陳柔賢
基本資料
姓名：
陳柔賢
電子信箱：
連絡電話/傳真：
TEL: 03-3281200#3775
FAX: 03-3277411
服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
林口長庚紀念醫院/ 神經內科系/ 動作障礙科/
主治醫師/ 副教授
機構地址：
333 桃園市龜山區復興街5號
個人網站：
研究領域：
研究興趣：
1.神經內科的運動障礙
2.神經內科的電生理學
3.神經內科的神經肌肉疾病
4.臨床神經生理學
5.神經科學（特別是神經可塑性）
個人簡歷
陳柔賢醫師1987年自中國醫藥學院醫學系畢業之後，就進入長庚醫院服務迄今。他於1991年完成神經內科專科醫師的認證，在神經科學的領域內孜孜不倦，在臨床服務與學術研究上斧鑿深刻、多所建樹。在30多年的長庚生涯中，陳柔賢醫師的簡歷可以分為三部分略述如下:
(一) 行政經驗豐富，在優越的執行力下，開創許多新的方向：
(a) 於2004-2015年，10年的動作障礙科主任職內，建構「經顱超音波黑質症密度自費檢測」、「帕金森治療中心」。其中帕金森治療中心，目前登錄有九百多位病人，是全台灣唯一且完整的前趨型態病人追蹤體系。
(b) 協助陸清松醫師接任第一任神經內科系系主任後，神經內科一、二科科系整合的規劃與系統制度，仍然運作迄今。
(c) 協助規劃並成立「神經科學研究中心」，且擔任第一期和第二期臨床神經生理學組負責人。
(d) 2011-2013出任台灣動作障礙學會理事長，創辦第一屆「帕金森氏病暨動作障礙台灣國際研討會(TIC-PDMD)」，每二年一次，明年已經邁入第五屆，每屆參與人數達六百人以上，成為亞太地區單一學會最重要的國際會議之一。
(e) 2015年再次籌備創辦第一屆「台灣國際神經醫學大會」(ITCN)首屆，與會者有13個國家1000人以上，同樣的2019年的第三屆(ITCN)與會者更達1200人以上。
(f) 2019年六月起接任第22屆台灣神經學學會理事長，負責第17屆亞澳地區神經學聯盟大會AOCN「Asian Oceanian Congress of Neurology」，此會議是Asian Oceanian Association of Neurology (AOAC)的官方會議，將有20個國家代表齊聚台灣，共襄盛舉。
(二) 學術研究積極，在良好的合作脈絡中，規劃前瞻性的研究方向：
(a) 自1995年起，擔任14個科技部研究計畫的主持人，19個科技部計劃的共同主持人，12個長庚研究計畫的主持人，和2個國衛院研究計畫的共同主持人，發表在SCI論文有92篇。
(b) 基於前述的(一)的行政經歷，建立了豐富的人脈網絡，和許多國際知名的研究單位負責人熟識，並進行廣泛的合作。如英國倫敦大學Quean Square of Neurology and Neuroscience Center、日本Ugawa教授、韓國BJ教授、荷蘭Bonifati教授等。
(c) 和國內多所研究單位有廣泛的合作，並和長庚大學的詹曉龍教授、陳思文教授、李冠逸副教授、張雅如教授等聯名進行研究計畫。
(三) 教學態度認真，在確實的親自參與中，成就提攜後進的成果：
(a) 規劃建立的「經顱磁刺激術實驗室」於2004年提出，2005年完成並招募黃英儒醫師自英國留學回國後加入，一年後交棒給黃英儒醫師，而此實驗室目前發展很好。
(b) 協助陸清松教授規劃NRC，並帶領葉篤學醫師、賴思佳醫師完成升任主治醫師的論文 (CV中的論文No.32, No.50)，並成為動作障礙科內Neurogenetics的主要負責人。
(c) 協助林衛邑醫師於臨床研究中進行大量帕金森病歷的收集，於2019年將重要成果發表在JAMA，陳柔賢醫師和黃英儒醫師為共同指導作者。
(d) 積極提攜後進並幫忙規劃臨床方向與研究視野：2016年協助馮博裕醫師完成升遷的論文，指導他進入「神經可塑性」的研究領域，目前馮醫師正在英國進修博士學位；2017年協助林宜穎醫師完成升遷的論文，指導林醫師進入「睡眠醫學」與「超音波介入治療」的領域；2019年協助Fellow陳翊捷醫師投稿完成升遷的主論文，指導她進入「帕金森氏病非動作障礙」的領域；目前仍繼續開創「神經退化性疾病步態異常量化評估與介入治療」的研究方向。
發表論文或著作等
Selected articles from peer-reviewed publications(2010-)
1. EK Tan, CS Lu, R Peng, YY Teo, YH Wu-Chou, RS Chen, YH Weng, CM Chen, HC Fung, LC Tan, ZJ Zhang, XK An, GJ Lee-Chen, MC Lee, S Fook-Chong, JM Burgunder, RM Wu, YR W. Analysis of the UCHL1 genetic variant in Parkinson’s disease among Chinese. Neurobiol Aging 2010;31(12):2194-2196.
2. Ying-Zu Huang, John C Rothwell, Chin-Song Lu, JiunJie Wang, Rou-Shayn Chen* Restoration of motor inhibition through an abnormal premotor-motor connection in dystonia. Movement Disorders 2010;25(6): 696-703.
3. YH Wu-Chou, TH Yeh, CY Wang, JJ Lin, CC Huang, HC Chang, SC Lai, RS Chen, YH Weng, CL Huang, CS Lu. High frequency of multiexonic deletion of GCH1 gene in a Taiwanese cohort of dopa-response dystonia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2010;153B(4):903-8.
4. Szu-Chia Lai, Shih-Ming Jung, Padraic Grattan-Smith, Ella Sugo, Yen-Wen Lin, Rou-Shayn Chen, Yah-Huei Wu-Chou, Anthony E, Lang, Chin-Song Lu. Neuronal Intranuclear Inclusion Disease: Two cases of Dopa-responsive Juvenile Parkinsonism with Drug-induced Dyskineisa. Movement Disorders 2010;25(9):1274-1279.
5. CL Huang, MY Lan, YY Chang, CY Hsu, SC Lai, RS Chen, HC Chang, CS Lu, YH Wu-Chou. Large SGCE deletion contributes to Taiwanese myoclonus-dystonia syndrome. Parkinsonism Relat Disord 2010;16(9):585-589.
6. Bao-Luen Chang , Chien-Ming Shih , Long-Sun Ro, Chin-Chang Huang , Rong-Kuo Lyu , Rou-Shayn Chen , Jiann-Der Lee , Li-Lian Chao , Hung-Chou Kuo. Acute neuroborreliosis with involvement of the central nervous system. J Neurol Sci 2010;295(1-2):10-15.
7. Wu HM, Lu CS, Huang CC, Lyu RK, Chen RS, Wu YR, Chen YC, Lai SC, Hung J, Tsai YT, Toh CH, Kuo HC. Asymmetric Involvement in Sporadic Creutzfeldt-Jakob Disease: Clinical, Brain Imaging, and Electroencephalographic Studies. European Neurology 2010;64(2):74-79.
8. Jiun Jie Wang, YauYau Wai, Wey-Yil Lin, Shu Hang Ng, Chi-Hong Wang, Ren Hsiang Hsieh, Chung Huang Hsieh, Rou-Shayn Chen, Chin-Song Lu. Microstructural Changes in Patients With Progressive Supranuclear Palsy: A DiffusionTensor Imaging Study. Journal of Magnetic Resonance Imaging 2010;32:69–75.
9. Ying-Zu Huang, John C. Rothwell, Chin-Song Lu,Wen-Li Chuang,Wey-Yil Lin, Rou-Shayn Chen*. Reversal of plasticity-like effects in the humanmotor cortex. J Physiol 2010; 19: 3683-3693.
10. Huang CL, Wu-ChoubYH, Lai SC, Chang HC, Yeh TH, Weng YH, Chen RS, Huang YZ and Lu CS*. Contribution of glucocerebrosidase mutation in a large cohort of sporadic Parkinson’s disease in Taiwan. Eur J Neurology 2011 Oct; 18(10): 1227-32.
11. Huang YZ, Rothwell JC, Lu CS, Chuang WL, Chen RS*. Abnormal bidirectional plasticity-like effects in Parkinson’s disease. Brain 2011; 134(Pt 8): 2312-2320.
12. Ying-Zu Huang, John C. Rothwell, Rou-Shayn Chen, Chin-Song Lu, Wen-Li Chuang. The theoretical model of theta burst form of repetitive transcranial magnetic stimulation. Clinical Neurophysiology 2011;122(5):1011-1018.
13. Chuang WL, Lu CS, Huang YZ, Chen RS*. Clinical characteristics of essential tremor in Taiwan: an exploratory-comparative study. Eur J Neurology 2012;19(1)135-141.
14. Chin-Song Lu, Szu-Chia Lai, Ruey-Meei Wu, Yi-Hsin Weng, Chia-Ling Huang, Rou-Shayn Chen, Hsiu-Chen Chang, Yah-Huei Wu-Chou**, Tu-Hsueh Yeh.** PLA2G6 Mutations in PARK14-Linked Young-Onset Parkinsonism and Sporadic Parkinson’s Disease. Am J Med Genet Part B 2012;159B(2):183-191.
15. Yeh TH, Lin JJ, Lai SC, Wu-Chou YH, Chen AC, Yueh KC, Chen RS, Lu CS*. Familial paroxysmal nonkinesigenic dyskinesia: clinical and genetic analysis of a Taiwanese family. 2012 J Neurol Sci 2012;323(1-2):80-84.
16. Min-Yu Lan, Ser-Chen Fu, Yung-Yee Chang, Yah-Huei Wu-Chou, Szu-Chia Lai, Rou-Shayn Chen, Chin-Song Lu. Clinical and genetic analysis of four Taiwanese families with autosomal dominant hereditary spastic paraplegia. J Formosan Med Asso 2012;111:380-385.
17. Ying-Zu Huang, Chin-Song Lu, John C. Rothwell, Chung-Chuan Lo, Wei-Li Chuang, Yi-hsin weng, Szu-Chia Lai, Rou-Shayn Chen*. Modulationof the disturbed motor network in dystonia by multisession suppression of premotor cortex. PLoS ONE 2012;7(10): e47574. doi:10.1371/journal.pone.0047574.
18. Yeh TH, Lai SC, Weng YH, Kuo HC, Wu-Chou YH, Huang CL, Chen RS, Chang HC, Traynor B, Lu CS*. Screening for C9orf72 repeat expansions in parkinsonian syndromes. 2013 Neurobiol of Aging.
19. Chen YL, Lin SW, Chuang LP, Lai SC, Chen RS, et al. (2013) Validation assessment of the Chinese version of the International Restless Legs Scale. Thoracic Medicine 28: 65–72.
20. Wan-Yu Hsu, Shang-Yeong Kwan, Kwong-Kum Liao, Rou-Shayn Chen*, Yung-Yang Lin*. Altered Inhibitory Modulation of Somatosensory Cortices in Paroxysmal Kinesigenic Dyskinesia. Movement Disorders 2013;28:1728-1731.
21. Wan-Yu Hsu, Kwong-Kum Liao, Yi-Jhan Tseng, Shang-Yeong Kwan, Rou-Shayn Chen*, Yung-Yang Lin*. Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia. Neurology 2013;81:353–360.
22. Shih-Wei Lin, Yen-Lung Chen, Kuo-Chin Kao, Cheng-Ta Yang, Li-Pang Chuang, Yu-Ting Chou, Szu-Chia La, Rou-Shayn Chen, Ning-Hung Chen*. Diseases in Patients Coming to a Sleep Center with Symptoms Related to Restless Legs Syndrome. PLoS ONE 2013; 8(8): e71499 doi:10.1371/journal.pone.0071499
23. Wu-Choua YH, Chen YT, Yeh TH, Chang HC, Weng YH, Lai SC, Huang CL, Chen RS, Huang YZ, Chen CC, Hung J, Chuang WL, Lin WY, Chen CH, Lu CS. Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort. Parkinsonism Relat Disord. 2013 Feb;19(2):251-255.
24. Chuang WL, Huang YZ*, Lu CS, Chen RS*. Reduced cortical plasticity and GABAergic modulation in essential tremor. Mov Disord 2014 Apr;29(4):501-507.
25. Yi-Jhan Tseng #, Rou-Shayn Chen#, Wan-Yu Hsu, Fu-Jung Hsiao, Yung-Yang Lin*. Reduced Motor Cortex Deactivation in Individuals Who Suffer from Writer’s Cramp. PLoS ONE 2014;9(5): e97561.doi:10.1371/journal.pone.0097561e47574.
26. Ching-chi Chiu, Tu-hsueh Yeh, Szu-chia Lai, Yi-hsin Weng, Yin-cheng Huang, Yi-chuan Cheng, Rou-Shayn chen, Ying-zu Huang, June Hung, Chiung-chu Chen, Wey-yil Lin, Hsiu-chen Chang, Yu-jie Chen, Chao-lang Chen, Hsin-yi Chen, Yan-wei Lin, Yah-huei Wu Chou, Chin-song Lu. Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease. Oncotarget 2016;7 (34):54215-54227.
27. Chia-wei Liou, Jiin-haur Chuang, Jin-bor Chen, Mao-meng Tiao, Pei-wen Wang, Sheng-teng Huang, T. L Huang, Wen-chin Lee, Shao-wen Weng, P. H Huang, Shang-der Chen, Rou-Shayn Chen, Chin-song Lu, Tsu-kung Lin. Mitochondrial DNA variants as genetic risk factors for Parkinson disease. European Journal of Neurology 2016;23(8):1289-1300.
28. Fu-Jung Hsiao, Wan-Yu Hsu, Wei-Ta Chen, Rou-Shayn Chen, Yung-Yang Lin. Abnormal Somatosensory Synchronization in Patients With Paroxysmal Kinesigenic Dyskinesia: A Magnetoencephalographic Study. Clinical EEG and Neuroscience 2016 July 2016 DOI: 10.1177/1550059416662575.
29. Po-yu Fong, Mark J Edwards, Chin-song Lu, Rou-Shayn chen, John C Rothwell, Kailash P Bhatia, Ying-zu Huang. Abnormal blink reflex recovery cycle in manifesting and nonmanifesting carriers of the DYT1 gene mutation Neuroreport 2016; 27(14):1046-1049.
30. Ni HC, Hung J, Wu CT, Wu YY, Chang CJ, Chen RS, Huang YZ. The Impact of Single Session Intermittent Theta-Burst Stimulation over the Dorsolateral Prefrontal Cortex and Posterior Superior Temporal Sulcus on Adults with Autism Spectrum Disorder. Front Neurosci. 2017 May 9;11:255. doi: 10.3389/fnins.2017.00255. PMID: 28536500; PMCID: PMC5423353. (SCI)
31. Kuan-yi Li ,Yi-hui Wu , Rou-shayn Chen. Interrater reliability of clinically performed manual
arm position and motion matching test. Neuropsychiatry (London) 2017, 7(4): 290–296.
33. Yi-Ying Lin, Rou-Shayn Chen*, Chin-Song Lu, Ying-Zu Huang, Yi-Hsin Weng, Tu-Hsueh Yeh, Wey-Yil
Lin, une Hung. Sleep disturbances in Taiwanese patients with Parkinson’s disease. Brain and
Behavior 2017;7(10): e00806 (Correspondence author)
32. Kuan-yi Li, Yu-pei Hsiao, Rou-shayn Chen, Ching-yi Wu. Effects of Wrist Weights on Kinematic and Myographic Movement Characteristics During a Reaching Task in Individuals With Parkinson Disease. Archives of Physical Medicine and Rehabilitation 2018; 99: 1303-1310.
33. Ying-Zu Huang, Rou-Shayn Chen, Po-Yu Fong, John C Rothwell, Wen-Li Chuang, Yi-Hsin Weng, Wey-Yil Lin, and Chin-Song Lu. Inter-cortical Modulation from Premotor to Motor Plasticity. The Journal of Physiology First published: 11 June 2018 https://doi.org/10.1113/JP276276.
34. Huang YZ, Rou-Shayn Chen, Fong PY, Rothwell JC, Chuang WL, Weng YH, Lin WY, Lu CS. Inter-cortical modulation from premotor to motor plasticity. Journal of Physiology-London. 2018 Sep;596(17):4207-4217. doi: 10.1113/JP276276. Epub 2018 Jul 5.
35. Lin WY, Lin MS, Weng YH, Yeh TH, Lin YS, Fong PY, Wu YR, Lu CS, Rou-Shayn Chen, Huang YZ *. Association of Antiviral Therapy With Risk of Parkinson Disease in Patients With Chronic Hepatitis C Virus Infection. JAMA Neurology 2019;76 (9):1019-1027.
36. Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Rou-Shayn Chen, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL. PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Molecular Neurobiology 2019 June,56(6) : 3835-3853.
37. Chiu CC, Yeh TH, Rou-Shayn Chen, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL.Upregulated expression of microRNA-204-5p leads to the death of dopaminergic cells by targeting DYRK1A-mediated apoptotic signaling cascade. Frontiers in cellular neuroscience.2019, 13:399.
38. Chiu CC, Wang HL, Weng YH, Rou-Shayn Chen, Chen CM, Yeh TH, Lu CS, Chen YJ, Liu YC, Huang YZ, Chang KH. Generation of induced pluripotent stem cells from a young-onset Parkinson's disease patient carrying the compound heterozygous PLA2G6 p.D331Y/ p.M358IfsX mutations. Stem cell research, 40, 101552.
39. Yang CY, Rou-Shayn Chen, Huang YZ. Analysis and Discrimination of Surface Electromyographic Features for Parkinson's Disease during Elbow Flexion Movements. J Mot Behav. 2019 Sep 20:1-9. doi: 10.1080/00222895.2019.1666081.
40. Wang HL, Lu CS, Yeh TH, Shen YM, Weng YH, Huang YZ, Rou-Shayn Chen, Liu YC, Cheng YC, Chang HC, Chen YL, Chen YJ, Lin YW, Hsu CC, Lin HL, Chiu CH, Chiu CC. Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease. J Clin Neurol. 2019 Oct;15(4):488-495. doi: 10.3988/jcn.2019.15.4.488.
41. Chan KA, Hsieh YC, Hsieh SF, Rou-Shayn Chen (2020). Changes in Pramipexole Utilization after Introduction of the Extended-Release Formulation: A Nationwide Study in Taiwan. Drugs-Real World Outcomes, 1-9.
42. Liu YC, Wang HL, Huang YZ, Weng YH, Rou-Shayn Chen, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW and Chen YJ ( 2020) Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models. Biochemical Pharmacology, 113919. (SCIE)(2019 impact factor:4.960)
43. Chen YC, Huang YZ, Weng YH, Chen CC, Hung J, Lin YY, Lin WY and Rou-Shayn Chen (2020) Nonmotor symptoms of 820 Taiwanese patients with Parkinson’s disease: an exploratory-comparative study. Journal of Neurology, 1-9.
44. Yang CY, Rou-Shayn Chen and Huang YZ (2020) Analysis and Discrimination of Surface Electromyographic Features for Parkinson’s Disease during Elbow Flexion Movements. Journal of motor behavior, 52(5): 625-633.
45. Chiu CC, Weng YH, Huang YZ, Rou-Shayn Chen, Liu YC, Yeh TH, Lu CS , Lin YW , Chen YJ, Hsu CC, CH Chiu CH Chiu, Wang YT, Chen WS, Liu SY & Wang HL(2020) (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model. Cell death & disease, 11(11), 1-14.
46. Chan KA, Hsieh YC, Hsieh SF, Rou-Shayn Chen (2020). Changes in Pramipexole Utilization after Introduction of the Extended-Release Formulation: A Nationwide Study in Taiwan. Drugs-Real World Outcomes, 1-9.
專利
完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
學歷
中國醫藥大學醫學士
經歷
長庚紀念醫院神經內科系動作障礙科主任
台灣動作障礙學會理事長
林口長庚醫院神經內科住院醫師暨總醫師
台灣神經學學會理事長
學會與認證
動作障礙學會會員
神經科專科醫師
台灣神經學學會員