neurozoe@gmail.com

連絡電話/傳真：
TEL: (03)328-1200#5236

服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
1.林口長庚醫院 神經內科部 

   動作障礙科 學術組副教授級主治醫師

2.長庚大學 醫學系 副教授

機構地址：
333 桃園市龜山區復興街5號

個人網站：

研究領域：
帕金森氏症、深部腦刺激術

個人簡歷

Dr. Chiung Chu Chen is Associate Professor of the Department of Medicine, Chang Gung University and Department of Neurology in Chang Gung Memorial Hospital (CGMH).

Dr. Chen graduated from Department of Medicine in China Medical University in 1995.She trained as a movement disorders specialist after her residency in Department of Neurology, CGMH in 2000. During her fellowship in the Division of Movement Disorders, she developed great interest in basal ganglia electrophysiology and functional neurosurgery in the treatment of movement disorders. In 1998, she was engaged in the establishment of the first Deep Brain Stimulation (DBS) therapy center in Taiwan, a center she continues to lead in CGMH.

In 2004, Dr. Chen did her research fellowship in Prof. Alim-Louis Benabid’s lab in INSERM, Grenoble, France. She was involved in clinical research both in intraoperative targeting and post-operative management for patients having undergone DBS surgery. She then started her PhD study in Sobell Department, Institute of Neurology, University College London under Prof. Peter Brown’s supervision between 2004 and 2008. Dr. Chen established her own lab in CGMH upon her return to Taiwan in 2008. In the past few years, she has expanded her group into a multidisciplinary research team, involving medical doctors, electrophysiologists, signal processing experts and engineers. The aim of this group is to investigate the “signature” neural activities in basal ganglia underlying the motor and non-motor symptoms in patients with PD and other movement disorders, and how these activities predict the therapeutic outcome of DBS surgery. The final aim of these studies is to translate the results of electrophysiological findings to improve the current modulation therapy for movement and neuropsychiatric disorders. The group has continued to receive funding from Ministry of Science and Technology (MOST), Taiwan, since 2008. Dr. Chen has also received joint funding from NHRI and MOST-ANR (Agent National Research, France). A new Brain Science and Technology grant of USD 2.2 million from MOST Taiwan was just granted to Dr. Chen’s group and her collaborators from National Yang Ming Chiao Tung University (NYCU), from Jan 2021.

Dr. Chen has developed three research lines in recent years, all relevant to her research interests in basal ganglia electrophysiology, movement disorders and DBS. First, she recorded local field potentials (LFPs) both during and after DBS surgery from patients with PD or dystonia. The results showed that the oscillatory activities in basal ganglia nuclei correlated with symptoms of these disorders. Her recent study on freezing of gait (FOG), a disabling Parkinsonian symptom, demonstrated that narrow band oscillations in STN are associated with FOG episodes. In addition, the intraoperative LFP recordings she developed helped target and predict the motor and psychiatric outcomes of DBS surgery. Second, she demonstrated that high frequency stimulation of the basal ganglia might impair the processing of physiological motor and learning in PD. These findings motivated the development of adaptive DBS for the treatment of PD. Last, she is engaged in the development of the next generation neuromodulator, consisting of sensing pathological neural activities and delivering stimulation on demand precisely for the treatment of PD and other disorders. To this end, she has been collaborating with NYCU to design a novel adaptive DBS. The final aim of her group is to integrate the clinical, electrophysiological and engineering domains to improve neuromodulation therapy for patients. 

發表論文或著作等

Selected articles from peer-reviewed publications (2010-)

1.    Yoshida F, Martinez-Torres I, Pogosyan A, Holl E, Petersen E, Chen CC, Foltynie T, Limousin P, Zrinzo LU, Hariz MI, Brown P.Value of subthalamic nucleus local field potentials recordings in predicting stimulation parameters for deep brain stimulation in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):885-9. 

2.    Chen CC *, Hsu YT, Chan HL, Chiou SM, Tu PH, Lee ST, Tsai CH, Lu CS, Brown P. Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson’s disease. Exp Neurol. 2010 Jul;224(1):234-40. 

3.    Lai SC, Jung SM, Grattan-Smith P, Sugo E, Lin YW, Chen RS, Chen CC, Wu-Chou YH, Lang AE, Lu CS. Neuronal intranuclear inclusion disease: two cases of dopa-responsive juvenile parkinsonism with drug-induced dyskinesia. Mov Disord. 2010 Jul 15;25(9):1274-9.  

4.    Pogosyan A, Yoshida F, Chen CC, Martinez-Torres I, Foltynie T, Limousin P, Zrinzo L, Hariz MI, Brown P. Parkinsonian Impairment Correlates With Spatially Extensive Subthalamic Oscillatory Synchronization. Neuroscience. 2010 Nov 24;171(1):245-57. 

5.    Chen CC*, Lin WY*, Chan HL, Hsu YT, Tu PH, Lee ST, Chiou SM, Tsai CH, Lu CS and Brown P. Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson’s disease. Exp Neurol. 2011 Sep; 231(1):91-6. (*The first two authors contributed equally to this study.) 

6.    Hsu YT, Lai HY, Chang YC, Chiou SM, Lu MK, Lin YC, Liu YL, Chen CC, Huang HC, Chien TF, Lin SZ, Chen YY, Tsai CH. The role of the sub-thalamic nucleus in the preparation of volitional movement termination in Parkinson's disease. Exp Neurol. 2012 Jan; 233(1):253-63.

7.    Wu-Chou YH, Chen YT, Yeh TH, Chang HC, Weng YH, Lai SC, Huang CL, Chen RS, Huang YZ, Chen CC, Hung J, Chuang WL, Lin WY, Chen CH, Lu CS. Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: a replication study in a Taiwanese cohort. Parkinsonism Relat Disord. 2013 Feb; 19(2):251-5. 

8.    Chen CC*, Lin WY*, Chan HL, Tu PH, Lee ST, Lu CS, Brown P. The impact of low-frequency stimulation of subthalamic region on self-generated isometric contraction in patients with Parkinson’s disease. Exp Brain Res. 2013 May; 227(1):53-62.

9.    E. Lalo, J. Riff, R. Parry, M. Jabloun, J. Roussel, C.-C. Chen, M.-L. Welter, O. Buttelli. Design of Technology and Technology of Design. Activity Analysis as a Resource for a Personalised Approach for Patients with Parkinson Disease., IRBM., 2016 April; 37(2):90-97.

10. Chiu CC, Yeh TH, Lai SC, Weng YH, Huang YC, Cheng YC, Chen RS, Huang YZ, Hung J, Chen CC, Lin WY, Chang HC, Chen YJ, Chen CL, Chen HY, Lin YW, Wu-Chou YH, Wang HL, Lu CS. Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease. Oncotarget. 2016 Aug 23; 7(34):54215-54227.

11. Lazzaro di Biase, John-Stuart Brittain*, Syed Ahmar Shah, David J. Pedrosa, Hayriye Cagnan, Alexandre Mathy, Chiung Chu Chen, Juan Francisco Martın-Rodr´guez,Pablo Mir, Lars Timmerman, Petra Schwingenschuh, Kailash Bhatia, Vincenzo Di Lazzaro and Peter Brown. Tremor stability index: a new tool for differential diagnosis in tremor syndromes. BRAIN 2017: 140; 1977-1986.

12. Chang HC, Lu CS, Chiou WD, Chen CC, Weng YH, Chang YJ. An 8-Week Low-Intensity Progressive Cycling Training Improves Motor Functions in Patients with Early-Stage Parkinson's Disease. J Clin Neurol. 2018 Apr; 14(2):225-233.

13. Petra Fischer, Chiung Chu Chen, Ya Ju Chang, Chien-Hung Yeh, Alek Pogosyan, Damian M. Herz, Binith Cheeran, Alexander L. Green, Tipu Z. Aziz, Jonathan Hyam, Simon Little, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Harutomo Hasegawa, Michael Samuel, Keyoumars Ashkan, Peter Brown and Huiling Tan. Alternating Modulation of Subthalamic Nucleus Beta Oscillations during Stepping. The Journal of Neuroscience. 2018 May; 38(22):5111-5121.

14. Syed A. Shah [Member, IEEE], Gerd Tinkhauser, Chiung Chu Chen, Simon Little, and Peter Brown. Parkinsonian Tremor Detection from Subthalamic Nucleus Local Field Potentials for Closed-Loop Deep Brain Stimulation. Conf Proc IEEE Eng Med Biol Soc. 2018 Dec; 2320–2324.

15. Po-Hsun Tu, Zhuo-Hao Liu, Chiung Chu Chen, Wey Yil Lin, Amy L. Bowes, Chin Song Lu, and Shih-Tseng Lee. Indirect Targeting of Subthalamic Deep Brain Stimulation Guided by Stereotactic Computed Tomography and Microelectrode Recordings in Patients with Parkinson’s Disease. Front Hum Neurosci. 2018 Dec; 12: 470.

16. Chiung Chu Chen. Is outcome of subthalamic nucleus deep brain stimulation in Parkinson disease predictable? Neurology. 2019 Mar; 92:1-2.

17. Chen CC, Yeh CH, Chan HL, Chang YJ, Tu PH, Yeh CH, Lu CS, Fischer P, Tinkhauser G, Tan H, Brown P. Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease. Neurobiology of Disease. 2019 Sep; 132:10465.

18. Chang Hsiu-Chen, Chen Chiung-Chu, Liaw Jiunn-Woei, Chiou Wei-Da, Weng Yi-Hsin, Chang Ya-Ju, Lu Chin-Song. The effects of dual-task in patients with Parkinson’s disease performing cognitive-motor paradigms. Journal of Clinical Neuroscience. 2020 Feb; 72: 72-78.

19. Chang, Hsiu-Chen*, Chen, Chiung-Chu*, Weng, Yi-Hsin, Chiou, Wei-Da, Chang, Ya-Ju, Lu, Chin-Song. The efficacy of cognitive-cycling dual-task training in patients with early-stage Parkinson’s disease: A pilot study. NeuroRehabilitation. 2020 May; 47:415-426. (*The first two authors contributed equally to this study.)

20. Helio A.G. Teive*, Chiung Chu Chen. Isolated focal dystonia: The mysterious pathophysiology is being unraveled. Neurology. 2020 Oct; 95(16):711-712.

21. Demy J.S. Kuipers, Wim Mandemakers, Chin-Song Lu, Simone Olgiati, Guido J. Breedveld, Christina Fevga, Vera Tadic, Miryam Carecchio, Bradley Osterman, Lena Sagi-Dain, Yah-Huei Wu-Chou, Chiung C. Chen, Hsiu-Chen Chang, Shey-Lin Wu, Tu-Hsueh Yeh, Yi-Hsin Weng, Antonio E. Elia, Celeste Panteghini, Nicolas Marotta, Martje G. Pauly, Andrea A. Kühn, Jens Volkmann, Baiba Lace, Inge A. Meijer, Krishna Kandaswamy, Marialuisa Quadri, Barbara Garavaglia, Katja Lohmann, Peter Bauer, Niccolò E. Mencacci, Steven J. Lubbe, Christine Klein, Aida M. Bertoli-Avella, and Vincenzo Bonifati*. EIF2AK2 missense variants associated with early-onset generalized dystonia. Annals of Neurology. 2021 Mar; 89(3):485-497.

專利

完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)

2013/07-now, Associate Professor level Attending Physician, Department of Neurology, Linkou Chang Gung Memorial Hospital

2015/02-now, Associate Professor, School of Medicine, Chang Gung University

2012/08-2015/02, Assistant Professor, School of Medicine, Chang Gung University

2007/07-2013/06, Assistant Professor level Attending Physician, Department of Neurology, Linkou Chang Gung Memorial Hospital

2004/10-2008/04, PhD student, Sobell Department of Motor Neuroscience & Movement Disorders, Institute of Neurology, London, UK

2004/03-2004/09, Research fellow, INSERM 318 France, INSERM 318 France

2003/08-2004/02, Research fellow, Imperial Collage, Imperial Collage, London, UK

2000/08-2012/07, Attending Physicians, Department of Neurology, Linkou Chang Gung Memorial Hospital

1999/08-2000/07, Fellow, Department of Neurology, Linkou Chang Gung Memorial Hospital

1995/08-1999/07, Resident doctor, Department of Neurology, Linkou Chang Gung Memorial Hospital