王鴻利

基本資料

姓名：
王鴻利

電子信箱：

hlwns@mail.cgu.edu.tw

連絡電話/傳真：
TEL: 03-211-8800, Ext. 5060

服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
長庚大學醫學院生理暨藥理學科 教授兼主任

機構地址：
桃園市龜山區文化一路259號

個人網站：

https://gibms.cgu.edu.tw/p/404-1079-7732.php?Lang=zh-tw

研究領域：
遺傳性神經系統疾病的分子病理機轉

個人簡歷

1990-1992

Research Fellow, Department of Neuroscience, Roche Institute of Molecular Biology, U.S.A.

1992-2001

Associate Professor, Department of Physiology, Chang Gung University College of Medicine 

2001-2008

Professor, Department of Physiology and Pharmacology, Chang Gung University College of Medicine 

2008-

Professor and Chairman, Department of Physiology and Pharmacology, Chang Gung University College of Medicine

發表論文或著作等

Selected Publications

1.     Chiu CC, Weng YH, Huang YZ, Chen RS, Liu YC, Yeh TH, Lu CS, Lin YW, Chen YJ, Hsu CC, Chiu CH, Wang YT, Chen WS, Liu SY, Wang HL* (2020) (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell Death and Disease, 11, 1018, doi:10.1038/s41419-020-03228-9.

1.     Liu YC, Wang HL (co-first author), Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC (2020) Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models. Biochemical Pharmacology, 175, 113919.

2.     Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL* (2019) Upregulated expression of microRNA-204-5p leads to the death of dopaminergic cells by targeting DYRK1A-mediated apoptotic signaling cascade. Frontiers in Cellular Neuroscience,13, 399-415.

3.     Chiu CC, Wang HL (co-first author), Weng YH, Chen RS, Chen CM, Yeh TH, Lu CS, Chen YJ, Liu YC, Huang YZ, Chang KH (2019) Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/p.M358IfsX mutations. Stem Cell Research, 40, 101552.

4. Wang HL, Lu CS, Yeh TH, Shen YM, Weng YH, Huang YZ, Chen RS, Liu YC, Cheng YC, Hsiu-Chen Chang HC, Chen YL, Chen YJ, Lin YW, Hsu CC, Lin HL, Chiu CH, Chiu CC (2019) Combined assessment of serum alpha-synuclein and Rab35 is a better biomarker for Parkinson's disease. Journal of Clinical Neurology, 15, 488-495.

5.     Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL* (2019) PARK14 (D331Y) PLA2G6 causes early-onset degeneration of substantia nigra dopaminergic neurons by inducing mitochondrial dysfunction, ER stress, mitophagy impairment and transcriptional dysregulation in a knockin mouse model. Molecular Neurobiology, 56, 3835-3853.

6.     Chiu CC, Yeh TH, Lu CS, Huang YC, Cheng YC, Huang YZ, Weng YH, Liu YC, Lai SC, Chen YL, Chen YJ, Chen CL, Chen HY, Lin YW, Wang HL* (2017) PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway. Oncotarget, 8, 79046-79060.

7.     Chiu CC, Yeh TH, Lai SC, Weng YH, Huang YC, Cheng YC, Chen RS, Huang YZ, Hung J, Chen CC, Lin WY, Chang HC, Wu-Chou YH,  Chen YJ, Chen CL, Chen HY, Lin YW, Wang HL*, Lu CS (2016) Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease. Oncotarget, 7, 54215-54227.

8.     Weng YH, Chen CY, Lin KJ, Chen YL, Yeh TH, Hsiao IT, Chen IJ, Lu CS, Wang HL* (2016) (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model. Experimental Neurology, 275, 104-115.

9.     Chou AH, Chen YL, Chiu CC, Yuan SJ, Weng YH, Yeh TH, Lin YL, Fang JM, Wang HL* (2015)

T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse. Neuropharmacology, 99, 308-317.

10.  Chiu CC, Yeh TH, Lai SC, Wu-Chou YH, Chen CH, Mochly-Rosen D, Huang YC, Chen YJ, Chen CL, Chang YM, Wang HL*, Lu CS (2015) Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental Neurology, 263, 244-253.

11.  Chou AH, Chen YL, Hu SH, Chang YM, Wang HL* (2014) Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation. Brain Research, 1583, 220-229.

12.  Huang YC, Wei KC, Chang CN, Chen PY, Hsu PW, Chen CP, Lu CS, Wang HL, Gutmann DH, Yeh TH (2014) Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma. PLoS One. 9, e108228

13.  Chou JS, Chen CY, Chen YL, Weng YH, Yeh TH, Lu CS, Chang YM, Wang HL* (2014) (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse. Neurobiology of Disease, 68, 190-199.

14.  Huang CY, Chen YL, Li AH, Lu JC, Wang HL* (2014) Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. Journal of Neuroinflammation. 2014, 11:7

15.  Wang HL*, Chang NC, Weng YH, Yeh TH (2013) XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. Biochimica et Biophysica Acta, Molecular Basis of Disease, 1832, 585-593.

16.   Wang HL*, Hu SH, Chou AH, Wang SS, Weng YH, Yeh TH (2013) H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse. Neuropharmacology, 70, 1-11.

17.  Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL* (2012) (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death & Differentiation, 19, 1623-1633.

18.  Kao DJ, Li AH, Chen JC, Luo RS, Chen YL, Lu JC, Wang HL* (2012) CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons. Journal of Neuroinflammation, 9,189.

19.  Chao PK, Lu KT, YL, Chen JC, Wang HL, Yang YL, Cheng MY, Liao MF, Ro LS (2012) Early Systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury. PLoS ONE, 7:e43680.

20.  Chou AH, Chen SY, Yeh TH, Weng YH, Wang HL* (2011) HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3. Neurobiology of Disease, 41, 481-488.

21.  Wang HL*, Chou AH, Wu AS; Chen SY, Weng YH, Kao YC, Yeh TH, Lu CS (2011) PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochimica et Biophysica Acta, Molecular Basis of Disease, 1812, 674-684.

22.  Chou AH, Lin AC; Hong KY, Hu SH, Chen YL, Chen JY and Wang HL* (2011) p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons. Neurochem. Int., 58, 145-152.

23.  Lee WS, Yan JY, Chiang YC, Hung TW, Wang HL, Chiou LC, Ho KI (2011) Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human mu-opioid and opioid receptor-like 1 receptors. Neurochem. Res., 36, 2008-2021.

24.  Lin YT, Ro LS, Wang HL Chen JC (2011) Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an invivo and in vitro study. Journal of Neuroinflammation, 8, 126.

25.  Wang HL*, Chou AH, Lin AC; Chen SY, Weng YH, Yeh TH (2010) Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons. Exp Neurol. 224, 486-494.

26.  Chen YL, Li AH, Yeh TH, Chou AH, Weng YS, Wang HL* (2010) Nocistatin excites rostral agranular insular cortex-periaqueductal gray projection neurons by enhancing transient receptor potential cation conductance via G(q/11)-PLC-protein kinase C pathway. Neuroscience. 168, 226-239.

27.  Chou AH, Chen CY, Chen SY, Chen WJ, Chen YL, Weng YS, Wang HL* (2010) Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation. Neurochem. Int., 56, 329-339.

28.  Chen YL, Li AH, Yeh TH, Chou AH, Wang HL* (2009) Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons. Mol Cell Neurosci 40, 76-88.

專利

完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)

學歷:

National Taiwan University, School of Pharmacy (B.S., 06/1983)

National Taiwan University, Institute of Pharmacology (M.S., 06/1985)

University of Pennsylvania, Department of Pharmacology (Ph.D., 04/1990)