陳家嬅

基本資料

姓名：
陳家嬅

電子信箱：

hareien1982@gmail.com

連絡電話/傳真：

TEL: (03)2118800 #5076

服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
長庚大學 / 解剖學科 / 助理教授

機構地址：
桃園市龜山區文化一路259號

個人網站：

研究領域：
腫瘤生物學、腦癌、單細胞RNA定序、空間轉錄體、生物資訊方法
細胞生物學、組織學、大體解剖學、胚胎學

個人簡歷

長庚大學解剖學科 / 助理教授  (2024/08~現仍在職) 

長庚大學分子醫學中心 / 博士後研究員  (2020/01~2024/08)  

林口長庚紀念醫院神經外科 / 博士後研究員  (2014/04~2020/01) 

台灣大學醫學院解剖暨細胞生物學研究所 / 研究助理  (2008/09~2009/07) 

台灣大學醫學院 / 解剖暨細胞生物學研究所 / 博士 (2009/09~2014/03)

台灣大學 / 生命科學院動物所 / 碩士 (2004/09~2007/06)

台灣大學 / 動物系動生組 / 學士 (2000/09-2004/06)

發表論文或著作等

1.          Ian Yi-Feng Chang, Hong-Chieh Tsai, Chia-Hua Chen, Hsiu-Chi Chen, Chia-Wen Huang, Gerald F. Cox, Fang-Min Huang, You-Yu Lin, Ko-Ting Chen, Ya-Jui Lin, Kuo-Chen Wei. (2024, Aug). CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden. Biomedical Journal, 47(4):100660. (SCI, 70/285(Q1), BIOCHEMISTRY & MOLECULAR BIOLOGY).

2.          Hung-Rong Yen, Wen-Chieh Liao, Chia-Hua Chen, Ying-Ai Su, Ying-Wei Huang, Chi Hsiao, Yu-Lun Chou, Yin-Hung Chu, Pin-Keng Shih, Chiung-Hui Liu (2024, May). Targeting chondroitin sulfate suppresses macropinocytosis of breast cancer cells by modulating syndecan-1 expression. Molecular Oncology.

3.          You-Cheng Lin*, Yin-Hung Chu*, Wen-Chieh Liao*, Chia-Hua Chen, Wen-Chuan Hsiao, Ying-Jui Ho, Meng-Yin Yang, and Chiung-Hui Liu (2023, Jul). CHST11-modified chondroitin 4-sulfate as a potential therapeutic target for glioblastoma. American Journal of Cancer Research, 13(7), 2998-3012. (SCI, 70/241(Q2), ONCOLOGY).

4.          Chia-Hua Chen, Kuo-Chen Wei, Wei-Chao Liao, You-Yu Lin, Hsiu-Chi Chen, Li-Ying Feng, Chiung-Hui Liu, Chiung-Yin Huang, Ko-Ting Chen, Chi-Sheng Wu, Yu-Sun Chang, Jau-Song Yu, Ian Yi-Feng Chang. (2022, Sep). Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan. Journal of Neurosurgery, 138(5),1325-1337. (SCI, 29/212, Surgery). 本人為第一作者.

5.          Kuo-Chen Wei, You-Cheng Lin, Chia-Hua Chen, Yin-Hung Chu, Chiung-Yin Huang, Wen-Chieh Liao, Chiung-Hui Liu. (2021, Nov). Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. American Journal of Cancer Research, 11(11), 5472-5484. (SCI, 70/241, oncology).

6.          Chia-Hua Chen, Ya-Jui Lin, You-Yu Lin, Chang-Hung Lin, Li-Ying Feng, Ian Yi-Feng Chang, Kuo-Chen Wei, Chiung-Yin Huang. (2021, Apr). Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients. Frontiers in Oncology, 11, 621432. (SCI, 85/241, oncology). 本人為第一作者.

7.          Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu. (2021, Mar). CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. American Journal of Cancer Research, 11(3), 812-826. (SCI, 70/241, oncology).

8.          Yu-Ju Wu C, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY, Chen PY. (2020, Feb). CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2. Neuro-oncology, 22(2), 253-266. (SCI, 4/212, clinical neurology).

9.          Chia-Hua Chen, PhD, Pin-Yuan Chen, MD, PhD, You-Yu Lin, PhD, Li-Ying Feng, BS, Shin-Han Chen, MSc, Chia-Yuan Chen, MSc, Yin-Cheng Huang, MD, PhD, Chiung-Yin Huang, PhD, Shih-Ming Jung, MD, Leslie Y. Chen, PhD, and Kuo-Chen Wei, MD (2019, Jan). Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery, 132(1),168-179. (SCI, 14/200, SURGERY; 37/197, CLINICAL NEUROLOGY). MOST 105-2314-B-182-019-MY3. 本人為第一作者.

10.      Kuo-Chen Wei, Chia-Yuan Chen, Li-Ying Feng, Wei-Tzu Huang, Chia-Hua Chen, Peng-Wei Hsu, Kai Wang, Leroy E. Hood, Leslie Y. Chen (2017, Jun). The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort. PLoS One, 12(6), e0178842. (SCI). MOST 105-2314-B-182A-053-MY2.

11.      Liao WC, Liu CH, Chen CH, Hsu WM, Liao YY, Chang HM, Lan CT, Huang MC, Shyu MK (2015, Apr). β-1,4-Galactosyltransferase III suppresses extravillous trophoblast invasion through modifying β1-integrin glycosylation. Placenta, 36(4), 357-364. (SCI, 13/80, OBSTETRIC & GYNECOLOGY).

12.      Liu CH, Hu RH, Huang MJ, Lai IR, Chen CH, Lai HS, Wu YM*, Huang MC*. (2014, Aug). C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin β1 glycosylation and activity. PLoS ONE, 9(8):e94995. (SCI, 11/63, MULTIDISCIPLINARY SCIENCES). nstc 099-3111-B-002-006.

13.      Chen CH, Wang, SH, Liu CH, Wu YL, Wang WJ, Huang J, Hung JS, Lai IR, Liang JT, Huang MC*. (2014, Jun). β-1,4-Galactosyltransferase III suppresses β1 integrin mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer. Carcinogenesis, 35(6):1258-1266. (SCI, 37/213, ONCOLOGY). nstc 099-2314-B-002-097-MY2. 本人為第一作者.

14.      Lu YC, Chen CN, Chu CY, Lu J, Wang BJ, Chen CH, Huang MC, Lin TH, Pan CC, Chen SS, Hsu WM, Liao YF, Wu PY, Hsia HY, Chang CC, Lee H. (2014, May). Calreticulin activates β1-integrin through fucosylation modification by fucosyltransferase-1 in J82 human bladder cancer cells. The Biochemical Journal, 460(1):69-78. (SCI, 61/291, BIOCHEMISTRY & MOLECULAR BIOLOGY). nstc 097-2311-B-002-002-MY3.

15.      Chang HH#, Chen CH#, Chou CH, Liao YF, Huang MJ, Chen YH, Wang WJ, Huang J, Hung JS, Ho WL, Jeng YM, Che MI, Lee H, Lu MY, Yang YL, Jou ST, Lin DT, Lin KH, Hsu WM*, Huang MC*. (2013, Apr). β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1 integrin and predicts poor prognosis in neuroblastoma. Clinical Cancer Research, 19(7):1705-1716. (SCI, 12/213, Oncology). nstc 098-2314-B-002-018-MY3. 本人為第一作者.

16.      Lee JJ, Chen CH#, Chen YS#, Huang MJ, Huang J, Hung, JS, Chen MT, Huang MC. (2013, Feb). COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2. PLoS ONE, 8(2):e56211. (SCI, 11/63, MULTIDISCIPLINARY SCIENCES). nstc 099-2314-B-002-097-MY2.

17.      Liao WC#, Chen CH#, Liu CH, Huang MJ, Chen CW, Hung JS, Chou CH, Chen CH, Che MI, Chang HM, Lan CT, Huang HC, Tseng GF, Shyu MK*, Huang MC*. (2012, Dec). Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta, 33(12), 1005-1011. (SCI, 13/80, OBSTETRICS & GYNECOLOGY ). nstc 101-2314-B-002-058.

18.      Hsu WM, Che MI, Liao YF, Chang HH, Chen CH, Huang YM, Jeng YM, Huang J, Quon MJ, Lee H, Huang HC, Huang MC (2011, Sep). B4GALNT3 expression predicts a favorable prognosis and suppresses cell migration and invasion via β₁ integrin signaling in neuroblastoma. The American journal of pathology, 179(3), 1394-1404.

專利

完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)

主要學歷

台灣大學醫學院 / 解剖暨細胞生物學研究所 / 博士 (2009/09~2014/03)

台灣大學 / 生命科學院動物所 / 碩士 (2004/09~2007/06)

台灣大學 / 動物系動生組 / 學士 (2000/09-2004/06)

現職與經歷

長庚大學解剖學科 / 助理教授  (2024/08~現仍在職) 

長庚大學分子醫學中心 / 博士後研究員  (2020/01~2024/08)  

林口長庚紀念醫院神經外科 / 博士後研究員  (2014/04~2020/01) 

台灣大學醫學院解剖暨細胞生物學研究所 / 研究助理  (2008/09~2009/07)