魏國珍

基本資料

姓名：
魏國珍

電子信箱：
kuochenwei@cgmh.org.tw

連絡電話/傳真：
TEL: +886-2-2263-0588 ext.6188 ; +886-3-3281200 ext.2412
FAX: +886-3-3285818

服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
新北市立土城醫院副院長
長庚紀念醫院神經外科教授
神經科學研究中心主任

機構地址：
土城院區：236新北市土城區金城路二段6號
林口醫學中心：桃園市龜山區復興街五號

個人網站：

研究領域：
神經外科
神經腫瘤學
奈米醫學
腦瘤轉譯醫學

個人簡歷

主要學歷

中山醫學大學醫學士 1978/ 9至1985/6

經歷

現職：新北市立土城醫院副院長 2020/4迄今

長庚紀念醫院神經外科教授 2016/7迄今

神經科學研究中心主任 2020/7迄今

經歷

林口長庚紀念醫院外科部腦神經外科主任 2012/1至2014/6

林口長庚紀念醫院外科部腦腫瘤神經外科主任 2008/7至2012/6

長庚大學醫學院醫學系副教授 2016/8-2020/12

長庚大學醫學院醫學系兼任講師 2004/8至2012/7

University of California, San Francisco, CA Brain Tumor Research Center 研究員 1999/7至2001/1

林口長庚紀念醫院外科部腦神經外科住院醫師 1989/7 至1993/6

林口長庚紀念醫院外科部一般外科住院醫師 1987/9 至1989/6

發表論文或著作等

(*: Corresponding author)

1. Wei KC, Chang CN, Lin PK. An intracranial aneurysm associated with a recurrent meningioma--a case report. Changgeng Yi Xue Za Zhi. 1994 Sep; 17(3): 284-288.

2. Liao JJ*, Cheng WC, Chang CN, Yang JT, Wei KC, Hsu YH, Lin TK. Reoperation for recurrent trigeminal neuralgia after microvascular decompression. Surgical Neurology. 1997 Jun; 47(6): 562-570. (SCI; <World Neurosurgery> IF2021=2.210; Surgery 123/211)

3. Li MH, Hsu JC, Chang CN, Wei KC. Passive pneumothorax with low flow apneic ventilation in thoracoscopic sympathectomy for palmar hyperhidrosis: technical note. Acta Neurologica Taiwanica. 1998 Mar; 7(1): 14-20.

4. Chang TC, Jung SM, Wei KC, Pai PC, Tseng CK, Chen SW*. Postoperative radiotherapy for adult intracranial low grade astrocytomas. Therapeutic Radiology and Oncology. 1998 Dec; 5(4): 269-276.

5. Yang JT, Chang CN, Hsu YH, Wei KC, Lin TK, Wu JH*. Increase in CSFNGF concentration is positively correlated with poor prognosis of postoperative hydrocephalic patients. Clinical Biochemistry. 1999 Nov; 32(8): 673-675. (SCI; IF2021=3.625; Medical laboratory technology 11/29)

6. Wei KC, Berger MS, Sehgal A*. Cloning, sequencing and expression analysis of a novel gene BR-1 that is expressed in normal human brain tissue but not in glioma tumor samples. Anticancer Research. 2002 Mar-Apr; 22(2A):745-753. (SCI; IF2021=2.435; Oncology 205/245)

7. Wei KC, Berger MS, Sehgal A*. Molecular characterization of a novel BR-2 gene that is down-regulated in human low grade glioma tumors. Anticancer Research. 2002 Mar-Apr; 22(2A): 649-657. (SCI; IF2021=2.435; Oncology 205/245)

8. Wei KC, Berger MS, Sehgal A*. Molecular characterization of a novel human brain tumor associated gene BR-3. Anticancer Research. 2002 May-Jun; 22(3): 1467-1474. (SCI; IF2021=2.435; Oncology 205/245)

9. Pai PC, Chuang CC, Wei KC, Tsang NM*, Tseng CK, Chang CN. Stereotactic radiosurgery for locally recurrent nasopharyngeal carcinoma. Head & Neck. 2002 Aug; 24(8): 748-753. (SCI; IF2021=3.821; Otorhinolaryngology 6/43)

10. Chang CN, Chen WC*, Wei KC, Ng SH, Ho YT, Huang YC, Fang FM, Lee P, Hong JH. High-dose-rate stereotactic brachytherapy for patients with newly diagnosed glioblastoma multiformes. Journal of Neuro-oncology. 2003 Jan; 61(1): 45-55. (SCI; IF2021=4.506; Clinical neurology 73/212) (Review article)

11. Tseng CK*, Tsang NM, Wei KC, Jiang TH, Pai BC, Chang TJ. Radiotherapy to primary CNS germinoma: how large an irradiated volume is justified for tumor control? Journal of Neuro-oncology. 2003 May; 62(3): 343-348. (SCI; IF2021=4.506; Clinical neurology 73/212)

12. Chuang CC, Chang CN, Tsang NM, Wei KC, Tseng CK, Chang JT, Pai PC*. Linear accelerator-based radiosurgery in the management of skull base meningiomas. Journal of Neuro-oncology. 2004 Jan; 66(1-2): 241-249. (SCI; IF2021=4.506; Clinical neurology 73/212)

13. Heller F, Hsu CM, Chuang CC, Wei KC, Wei FC*. Anterolateral thigh fasciocutaneous flap for simultaneous reconstruction of refractory scalp and dural defects. Report of two cases. (Case Reports) Journal of Neurosurgery. 2004 Jun; 100(6): 1094-1097. (SCI; IF2021=5.408; Surgery 23/211)

14. Pai PC, Tsang NM, Tseng CK, Hao SP, Kuo TT, Wei KC, Hsueh C, Chuang CC*. Prevalence of LMP-1 gene in tonsils and non-neoplastic nasopharynxes by nest-polymerase chain reaction in Taiwan. Head & Neck. 2004 Jul; 26(7): 619-624. (SCI; IF2021=3.821; Otorhinolaryngology 6/43)

15. Liau CT*, Wei KC, Tseng CK, Jung SM. Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. Chang Gung Medical Journal. 2005 Jan; 28(1): 16-23. (SCI, as Biomedical Journal; IF2021=7.892; Biochemistry & molecular biology 47/296)

16. Toh CH, Chen YL, Wong HF*, Wei KC, Ng SH. Rosai-Dorfman disease with dural sinus invasion. Two case report. Journal of neurosurgery. 2005 Mar; 102(3): 550-554. (SCI; IF2021=5.408; Surgery 23/211)

17. Chuang CC, Chang CN, Wei KC, Liao CC, Hsu PW, Huang YC, Chen YL, Lai LJ, Pai PC*. Surgical treatment for severe visual compromised patients after pituitary apoplexy. Journal of Neuro-Oncology. 2006 Oct; 80(1): 39-47. (SCI; IF2021=4.506; Clinical neurology 73/212)

18. Huang YC, Tseng CK, Chang CN, Wei KC, Liao CC, Hsu PW*. LINAC radiosurgery for intracranial cavernous malformation: 10-year experience. Clinical Neurology and Neurosurgery. 2006 Dec; 108(8): 750-756. (SCI; IF2021=1.886; Surgery 145/211)

19. Pai PC, Tseng CK, Chuang CC, Wei KC, Hao SP, Hsueh C, Chang KP, Tsang NM*. Polymorphism of C-terminal activation region 2 of Epstein-Barr virus latent membrane protein 1 in predicting distant failure and post-metastatic survival in patients with nasopharyngeal carcinoma. Head & Neck. 2007 Feb; 29(2):109-119. (SCI; IF2021=3.821; Otorhinolaryngology 6/43)

20. Wang TH, Wei KC, Hsiung CA, Maloney SA, Eidex RB, Posey DL, Chou WH, Shih WY, Kuo HS*. Optimizing severe acute respiratory syndrome response strategies: lessons learned from quarantine. American Journal of Public Health. 2007 Apr; 97(Suppl1): S98-100. (SCI; IF2021=11.480; Public, environmental & occupational health 13/210)

21. Toh CH*, Wong AM, Wei KC, Ng SH, Wong HF, Wan YL. Peritumoral edema of meningiomas and metastatic brain tumors: differences in diffusion characteristics evaluated with diffusion-tensor MR imaging. Neuroradiology. 2007 Jun; 49(6): 489-494. (SCI; IF2021=2.995; Radiology, nuclear medicine & medical imaging 78/136)

22. Hsu PW, Chang CN, Tseng CK, Wei KC, Wang CC, Chuang CC, Huang YC*. Treatment of epileptogenic cavernomas: surgery versus radiosurgery. Cerebrovascular Diseases. 2007 Jun; 24(1): 116-120. (SCI; IF2021=3.104; Peripheral vascular disease 38/67)

23. Toh CH*, Castillo M, Wong AM, Wei KC, Wong HF, Ng SH, Wan YL. Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. American Journal of Neuroradiology. 2008 Mar; 29(3): 471-475. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

24. Chuang WY, Yeh CJ, Chu PH, Liao CC, Wu CT, Chuang CC, Pai PC, Tseng CK, Jung SM*, Wei KC, Chang CN. Expression of thyroid transcription factor-1 in brain metastases: A useful indicator of pulmonary origin. Journal of Clinical Neuroscience. 2008 Jun; 15(5): 643-646. (SCI; IF2021=2.116; Clinical neurology 172/212)

25. Wang TH, Wei KC, Jiang DD, Chiu CH, Chang SC, Wang JD*. Unexplained Deaths and Critical Illnesses of Suspected Infectious Cause, Taiwan, 2000-2005. Emerging Infectious Diseases. 2008 Oct; 14(10): 1653-1655. (Dispatches) (SCI; IF2021=16.126; Immunology 13/161)

26. Toh CH*, Castillo M, Wong AM, Wei KC, Wong HF, Ng SH, Wan YL. Differentiation between classic and atypical meningiomas with use of diffusion tensor imaging. American Journal of Neuroradiology. 2008 Oct; 29(9): 1630-1635. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

27. Lu YJ, Chang CN, Pai PC, Wei KC, Chuang CC*. Isolated sphenoid sinusitis or mucocele: a potential complication of endonasal transsphenoidal surgery. Journal of Neuro-Oncology. 2009 Jan; 91(1): 63-67. (SCI; IF2021=4.506; Clinical neurology 73/212)

28. Huang BR, Chen PY, Huang CY, Jung SM, Ma YH, Wu T, Chen JP*, Wei KC*. Bioavailability of magnetic nanoparticles to the brain. Journal of Magnetism and Magnetic Materials. 2009 May; 321(10): 1604-1609. (SCI, EI; IF2021=3.097; Physics, condensed matter 35/69)(co-corresponding author)

29. Chen CC, Hsu PW, Erich Wu TW, Lee ST, Chang CN, Wei KC, Chuang CC, Wu CT, Lui TN, Hsu YH, Lin TK, Lee SC, Huang YC*. Stereotactic brain biopsy: Single center retrospective analysis of complications. Clinical Neurology and Neurosurgery. 2009 Dec; 111(10): 835-839. (SCI; IF2021=1.886; Surgery 145/211)

30. Wei KC*, Huang CY, Chen PY, Feng LY, Wu TW, Chen SM, Tsai HC, Lu YJ, Tsang NM, Tseng CK, Pai PC, Shin JW*. Evaluation of the prognostic value of CD44 in glioblastoma multiforme. Anticancer Research. 2010 Jan; 30(1): 253-259. (SCI; IF2021=2.435; Oncology 205/245) (first and co-corresponding author)

31. Hsu PW, Chang CN, Lee ST, Huang YC, Chen HC, Wang CC, Hsu YH, Tseng CK, Chen YL, Wei KC*. Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator -based radiosurgery. Journal of Clinical Neuroscience. 2010 May; 17(5): 556-560. (SCI; IF2021=2.116; Clinical neurology 172/212)

32. Liu HL, Hua MY, Chen PY, Chu PC, Pan CH, Yang HW, Huang CY, Wang JJ, Yen TC, Wei KC*. Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology. 2010 May; 255(2): 415-425. (SCI; IF2021=29.146; Radiology, nuclear medicine & medical imaging 1/136)

33. Liu ZH, Chang CN, Pai PC, Wei KC, Jung SM, Chen NY, Chuang CC*. Clinical features and surgical outcome of clinical and subclinical pituitary apoplexy. Journal of Clinical Neuroscience. 2010 Jun; 17(6): 694-699. (SCI; IF2021=2.116; Clinical neurology 172/212)

34. Liu HL, Hua MY, Yang HW, Huang CY, Chu PC, Wu JS, Tseng IC, Wang JJ, Yen TC, Chen PY*, Wei KC*. Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain. Proc Natl Acad Sci USA. 2010 Aug; 107(34): 15205-15210. (SCI; IF2021=12.779; Multidisciplinary sciences 9/73) (co-corresponding author)

35. Chen PY, Liu HL, Hua MY, Yang HW, Huang CY, Chu PC, Lyu LA, Tseng IC, Feng LY, Tsai HC, Chen SM, Lu YJ, Wang JJ, Yen TC, Ma YH, Wu T, Chen JP, Chuang JI, Shin JW, Hsueh C, Wei KC*. Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment. Neuro-oncology. 2010 Oct; 12(10): 1050-1560. (SCI; IF2021=13.029; Clinical neurology 8/212)

36. Kuo HC*, Chen SR, Jung SM, Wu Chou YH, Huang CC, Chuang WL, Wei KC, Ro LS*. Neurofibromatosis 2 with peripheral neuropathies: Electrophysiological, pathological and genetic studies of a Taiwanese family. Neuropathology. 2010 Oct; 30(5): 515-523. (SCI; IF2021=2.076; Pathology 55/77)

37. Lee CC, Jung SM, Lin CY, Wei KC*. Hypopharyngeal squamous cell carcinoma with hematogenous intracranial metastases: case report. Neurosurgery. 2010 Dec; 67(6): E1857-E1862. (SCI; IF2021=5.315; Surgery 26/211)

38. Hua MY*, Liu HL, Yang HW, Chen PY, Tsai RY, Huang CY, Tseng IC, Lyu LA, Ma CC, Tang HJ, Yen TC, Wei KC*. The effectiveness of a magnetic nanoparticle-based delivery system for BCNU in the treatment of gliomas. Biomaterials. 2011 Jan; 32(2): 516-527. (SCI; IF2021=15.304; Engineering, biomedical 4/98) (co-corresponding author)

39. Huang YC, Wei KC, Chang CH, Yang JT, Ho JT, Shen CC, Su CF, Cho DY, Ma HI, Lin JW, Lee EJ, Wu JJ, Tsai MD, Chang CK, Howng SL, Chang CN*. A retrospective survey of patients with malignant gliomas treated in the neuro-oncological care system under the Universal National Health Insurance program in Taiwan. Journal of Clinical Neuroscience. 2011 Jun; 18(6): 784-788. (SCI; IF2021=2.116; Clinical neurology 172/212)

40. Yang HW, Hua MY, Liu HL, Huang CY, Tsai RY, Lu YJ, Chen JY, Tang HJ, Hsien HY, Chang YS, Yen TC, Chen PY*, Wei KC*. Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas. Biomaterials. 2011 Sep; 32(27): 6523 -6532. (SCI; IF2021=15.304; Engineering, biomedical 4/98) (co-corresponding author)

41. Toh CH, Wei KC, Ng SH, Wan YL, Lin CP*, Castillo M. Differentiation of brain abscesses from necrotic glioblastomas and cystic metastatic brain tumors with diffusion tensor imaging. American Journal of Neuroradiology. 2011 Oct; 32(9): 1646-1651. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

42. Liu HL, Chen PY, Yang HW, Wu JS, Tseng IC, Ma YJ, Huang CY, Tsai HC, Chen SM, Lu YJ, Huang CY, Hua MY, Ma YH, Yen TC, Wei KC*. In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low-frequency-ultrasound-induced blood-brain barrier opening in swine. Journal of Magnetic Resonance Imaging. 2011 Dec; 34(6): 1313-1324. (SCI; IF2021=5.119; Radiology, nuclear medicine & medical imaging 33/136)

43. Lu YJ, Wei KC, Ma CC, Yang SY, Chen JP*. Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids and Surfaces B: Biointerfaces. 2012 Jan; 89:1-9. (SCI; IF2021=5.999; Biophysics 11/72)

44. Ting CY, Fan CH, Liu HL*, Huang CY, Hsieh HY, Yen TC, Wei KC, Yeh CK*. Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment. Biomaterials. 2012 Jan; 33(2): 704-712. (SCI; IF2021=15.304; Engineering, biomedical 4/98)

45. Liu HL, Yang HW, Hua MY, Wei KC*. Enhanced therapeutic agent delivery through magnetic resonance imaging-monitored focused ultrasound blood-brain barrier disruption for brain tumor treatment: an overview of the current preclinical status. Neurosurgical focus. 2012 Jan; 32(1): E4. (Invited Review) (SCI; IF2021=4.332; Surgery 38/211)

46. Chen L 1*, Wei KC1, Huang ACH1, Wang K, Huang CY, Yi D, Tang CY, Galas D, Hood L*. RNASEQR - A streamlined and accurate RNA-seq sequence analysis program. Nucleic Acids Research. 2012 Mar; 40(6): E42. (SCI; IF2021=19.160; Biochemistry & molecular biology 8/296 )(1co-first author)

47. Lu YJ, Yang HW, Hung SC, Huang CY, Li SM, Ma CC, Chen PY, Tsai HC, Wei KC*, Chen JP*. Improving thermal stability and efficacy of BCNU in treating glioma cells using PAA-functionalized graphene oxide. International Journal of Nanomedicine. 2012 Mar; 7: 1737-1747. (SCI; IF2021=7.033; Pharmacology & pharmacy 31/279) (co-corresponding author)

48. Toh CH, Wei KC, Ng SH, Wan YL, Castillo M, Lin CP*. Differentiation of tumefactive demyelinating lesions from high-grade gliomas with the use of diffusion tensor imaging. American Journal of Neuroradiology. 2012 May; 33(5): 846-851. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

49. Tsai HC, Wei KC, Tsai CN, Huang YC, Chen PY, Chen SM, Lu YJ, Lee ST*. Effect of valproic acid on the outcome of glioblastoma multiforme. British Journal of Neurosurgery. 2012 Jun; 26(3): 347-354. (SCI; IF2021=1.124; Surgery 183211)

50. Chen YC, Liao LC, Lu PL, Lo CL, Tsai HC, Huang CY, Wei KC, Yen TC, Hsiue GH*. The accumulation of dual pH and temperature responsive micelles in tumors. Biomaterials. 2012 Jun; 33(18): 4576-4588. (SCI; IF2021=15.304; Engineering, biomedical 4/98)

51. Wang PH, Liu HL, Hsu PH, Lin CY, Chris Wang CR, Chen PY, Wei KC, Yen TC, Li ML*. Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model. Journal of Biomedical Optics. 2012 Jun; 17(6): 061222. (SCI; IF2021=3.758; Optics 29/101)

52. Chen CC, Hsu PW, Lee ST, Chang CN, Wei KC, Wu CT, Hsu YH, Lin TK, Lee SC, Huang YC*. Brain surgery in patients with liver cirrhosis. Journal of Neurosurgery. 2012 Aug; 117(2): 348-353. (SCI; IF2021=5.408; Surgery 23/211)

53. Yang HW, Hua MY, Liu HL, Huang CY, Wei KC*. Potential of magnetic nanoparticles for targeted drug delivery. Nanotechnology, science and applications. 2012 Aug; 5: 73-86. (review article)(SCI; IF2021=n/a)

54. Toh CH*, Wei KC, Chang CN, Hsu PW, Wong HF, Ng SH, Castillo M, Lin CP. Differentiation of pyogenic brain abscesses from necrotic glioblastomas with use of susceptibility-weighted imaging. American Journal of Neuroradiology. 2012 Sep; 33(8): 1534-1538. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

55. Lin YC, Chan TH, Chi CY, Ng SH, Liu HL, Wei KC, Wai YY, Wang CC, Wang JJ*. Blind estimation of arterial input function in dynamic contrast-enhanced MRI using purity maximization. Magnetic Resonance in Medicine. 2012 Nov; 68(5): 1439-1449. (SCI; IF2021=3.737; Radiology, nuclear medicine & medical imaging 56/136)

56. Wei KC, Tsai HC, Lu YJ, Yang HW, Hua MY, Wu MF, Chen PY, Huang CY, Yen TC, Liu HL*. Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening: a preliminary study in swine. American Journal of Neuroradiology. 2013 Jan; 34(1): 115-120. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

57. Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, Berger MS, Forsayeth JR, Bankiewicz K, James CD*. Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts. Neuro-oncology. 2013 Feb; 15(2): 189-197. (SCI; IF2021=13.029; Clinical neurology 8/212)

58. Hsu PH, Wei KC, Huang CY, Wen CJ, Yen TC, Liu CL, Lin YT, Chen JC, Shen CR*, Liu HL*. Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound. PLoS One. 2013 Feb; 8(2): e57682. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

59. Fan CH, Ting CY, Liu HL*, Huang CY, Hsieh HY, Yen TC, Wei KC, Yeh CK*. Antiangiogenic- targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment. Biomaterials. 2013 Mar; 34(8): 2142-2255. (SCI; IF2021=15.304; Engineering, biomedical 4/98)

60. Wei KC*, Chu PC, Wang HY, Huang CY, Chen PY, Tsai HC, Lu YJ, Lee PY, Tseng IC, Feng LY, Hsu PW, Yen TC, Liu HL*. Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study. PLoS One. 2013 Mar; 8(3): e58995. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

61. Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, Feng LY, Tsai HC, Lui TN, Hsueh C, Wei KC*. MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6. World Journal of Surgical Oncology. 2013 Apr; 11(1): 87. (SCI; IF2021=3.253; Surgery 68/211)

62. Chu PC, Chai WY, Hsieh HY, Wang JJ, Wey SP, Huang CY, Wei KC, Liu HL*. Pharmacodynamic analysis of magnetic resonance imaging-monitored focused ultrasound-induced blood-brain barrier opening for drug delivery to brain tumors. Biomed Research International. 2013 Apr; 2013: 627496. (SCI; IF2021=3.246; Biotechnology & Applied Microbiology 90/158)

63. Toh CH*, Wei KC, Chang CN, Ng SH, Wong HF. Differentiation of Primary Central Nervous System Lymphomas and Glioblastomas: Comparisons of Diagnostic Performance of Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging without and with Contrast-Leakage Correction. American Journal of Neuroradiology. 2013 Jun; 34(6): 1145-1149. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

64. Yang HW, Liu HL, Li ML, Hsi IW, Fan CT, Huang CY, Lu YJ, Hua MY, Chou HY, Liaw JW, Ma CC*, Wei KC*. Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. Biomaterials. 2013 Jul; 34(22): 5651-5660. (SCI; IF2021=15.304; Engineering, biomedical 4/98) (co-corresponding author)

65. Yang HW, Hua MY, Hwang TL, Lin KJ, Huang CY, Tsai RY, Ma CC, Hsu PH, Wey SP, Hsu PW, Chen PY, Huang YC, Lu YJ, Yen TC, Feng LY, Lin CW, Liu HL*, Wei KC*. Non-Invasive Synergistic Treatment of Brain Tumors by Targeted Chemotherapeutic Delivery and Amplified Focused Ultrasound-Hyperthermia Using Magnetic Nanographene Oxide. Advanced Materials. 2013 Jul; 25(26): 3605-3611. (SCI; IF2021=32.086; Chemistry, physical 4/163) (co-corresponding author)

66. Yan JL, Chang CN*, Chuang CC, Hsu PW, Lin JD, Wei KC, Lee ST, Tseng JK, Pai PC, Chen YL. Long-term follow-up of patients with surgical intractable acromegaly after linear accelerator radiosurgery. Journal of the Formosan Medical Association. 2013 Jul; 112(7): 416-420. (SCI; IF2021=3.871; Medicine, general & internal 61/172)

67. Yang HW, Lu YJ, Lin KJ, Hsu SC, Huang CY, She SH, Liu HL, Lin CW, Xiao MC, Wey SP, Chen PY, Yen TC, Wei KC*, Ma CC*. EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy. Biomaterials. 2013 Sep; 34(29): 7204-7214. (SCI; IF2021=15.304; Engineering, biomedical 4/98) (co-corresponding author)

68. Tsai SW*, Liaw JW, Kao YC, Huang MY, Lee CY, Rau LR, Huang CY, Wei KC, Ye TC. Internalized Gold Nanoparticles Do Not Affect the Osteogenesis and Apoptosis of MG63 Osteoblast-Like Cells: A Quantitative, In Vitro Study. PLoS One. 2013 Oct; 8(10): e76545. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

69. Yan JL, Wei KC*. Tubercular temporalis abscess with skull and dural invasion. Surgical Infections. 2013 Oct; 14(5): 473-475. (SCI; IF2021=1.853; Surgery 147/211) (case report)

70. Liao HI, Wang CC, Wei KC, Chang CN, Hsu YH, Lee ST, Huang YC, Chen HC, Hsu PW*. Fractionated stereotactic radiosurgery using the Novalis system for the management of pituitary adenomas close to the optic apparatus. Journal of Clinical Neuroscience. 2014 Jan; 21(1): 111-115. (SCI; IF2021=2.116; Clinical neurology 172/212)

71. Toh CH*, Wei KC, Chang CN, Peng YW, Ng SH, Wong HF, Lin CP. Assessment of angiographic vascularity of meningiomas with dynamic susceptibility contrast-enhanced perfusion-weighted imaging and diffusion tensor imaging. American Journal of Neuroradiology. 2014 Feb; 35(2): 263-269. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

72. Liu HL*, Jan CK, Chu PC, Hong JC, Lee PY, Hsu JD, Lin CC, Huang CY, Chen PY, Wei KC*. Design and experimental evaluation of a 256-channel dual-frequency ultrasound phased-array system for transcranial blood-brain barrier opening and brain drug delivery. IEEE Transactions on Biomedical Engineering. 2014 Apr; 61(4): 1350-1360. (SCI; IF2021=4.756; Engineering, biomedical 37/98)

73. Fan CH, Liu HL, Ting CY, Lee YH, Huang CY, Ma YJ, Wei KC, Yen TC*, Yeh CK*. Submicron-bubble-enhanced focused ultrasound for blood-brain barrier disruption and improved CNS drug delivery. PLoS One. 2014 May; 9(5): e96327. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

74. Zheng YC, Jung SM, Lee ST, Chang CN, Wei KC, Hsu YH, Wu CT, Liao CC, Lin CL, Lu YJ, Huang YC*. Adult supratentorial extra-pineal primitive neuro-ectodermal tumors. Journal of Clinical Neuroscience. 2014 May; 21(5): 803-809. (SCI; IF2021=2.116; Clinical neurology 172/212)

75. Wang YC, Huang YC, Chen HC, Wei KC, Chang CN, Lee ST, Wu CT, Tseng CK, Wang CC, Chen YL, Hsu PW*. Linear accelerator stereotactic radiosurgery in the management of intracranial arteriovenous malformations: long-term outcome. Cerebrovascular Diseases. 2014 Jul; 37(5): 342-349. (SCI; IF2021=3.104; Peripheral vascular disease 38/67)

76. Yang HW, Huang CY, Lin CW, Liu HL, Huang CW, Liao SS, Chen PY, Lu YJ, Wei KC*, Ma CC*. Gadolinium-functionalized nanographene oxide for combined drug and microRNA delivery and magnetic resonance imaging. Biomaterials. 2014 Aug; 35(24): 6534-6542. (SCI; IF2021=15.304; Engineering, biomedical 4/98) (co-corresponding author)

77. Lu YJ, Lin CW, Yang HW, Lin KJ, Wey SP, Sun CL, Wei KC, Yen TC, Lin CI, Ma CC*, Chen JP*. Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy. Carbon. 2014 Aug; 74: 83-95. (SCI; IF2021=11.307; Materials science, multidisciplinary 40/345)

78. Lu YC, Luo PC, Huang CW, Leu YL, Wang TH, Wei KC, Wang HE, Ma YH*. Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle-cell interaction. Nanoscale. 2014 Sep; 6(17): 10297-12306. (SCI; IF2021=8.307; Physics, applied 23/161)

79. Huang YC, Wei KC, Chang CN, Chen PY, Hsu PW, Chen CP, Lu CS, Wang HL, Gutmann DH, Yeh TH*. Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma. PLoS One. 2014 Sep; 9(9): e108228. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

80. Chai WY, Chu PC, Tsai MY, Lin YC, Wang JJ, Wei KC, Wai YY*, Liu HL*. Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood-brain barrier opening and brain drug delivery. Journal of Controlled Release. 2014 Oct; 192: 1-9. (SCI; IF2021=11.467; Pharmacology & pharmacy 12/279)

81. Toh CH*, Wei KC, Chang CN, Ng SH, Wong HF, Lin CP. Differentiation of Brain Abscesses from Glioblastomas and Metastatic Brain Tumors: Comparisons of Diagnostic Performance of Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging before and after Mathematic Contrast Leakage Correction. PLoS One. 2014 Oct; 9(10): e109172. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)

82. Liu HL*, Huang CY, Chen JY, Wang HYJ, Chen PY, Wei KC*. Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment. PLoS One. 2014 Dec; 9(12): e114311. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73)(co-corresponding author)

83. Zheng YC, Chen CC, Wei KC, Chen JF, Lee ST, Liao CC*. Tropical pyomyositis of erector spinae complicated with spinal epidural abscess. Clinical Neurology and Neurosurgery. 2015 Jan; 128: 84-89. (SCI; IF2021=1.886; Surgery 145/211)

84. Wang YC, Chuang CC, Wei KC, Hsu YH, Hsu PW, Lee ST, Wu CT, Tseng CK, Wang CC, Chen YL, Jung SM, Chen PY*. Skull base atypical meningioma: Long term surgical outcome and prognostic factors. Clinical Neurology and Neurosurgery. 2015 Jan; 128: 112-116. (SCI; IF2021=1.886; Surgery 145/211)

85. Wang JC*, Karmakar RS, Lu YJ, Huang CY, Wei KC. Characterization of Piezoresistive PEDOT:PSS Pressure Sensors with Inter-Digitated and Cross-Point Electrode Structures. Sensors. 2015 Jan; 15(1): 818-831. (SCI; IF2021=3.847; Instruments & instrumentation 19/64)

86. Fan CH, Ting CY, Chang YC, Wei KC, Liu HL*, Yeh CK*. Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery. Acta Biomaterialia. 2015 Mar; 15: 89-101. (SCI; IF2021=10.633; Engineering, biomedical 13/98)

87. Chen PY, Hsieh HY, Huang CY, Lin CY, Wei KC, Liu HL*. Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study. Journal of Translational Medicine. 2015 Mar; 13: 93. (SCI; IF2021=8.459; Medicine, research & experimental 25/139)

88. Liao AH, Chou HY, Hsieh YL, Hsu SC, Wei KC, Liu HL*. Enhanced Therapeutic Epidermal Growth Factor Receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment. Journal of Medical and Biological Engineering. 2015 Apr; 35(2): 156-164. (SCI; IF2021=2.213; Engineering, biomedical 75/98)

89. Lin CW1, Wei KC1, Liao SS, Huang CY, Sun CL, Wu PJ, Lu YJ, Yang HW*, Ma CC*. A reusable magnetic graphene oxide-modified biosensor for vascular endothelial growth factor detection in cancer diagnosis. Biosensors & Bioelectronics. 2015 May; 67: 431-437. (SCI; IF2021=12.545; Chemistry, analytical 3/87) (1co-first author)

90. Lin CY, Hsieh HY, Pitt WG, Huang CY, Tseng IC, Yeh CK, Wei KC*, Liu HL*. Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery. Journal of Controlled Release. 2015 Aug; 212: 1-9. (SCI; IF2021=11.467; Pharmacology & pharmacy 12/279) (co-corresponding author)

91. Chang YW, Su YJ, Hsiao M, Wei KC, Lin WH, Liang CL, Chen SC, Lee JL*. Diverse Targets of β-Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse. Cancer Research. 2015 Aug; 75(16): 3398-3410. (SCI; IF2021=13.312; Oncology 20/245)

92. Chen KT, Wu TW, Chuang CC, Hsu YH, Hsu PW, Huang YC, Lin TK, Chang CN, Lee ST, Wu CT, Tseng CK, Wang CC, Pai PC, Wei KC, Chen PY*. Corpus callosum involvement and postoperative outcomes of patients with gliomas. Journal of Neuro-Oncology. 2015 Sep; 124(2): 207-214. (SCI; IF2021=4.506; Clinical neurology 73/212)

93. Lin SY, Yang CC, Wu YM, Tseng CK, Wei KC, Chu YC, Hsieh HY, Wu TH, Pai PC, Hsu PW, Chuang CC*. Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study. Biomedical Journal. 2015 Sep-Oct; 38(5): 439-449. (SCI; IF2021=7.892; Biochemistry & molecular biology 47/296)

94. Chen PY, Wei KC, Liu HL*. Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood-brain barrier opening. Human Vaccines & Immunotherapeutics. 2015 Nov; 11(11): 2682-2687. (Commentary) (SCI; IF2021=4.526; Biotechnology & applied microbiology 54/158)

95. Lee CC, Chen CM, Lee ST, Wei KC, Pai PC, Toh CH, Chuang CC*. Prediction of Long-term Post-operative Testosterone Replacement Requirement Based on the Pre-operative Tumor Volume and Testosterone Level in Pituitary Macroadenoma. Scientific Reports. 2015 Nov; 5: 16194. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

96. Yeh WL, Lin HY, Huang CY, Huang BR, Lin C, Lu DY*, Wei KC*. Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/ anti-apoptosis-related proteins. Oncotarget. 2015 Nov; 6(35): 37770-37781. (co-corresponding author)

97. Su YJ, Lin WH, Chang YW, Wei KC, Liang CL, Chen SC, Lee JL*. Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties. Oncotarget. 2015 Nov; 6(35): 38029-38045.

98. Wang PH, Yeh CH, Jung SM, Wei KC, Toh CH*. Advanced Magnetic Resonance Imaging Findings of Anaplastic Papillary Glioneuronal Tumor. Journal of Radiological Science. 2016 Mar; 41: 29-33. (case report)

99. Li SS1, Lin CW1, Wei KC1, Huang CY, Hsu PH, Liu HL, Lu YJ, Lin SC, Yang HW*, Ma CC*. Non-invasive screening for early Alzheimer's disease diagnosis by a sensitively immunomagnetic biosensor. Scientific Reports. 2016 Apr; 6: 25155. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73) (1co-first author)

100. Chen CT, Lee CY, Lee ST, Chang CN, Wei KC, Wu CT*. Neurenteric cysts: risk factors and management of recurrence. Acta Neurochirurgica. 2016 Jul; 158(7):1325-1331. (SCI; IF2021=2.816; Surgery 86/211)

101. Lin CY*, Hsieh HY, Chen CM, Wu SR, Tsai CH, Huang CY, Hua MY, Wei KC, Yeh CK, Liu HL*. Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson's Disease Mouse Model. Journal of Controlled Release. 2016 Aug; 235: 72-81. (SCI; IF2021=11.467; Pharmacology & pharmacy 12/279)

102. Wei KC, Lin FW, Huang CY, Ma CC, Chen JY, Feng LY, Yang HW*. 1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents. International Journal of Nanomedicine. 2016 Aug; 11: 4065-4075. (SCI; IF2021=7.033; Pharmacology & pharmacy 31/279)

103. Liu HL, Hsu PH, Lin CY, Huang CW, Chai WY, Chu PC, Huang CY, Chen PY, Yang LY, Kuo JS, Wei KC*. Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment. Radiology. 2016 Oct; 281(1): 99-108. (SCI; IF2021=29.146; Radiology, nuclear medicine & medical imaging 1/136)

104. Wang YC, Chuang CC, Wei KC, Chang CN, Lee ST, Wu CT, Hsu YH, Lin TK, Hsu PW, Huang YC, Tseng CK, Wang CC, Chen YL, Chen PY*. Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas. Scientific Reports. 2016 Oct; 6: 35743. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

105. Fan CH, Chang EL, Ting CY, Lin YC, Liao EC, Huang CY, Chang YC, Chan HL, Wei KC, Yeh CK*. Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery. Biomaterials. 2016 Nov; 106: 46-57. (SCI; IF2021=15.304; Engineering, biomedical 4/98)

106. Yang HW, Tsai RY, Chen JP, Ju SP, Liao JF, Wei KC, Zou WL, Hua MY*. Fabrication of a Nanogold-Dot Array for Rapid and Sensitive Detection of Vascular Endothelial Growth Factor in Human Serum. ACS Applied Materials & Interfaces. 2016 Nov; 8(45): 30845-30852. (SCI; IF2021=10.383; Materials science, multidisciplinary 49/345)

107. Tsai MT, Zhang JW, Liu YH, Yeh CK, Wei KC, Liu HL*. Acoustic-actuated optical coherence angiography. Optics Letters. 2016 Dec; 41(24): 5813-5816. (SCI; IF2020=3.776; Optics 22/99)

108. Chuang CC, Lin SY, Pai PC, Yan JL, Toh CH, Lee ST, Wei KC, Liu ZH, Chen CM, Wang YC, Lee CC*. Different Volumetric Measurement Methods for Pituitary Adenomas and Their Crucial Clinical Significance. Scientific Reports. 2017 Jan; 7: 40792. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

109. Yang CL, Chen JP, Wei KC, Chen JY, Huang CW, Liao ZX*. Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle. Nanomaterials. 2017 Apr 13; 7(4): 85. (SCI; IF2021=5.719; Physics, applied 37/161)

110. Lee TH, Yeh JC, Tsai CH, Yang JT, Lou SL, Seak CJ, Wang CY, Wei KC*, Liu HL*. Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat. Scientific Reports. 2017 May; 7(1): 1638. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73) (co-corresponding author)

111. Wei KC1, Chen CY1, Feng LY, Huang WT, Chen CH, Hsu PW, Wang K, Hood LE, Chen LY*. The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort. PLoS One. 2017 Jun; 12(6): e0178842. (SCI; IF2021=3.752; Multidisciplinary sciences 29/73) (1co-first author)

112. Chang EL, Ting CY, Hsu PH, Lin YC, Liao EC, Huang CY, Chang YC, Chan HL, Chiang CS, Liu HL, Wei KC, Fan CH, Yeh CK*. Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors. Journal of Controlled Release. 2017 Jun; 255: 164-175. (SCI; IF2021=11.467; Pharmacology & pharmacy 12/279)

113. Lin FW, Chen PY, Wei KC, Huang CY, Wang CK, Yang HW*. Rapid In Situ MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor. Theranostics. 2017 Jun; 7(9): 2524-2536. (SCI; IF2021=11.600; Medicine, research & experimental 13/139)

114. Chen PY, Yeh CK, Hsu PH, Lin CY, Huang CY, Wei KC*, Liu HL*. Drug-carrying microbubbles as a theranostic tool in convection-enhanced delivery for brain tumor therapy. Oncotarget. 2017 Jun; 8(26): 42359-42371. (co-corresponding author)

115. Liao JF, Lee JC, Lin CK, Wei KC, Chen PY, Yang HW*. Self-Assembly DNA Polyplex Vaccine inside Dissolving Microneedles for High-Potency Intradermal Vaccination. Theranostics. 2017 Jun; 7(10): 2593-2605. (SCI; IF2021=11.600; Medicine, research & experimental 13/139)

116. Lin TK, Yeh TH, Hsu PW, Chuang CC, Tu PH, Chen PY, Jung SM, Wei KC, Huang YC*. Primary Central Nervous System Lymphomas of the Brain: A Retrospective Analysis in a Single Institution. World Neurosurgery. 2017 Jul; 103: 550-556. (SCI; IF2021=2.210; Surgery 123/211)

117. Lin YJ, Chiu HY, Chiou MJ, Huang YC, Wei KC, Kuo CF, Hsu JT, Chen PY*. Trends in the incidence of primary malignant brain tumors in Taiwan and correlation with comorbidities: A population-based study. Clinical Neurology and Neurosurgery. 2017 Aug; 159: 72-82. (SCI; IF2021=1.886; Surgery 145/211)

118. Wang HH, Chang TY, Lin WC, Wei KC*, Shin JW*. GADD45A plays a protective role against temozolomide treatment in glioblastoma cells. Scientific Reports. 2017 Aug; 7(1): 8814. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73) (co-corresponding author)

119. Liu YS, Lin HY, Lai SW, Huang CY, Huang BR, Chen PY, Wei KC*, Lu DY*. MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma. Oncogene. 2017 Aug; 36(35): 5006-5022. (SCI; IF2021=8.756; Genetics & heredity 16/175) (co-corresponding author)

120. Karmakar RS, Lu YJ, Fu Y, Wei KC, Chan SH, Wu MC, Lee JW, Lin TK, Wang JC*. Cross-Talk Immunity of PEDOT:PSS Pressure Sensing Arrays with Gold Nanoparticle Incorporation. Scientific Reports. 2017 Sep; 7(1): 12252. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

121. Wang HH, Liao CC, Chow NH, Huang LL, Chuang JI, Wei KC*, Shin JW*. Whether CD44 is an applicable marker for glioma stem cells. American Journal of Translational Research. 2017 Nov 15; 9(11): 4785-4806. (SCI; IF2021=3.940; Oncology 137/245) (co-corresponding author)

122. Tsai MT, Zhang JW, Wei KC, Yeh CK, Liu HL*. Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography. Biomedical Optics Express. 2018 Feb; 9(2): 507-517. (SCI; IF2021=3.562; Optics 31/101)

123. Wang YC, Chuang CC, Tu PH, Wei KC, Wu CT, Lee CC, Liu ZH, Chen PY*. Seizures in surgically resected atypical and malignant meningiomas: Long-term outcome analysis. Epilepsy Research. 2018 Feb; 140: 82-89. (SCI; IF2021=2.991; Clinical neurology 134/212)

124. Lin YJ, Chen KT, Lee CC, Toh CH, Wu TE, Huang YC, Hsu PW, Lu YJ, Chuang CC, Chen PY*, Wei KC. Anterior Skull Base Tumor Resection by Transciliary Supraorbital Keyhole Craniotomy: A Single Institutional Experience. World Neurosurgery. 2018 Mar; 111: e863-e870. (SCI; IF2021=2.210; Surgery 123/211)

125. Lin CY, Li RJ, Huang CY, Wei KC*, Chen PY*. Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery. Journal of Drug Targeting. 2018 Apr; 26(4): 325-332. (SCI; IF2021=5.016; Pharmacology and pharmacy 76/279) (co-corresponding author)

126. Liau CT*, Chou WC, Wei KC, Chang CN, Toh CH, Jung SM. Female sex, good performance status, and bevacizumab-induced hypertension associated with survival benefit in Asian patients with recurrent glioblastoma treated with bevacizumab. Asia-Pacific Journal of Clinical Oncology. 2018 Apr; 14(2): e8-e14. (SCI; IF2021=1.926; Oncology 223/245)

127. Lin TY1, Wei KC1, Ju SP, Huang CY, Yang HW*. Diagnosis by simplicity: an aptachip for dopamine capture and accurate detection with a dual colorimetric and fluorometric system. Journal of Materials Chemistry B. 2018 May; 6(20): 3387-3394. (SCI; IF2021=7.571; Materials science, biomaterials 10/44) (1co-first author)

128. Chang WH, Pei YC, Wei KC, Chao YP, Chen MH, Yeh HA, Jaw FS, Chen PY*. Intraoperative linguistic performance during awake brain surgery predicts postoperative linguistic deficits. Journal of Neuro-Oncology. 2018 Aug; 139(1): 215-223. (SCI; IF2021=4.506; Clinical neurology 73/212)

129. Yen HC*, Lin CL, Chen BS, Chen CW, Wei KC, Yang ML, Hsu JC, Hsu YH. Alterations of the levels of primary antioxidant enzymes in different grades of human astrocytoma tissues. Free Radical Research. 2018 Aug; 52(8): 856-871. (SCI; IF2021=4.354; Biochemistry & molecular biology 141/296)

130. Tu PH, Chen CT, Chen CC, Chen JF, Wu CT, Wei KC, Liu ZH*. Symptomatic cord compression by paraspinal musculature following cervical laminectomy: rare complication. European Spine Journal. 2018 Aug; 27(8): 1815-1823. (SCI; IF2021=2.721; Orthopedics 40/86).

131. Tsai HC, Tsai CH, Chen WS, Inserra C, Wei KC*, Liu HL*. Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening. Scientific Reports. 2018 Dec; 8(1): 17720. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73) (co-corresponding author)

132. Chen KT, Wei KC, Liu HL*. Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment. Frontiers in Pharmacology. 2019 Feb; 10: 86. (SCI; IF2021=5.988; Pharmacology & pharmacy 50/279) (Review)

133. Pang HH, Chen PY, Wei KC, Huang CW, Shiue YL, Huang CY*, Yang HW*. Convection-Enhanced Delivery of a Virus-Like Nanotherapeutic Agent with Dual-Modal Imaging for Besiegement and Eradication of Brain Tumors. Theranostics. 2019 Feb; 9(6): 1752–1763. (SCI; IF2021=11.600; Medicine, research & experimental 13/139)

134. Toh CH*, Liau CT, Wei KC, Castillo M. Baseline multicentric tumors, distant recurrences and leptomeningeal dissemination predict poor survival in patients with recurrent glioblastomas receiving bevacizumab. Journal of Neuro-Oncology. 2019 Mar; 142(1): 149-159 (SCI; IF2021=4.506; Clinical neurology 73/212)

135. Pang HH, Huang CY , Chou YW , Lin CJ , Zhou ZL , Shiue YL , Wei KC* , Yang HW*. Bioengineering fluorescent virus-like particle/RNAi nanocomplexes act synergistically with temozolomide to eradicate brain tumors. Nanoscale. 2019 Apr; 11(17): 8102-8109. (SCI; IF2021=8.307; Physics, applied 23/161) (co-corresponding author)

136. Wang YC, Lee CC, Takami H, Shen S, Chen KT, Wei KC, Wu MH, Worrell G, Chen PY*. Awake craniotomies for epileptic gliomas: intraoperative and postoperative seizure control and prognostic factors. Journal of Neuro-Oncology. 2019 May; 142(3): 577-586. (SCI; IF2021=4.506; Clinical neurology 73/212)

137. Chang CW, Hsu PW, Wei KC, Chang CW, Fung HC, Hsih MS, Hsu WC, Ro LS, Chang CN, Wang JJ, Wu YR*, Chen ST*. CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan. Scientific Reports. 2019 Aug 27; 9: 12387. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

138. Yeap MC, Tu PH, Liu ZH, Hsieh PC, Liu YT, Lee CY, Lai HY, Chen CT, Huang YC, Wei KC, Wu CT, Chen CC*. Long-Term Complications of Cranioplasty Using Stored Autologous Bone Graft, Three-Dimensional Polymethyl Methacrylate, or Titanium Mesh After Decompressive Craniectomy: A Single-Center Experience After 596 Procedures. World Neurosurgery. 2019 Aug; 128: e841-e850. (SCI; IF2021=2.210; Surgery 123/211)

139. Deng WC, Yan JL, Chuang CC, Wei KC, Chang CN, Wu CT, Chen HC, Wang CC, Tseng CK, Hsu PW*. Adjuvant Radiation Therapy Compared to Observation Alone for Postoperative Residual Non-functional Pituitary Adenomas. World Neurosurgery. 2019 Aug; 128: e1024-e1033. (SCI; IF2021=2.210; Surgery 123/211)

140. Yeap MC, Chen CC, Liu ZH, Hsieh PC, Lee CC, Liu YT, Yi-Chou Wang A, Huang YC, Wei KC, Wu CT, Tu PH*. Postcranioplasty seizures following decompressive craniectomy and seizure prophylaxis: a retrospective analysis at a single institution. Journal of Neurosurgery. 2019 Sep; 131(3): 936-940. (SCI; IF2021=5.408; Surgery 23/211)

141. Lin CJ, Lin CY, Lin YT, Huang CY, Wei KC, Chen JC, Lee-Chen GJ, Liu HL*. Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery. Biochemical and Biophysical Research Communications. 2019 Sep; 517(1): 77-83. (SCI; IF2021=3.322; Biophysics 39/72)

142. Lin CY, Tsai CH, Feng LY, Chai WY, Lin CJ, Huang CY, Wei KC, Yeh CK, Chen CM*, Liu HL*. Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model. Brain Stimulation. 2019 Sep-Oct; 12(5): 1143-1150. (SCI; IF2021=9.184; Clinical neurology 17/212)

143. Wang JC*, Karmakar RS, Lu YJ*, Chan SH, Wu MC, Lin KJ, Chen CK, Wei KC, Hsu YH. Miniaturized Flexible Piezoresistive Pressure Sensors: Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate) Copolymers Blended with Graphene Oxide for Biomedical Applications. ACS Applied Materials & Interfaces. 2019 Sep; 11(37): 34305-34315. (SCI; IF2021=10.383; Materials science, multidisciplinary 49/345)

144. Ho YJ, Chu SW, Liao EC, Fan CH, Chan HL, Wei KC, Yeh CK*. Normalization of Tumor Vasculature by Oxygen Microbubbles With Ultrasound. Theranostics. 2019 Sep; 9(24): 7370-7383. (SCI; IF2021=11.600; Medicine, research & experimental 13/139)

145. Chen PY, Wu CYJ, Fang JH, Chen HC, Feng LY, Huang CY, Wei KC, Fang JY*, Lin CY*. Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment. Frontiers in Immunology. 2019 Oct; 10: 2395 (SCI; IF2021=8.786; Immunology 33/161)

146. Chen CH1, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC1*. Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery. 2020 Jan; 132(1): 168-179. (SCI; IF2021=5.408; Surgery 23/211) (1co-first author)

147. Liao WC, Liao CK, Tseng TJ, Ho YJ, Chen YR, Lin KH, Lai TJ, Lan CT, Wei KC, Liu CH*. Chondroitin Sulfate Synthase 1 Enhances Proliferation of Glioblastoma by Modulating PDGFRA Stability. Oncogenesis. 2020 Feb; 9(2): 9 (SCI; IF2021=6.524; Oncology 61/245)

148. Wu CY, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY*, Chen PY*. CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology. 2020 Feb; 22(2): 253-266. (SCI; IF2021=13.029; Clinical neurology 8/212)

149. Chen PA, Chen YC, Wei KC, Chen KT*. Awake Craniotomy for a Left Pan-Hippocampal Diffuse Low Grade Glioma in a Deaf-Mute Patient Using Sign Language. World Neurosurgery. 2020 Feb; 134: 629-634 (SCI; IF2021=2.210; Surgery 123/211) (case report)

150. Hsu YP, Li NS, Chen YT, Pang HH, Wei KC, Yang HW*. A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone. Biosensors & Bioelectronics. 2020 Mar; 151: 111960. (SCI; IF2021=12.545; Chemistry, analytical 3/87)

151. Yeh YC, Wei KC, Chen KT*. Transmastoid Presigmoid Retrolabyrinthine Approach for Removal of Pontine Cavernous Malformation: How I Do It. Acta Neurochirurgica. 2020 May; 162(5): 1131-1135. (SCI; IF2021=2.816; Surgery 86/211)

152. Chen KT, Lin YJ, Chai WY, Lin CJ, Chen PY, Huang CY, Kuo JS, Liu HL, Wei KC*. Neuronavigation-guided focused ultrasound (NaviFUS) for transcranial blood-brain barrier opening in recurrent glioblastoma patients: clinical trial protocol. Annals of Translational Medicine. 2020 Jun; 8(11): 673. (SCI; IF2021=3.616; Medicine, research & experimental 85/139)

153. Huang CW, Chang YH, Lee HH, Wu JY, Huang JX, Chung YH, Hsu ST, Chow LP, Wei KC, Huang FT*. Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma. FASEB Journal. 2020 Jul; 34(7): 9678-9693. (SCI; IF2021=5.834; Biology 16/94)

154. Li NS, Chen YT, Hsu YP, Pang HH, Huang CY, Shiue YL, Wei KC*, Yang HW*. Mobile Healthcare System Based on the Combination of a Lateral Flow Pad and Smartphone for Rapid Detection of Uric Acid in Whole Blood. Biosensors & Bioelectronics. 2020 Sep; 164: 112309. (SCI; IF2021=12.545; Chemistry, analytical 3/87) (co-corresponding author)

155. Toh CH*, Castillo M, Wei KC, Chen PY. MRS as an Aid to Diagnose Malignant Transformation in Low-Grade Gliomas with Increasing Contrast Enhancement. American Journal of Neuroradiology. 2020 Sep; 41(9): 1592-1598. (SCI; IF2021=4.966; Radiology, nuclear medicine & medical imaging 35/136)

156. Hsu WL, Huang CY, Hsu YP, Hwang TL, Chang SH, Wang HYJ, Feng LY, Tzou SJ, Wei KC*, Yang HW*. On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management. Chemical Engineering Journal. 2020 Oct; 398: 125536. (SCI; IF2021=16.744; Engineering, chemical 4/142) (co-corresponding author)

157. Pang HH, Ke YC, Li NS, Chen YT, Huang CY, Wei KC*, Yang HW*. A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level. Biosensors & Bioelectronics. 2020 Oct; 165: 112325. (SCI; IF2021=12.545; Chemistry, analytical 3/87) (co-corresponding author)

158. Huang SH, Wang CC, Wei KC, Chang CN, Chuang CC, Chen HC, Lin YJ, Chen KT, Pai PC, Hsu PW*. Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study. Scientific Reports. 2020 Oct; 10(1): 18500. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

159. Chen HY, Chuang CC, Chen HC, Wei KC, Chang CN, Liu ZH, Lee CC, Wang CC, Pai PC, Hsu PW*. Clinical outcomes of fractionated stereotactic radiosurgery in treating perioptic meningiomas and schwannomas: A single-institutional experience. Journal of Clinical Neuroscience. 2020 Nov; 81: 409-415. (SCI; IF2021=2.116; Clinical neurology 172/212)

160. Karmakar RS, Wang JC, Huang YT, Lin KJ, Wei KC, Hsu YH, Huang YC, Lu YJ*. Real-Time Intraoperative Pressure Monitoring to Avoid Surgically Induced Localized Brain Injury Using a Miniaturized Piezoresistive Pressure Sensor. ACS Omega. 2020 Nov; 5(45): 29342-29350. (SCI; IF2021=4.132; Chemistry, multidisciplinary 73/179)

161. Lin SS, Niu CC, Yuan LJ, Tsai TT, Lai PL, Chong KY, Wei KC, Huang CY, Lu ML, Yang CY, Ueng SWN*. Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment. Journal of Orthopaedic Surgery and Research. 2021 Jan; 16(1): 16. (SCI; IF2021=2.677; Orthopedics 43/86)

162. Li YC, Chiu HY, Lin YJ, Chen KT, Hsu PW, Huang YC, Chen PY*, Wei KC. The Merits of Awake Craniotomy for Glioblastoma in the Left Hemispheric Eloquent Area: One Institution Experience. Clinical Neurology and Neurosurgery. 2021 Jan; 200: 106343. (SCI; IF2021=1.886; Surgery 145/211)

163. Chen KT, Chai WY, Lin YJ, Lin CJ, Chen PY, Tsai HC, Huang CY, Kuo JS, Liu HL*, Wei KC*. Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors. Science Advances. 2021 Feb; 7(6): eabd0772. (SCI; IF2021=14.972; Multidisciplinary sciences 7/73) (co-corresponding author)

164. Chen CH, Lin YJ, Lin YY, Lin CH, Feng LY, Chang IY, Wei KC, Huang CY*. Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients. Frontiers in Oncology. 2021 Apr; 11: 621432. (SCI; IF2021=5.738; Oncology 78/245)

165. Lee CC, Wang YC, Liu YT, Huang YC, Hsu PW, Wei KC, Chen KT, Lin YJ, Chuang CC*. Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review. International Journal of Endocrinology. 2021 Apr; 2021: 6659152. (SCI; IF2021=2.803; Endocrinology & metabolism 113/146)

166. Ho YJ, Chang HC, Lin CW, Fan CH*, Lin YC, Wei KC, Yeh CK*. Oscillatory behavior of microbubbles impacts efficacy of cellular drug delivery. Journal of Controlled Release. 2021 May; 333: 316-327. (SCI; IF2021=11.467; Pharmacology & pharmacy 12/279)

167. Yan JL*, Toh CH, Ko L, Wei KC, Chen PY*. A Neural Network Approach to Identify Glioblastoma Progression Phenotype from Multimodal MRI. Cancers. 2021 May; 13(9): 2006. (SCI; IF2021=6.575; Oncology 60/245)

168. Kang Y, Wei KC, Toh CH*. Can We Predict Intraoperative Blood Loss in Meningioma Patients? Application of Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging. Journal of Neuroradiology. 2021 Jun; 48(4): 254-258. (SCI; IF2021=4.600; Radiology, nuclear medicine & medical imaging 42/136)

169. Huang CW, Chuang CP, Chen YJ, Wang HY, Lin JJ, Huang CY, Wei KC, Huang FT*. Integrin α2β1-targeting ferritin nanocarrier traverses the blood-brain barrier for effective glioma chemotherapy. Journal of Nanobiotechnology. 2021 Jun; 19: 180 (SCI; IF2021=9.429; Biotechnology & applied microbiology 14/158)

170. Chen KT, Wei KC*, Liu HL*. Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications. Pharmaceutics. 2021 Jul; 13(7): 1084. (SCI; IF2021=6.525; Pharmacology & pharmacy 39/279) (co-corresponding author) (Review article)

171. Fan CH1, Wei KC1, Chiu NH, Liao EC, Wang HC, Wu RY, Ho YJ, Chan HL, Wang TA, Huang YZ, Hsieh TH, Lin CH, Lin YC, Yeh CK*. Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson's Disease. Nano Letters. 2021 Jul; 21(14): 5967-5976. (SCI; IF2021=12.262; Physics, applied 13/161) (1co-first author)

172. Lin YJ, Wei KC, Chen PY, Lim M*, Hwang TL*. Roles of Neutrophils in Glioma and Brain Metastases. Frontiers in Immunology. 2021 Aug; 12: 701383. (SCI; IF2021=8.786; Immunology 33/161) (Review article)

173. Wong AM, Siow TY, Wei KC, Chen PY, Toh CH*, Castillo M. Prediction of Malignant Transformation of WHO II Astrocytoma Using Mathematical Models Incorporating Apparent Diffusion Coefficient and Contrast Enhancement. Frontiers in Oncology. 2021 Sep 29; 11: 744827. (SCI; IF2021=5.738; Oncology 78/245)

174. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Chen YR, Wang HT*. Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. Frontiers in Oncology. 2021 Oct 1; 11: 722754. (SCI; IF2021=5.738; Oncology 78/245)

175. Wei KC, Lin YC, Chen CH, Chu YH, Huang CY, Liao WC, Liu CH*. Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. American Journal of Cancer Research. 2021 Nov; 11(11): 5472-5484. (SCI; IF2021=5.942; Oncology 71/245)

176. Wang HL, Yeh TH, Huang YZ, Weng YH, Chen RS, Lu CS, Wei KC, Liu YC, Chen YL, Chen CL, Chen YJ, Lin YW, Hsu CC, Chiu CH, Chiu CC*. Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population. Neurobiology of Aging. 2021 Nov; 107: 189-196. (SCI; IF2021=5.133; Neurosciences 89/274)

177. Huang YC, Lai JC, Peng PH, Wei KC, Wu KJ*. Chromatin accessibility analysis identifies GSTM1 as a prognostic marker in human glioblastoma patients. Clinical Epigenetics. 2021 Nov; 13(1): 201. ()

178. Wei KC*, Hsu PW, Tsai HC, Lin YJ, Chen KT, Toh CH, Huang HL, Jung SM, Tseng CK, Ke YX. Safety and tolerability of asunercept plus standard radiotherapy/temozolomide in Asian patients with newly-diagnosed glioblastoma: a phase I study. Scientific Reports. 2021 Dec; 11: 24067. (SCI; IF2021=4.996; Multidisciplinary sciences 19/73)

179. Li YC, Chiu HY, Wei KC, Lin YJ, Chen KT, Hsu PW, Huang YC, Chen PY*. Using cortical function mapping by awake craniotomy dealing with the patient with recurrent glioma in the eloquent cortex. Biomedical Journal. 2021 Dec; 44(6 Suppl 1): S48-S53. (SCI; IF2021=7.892; Biochemistry & molecular biology 47/296)

180. Lin SY, Tsan DL, Chuang CC, Yang CC, Pai PC, Wang CL, Wu YM, Lee CC, Lin CH, Wei KC, Chou WC*. Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan. Frontiers in Oncology. 2022 Jan; 11: 784635. (SCI; IF2021=5.738; Oncology 78/245)

181. Yeap MC, Chen CC, Chen CT, Liu ZH, Wu CT, Hsieh PC, Lai HY, Wang YC, Chang TW, Lee CC, Liu YT, Huang YC, Wei KC, Tu PH*. Predictive Value of Swab Cultures for Cryopreserved Flaps During Delayed Cranioplasties. World Neurosurgery. 2022 Jan; 157: e173-e178. (SCI; IF2021=2.210; Surgery 123/211)

182. Yen HC*, Chen BS, Yang SL, Wu SY, Chang CW, Wei KC, Hsu JC, Hsu YH, Yen TH, Lin CL*. Levels of Coenzyme Q10 and Several COQ Proteins in Human Astrocytoma Tissues Are Inversely Correlated with Malignancy. Biomolecules. 2022 Feb; 12(2): 336. (SCI; IF2021=6.064; Biochemistry & molecular biology 75/296)

183. Yan JL*, Chen MY, Chen YL, Chuang CC, Hsu PW, Wei KC, Chang CN*. Surgical Outcome and Evaluation of Strategies in the Management of Growth Hormone-Secreting Pituitary Adenomas After Initial Transsphenoidal Pituitary Adenectomy Failure. Frontiers in Endocrinology. 2022 Apr; 13: 756855. (SCI; IF2021=6.055; Endocrinology & metabolism 33/146)

184. Lin YJ, Huang CY, Shen YC, Wei KC, Chuang CC, Hsu PW, Huang YC, Hwang TL*, Chen PY*. A manzamine-derived compound as a potential therapeutic agent for glioma by inducing apoptosis and cell cycle arrest. American Journal of Cancer Research. 2022 Apr; 12(4): 1740-1751. (SCI; IF2021=5.942; Oncology 71/245)

185. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Huang CH, Wang HT*. Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines. Neuromolecular Medicine. 2022 Jun; 24(2): 113-124. (SCI; IF2021=4.103; Neurosciences 122/274)

186. Lee CC, You JF, Wang YC, Lan SW, Wei KC, Chen KT, Huang YC, Wu TE, Huang AP*. Gross Total Resection Promotes Subsequent Recovery and Further Enhancement of Impaired Natural Killer Cell Activity in Glioblastoma Patients. Brain Sciences. 2022 Aug; 12(9): 1144. (SCI; IF2021=3.333; Neurosciences 175/274)

187. Chiou SY, Zhang ZY, Liu HL, Yan JL, Wei KC, Chen PY*. Augmented Reality Surgical Navigation System for External Ventricular Drain. Healthcare (Basel). 2022 Sep; 10(10): 1815. (SCI; IF2021=3.160; Health policy & services 35/88)

188. Huang SH, Chuang CC, Wang CC, Wei KC, Chen HC, Hsu PW*. Risk factors for peritumoral edema after radiosurgery for intracranial benign meningiomas: a long-term follow-up in a single institution. Neurosurgical Focus. 2022 Nov; 53(5): E7. (SCI; IF2021=4.332; Surgery 38/211)

189. Lin SY, Chuang CC, Huang YC*, Pai PC, Lee CC, Wei KC, Tseng CK, Yang CC*. Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation. Applied Neuropsychology: Adult. Early published online on 27 Mar 2022. doi: 10.1080/23279095.2022.2048830 . (SCI; IF2021=2.050; Psychology 62/79)

190. Chen CH1, Wei KC1, Liao WC1, Lin YY, Chen HC, Feng LY, Liu CH, Huang CY, Chen KT, Wu CS, Chang YS, Yu JS, Chang IY*. Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan. Journal of Neurosurgery. Early published online on 23 Sep 2022. doi: 10.3171/2022.7.JNS2250 . (SCI; IF2021=5.408; Surgery 23/211) (1co-first author)

191. Wang HJ*, Huang CY, Wei KC, Hung KC. A Mass Spectrometry Imaging and Lipidomic Investigation Reveals Aberrant Lipid Metabolism in the Orthotopic Mouse Glioma. Journal of Lipid Research. Early published online on 20 Oct 2022. doi: 10.1016/j.jlr.2022.100304 . (SCI; IF2021=6.676; Biochemistry & molecular biology 60/297)

192. Hsu PW, Lee CC, Huang YC, Wei KC, Chen HC, Wang CC, Yip PK, Liu ZH*. Correlation between initial tumor enlargement and magnetic resonance imaging characteristics following linear accelerator-based stereotactic radiosurgery for acoustic neuromas. Strahlentherapie und Onkologie. Early published online on 3 Nov 2022. doi: 10.1007/s00066-022-02011-3 . (SCI; IF2021=4.033; Radiology, nuclear medicine & medical imaging 52/136)

專利

1. I389702: Magnetic nano composite for inhibition/treatment of tumor and method for preparing the same. Hua, Mu-Yi; Yang, Hong-Wei; Cai, Rong-Yuan; Wei, Guo-Zhen; Chen, Pin-Yuan; Huang, Qiong-ying. 2013/3/21.

2. I445550: Magnetic nano particle composite with multiple reactive functional groups and method of preparing the same. Hua, Mu-Yi; Liu, Hao-Li; Yang, Hong-Wei; Wei, Guo-Zhen; Chen, Pin-Yuan; Cai, Rong-Yuan. 2014/7/21.

3. I488613: System for guiding focused ultrasound energy release using surgical navigation system and method thereof. Liu, Hao-Li; Cai, Hong-Jie; Lu, Yu-Ren; Wei, Guo-Zhen. 2015/6/21.

4. I536950: A pressure detecting monitor system for an in vivo operation. Lai, Chao-Sung; Wei, Kuo Chen; Wang, Jer Chyi; Hua, Mu Yi; Lu, Yu Jen; Huang, Chiung Yin; Su, Sheng Kai. 2016/6/11.

5. I552730: 超音波收發處理系統及其處理方法(translation: Ultrasonic transceiver processing system and processing method). Liu, Hao Li; Tsai, Chih Hung; Wei, Kuo Chen; Chen, Pin Yuan. 2016/10/11.

6. I562801: Method for ultrasound-mediated delivery system to monitor molecular penetration. Liu, Hao Li; Wei, Kuo Chen; Chen, Pin Yuan; Hsu, Po Hung; Chu, Po Chun; Chai, Wen Yen; Lin, Chung Yin. 2016/12/21.

7. I583395: 促進細胞攝入粒子之混合物及其製備方法(The mixture of particles to promote uptake of cell and preparation method). Ma, Yun-Hua; Lu, Yan-Li; Wu, Jian-De; Wei, Guo-Zhen; Lu, Yi-Qing. 2017/5/21.

8. I636768: Surgery assistant system. Chen, Pin-Yuan; Wei, Kuo-Chen; Zhang, Wei-Han; Pei, Yu-Cheng; Zhao, Yi-Ping. 2018/10/1.

9. I678181: 手術導引系統 (Surgical navigation system.) Liu, Hao-Li, Chiou, Shin-Yan, Liao, Chen-Yuan, Lin, Wen-Yen, Chen, Pin-Yuan; Wei, Kuo-Chen. 2019/12/1.

10. I741196: 整合擴增實境之手術導航方法及系統 (Surgical navigation method and system integrating augmented reality.) Chiou, Shin-Yan; Liu, Hao-Li; Liao, Chen-Yuan; Chen, Pin-Yuan; Wei, Kuo-Chen. 2021/10/1.

11. I751122: Use of bevacizumab in manufacture of medicament for treating brain tumor and kit thereof. Liu, Hao-Li; Chu, Po-Chun; Chang, Ting-Kuang; Wei, Kuo-Chen; Chen, Pin-Yuan; Huang, Chiung-Yin. 2022/1/1.

完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
Education：

1978/9/1 – 1985/6/30: M.D., Chung Shan Medical University, Taichung, Taiwan.

(7/1/1984-6/30/1985: Rotating internship)

1987/9/1 – 1989/6/30: Residency, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

1989/7/1 – 1993/6/30: Residency, Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

Post-Graduate Education/Training：

1999/7/1 – 2001/1/31: Post MD research, Brain Tumor Research Center, University of California, San Francisco, CA

Academic Appointment：

2004/8/1 – 2012/7/31:

Adjunct instructor, School of Medicine, Chang Gung University, Taoyuan, Taiwan

2012/8/1 – 2014/8/31:

Adjunct assistant professor, School of Medicine, Chang Gung University, Taoyuan, Taiwan

2013/7/1 – 2016/6/30:

Associate professor, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2014/9/1 – 2017/1/31

Assistant professor, School of Medicine, Chang Gung University, Taoyuan, Taiwan

2016/7/1 – present

Professor, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2017/2/1 – 2020/7/31

Associate professor, School of Medicine, Chang Gung University, Taoyuan, Taiwan

2020/8/1 – present

Professor, School of Medicine, Chang Gung University, Taoyuan, Taiwan

Employment Record：

1993/9/1 – present:

Full-time attending physician, Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2008/7/1 – 2012/6/30:

Chief, Division of Brain Tumor, Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2012/1/1 – 2014/6/30:

Chief, Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2013/9/1 – 2017/6/30,

2018/7/1 – 2020/6/30

Vice chairman, Department of Surgery, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan

2020/3/21 –present

Vice superintendent, New Taipei City Municipal Tucheng Hospital, New Taipei City, Taiwan

Board Certification：

Physician license: no.013829, 1986-present

Surgeon license: no.002595, 1991-present

Specialty: neurosurgeon license no.000253, 1993-present

neurocritical care no.0055, 2011-present

surgical oncologist no.1011109, 2012-present

Professional Affiliations：

Member of Taiwan Surgical Association

Member of Taiwan Neurosurgical Society

Member of Taiwan Neurosurgical Spine Society

Member of Taiwan Society for Neuro-Oncology

Member of Taiwan Society for Skull Base Surgery

Member of Taiwan Society for Stereotactic Functional Neuosurgery and Radiosurgery

International member of American Association of Neurological Surgeons, since March 2011

Member of the Chinese Oncology Society

Professional Activities：

At Institute

Member of Tissue Bank Committee, Chang Gung Memorial Hospital Linkou Branch, 2010-2017.

Deputy director, Cancer Center, Chang Gung Memorial Hospital Linkou Branch, 2013-2020.

Chairman, Ward Committee, Chang Gung Memorial Hospital Linkou Branch, 2015-2016.

Vice chairman, Medical Education Committee, Chang Gung Memorial Hospital Linkou Branch, 2015-2016

Vice chairman, Medical Research Project Evaluation Committee, Chang Gung Memorial Hospital Linkou Branch, 2017.

Vice chairman, Operation Room Committee, Chang Gung Memorial Hospital Linkou Branch, 2017-2020.

Director, Center for Acdemia and Industry Cooperation, Chang Gung Memorial Hospital Linkou Branch, 2019-2020.

Director, Neuroscience Research Center, Chang Gung Memorial Hospital Linkou Branch, 2020-2023.

Chairman, Research and Development Achievements Committee, Chang Gung Medical Foundation, 2020-present.

National

Medical consulting member, Centers for Disease Control, R.O.C.(Taiwan), 2004-2005, 2007-2009.

Medical personnel of global budgets review (2008-2010) and medical service review (2012-2014), Bureau of National Health Insurance, Department of Health, Executive Yuan, R.O.C.

Expert representative, National Health Insurance Dispute Mediation Committee, Ministry of hearth and Welfare, R.O.C, 2013-2018.

Expert representative, Regenerative Medicine Committee, Food and Drug Administration, Ministry of hearth and Welfare, R.O.C, 2016-2019.

Expert representative, The National Health Insurance Pharmaceutical Benefit and Reimbursement Schedule, National Health Insurance Administration, Ministry of hearth and Welfare, R.O.C, 2017-2020.

Member of Board of Directors (2007-2009, 2013-2017), Secretary General (2011-2013) and Chairman (2017-2019), Taiwan Society for Neuro-Oncology, R.O.C.

Member of Board of Directors, Taiwan Society for Stereotactic Functional Neuosurgery and Radiosurgery, 2009-2015.

Vice chairman of Insurance and Medical Affair Committee (2009-2011), member of Board of Directors (2013-2019), member of Board of Supervisors (2018-2020), Chairman of Neuro-Oncology Committee (2017-2019), Secretary General (2020-2022), Taiwan Neurosurgical Society.

Member of Board of Directors (2011-2013), member of health insurance committee, and member of new medial technique committee (2015-2017), Taiwan Neurosurgical Spine Society.

Member of Board of Supervisors (2018-2022), member of Selection Committee (2018-2022), Taiwan Surgical Association.

Chairman, Board of Health Insurance, Taiwan Society for Neurovascular and Interventional Surgery, 2019-2021.

Facility chief, Shenkeng Group Quarantine Facility (temporary COVID-19 quarantine program), New Taipei City, Taiwan R.O.C., Jun-Jul 2021, May-Jun 2022.

Facility chief, First Yehliu Group Quarantine Facility, Second Yehliu Group Quarantine Facility (temporary COVID-19 quarantine program), New Taipei City, Taiwan R.O.C., Sep 2021.

International

Congress President, the 16th Meeting of the Asian Society for Neuro-Oncology: Taipei, Sep 26-29, 2019.

Research Interest：

Neurosurgery: intraoperative monitoring

Biosignatures of brain tumor

Drug delivery system for brain tumor: focused ultrasound for blood-brain barrier opening, nanotechnology

Research Project*：

* Kuo-Chen Wei as principal investigator

A. Biosignatures of Brain Tumor

1. Pre-Clinical Study of Brain Tumor Vaccine. 腦瘤疫苗之前趨研究

(Supported by National Science Council, no.92-2314-B-182A-134/ NMRPG2109, 2003/8/1-2004/10/31)

2. The Study of A-protein and glial cell specific Ag in CNS. 中樞神經系統膠質細胞A-蛋白質之研究

(Supported by National Health Research Institute, no.NHRI-EX92/93-9233NI/ HMRPG2002-03, 2003/1/1-2004/12/31)

3. The Specific Antigen of Malignant Glioma. 惡性膠質細胞之基因表現

(Sponsor by Terry Fox Foundation, no.SMRP G32041, 2003/7/1-2004/12/31)

4. Disease Proteomics: translation of medical resource to clinical and research application – proteomic analysis of serum biomarkers of brain tumor. 疾病蛋白質體整合型計劃：腦瘤血清腫瘤標記的蛋白質分析

(Supported by Chang Gung Memorial Hospital, no. CMRPG33098, 2004/10/1-2007/9/30)

5. Study of glial cell specific antigens in CNS. 中樞神經膠質細胞特殊抗原之研究

(Sponsor by National Health Research Institute, no.NHRI-EX95~99-9507NI/ HMRPG350011-15, 2006/1/1-2010/12/31)

6. Establish the cancer epigenome: from epigenetic profiling to clinical applications - Epigenomic profiling of malignant brain tumors. 整合型建構癌症表觀基因組：從表觀基因譜到臨床應用之研究子計劃三-惡性腦瘤表觀基因譜之建立

(Supported by Chang Gung Memorial Hospital, no. CMRPG380621-22, 2009/5/1-2012/1/31)

7. Establishment of microRNA profile and evaluation of its value in molecular diagnostic of glioblastoma multiforme. 微小RNA在惡性腦瘤之表現譜建立以及作為分子診斷標的之評估

(Supported by Department of Health, Executive Yuan, no.DOH99-TD-I-111-TM002/ PMRPG390011, 2010/1/1-2010/12/31)

8. Establishment of microRNA profile and evaluation of its value in molecular diagnostic of glioblastoma multiforme. 建立惡性腦瘤微小RNA表現譜以及評估其作為臨床診斷因子之潛力

(Supported by Chang Gung Memorial Hospital, no. CMRPG392101-03, 2010/12/1-2013/11/30)

9. Study and Application of Glial Cell Specific Antigens in CNS中樞神經特殊抗原之研究與應用

(Sponsor by National Health Research Institute, no.NHRI-EX100~104-10004NI/ HMRPG3A0011-14, HMRPD1A0125, 2011/1/1-2015/12/31)

10. Comprehensive investigation of genetic and transcriptomic biosignatures for human glioblastoma multiform. 全面性研究人類惡性腦膠質瘤之基因與基因轉錄生物標記

(Supported by Chang Gung Memorial Hospital, no. CMRPG3B1011-13, 2012/7/1-2015/6/30)

11. Identification and characterization of malignant brain tumor stem cells惡性腦幹細胞之分離、鑑定與特性分析

(Supported by Chang Gung Memorial Hospital, no.CMRPG3D0101-3, 2014/1/1-2016/12/31)

12. Establishment of brain tumor data bank整合型林口長庚醫院腫瘤初代細胞株之建立與應用子計畫一：腦腫瘤細胞資料庫之建立

(Supported by Chang Gung Memorial Hospital, no. CMRPG3D0491-3; 2014/2/1-2016/12/31)

13. Brain tumor: Study on the malignant brain tumor characters and treatments整合型台灣多中心提升癌症存活率轉譯研究子計畫五︰腦瘤研究-惡性腦瘤之生物特徵及治療方法研究

(Supported by Chang Gung Memorial Hospital, no.CMRPG3D1111-3, 2014/6/1-2017/5/31)

14. Evaluation of the RBE (relative biological effectiveness) of proton therapy on brain tumors整合型三度空間立體定位質子放射手術的臨床應用及相關研究子計畫五:質子放射治療對腦瘤細胞的生物效應探討

(Supported by Chang Gung Memorial Hospital, no.CIRPG3D0051-3, 2014/6/1-2017/8/31)

15. 整合型An image based translational platform for oncology study: from diagnosis if glioma之子計畫三:以分子影像輔助腦瘤質子治療之應用與開發

(Supported by Chang Gung Memorial Hospital, no.CIRPG3E0031-2, 2015/7/1-2017/6/31)

16. Study the biological factors for glial cell malignancy and development of brain drug delivery system 探討影響中樞神經膠質細胞惡性度進展之生物因子與新穎腦疾療法開發

(Supported by National Health Research Institute, no. NHRI-EX105-10502NI, no.HMRPD1F0011-5, 2016/1/1-2022/12/31)

17. Insulin-like growth factor binding protein 3 (IGFBP3) as a graderelatedprognostic factor and a therapeutic target of gliomas and the molecular mechanism of IGFBP3-regulated cell behavior. IGFBP3成為腦癌之期數相關預後因子和標靶治療的可能性及其調控腦癌細胞行為的分子機制

(Supported by Ministry of Science and Technology, no.105/6/7-2314-B-182-019-MY3, no. NMRPD1F0851-3, 2016/8/1-2019/10/31)

18. The role of miR-139 in glioma stemness and progression. miR-139在腦癌幹細胞特性及疾病進程中所扮演的角色

(Supported by Chang Gung Memorial Hospital, no. CMRPG3J1261, CMRPVVJ0042, 2019/10/1-2021/9/30)

19. The clinical significance of Fucosyltransferase 8 (FUT8) expression and its impact on tumor physiology in glioma. 岩藻糖基轉移酶8（FUT8）表現對惡性腦癌的臨床意義及其對腫瘤生理的影響

(Supported by by Ministry of Science and Technology, no.108-2314-B-182-019-MY2, no. NMRPD1J0481-2, 2019/8/1-2021/7/31)

B. Nanomedicine and Drug Delivery for Brain Tumor Treatment

1. Magnetic targeting delivery of anti-angiogenesis therapy: using magnetic force to enhance antivascular tumor treatment. 磁場導引抗血管新生療法：利用磁場導引強化抗血管新生之腫瘤治療

(Supported by Chang Gung Memorial Hospital長清計劃, no.CMRPG350191-93, 2006/1/1-2009/1/31)

2. Using rat brain tumor model to detect the therapeutic effect of cancer drug deliver micelles in central nerve system tumor利用老鼠腦瘤模式研究多功能奈米複合型微胞對中樞神經惡性腫瘤之治療效果

(Supported by Chang Gung Memorial Hospital, no.CMRPG380041, 2009/1/1-2009/12/31)

3. Focused Ultrasound, Combined with Magnetic Targeting, Enhances Nanoparticle Drug Delivery for Glioma Chemotherapy. 運用聚焦超音波合併磁導奈米微粒對腦瘤化學治療效率之改善

(Supported by Department of Health, Executive Yuan, and the National Program on Nano Technology奈米國家型科技計畫, no.DOH98~100-TD-N-111-002/ DMRPG380011-380013, 2009/3/1-2012/2/28)

4. Development of magnetic resonance compatible radiofrequency therapeutic ultrasound driving system: evidence in animal model (brain). 磁振影像相容之治療用超音波射頻驅動系統開發:動物實驗驗證(腦部)

(Supported by Ministry of Economic Affairs經濟部學研計畫, no.GMRPG380091, 2009/6/1-2010/5/31)

5. Investigation of the therapeutic effect against malignant brain tumor of multifunctional micelle drug delivery system. 多功能奈米微胞藥物傳遞系統對惡性腦瘤之治療效果探討

(Supported by Chang Gung Memorial Hospital長清計劃, no. CMRPG390071, 2010/1/1-2010/12/31)

6. Development of implanted nano-micelle drug carrier — establishment of post-brain tumor recession animal model. 植入型腫瘤標的之奈米微胞藥物開發-腦腫瘤手術後動物模式開發

(Supported by Industrial Technology Research Institute, PMRPG390111-12, 2010/1/1-2011/12/20; total funding 2,550,000 NTD)

7. Using hydrophobically modified chitosan as drug carrier for malignant brain tumor treatment. 應用修飾甲殼素為基質之奈米藥物載體於惡性腦瘤之治療效益評估

(Supported by Chang Gung Memorial Hospital, no.CMRPG3A0031, 2011/1/1-2011/12/31)

8. Development of innovative nanoparticle brain tumor therapeutic system整合型創新奈米腦瘤治療系統之開發計畫

(Supported by Chang Gung Memorial Hospital, no.CMRPG3A0501-03, 2011/6/1-2014/5/31)

9. Validation of focused ultrasound induced enhanced drug delivery effect in brain by swine model.以大動物模式及立體定位系統驗證聚焦超音波促進腦部藥物傳遞之效率

(Supported by Chang Gung Memorial Hospital, no.CMRPG3A0531, 2011/6/1-2012/5/31)

10. Application of high efficiency nano therapeutic platform in treatment of malignant brain tumor.高效能奈米治療平台於惡性腦瘤之應用

(Supported by National Science Council國科會奈米國家型計畫, no.100-2120-M-182A-001/ NMRPG3A0171, 2011/8/1-2012/7/31)

11. Investigation for poly (aspartic acid) copolymers as molecular targeting nano-drug carriers and its application on central nerve system tumor therapy. 以聚胺基酸聚合物作為智慧型奈米藥物載體及其治療中樞神經惡性腫瘤之效果評估

(Supported by Chang Gung Memorial Hospital, no.CMRPG3B0451, 2012/2/1-2013/1/31)

12. Application of high efficiency nano therapeutic platform in treatment of malignant brain tumor高效能奈米治療平台於惡性腦瘤之應用

(Supported by National Science Council國科會奈米國家型計畫-產學合作計畫, no.100-2120-M-182A-002-CC1, 102-2120-M -182A-002-CC1, 103-2120-M-182A-001-CC1/ NCRPG3B0011-13, NCRPG3BS011-13, NCRPD1DP031, 2012/6/1-2015/8/31)

13.Development of fluorescent grapheme nanosheets with BBB permeation for drug and gene co-delivery in malignant brain tumor treatment多功能奈米石墨烯藥物載體之開發與治療惡性腦瘤效益評估

(Supported by Chang Gung Memorial Hospital, no.CMRPG3C0351, 2013/1/1-2013/12/31)

14.Multifunctional liposomes to deliver chemotherapeutic agents and photosensitizer for targeted chemotherapy and photodynamic diagnosis, therapy in brain tumor多功能微脂體化學藥物載體於腦腫瘤化學治療與光動力治療及影像診斷之應用

(Supported by Chang Gung Memorial Hospital長清計畫, no.CMRPG3D0571, 2014/2/1-2015/1/31)

15. NaviFUS: Evaluation and consultation of regulatory/ clinical pathway of focused ultrasound brain drug delivery systemNaviFUS：聚焦式超音波腦部藥物釋放技術之臨床化法規專利評估

(Supported by Ministry of Science and Technology, no.103-2622-B-182A-001, NMRPG3D0041, 2014/2/1-2014/10/31)

16. Development of novel nanobubble for enhancement of brain tumor chemotherapy efficacy長清整合型惡性腦瘤化學治療藥物之開發與效率改善應用之子計劃一：開發創新奈米微氣泡以促進腦瘤化學治療效率

(Supported by Chang Gung Memorial Hospital長清計畫, no.CMRPG3E1261-2, 2015/5/1-2017/7/30)

17. Gold nanorods-incorporated magnetic mesoporous nanoparticles for heat- and redox-triggered drug/siRNA delivery and near-infrared photothermal therapy以磁性奈米金桿作為可攜帶基因及化療藥物之近紅外線光熱腫瘤治療平台

(Supported by Chang Gung Memorial Hospital, no.CMRPG3E2041-3, 2015/11/1-2018/12/31)

18. Nanobubble enhanced focused-ultrasound/ convection-enhanced brain drug delivery以奈米氣泡增進聚焦超音波/增強對流傳輸在腦部藥物遞送

(Supported by Ministry of Science and Technology, no.105/6/7-2811-M-182-001, no. NMRPD1F0061-3, 2016/8/1-2019/7/31)

19. Fluoresent virus-like-particles for RAN interference and tumor suppressor gene (p53) delivery in cancer treatment. 螢光類病毒粒子攜帶RNAi與自殺基因(p53)應用於癌症基因治療

(Supported by Chang Gung Memorial Hospital, no. CMRPG3G1261-2, 2017/8/1-2019/7/31)

20. 超音波於腦腫瘤血管正常化之研究

(Supported by Chang Gung Memorial Hospital 長清計畫, no. CMRPG3H0221, 2018/1/1 -2018/12/31)

21. Enhancing drug delivery of brain tumor with B10 drug-encapsulated microbubbles負載含硼藥物之微氣泡結合聚焦式超音波於強化腦瘤藥物遞送成效

(Supported by Chang Gung Memorial Hospital 長清計畫, no. CORPG3I0111, 2019/1/1 -2019/12/31)

22. Development of rapid in situ gelation by blue light-triggering forenhanced chemo-radio therapy in brain tumor開發藍光誘導快速原位凝膠系統應用於惡性腦癌化療與放療增強治療

(Supported by Chang Gung Memorial Hospital, no. CMRPG3J0091-2, 2019/1/1 -2020/12/31)

23. Development of silicon dioxide carrier for brain tumor therapeutic delivery 二氧化矽載藥奈米粒子腦瘤藥物開發

(Supported by 奈力生醫股份有限公司, no. 產學合作計畫SCRPD1J0091, 2019/5/1 -2020/1/31)

24. Sonogenetic-induced dopaminergic neurons regeneration in Parkinson’s Disease animal model超音波遺傳學誘發之多巴胺神經修復於帕金森氏症動物模型研究

(Supported by Chang Gung Memorial Hospital 長清計畫, no. CORPG3K0091, 2020/1/1 -2020/12/31)

25. Assessing the effect of hyperbaric oxygen combined focused ultrasound to promote the therapeutic effect of brain tumors整合型發展高壓氧醫學新的應用方向之子計畫三：評估高壓氧合併聚焦超音波促進腦瘤治療效應之影響

(Supported by Chang Gung Memorial Hospital, no. CMRPVVK0011-2, 2020/9/1 -2022/8/31)

26. Study the potential of sonosensitizer-mediated sonodynamic therapy on malignant brain tumor treatment探討以聲敏感劑輔助聲動力療法作為惡性腦瘤治療之可行性

(Supported by Chang Gung Memorial Hospital, no. CMRPVVL0141, 2021/7/1 -2022/6/30)

27. Study the effect of regulating tumor microenvironment as enhancement for brain tumor radiotherapy探討以調控腫瘤周邊微環境作為協助腦瘤放射治療之效應

(Supported by Ministry of Science and Technology, no.110-2314-B-182A-154-MY3, NMRPVVL6021, 2021/8/1 -2022/7/31)

C. Other projects

1. ABT-414 alone or ABT-414 plus temozolomide vs. lomustine or temozolomide for recurrent glioblastoma: a randomized phase II study of the EORTC Brain Tumor Group. 單獨使用ABT-414或ABT-414加上temozolomide相較於lomustine或temozolomide對復發性神經膠母細胞瘤的研究：一項EORTC腦瘤團隊所進行的隨機分配第II期試驗

(Supported by AbbVie Inc., no.XMRPG3E0921-5, 2015/10/13-2020/10/31)

2. A phase I/II study of CAN008 plus concomitant temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme. CAN008與Temozolomide在放射治療期間以及放療結束後合併使用,用於新診斷的多型性神經膠母細胞瘤患者的第一/二期臨床試驗

(Supported by CANbridge Life Sciences Ltd., no.XMRPG3F0621-4, 2016/8/16-2020/2/29)

3. A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1). ABT-414合併同步化學放射治療以及輔助性Temozolomide用於診斷出多型性神經膠母細胞瘤(GBM)並有表皮生長因子受體(EGFR)增殖之受試者的一項隨機分配、安慰劑對照、第2b/3期試驗(Intellance 1)

(Supported by AbbVie Inc., no.XMRPG3F0881-4, 2016/10/21-2020/4/22)

4. A Randomized, Multicenter, Phase 2 Study of DSP-7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma following Initial Therapy. 一項隨機分配、多中心、第2期試驗，以DSP-7888乳劑併用Bevacizumab相較於單獨使用Bevacizumab，對象為接受初步治療後膠質母細胞瘤復發或惡化的病患

(Supported by Boston Biomedical Inc., no. XMRPG3H0161-4, 2018/2/6-2022/2/28)

5. A FIH feasibility study to evaluate the safety of transient disruption of blood-brain barrier in recurrent glioblastoma multiforme (GBM) patients using NaviFUS System. 一項首次應用於人體，開放性，以NaviFUS系統評估復發性多形性膠質母細胞瘤患者血腦障壁暫時性開啟的安全性暨可行性研究

(Supported by NaviFUS Corporation浩宇生醫股份有限公司, XMRPG3H0571-2, 2018/5/29-2019/11/22)

6. An open label, prospective, pilot study to evaluate the efficacy and safety of best physician’s choice of standard of care combined with or without NaviFUS system in patients with recurrent glioblastoma multiforme. 一項開放，前瞻，先導型研究，以評估醫師選擇的最佳標準療法與NaviFUS系統合用與否對復發性多形性膠質母細胞瘤患者的有效性和安全性

(Supported by NaviFUS Corporation浩宇生醫股份有限公司, XMRPG3K0351-3, 2020/5/22-2022/8/31)

7. Phase 1B Trial of ADI-PEG 20 plus Radiotherapy and Temozolomide in Subjects with Newly Diagnosed Glioblastoma Multiforme (GBM). ADI-PEG 20併用放射治療及Temozolomide於新診斷多形性神經膠質母細胞病患之第1B期臨床試驗

(Supported by TDW Pharmaceuticals Inc.瑞華新藥研發股份有限公司, XMRPG3K0411-6, 2020/6/16-2025/6/30)

8. An open label, prospective, pilot study to evaluate the safety and preliminary efficacy of the combination of focused ultrasound with re-irradiation for the treatment patients with recurrent glioblastoma multiforme using NaviFUS system一項開放，前瞻，先導性研究，以評估NaviFUS系統與再次放射治療合用對復發性多形性膠質母細胞瘤患者的安全性和初步療效

(Supported by NaviFUS Corporation浩宇生醫股份有限公司, no. XMRPG3L1201-2, 2021/6/8 -2022/11/27)

9. Study the potential of serum IgM antibody for precise rapid COVID 19 detetion探討以血清IgM抗體快篩準確偵測新冠肺炎之可行性

(Supported by Chang Gung Memorial Hospital, no. CORPVVL0051, 2021/7/1 -2022/6/30)

Honor or Awards：

2014 Chien-Tien Hsu’s Cancer Research Award, The Chinese Oncology Society: Taipei, May 2-4, 2014.

Potential Award of Healthcare, 2014 Taiwan Healthcare and Agricultural Biotech industries Innovation and Excellence Awards: Taipei, September 23, 2014.

2015 Distinguished Teaching Faculty: Chang Gung University, 2015.

Academic Research Innovation, the 12th National Innovation Award, the Institute for Biotechnology and Medicine Industry: Taipei, December 24, 2015.

2016 Principal Investigator of Outstanding Innovative Research Grant: National Health Research Institute, Taiwan (R.O.C.), January 2016.

2016 Award for Excellent Contributions in Technology Transfer: Ministry of Science and Technology, Taiwan (R.O.C), February, 2017.

2017 Chang Gung Medical Research Award: Chang Gung Memorial Hospital Linkou Branch, Chang Gung Medical Foundation, January, 2018.

Clinical Innovation, the 16th National Innovation Award, the Institute for Biotechnology and Medicine Industry: Taipei, December 24, 2019.

2021 Taiwan Medical Role Model Award, Taiwan Medical Association: Taipei, November 6, 2021.

Clinical Innovation, the 18th National Innovation Award, Research Center for Biotechnology and Medicine Policy: Taipei, December 17, 2021.

Medical Education and Research Award, the 10th Medical Charity Award, Department of Hearth, New Taipei City Government: New Taipei City, November 8, 2022.