梁淑鈴
基本資料
姓名：
梁淑鈴
電子信箱：
連絡電話/傳真：
TEL: 03-2118800-3688
FAX: 03-2118700
服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
長庚大學醫學院/生物醫學研究所/生理暨藥理學科/助理教授
機構地址：
桃園市龜山區文化一路259號
個人網站：
https://gibms.cgu.edu.tw/p/404-1079-7725.php?Lang=zh-tw
研究領域：
突觸電生理；腦女性化；生殖生理
個人簡歷
梁助理教授畢業於國立陽明大學生理學研究所博士班(1997-2001)，師承於潘震澤教授，修讀期間主要研究多巴胺神經元第二及第三型受器對雌鼠下視丘結節漏斗多巴胺神經元的日變週期節律的調控，優異研究成果榮獲第一屆國際腦研究機構的獎助金(IBRO School of Brain Function, 2000)。之後前往美國兩間實驗室繼續博士後研究，先是位於賓州大學暨費城兒童醫院Coulter, DA教授實驗室(2001-2007)，主要研究星型膠細胞與丙胺基丁酸神經元之間的一個胺基酸代謝路徑(麩醯胺酸-麩胺酸循環；Glutamine-Glutamate Cycle；GGC)如何調控海馬迴神經元的丙胺基丁酸突觸效能，及GGC在導致癲癇發作所扮演的角色。之後前往馬里蘭大學醫學院巴爾地摩校區McCarthy, MM及Alger, BE教授實驗室(2007-2008)，期間主要研究雌二醇媒介麩胺酸神經元突觸效能改變，進而導致雄幼鼠腦去女性化的細胞機制，此外也研究發育過程中海馬迴神經元釋放內源性嗎啡胺(Endocannabinoids)的突觸細胞訊息機制。期間因出色的研究成果也被晉升為副研究員(2008)。梁助理教授於2009加入長庚大學生理學科教職至今。任教期間曾獲國科會優秀研究人才獎(2011)，受邀擔任紐西蘭皇家科學院院外研究計畫審查委員(2014)，獲中華民國專利(2019)，所指導的研究生也連續獲得生物醫學聯合學術年會中國生理學會論文競賽第三名及長庚大學生物醫學研究所碩士論文競賽第二名的佳績(2017~2018)。目前主要的研究方向包括大鼠腦女性化(Feminization)的細胞機制及古科鹼及安非他命轉錄胜肽(Cocaine- and amphetamine-regulated transcript peptide ; CART)對大鼠投射到胃及盲腸的迷走神經運動背核神經元的放電活性及突觸輸入的調控等。
發表論文或著作等
Journal Articles (peer-reviewed):
1. Liang SL*, Tong YS, Hwang LL, Huang YZ, Chen CY, (2021) CART peptides differently regulate firing rates and GABAergic synaptic inputs of DMV neurons innervating the stomach and cecum of adult male rats. Neuroendocrinology(Revised) (*, corresponding author)
2. Liang SL (2018) The glutamine-glutamate cycle regulates synaptic glutamate release in ventrolateral ventromedial nucleus of the hypothalamus of perinatal female rats. J. Neuroendocrinol. 30: e12642.
3. Liang SL*, Alger BE, McCarthy MM (2014) Developmental increase in hippocampal endocannabinoid mobilization: roles of metabotropic glutamate receptor subtype 5 and phospholipase C. J. Neurophysiol. 112:2605-2615. (*, corresponding author)
4. Liang SL*, Hsu SC, Pan JT (2014) Involvement of dopamine D2 receptor in the diurnal changes of tuberoinfundibular dopaminergic neuron activity and prolactin secretion in female rats. J. BioMed. Sci. 21:37. (*, corresponding author).
5. Liang SL*, Pan JT (2012) An endogenous dopaminergic tone acting on dopamine D3 receptors may be involved in diurnal changes of tuberoinfundibular dopaminergic neuron activity and prolactin secretion in estrogen-primed ovariectomized rats. Brain Res. Bull. 87:334-339. (*, corresponding author).
6. Liang SL*, Pan JT (2011) The spontaneous firing rates of dopamine-inhibited dorsomedial arcuate neurons exhibit a diurnal rhythm in brain slices obtained from ovariectomized plus estrogen-treated rats. Brain Res. Bull. 85:189-193. (*, corresponding author)
Published Abstracts:
1. Liang SL, Chen RS: Perinatal interruption of glutamine-glutamate cycle (GGC) permanently compromises GGC-dependent basal excitatory and inhibitory synaptic transmissions in the hypothalamic neurons of estrous female rats. The 35th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 21-22, 2020. (Accepted)
2. Lin YS, Liang SL: Blockade of neuronal glutamine uptake during brain development differently changes fertility of female rats. The 34th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 23-24, 2019. (P061, enter the final poster contest held by The Chinese Physiological Society).
3. Lin YS, Liang SL: Neonatal disruptions of the glutamate-glutamine cycle reduce the expression of sexual behavior and fertility of female rats. The 33th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 24-25, 2018. (PY073; The third place in the poster contest held by The Chinese Physiological Society).
4. Tong YS, Hwang LL, Chen CY, Liang SL: Different regulations of CART peptides on firing rates and synaptic inputs of DMV neurons innervating stomach and cecum in rats. The 32th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 25-26, 2017. (PY060; The third place in the poster contest held by The Chinese Physiological Society).
5. Tong YS, Hwang LL, Chen CY, Liang SL: Retrograde Labeling in vivo of vagal preganglionic neurons innervating stomach and cecum in rats by the carbocyanine dye DiO. The 31th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 26-27, 2016. (P138).
6. Yeh CY, Liang SL: Sex differential effects of neonatal pretreatments of fluoroacetate or MSO to disrupt glutamate-glutamine cycle on adult reproductive behaviors in rats. EMBO Conference on neural development- function and dysregulation. Taiwan, Taipei, Dec 4-8, 2015. (p32)
7. Liang SL, Hsu SC: Diurnal changes of dopamine D2 and D3 receptor mRNA expression in medial basal hypothalamus of estrogen-primed ovariectomized rats. The 28th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 23-24, 2013. (P564)
8. Liang SL, Lim SC: Blockade of neuronal glutamine uptake reduces quantal GABA content under active synapse in the medial basal hypothalamus of neonatal rats. The 27th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 17-18, 2012. (P415)
9. Liang SL: Blockade of glutamate-glutamine cycle does not change vesicular GABA content in neurons of neonatal hypothalamus under basal neuronal activity. The 7th Federation of Asian-Oceanian Physiology Society (FAOPS) Congress, Taiwan, Taipei, Sep 11-14, 2011. (PT05)
10. Liang SL, Huang YH: Sex differences in astrocytic glutamine synthetase and spinophilin protein expressions in neonatal hypothalamic brain slices. The 26th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, Mar 19-20, 2011. (P848)
中文文章:
1. 梁淑鈴 (2011, 十月):簡介腦神經疾病與星狀膠細胞麩胺酸—麩胺醯胺循環異常的關連。長庚醫訊，32卷10期，增刊第54-57頁。
專利
利用麩醯胺酸來改善性功能障礙, 中華民國，台灣, 長庚大學; 長庚醫療財團法人林口長庚紀念醫院; 林口神經科學中心, 梁淑鈴, I652059, 2019/3/1~2037/3/16
完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
Education
Year
Degree (Major)
Institution
1997, 9 -
2001, 6
Ph.D. (Physiology)
Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Taiwan. ROC.
1995, 9 -
1997, 6
M.S. (Physiology)
Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Taiwan. ROC.
1990, 9 -
1993, 6
B.S. (Medical Technology)
Department of Medical Technology, China Medical College, Taichung, Taiwan, ROC.
Professional Experience
Year
Position
Institution
2009, 2 - Present
Assistant Professor
Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan.
2008, 2 – 2008, 10
Research Associate
Program in Neuroscience, Department of Physiology, University of Maryland, Baltimore, Baltimore, Maryland, USA.
2007,7 – 2008, 1
Postdoctoral Fellow
Program in Neuroscience, Department of Physiology, University of Maryland, Baltimore, Baltimore, Maryland, USA.
2001, 9 – 2007, 6
Postdoctoral Fellow
Division of Neurology, the Children's Hospital of Philadelphia/ Institute of Neuroscience, University of Pennsylvania, Philadelphia, USA.
1993, 8 – 1995, 7
Teaching Assistant
Department of Medical Technology, China Medical College, Taichung, Taiwan, ROC.
Awards and Honors
1. The third place in the poster contest held by the Chinese Physiological Society in the 33th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, 2018.
2. The third place in the poster contest held by the Chinese Physiological Society in the 32th Joint Annual Conference of Biomedical Science, Taiwan, Taipei, 2017.
3. The Marsden Fund Referee. The Marsden Fund is affiliated by New Zealand Government and is administered by the Royal Society of New Zealand. 2014.
4. Editorial Board Member in Journal “Animal cells and systems”, The Official Journal of the Korean Society for integrative Biology. 2010~2013.
5. National Science Council Outstanding Researcher Award, 2011.
Professional Affiliations
The Chinese Physiological Society (1996 - present)
Taiwan Neuroscience Society (1996 - present)
American Society for Neuroscience (1998 - 2010)
Research Supports
2021 - 2022 Principle investigator. “Explore the cellular mechanism of glutamate synaptic plasticity on the regulation of brain and behavioral feminizations in the hypothalamus of neonatal rats: developmental changes and the role of estradiol”. Chang Gung Medical Foundation, Taiwan.
2020 - 2021 Principle investigator. “Exploring the role of glutamine-glutamate cycle in the regulation of brain feminization during development-reproductive behavior、fertility and synaptic plasticity studies”. Chang Gung Medical Foundation, Taiwan.
2017 - 2019 Principle investigator. “Explore the mechanism of hypothalamus glutamate synaptic plasticity on the regulation of sexual differentiation during neonatal critical period”, from Ministry of Science and Technology, Taiwan.
2016 - 2020 Principle investigator. “Roles of cocaine- and amphetamine-regulated transcript peptide (CART) in the regulation of excitatory and inhibitory inputs to the neurons of dorsal motor nucleus of vagus (DMV) innervating to the stomach and cecum”, from Chang Gung Medical Foundation, Taiwan.
2013 - 2016 Principle investigator. “Roles of G-protein coupled-receptors and phospholipids C in the mediation of endocannabinoids mobilization during postnatal brain development”, from Chang Gung Medical Foundation, Taiwan.
2014 - 2015 Principle investigator.” Role of astrocyte glutamate-glutamine cycle in the regulation of vesicular glutamate content under active synapses during the sensitive period of brain sexual differentiation”, from Ministry of Science and Technology, Taiwan.
2009 - 2012 Principle investigator. “Failure of astrocyte glutamate-glutamine cycle as an early marker of temporal lobe epilepsy”, from Chang Gung Medical Foundation, Taiwan.
2009 - 2011 Principle investigator. “Estrogen regulates GABA vesicular contents via modulation of astrocyte glutamate-glutamine cycle: implications for sex difference”, from National Science Council, Taiwan.
Invited Presentation
May 25, 2017 “Sex-linked differences in dependence on the glutamine-glutamate cycle to sustain synaptic glutamate release in the neonatal hypothalamus determine feminization and defeminization behaviors and are regulated by estradiol receptor activation in rats”- Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan.
Oct 27, 2010 “Roles of astrocytic glutamate-glutamine cycle in regulating synaptic GABA release in normal and epileptic brains”-School of Post-Baccalaureate Chinese Medicine, I-Shou University, Kaohsiung, Taiwan.