陳景宗
基本資料
姓名：
陳景宗
電子信箱：
連絡電話/傳真：
TEL: (03)2118800x5282
FAX: (03)2118700
服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
長庚大學
生物醫學研究所
生理暨藥理學科
教授
機構地址：
桃園市龜山區文化一路259號
個人網站：
https://gibms.cgu.edu.tw/p/404-1079-7732.php?Lang=zh-tw
研究領域：
藥物成癮、帕金森氏症、焦慮與憂鬱、神經胜肽
個人簡歷
陳景宗教授1979年畢業於台灣大學動物系動物生物組，於1981年赴美在伊利諾大學香檳校區獲得生理及生物物理學碩士與博士學位，之後1987赴波士頓大學醫學院從事博士後的研究，並於1990年轉往麻州醫學院擔任講師，從事有關神經生理與細胞生物的研究。1993年返台在長庚大學藥理學科擔任副教授，開始有關藥物成癮和帕金森氏症的動物模式開發與相關的研究工作，並於2003年開始擔任生理暨藥理科主任一職，2005年升等教授後於2008年擔任生物醫學研究所所長一職至今；期間並於2007-2016年間，兼任國立政治大學神經科學研究所教授。陳教授長期以來參加台灣藥理學會、生理學會以及基礎神經學會的活動並為學會會員，並且擔任數屆生理學會與基礎神經學會理事，協助學會辦理各項學術活動和研討會，目前並擔任科技部生物司型態及生理醫學學門召集人一職，並且擔任Biomedical Journal和中國生理學期刊的執行編輯。
陳教授長期以來的研究以藥物成癮為主，利用神經化學與行為表現作為研究的主軸，並以細胞株實驗探討特定蛋白的細胞訊息傳導機制，活體實驗以行為致敏化和場地制約行為為主，最近成功開發光遺傳學的技術應用於神經迴路的分析，以探討成癮記憶與藥物復犯的神經投射路徑；另外也利用小分子核醣核酸分析甲基安非他命行為致敏化的分子機制。此外，基於對大腦多巴胺系統的興趣，研究團隊也開發帕金森氏症的動物模式，研究側腦室幹細胞對帕金森動作障礙的影響，以及左多巴誘發病變動物產生異動症的成因，最近則探討帕金森失智症與腦部免疫反應的關聯。這些研究確認陳教授在多巴胺研究領域上的專精和深入。
發表論文或著作等
Publication since 2010:
H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen and J-J Wang (2010) In vivo assessment of macrophage CNS infiltration during disruption of the blood–brain barrier with focused ultrasound: a magnetic resonance imaging study, Journal of Cerebral Blood Flow & Metabolism, 30:177-186.
C.H. Hsieh, H.Y. Li and J.C. Chen (2010) Nitric oxide and interleukin-1b mediate noradrenergic induced corticotrophin-releasing hormone release in organotypic cultures of rat paraventricular nucleus, Neuroscience, 165:1191-1202.
F. Kersanté, J.-Y. Wang, J.-C. Chen, C. Mollereau and Jean-Marie Zajac (2011) Anti-opioid effects of neuropeptide FF receptors in the ventral tegmental area, Neuroscience Letters, 488: 305-309.
Y.-L. Shen, J.-C. Chen and R.-M. Liao (2011) Place conditioning and neurochemical responses elicited by the after effect of acute stressor exposure to an elevated stand, Neuroscience Letters, 504:156-159.
Y.T. Lin and J.C. Chen (2011) The involvement of dorsal root ganglia BDNF-TrkB in inflammatory pain in vivo and in vitro, Journal of Neuroinflammation, 8:126-147.
D.-J. Kao, Allen H Li, J.C. Chen, R.S. Luo, Y.L. Chen, J.C. Lu and H.L. Wang (2012) CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons, Journal of Neuroinflammation, 9:189.
P.K. Chao, K.T. Lu, Y.L. Lee, J.C. Chen, H.L. Wang, Y.L. Yang, M.Y. Cheng, M.F. Liao, L.S. Ro (2012) Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury, PLoS ONE, 8:1-13.
H.T. Chen, N.Y. Ruan, J.C. Chen* and Z.Y. Lin* (2012), Dopamine D2 receptor-mediated Akt/GSK3b signaling: Initiation by D2S receptor and role in quinpirole-induced behavioral activation, ASN NEURO, 4(6). (*, co-corresponding)
C.C. Lin, H.L. Hsieh, R.H. Shih, P.L. Chi, S.E. Cheng, J.C. Chen* and C.M. Yang* (2012) NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin- induced matrix metalloproteinase-9 expression and cell migration in brain astrocytes, Cell Communication and Signaling, 10:35. (*, co-corresponding)
L.H. Chow, P.L. Tao, J.C. Chen, R.M. Liao, E.P. Chang and E.Y.K. Huang (2013) A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats. Peptides, 39:21-28.
T.C. Wu, H.T. Chen, H.Y. Chang, C.Y. Yang, M.C. Hsiao, M.-L. Cheng and J.-C. Chen (2013) Mineralocorticoid receptor antagonist prevents chronic corticosterone induced depression-like behaviors, Psychoneuroendocrinology, 38:871-883.
C.L. Lao, C.S. Lu and J.C. Chen (2013) Dopamine D3 receptor activation promotes neural stem / progenitor cell proliferation through AKT and ERK1/2 pathways and expands type-B and type–C cells in adult subventricular zone, Glia, 61:475–489.
P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu (2013) Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, PLoS ONE, 8(2): e57682.
C.L. Lao, Y.H. Kuo, Y.T. Hsieh and J.C.Chen (2013), Intranasal and subcutaneous administration of dopamine D3 receptor agonists functionally restores nigrostriatal dopamine in MPTP-treated mice, Neurotoxicity Research, 24:523-531.
Y.C. Chiang, Y.N. Lo and J.C. Chen (2013) Dopamine D2 receptors crosstalk with cannabinoid CB1 receptors at ERK1/2 signal and regulate Cnr1 promoter activity, Journal of Neurochemistry, 127:163-176.
H.T. Chen and J.C. Chen (2014) Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity, Learning and Memory, 22:149-158.
S.C. Kao, Y.T. Lin, Y.J. Dey and J.C. Chen (2015) The effects of Neuropeptide FF receptor subtype 2 over-expression on nociception and morphine tolerance, European Journal of Pain, 20:895-906.
Y.T. Lin, T.Y. Liu, C.Y. Yang, Y.L. Yu, T.C. Chen, Y.J. Day, C.C. Chang, G.J. Huang and J.C. Chen (2016) NPFFR2 stimulates stress-related depressive behaviors through HPA axis modulation, Psychoneuroendocrinology, 71:73-85.
W.Y. Tzeng, H.H. Wu, C.Y. Wang, J.C. Chen, L. Yu and C.F. Cherng (2017) Sex differences in stress and group housing effects on the number of newly proliferated cells and neuroblasts in middle-aged dentate gyrus. Frontiers in Behavioral Neuroscience, 10, 249.
Y-T Lin, H-L Liu, Y-J Day, C-C Chang, P-H Hsu and J.C. Chen (2017) Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice, Experimental Neurology, 291:62-73.
Q-C Moa and J.C. Chen (2017) Reduced neuregulin 1 expression in the medial prefrontal cortex of rat ketamine model for schizophrenia, Neuropsychiatry, 7(3):640-647.
S.F. H. Waqas, A.C. Hoang, Y.-T. Lin, G. Ampem, A. Hind, L. Balogh, J.C. Chen, I. Gerling, J.-S. Lim, S. Nam, J. Martinez-Ibanez, S. Paschke, J. Real, R. Quillet, S. Ayachi, S. Frederic, M. Schneider, C. Seroogy , J. Thuroczy, T. Röszer (2017) Neuropeptide-FF increases M2 activation and self-renewal of adipose tissue macrophages. Journal of Clinical Investigation, JCI90152.
S.Y. Chang, T.S. Hsieh, W.R. Chen, J.C. Chen and C Chou (2017) Measurement of tissue- radiation dosage using a thermal steady-state elastic shear wave, Journal of Biomedical Optics, 22(8), 085001.
Y.T. Lin, Y.L. Yu, W.C. Hong, T.S. Yeh, T.C. Chen and J.C. Chen (2017) NPFFR2 activates the HPA axis and induces anxiogenic effects in rodents, International Journal of Molecular Sciences, 18, 1810.
P-K Chang, L. Yu and J.C. Chen (2018) Dopamine D3 receptor blockade rescue hyper-dopamine activity-induced deficit in novel object recognition memory, Neuropharmacology, 133:216-223.
Y.T. Lin and J.C. Chen (2018) Dorsal root ganglia isolation and primary culture to study neurotransmitter release, JOVE, e57569.
S.H. Huang, L.M. Lee, P.R. Huang and J.C.Chen (2018) Up-regulation of mTOR-dependent signaling in the ventral striatum determines the behavioral sensitization to methamphetamine, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 86:331-339.
Y.T. Lin and J.C. Chen (2019) Neuropeptide FF modulates neuroendocrine and energy homeostasis through hypothalamic signaling, Chinese Journal of Physiology, 62:47-52.
C.W. Kao, Y.Y. Tseng, K.S. Liu, Y.W. Liu, J.C. Chen, H.L. He, Y.C. Kau and S.J. Liu (2019) Anesthetics and human epidermal growth factor incorporated into anti-adhesive nanofibers provide sustained pain relief and promote healing of surgical wounds, International Journal of Nanomedicine, 14:4007-4016.
C-J Lin, C-Y Lin, Y-T Lin, C-Y Huang, K-C Wei, J-C Chen, G-J Lee-Chen and H-L Liu (2019) Microbubble-facilitated ultrasound pulsation promotes direct alpha-synuclein gene delivery, Biochemical and Biophysical Research Communications, 517(1):77-83.
Y-H Hsu, H-Y Chen, J.C. Chen, Y-H Yu, Y-C Chou, Steve W-N Ueng *, S-J Liu (2019) Resorbable beads provide extended release of antifungal medication: in vitro and in vivo analyses, Pharmaceutics, 11(11): 550.
P-K Chang, J. Chu, Y-T Tsai, Y-H Lai and J-C Chen (2020) Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice, Journal of Biomedical Science, 27:16.
J-M Chen, K-C Liu, W-L Yeh, J-C Chen and S-J Liu (2020) Sustained release of levobupivacaine, lidocaine and acemetacin from electrosprayed microparticles: In vitro and in vivo studies, International Journal of Molecular Sciences, 21, 1093.
Y-Y Kuo, J-K Lin, Y-T Lin, J-C Chen, Y-M Kuo, P-S Chen, S-N Wu and P-C Chen (2020) Glibenclamide restores dopaminergic reward circuitry in obese mice through interscapular brown adipose tissue, Psychoneuroendocrinology, 118, 104712.
Y-T Lin, Z. Yu, S-C Tsai and J-C Chen (2020) Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion, The Journal of Headache and Pain, 21:87.
C-L Jhang, H-Y Lee, J-C Chen, W-L Liao (2020) Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder, Human Molecular Genetics, 29(14):2408-2419.
P-K Chang, K-Y Chien and J-C Chen (2020) Dopamine transporter is downregulated and its association with chaperone protein Hsc70 is enhanced by activation of dopamine D3 receptor, Brain Research Bulletin, 165:263-271.
I.M. Liao and J.C. Chen (2021) Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response, Behavioral Brain Research, 396 112925.
Y-T Lin, Y-L Huang, S-C Tsai and J-C Chen (2021) Ablation of NPFFR2 in mice reduces response to single prolonged stress model. Cells, accepted.
專利
L-dopa 化合物, 中華民國, 財團法人工業技術研究院, 高愛華 林秋杏 蘇珍儀 黃必燦 莊孟均 黃崇雄 王惠柏 陳景宗, I317218, 2009年11月21日~2024年9月12日
完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
Education:
Postdoctoral Fellow: Dr. Ladislav Volicer, Department of Pharmacology, Boston University School of Medicine, Boston, MA. 1987-1990
Ph.D.: Dr. Victor D. Ramirez, Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign, Illinois. 1983-1987.
Thesis: Prolactin Effect on Nigrastriatal and Mesolimbic Dopaminergic neurons
M.S.: Department of Physiology and Biophysics, University of Illinois at Urbana-
Champaign, Illinois. 1981-1983.
B.S.: Department of Zoology, National Taiwan University, Taipei, Taiwan.
1975-1979.
Professional Experience:
2008- Director, Graduate Institute of Biomedical Sciences, Chang-Gung University, Taoyuan, Kwei-Shan, Taiwan, R.O.C.
2007-2016 Adjunct faculty, Institute of Neuroscience, National Cheng-Chi University
2005- Professor, Department of Physiology & Pharmacology, Chang-Gung University
2003-2008 Chairman, Department of Physiology & Pharmacology, Chang-Gung University, Tao-Yuan, Kwei-Shan, 333 Taiwan, R.O.C.
1993-2004 Associate Professor, Department of Pharmacology, Chang-Gung University, Tao-Yuan, Kwei-Shan, Taiwan, R.O.C.
1992-1993 Senior Biochemist, Quality Controlled Biochemicals Inc., Hopkinton, MA., USA.
1990-1992 Instructor, University of Mass. Medical School, Department of Pharmacology, Worcester, MA., USA.
1989-1990 Scientific Staff, University Hospital, Boston University School of Medicine, Department of Psychiatry, Boston, MA., USA.
1987-1989 Research Associate, Department of Pharmacology, Boston University, School of Medicine, Boston, MA., USA.
1981-1987 Teaching and Research Assistant, Department of Physiology and Biophysics, University of Illinois at Urbana-Champaign, IL., USA.
Professional Affiliations:
Society for Neuroscience (USA, since 1982)
Society of Taiwan Pharmacology (Taiwan, ROC, since 1994)
Society of Chinese Physiology (Taiwan, ROC)
Society of Basic Neuroscience (Taiwan, ROC)
Taiwan Addiction Society