陳瓊美
基本資料
姓名：
陳瓊美
電子信箱：
cmchen@cgmh.org.tw
連絡電話/傳真：
TEL: (03) 3281200 EXT: 8340
服務機構 / 服務單位 / 現任職稱 (可多項填寫)：
Professor, Department of Neurology, Chang Gung Memorial Hospital.
Associated professor, College of Medicine, Chang-Gung University.
機構地址：
5, Fuxing Street, Kui Shan Township, Taoyuan County 33305, 333
個人網站：
研究領域：
1. Genetics and Molecular Biology
2. Clinical Neuromedicine
3. Huntington's disease, Parkinson's disease and movement disorders
4. Neurodegenerative diseases
個人簡歷
Language: Formosan, Chinese, English
Education:
Sep 1980-June 1987 Taipei Medical College, Taipei, Taiwan, M.D.
Post-Graduate Education:
May 1994-April 1995 Research Fellow, Movement Disorders, Institute of
Neurology, The National Hospital for Neurology and
Neurosurgery, Queen Square, London, U.K.
Oct 1998-Aug 2002 Ph.D. Division of Molecular Genetics, Institute of
Biochemistry and life Sciences, University of Glasgow,
U.K.
Academic appointment:
2010 ~ Present, Professor, Department of Neurology, Chang Gung Memorial Hospital.
2007 ~ 2010, Associated professor, Department of Neurology, Chang Gung Memorial
Hospital.
2009 ~ Present, Associated professor, College of Medicine, Chang-Gung University.
Employment Record:
1992—Present Attending Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
2004—Present Physician Scientist, Chang Gung Memorial Hospital, Taipei,
Taiwan.
1987—1991 Resident Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
1991—1992 Fellowship Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
Board Certification: September 1990, Specialist in Neurology
發表論文或著作等
1. Chen CM, Yen CY, Chen WL, Lin CH, Wu YR, Chang KH, Lee-Chen GJ.
Pathomechanism Characterization and Potential Therapeutics Identification for
Parkinson's Disease Targeting Neuroinflammation. Int J Mol Sci. 2021 Jan
21;22(3):1062.
2. Wu YR, Chang KH, Chao CY, Lin CH, Chen YC, Liu TW, Lee-Chen GJ, Chen
CM*. Association of SOD2 p.V16A polymorphism with Parkinson's disease: A
meta-analysis in Han Chinese. J Formos Med Assoc. 2021 Jan;120(1 Pt
2):501-507.
3. Chiu YJ, Lin SA, Chen WL, Lin TH, Lin CH, Yao CF, Lin W, Wu YR, Chang
KH, Lee-Chen GJ, Chen CM*. Pathomechanism characterization and potential
therapeutics identification for SCA3 targeting neuroinflammation. Aging (Albany
NY). 2020 Nov 10;12(23):23619-23646.
4. Lin CH, Wei PC, Chen CM, Huang YT, Lin JL, Lo YS, Lin JL, Lin CY, Wu YR,
Chang KH, Lee-Chen GJ. Lactulose and Melibiose Attenuate MPTP-Induced
Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of
Neuroinflammation and Up-Regulation of Autophagy. Front Aging Neurosci.
2020 Jul 24;12:226. (co-first author)
5. Lin TH, Chiu YJ, Lin CH,…Chen CM*. Exploration of multi-target effects of
3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models
[published online ahead of print, 2020 Jun 4]. Aging Cell.
2020;10.1111/acel.13169. doi:10.1111/acel.13169 (IF:7.346)
6. Chang KH, Chen CM*. The Role of Oxidative Stress in Parkinson's Disease.
Antioxidants (Basel). 2020 Jul 8;9(7):597. doi: 10.3390/antiox9070597.
7. Chen CM, Lin CH, Wu YR, et al. Lactulose and Melibiose Inhibit α-Synuclein
Aggregation and Up-Regulate Autophagy to Reduce Neuronal
Vulnerability. Cells. 2020;9(5):E1230. (IF: 5.656)
8. Chen CM, Chen WL, Yang ST, Lin TH, Yang SM, Lin W, Chao CY, Wu YR,
Chang KH, Lee-Chen GJ. New Synthetic
3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine
Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB,
NRF2, and Reduction of AMPKα in SCA17 Cell Models. Oxid Med Cell Longev.
2020;2020:3129497.
9. Lin CY, Lin YC, Huang CY, Wu SR, Chen CM*., Liu HL*.
Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome
complex: Preclinical investigation for Parkinson's disease treatment. J Control
Release. 2020;321:519-528. (IF: 7.901)
10. Chang KH, Wu YR, Chen YC, Fung HC, Chen CM*. Association of genetic
variants within HLA-DR region with Parkinson's disease in Taiwan [published
correction appears in Neurobiol Aging. 2020 Apr 6]. Neurobiol Aging. 2020
Mar;87:140.e13-140.e18.
11. Liu TW, Wu YR, Chen YC, Fung HC, Chen CM*. Association of RIT2 and
RAB7L1 with Parkinson's disease: a case-control study in a Taiwanese cohort and
a meta-analysis in Asian populations. Neurobiol Aging. 2020
Mar;87:140.e5-140.e11
12. Chang KH, Wu YR, Chen YC, Wu HC, Chen CM*. Association between CSF1
and CSF1R Polymorphisms and Parkinson's Disease in Taiwan. J Clin Med. 2019
Sep 24;8(10). (IF: 5.688)
13. I-Cheng Chen, Kuo-Hsuan Chang, Yi-Jing Chen, Yi-Chun Chen, Guey-Jen Lee-Ch
en, Chiung-Mei Chen*. Pueraria lobata and Daidzein Reduce Cytotoxicity by
Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons.
Oxidative Medicine and Cellular Longevity. Volume 2019, Article ID 8130481. (IF:
4.936)
14. Wei PC, Lee-Chen GJ, Chen CM, Wu YR, Chen YJ, Lin JL, Lo YS, Yao CF,
Chang KH. Neuroprotection of Indole-Derivative Compound NC001-8 by the
Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models. Oxid Med
Cell Longev. 2019 Oct 31;2019:5074367.
15. Lin CY, Tsai CH, Feng LY, Chai WY, Lin CJ, Huang CY, Wei KC, Yeh CK,
Chen CM*, Liu HL*. Focused ultrasound-induced blood brain-barrier opening
enhanced vascular permeability for GDNF delivery in Huntington's disease mouse
model. Brain Stimul. 2019;12(5):1143-1150. (IF: 6.919)
16. Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang
CP, Chan YC, Lin CH, Liu FT, Chern Y. Galectin-3 is required for the
microglia-mediated brain inflammation in a model of Huntington's disease. Nat
Commun. 2019;10(1):3473. (IF:11.878)
17. Chang KH, Lee-Chen GJ, Huang CC, Lin JL, Chen YJ, Wei PC, Lo YS, Yao CF,
Kuo MW, Chen CM*. Modeling Alzheimer's Disease by Induced Pluripotent Stem
Cells Carrying APP D678H Mutation. Mol Neurobiol. 2019 Jun;56(6):3972-3983.
(IF: 5.076)
18. Chen CM, Chen WL, Hung CT, Lin TH, Lee MC, Chen IC, Lin CH, Chao CY,
Wu YR, Chang KH, Hsieh-Li HM, Lee-Chen GJ. Shaoyao Gancao Tang
(SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts
neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models.
Aging (Albany NY). 2019;11(3):986-1007. (IF: 5.179)
19. Chen IC, Chang CN, Chen WL, Lin TH, Chao CY, Lin CH, Lin HY, Cheng ML,
Chiang MC, Lin JY, Wu YR, Lee-Chen GJ, Chen CM*. Targeting Ubiquitin
Proteasome Pathway with Traditional Chinese Medicine for Treatment of
Spinocerebellar Ataxia Type 3. Am J Chin Med. 2019 Jan 7:1-33 (IF: 3.12).
20. Chen YC, Chiu YJ, Lin CH, Hsu WC, Wu JL, Huang CH, Lin CW, Yao CF,
Huang HJ, Lo YS, Chen CM, Wu YR, Chang KH, Lee-Chen GJ, Mei Hsieh-Li H.
Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease
Cell and Mouse Models for Neuroprotection and Cognitive Improvement. J
Alzheimers Dis. 2019;67(2):737-756. (IF: 3.517).
21. Chang KH, Chen CM, Chen YC, Fung HC, Wu YR. Polymorphisms of
ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with
Parkinson's Disease in Taiwan. Parkinsons Dis. 2019 Jan 2;2019:3489638. (co-first
author) (IF: 2.117)
22. Chen YC, Chang KH, Chen CM*. Genetic Polymorphisms Associated with
Spontaneous Intracerebral Hemorrhage. Int J Mol Sci. 2018 Dec 4;19(12). (IF:
4.183)
23. Lee SY, Chiu YJ, Yang SM, Chen CM, Huang CC, Lee-Chen GJ, Lin W, Chang
KH. Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction,
antioxidation, and neuroprotection. CNS Neurosci Ther. 2018
Dec;24(12):1286-1298.
24. Chen IC, Lin TH, Hsieh YH, Chao CY, Wu YR, Chang KH, Lee MC, Lee-Chen
GJ, Chen CM*. Formulated Chinese Medicine Shaoyao Gancao Tang Reduces
Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and
Anti-Inflammation. Oxid Med Cell Longev. 2018:9595741.
https://doi.org/10.1155/2018/9595741 (IF: 4.936)
25. Chiu YJ, Lee CM, Lin TH, Lin HY, Lee SY, Mesri M, Chang KH, Lin JY,
Lee-Chen GJ, Chen CM.* Chinese Herbal Medicine Glycyrrhiza inflate Reduces
Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and
Anti-Inflammation. Am J Chin Med. 2018 Oct 4:1-25. doi:
10.1142/S0192415X18500799. (IF: 3.12)
26. Chang KH, Cheng ML, Tang HY, Huang CY, Wu YR, Chen CM.* Alternations
of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson’s
Disease. Mol Neurobiol. 2018;55(8):6319-6328. (IF: 5.076)
27. Chang KH, Cheng ML, Chiang MC, Chen CM*. Lipophilic antioxidants in
neurodegenerative diseases. Clin Chim Acta. 485 (2018) 79–87 (IF: 2.926).
28. Chen CM, Chen WL, Hung CT, Lin TH, Chao CY, Lin CH, Wu YR, Chang KH,
Yao CF, Lee-Chen GJ, Su MT, Hsieh-Li HM. The indole compound NC009-1
inhibits aggregation and promotes neurite outgrowth through enhancement of
HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice.
Neurotoxicology. 2018 Jun 21;67:259-269. (IF: 3.1)
29. Chang KH, Lee GC, Huang CC, Kuo HC, Chen CM, Hsiao YC, Hsu HC, Hsu KJ,
Lin CH, Chang CW, Lee-Chen GJ, Wu YR. Genetic and functional characters of
GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.
Parkinsonism Relat Disord. 2018 Jun;51:61-66. (IF: 4.721)
30. Wu HC, Chen CM, Chen YC, Fung HC, Chang KH, Wu YR*. DLG2, but not
TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's
disease in a Taiwanese population. Neurobiol Aging. 2018;64:158.e1-158.e6. (IF:
5.153)
31. Huang YH, Chen CM, Lee YS, Chang KH, Chen HW, Chen YC*. Detection of
mitochondrial DNA with 4977 bp deletion in leukocytes of patients with ischemic
stroke. PLoS One. 2018;13(2):e0193175.
32. Chang CW, Wu HC, Lyu RK, Lo YS, Chen CM, Ro LS, Chang HS, Huang CC,
Liao MF, Wu YR, Kuo HC, Chu CC, Weng YC, Wei PT, Lo AL, Chang KH*.
Elevated serum levels of endothelin-1 in patients with chronic inflammatory
demyelinating polyneuropathy. Clin Chim Acta. 2018;476:49-53. (IF: 2.926).
33. Chang KH, Wu YR, Chen CM*. Down-regulation of miR-9* in the peripheral
leukocytes of Huntington’s disease patients. Orphanet Journal of Rare Diseases
2017;12:185. (IF:3.478).
34. Chen CM, Wu YR, Chang KH. Altered aconitase 2 activity in Huntington's
disease peripheral blood Cells and mouse model striatum. Int J Mol Sci.
2017;18(11). pii: E2480. doi: 10.3390/ijms18112480. (IF:3.226).
35. Tang HY, Chiu DT, Lin JF, Huang CY, Chang KH, Lyu RK, Ro LS, Kuo HC,
Cheng ML, Chen CM*. Disturbance of Plasma Lipid Metabolic Profile in
Guillain-Barre Syndrome. Sci Rep. 2017 Aug 15;7(1):8140. (IF:4.259).
36. Tang HY, Ho HY, Chiu DT, Huang CY, Cheng ML, Chen CM*. Alterations of
plasma concentrations of lipophilic antioxidants are associated with Guillain-Barre
syndrome. Clin Chim Acta. 2017 May 2;470:75-80. (IF: 2.873).
37. Chen IW, Chen CM, Wu YR, Hua MS. Patterns of False Memory in Patients with
Huntington's Disease. Arch Clin Neuropsychol. 2017 Mar 17:1-10.
38. Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei
J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H,
Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew
FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M,
Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F,
Liu J, Tan EK. Genome-wide association study of Parkinson's disease in East
Asians. Hum Mol Genet. 2017 Jan 1;26(1):226-232. (IF: 4.9)
39. Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y, Lin CJ.
Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
Hum Mol Genet. Hum Mol Genet. 2017 Feb 1;26(3):467-478. (IF: 4.9)
40. Chang KH, Chen CM, Lin CH, et al. Functional properties of LRRK2 mutations in
Taiwanese Parkinson disease. J Formos Med Assoc. 2017 Mar;116(3):197-204
(Co-first author). (IF: 2.018)
41. Chen CM, Chen IC, Chen YL, et al., Medicinal herbs Oenanthe javanica (Blume)
DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human
cells from MPP + damage via inducing FBXO7 expression. Phytomedicine. 2016
Nov 15;23(12):1422-1433. (IF: 2.937).
42. Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF,
Wu YR, Kuo HC, Chu CC, Chen CM*. Increased serum concentrations of
transforming growth factor-β1 (TGF-β1) in patients with Guillain-Barré syndrome.
Clin Chim Acta. 2016 Jul 20;461:8-13. (IF:2.799)
43. Lin CY, Hsieh HY, Chen CM, Wu SR, Tsai CH, Huang CY, Hua MY, Wei KC,
Yeh CK, Liu HL*. Non-invasive, neuron-specific gene therapy by focused
ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model.
J Control Release. 2016 May 26;235:72-81. (IF = 7.705, 10/254 in “Pharmacology
& Pharmacy”).
44. Chang YC, Lin CW, Hsu CM, Lee-Chen GJ, Su MT, Ro LS, Chen CM, Huang
HJ, Hsieh-Li HM. Targeting the prodromal stage of spinocerebellar ataxia type 17
mice: G-CSF in the prevention of motor deficits via upregulating chaperone and
autophagy levels. Brain Res. 2016 May 15;1639:132-48.
45. Cheng ML, Chang KH, Wu YR, Chen CM.* Metabolic disturbances in plasma as
biomarkers for Huntington's disease. J Nutr Biochem. 2016 May;31:38-44. (IF:
4.668)
46. Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY,
Wu YR, Lin JY, Lee-Chen GJ, Chen CM.* The aqueous extract of Glycyrrhiza
inflata can upregulate unfolded protein response-mediated chaperones to reduce
tau misfolding in cell models of Alzheimer’s disease. Drug Des Devel Ther.
2016;10:885–896. (IF: 3.028)
47. Chang KH, Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu
HC, Chen CM.* Impairment of proteasome and anti-oxidative pathways in the
induced pluripotent stem cell model for sporadic Parkinson's disease. Parkinsonism
Relat Disord. 2016 Mar;24:81-88. (IF:3.972)
48. Chen CM, Chen YC, Chiang MC, Fung HC, Chang KH, Lee-Chen GJ, Wu YR.
Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C
polymorphisms, with Parkinson's disease in Taiwan. Neurobiol Aging. 2016
Mar;39:221.e1-5 (IF: 5.153)
49. Chen YC, Wu YR, Mesri M, Chen CM*. Associations of Matrix
Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson
Disease in Taiwan. Medicine (Baltimore). 2016 Feb;95(5):e2672. (IF: 5.723)
50. Lin CH, Wu YR, Yang JM, Chen WL, Chao CY, Chen IC, Lin TH, Wu YC, Hsu
KC, Chen CM, Lee GC, Hsieh-Li HM, Lee CM, Lee-Chen GJ. Novel Lactulose
and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models
of Spinocerebellar Ataxia 3. CNS Neurol Disord Drug Targets. 2016;15(3):351-9.
51. Chen YC, Ho WM, Lee YS, Chen HW, Chen CM*. Polymorphisms in the
Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous
Deep Intracerebral Hemorrhage in the Taiwan Population. PLoS One. 2015 Nov
9;10(11):e0142482. (IF: 3.234).
52. Chang KH, Wu YR, Chen YC, Fung HC, Lee-Chen GJ, Chen CM*. STK39, But
Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With
Han-Chinese Parkinson's Disease in Taiwan. Medicine (Baltimore). 2015
Oct;94(41):e1690.
53. Weng YC, Chen CM, Chen YC, Fung HC, Chang CW, Chang KH, Wu YR.
Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's
disease among Taiwanese. J Formos Med Assoc. 2016 Sep;115(9):728-33.
54. Chiu FL, Lin JT, Chuang CY, Chien T, Chen CM, Chen KH, Hsiao HY, Lin YS,
Chern Y, Kuo HC. Elucidating the role of the A2A adenosine receptor in
neurodegeneration using neurons derived from Huntington's disease iPSCs. Hum
Mol Genet. 2015 Nov 1;24(21):6066-79.
55. Chen YC, Huang CJ, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen
CM*. Protein Kinase Cη Polymorphism and the Susceptibility to Ischemic Stroke
in the Taiwan Population. Biomed J. 2015 Sep-Oct;38(5):433-8.
56. Chen CM, Lin YS, Wu YR, et al., High Protein Diet and Huntington's Disease.
PLoS One. 2015 May 19;10(5):e0127654 (IF: 3.234).
57. Lee GC, Lin CH, Tao YC, Yang JM, Hsu KC, Huang YJ, Huang SH, Kung PJ,
Chen WL, Wang CM, Wu YR, Chen CM, Lin JY, Hsieh-Li HM, Lee-Chen GJ.
The potential of lactulose and melibiose, two novel trehalase-indigestible and
autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease
treatment.Neurotoxicology. 2015 May;48:120-30.
58. Ho WM, Chen CM, Lee YS, Chang KH, Chen HW, Chen ST, Chen YC.
Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous
Deep Intracerebral Hemorrhage in the Taiwan Population. PLoS One. 2015 May
1;10(5):e0125397.
59. Chang KH, Ro LS, Lyu RK, Chen CM*. Biomarkers for neuromyelitis optica.Clin
Chim Acta. 2015 Feb 2;440C:64-71. (IF: 2.764, MEDICAL LABORATORY
TECHNOLOGY 7/31=22.58%).
60. Chang KH, Wu YR, Chen YC, and Chen CM*. Plasma Inflammatory biomarkers
for Huntington’s disease patients and mouse model. Brain, Behavior, and Immunity,
44 (2015) 121–127. (IF: 6.128, NEUROSCIENCES 27/252=10.71%).
61. Lee LC, Chen CM, Wang PR, Su MT, Lee-Chen GJ, Chang CY. Role of High
Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis. PLoS One. 2014 Dec
30;9(12):e115809. (IF: 3.234). (co-first author)
62. Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM,
Chang KH, Janreddy D, Lee-Chen GJ, Yao CF. The potential of indole and
a synthetic derivative for polyQ aggregationreduction by enhancement of the
chaperone and autophagy systems. ACS Chem Neurosci. 2014;5(10):1063-74.
63. Hsu TC, Wang CK, Yang CY, Lee LC, Hsieh-Li HM, Ro LS, Chen CM,
Lee-Chen GJ, Su MT. Deactivation of TBP contributes to SCA17 pathogenesis.
Hum Mol Genet. 2014;23(25):6878-93 (IF: 6.677, GENETICS & HEREDITY
16/165=9.69%).
64. Chen CM, Chen IC, Huang YC, et al. FBXO7 Y52C Polymorphism as a Potential
Protective Factor in Parkinson's Disease. PLoS One. 2014 Jul 16;9(7):e101392. (IF:
3.534, MULTIDISCIPLINARY SCIENCES 8/55=14.54%).
65. Hsiao HY, Chiu FL, Chen CM, Wu YR, Chen HM, Chen YC, Kuo HC, Chern Y.
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.
Hum Mol Genet. 2014 Aug 15;23(16):4328-44. (IF: 6.677, GENETICS &
HEREDITY 16/165=9.69%).
66. Chen CM, Weng YT, Chen WL, et al. Aqueous extract of Glycyrrhiza inflata
inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE
pathways in cell models of spinocerebellar ataxia 3. Free Radic Biol Med. 2014
Jun;71:339-50. (IF:5.710, ENDOCRINOLOGY & METABOLISM
15/124=12.09%)
67. Lin CH, Wu YR, Chen WL, Wang HC, Lee CM, Lee-Chen GJ, Chen CM*.
Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's
disease is associated with loss of Mg2+ efflux function. Parkinsonism Relat
Disord. 2014 Jun;20(6):600-3. (IF: 4.126, CLINICAL NEUROLOGY
31/194=15.97%).
68. Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen
YC, Lee-Chen GJ, Chen CM*. Aqueous extract of Gardenia jasminoides targeting
oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar
ataxia 3. Neuropharmacology. 2014 Jun;81:166-75. (IF: 4.819,
PHARMACOLOGY & PHARMACY 23/256 =8.98%).
69. Lee LC, Weng YT, Wu YR, Soong BW, Tseng YC, Chen CM*, Lee-Chen GJ.
Downregulation of proteins involved in the endoplasmic reticulum stress response
and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17. J
Neural Transm. 2014;Jun;121(6):601-10. (IF: 2.871, CLINICAL NEUROLOGY
64/194=32.98%)
70. Chen CM, Wu CH, Hsieh CH, Lin CH, Chen IC, Chen YC, Lee LC, Lee CM,
Tseng YC, Lee-Chen GJ, Wu YR. HTRA2 variations in Taiwanese Parkinson's
disease. J Neural Transm. 2014 May;121(5):491-8. (IF: 2.871, CLINICAL
NEUROLOGY 64/194=32.98%)
71. Wu YR, Chang KH , Chang WT, Hsiao YC, Hsu HC, Jiang PR, Chen YC, Chao
CY, Chang YC, Lee BH, Hu FJ, Chen WL, Lee-Chen GJ, Chen CM* Genetic
variants of LRRK2 in Taiwanese Parkinson’s disease. PLoS One.
2013;8(12):e82001. (IF: 3.534, MULTIDISCIPLINARY SCIENCES
8/55=14.54%).
72. Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu
YR. Association between PARK16 and Parkinson's disease in the Han Chinese
population: a meta-analysis. Neurobiol Aging. 2013 Oct;34(10):2442.e5-9. (IF:
5.013, GERIATRICS & GERONTOLOGY 4/49=8.16%).
73. Chen IC, Lin HY, Hsiao YC, Chen CM, Wu YR, Shiau HC, Shen YF, Huang KS,
Su MT, Hsieh-Li HM, Lee-Chen GJ. Internal Ribosome Entry Segment Activity of
ATXN8 Opposite Strand RNA. PLoS One. 2013 Sep 11;8(9):e73885. (IF: 3.534,
MULTIDISCIPLINARY SCIENCES 8/55=14.54%).
74. Yu SW, Chen CM, Chen YC, Chang CW, Chang HS, Lyu RK, Ro LS, Wu YR.
SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population.
PLoS One. 2013;8(8):e71919 (IF: 3.534, MULTIDISCIPLINARY SCIENCES
8/55=14.54%).
75. Tseng WE, Chen CM, Chen YC, Yi Z, Tan EK, Wu YR. Genetic Variations of
GAK in Two Chinese Parkinson's Disease Populations: A Case-Control Study.
PLoS One. 2013 Jun 24;8(6):e67506. (IF: 3.534, MULTIDISCIPLINARY
SCIENCES 8/55=14.54%).
76. Hung CH, Chang KH, Wu YM, Chen YL, Lyu RK, Chang HS, Wu YR, Chen CM,
Huang CC, Chu CC, Liao MF, Wai YY, Hsu SP, Ro LS. A comparison of benign
and inflammatory manifestations of Tolosa-Hunt syndrome. Cephalalgia. 2013
Jul;33(10):842-52. (IF: 4.121, CLINICAL NEUROLOGY 32/194 =16.49%).
77. Wu YR, Foo JN, Tan LC, Chen CM, Prakash KM, Chen YC, Bei JX, Au WL,
Chang CW, Wong TY, Liu JJ, Zhao Y, Tan EK. Identification of a novel risk
variant in the FUS gene in essential tremor. Neurology. 2013 Aug 6;81(6):541-4.
(IF: 8.303, CLINICAL NEUROLOGY 8/194=4.12%).
78. Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC,
Lee-Chen GJ, Wu YR. Association between GRN rs5848 polymorphism and
Parkinson's disease in Taiwanese population. PLoS One. 2013;8(1):e54448. (IF:
3.534, MULTIDISCIPLINARY SCIENCES 8/55=14.54%).
79. Chen YC, Lee YS, Shih CC, Wu T, Chen CM*. Mutations of proline-rich
transmembrane protein-2 and paroxysmal kinesigenic dyskinesia in Taiwan. Mov
Disord. 2013 Sep;28(10):1459-60 (IF: 5.634, CLINICAL NEUROLOGY
14/194=7.21%).
80. Chang KH, Chen WL, Lee LC, Lin CH, Kung PJ, Lin TH, Wu YC, Wu YR, Chen
YC, Lee-Chen GJ, and Chen CM*. Aqueous Extract of Paeonia lactiflora and
Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of
Spinocerebellar Ataxia 3. Evid Based Complement Alternat Med.
2013;2013:471659. doi: 10.1155/2013/471659. (IF: 2.175, INTEGRATIVE &
COMPLEMENTARY MEDICINE 6/22 =27.27%).
81. Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC,
Hsu WC, Ro LS. Distinct features between longitudinally extensive transverse
myelitis presenting with and without anti-aquaporin 4 antibodies. Mult Scler. 2013
Mar;19(3):299-307. (IF: 4.863, CLINICAL NEUROLOGY 23/194=11.85%).
82. Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC,
Hsu WC, Kuo HC, Chu CC, Chen CM*. Analyses of haptoglobin level in the
cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple
sclerosis. Clin Chim Acta. 2013 Feb 18;417:26-30 (IF: 2.764, MEDICAL
LABORATORY TECHNOLOGY 7/31=22.58%).
83. Chen YC, Wu YR, Wu YC, Lee-Chen GJ, Chen CM*. Genetic analysis of
NFE2L2 promoter variation in Taiwanese Parkinson's disease. Parkinsonism Relat
Disord. 2013 Feb;19(2):247-50. (IF: 4.126, CLINICAL NEUROLOGY
31/194=15.97%).
84. Chen IC, Wu YR, Yang SJ, Kao SH, Chen YC, Chang KH, Lee CM, Lee-Chen GJ,
Chen CM*. ATXN8 -62 G/A promoter polymorphism and risk of Taiwanese
Parkinson's disease. Eur J Neurol. 2012 Nov;19(11):1462-9. (IF:4.162).
85. Chang K-H, Chen Y-C, Wu Y-R, Lee W-F, Chen C-M.* Downregulation of
Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of
Huntington's Disease Patients. PLoS ONE 2012;7(9): e46492.
86. Chen YC, Chen P, Wu YR, Shie SS, Chen ST, Lee-Chen GJ, Chen CM.* Protein
kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the
Taiwan population. Neurosci Lett. 2012 Oct 24;528(2):170-3.
87. Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC,
Hsu WC, Ro LS. Distinct features between longitudinally extensive transverse
myelitis presenting with and without anti-Aquaporin 4 antibodies. Mult Scler. 2012
Jul 24. [Epub ahead of print]
88. Wu YR, Tan LC, Fu X, Chen CM, Au WL, Chen L, Chen YC, Prakash KM,
Zheng Y, Lee-Chen GJ, Zhao Y, Zeng JS, Tan EK, Pei Z. LRRK2 A419V Is Not
Associated with Parkinson's Disease in Different Chinese Populations. PLoS ONE.
2012;7(7):e36123.
89. Lee LC, Chen CM, Wang PR, Wang HC, Hsieh HH, Su MT, Li-Hsieh HM, Wu
CH, Lee GC, Lee-Chen Guey-Jen Lin JY. Role of the CCAAT-Binding Protein
NFY in SCA17 Pathogenesis. PLoS One. 2012;7(4):e35302. (co-first author).
(IF:4.092)
90. Chiang HL, Lee-Chen GJ, Chen CM, Chen YC, Lee CM, Liao MH, Wu YR.
Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease.
Parkinsonism Relat Disord. 2012 May;18(4):391-3.
91. Su FC, Chen CM, Chen YC, Wu YR. LINGO-2 polymorphism and the risk of
Parkinson's disease in Taiwan. Parkinsonism Relat Disord. 2012 Jun;18(5):609-11.
92. Chang KH, Chuang TJ, Lyu RK, Ro LS, Wu YR, Chang HS, Huang CC, Kuo HC,
Hsu WC, Chu CC , Chen CM*.Identification of Gene Networks and Pathways
Associated with Guillain-Barre Syndrome. PLoS ONE. 2012;7(1): e29506.
93. Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC, Kuo HC, Chu CC,
Hsu WC, Ro LS. Distinct features between longitudinally extensive transverse
myelitis presenting with and without anti-Aquaporin 4 antibodies. Mult Scler. 2012
Jul 31. Mar;19(3):299-307.
94. Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT. Oxidative markers in
spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as
an independent predictor of the 30-day outcome. J Neurosurg. 2011
Dec;115(6):1184-90.
95. Chen CM, Lin CH, Juan HF, Hu FJ, Hsiao YC, Chang HY, Chao CY, Chen IC,
Lee LC, Wang TW, Chen YT, Chen YT, Lee-Chen GJ, Wu YR. ATP13A2
variability in Taiwanese Parkinson's disease. Am J Med Genet B Neuropsychiatr
Genet. 2011 Sep;156(6):720-9.
96. Lyu RK, Huang YC, Wu YR, Kuo HC, Ro LS, Chen CM, Chang HS.
Electrophysiological features of Hirayama disease. Muscle Nerve. 2011
Aug;44(2):185-90.
97. Chen CM. Mitochondrial Dysfunction, Metabolic Deficits, and Increased
Oxidative Stress in Huntington's Disease. Chang Gung Med J. 2011
Mar-Apr;34(2):135-52.
98. Chang YC, Lin CY, Hsu CM, Lin HC, Chen YH, Lee-Chen GJ, Su MT, Ro LS,
Chen CM, Hsieh-Li HM. Neuroprotective effects of granulocyte-colony
stimulating factor in a novel transgenic mouse model of SCA17. J Neurochem.
2011 May 10. doi: 10.1111/j.1471-4159.2011.07304.x. [Epub ahead of print]
99. Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, Yeh WY, Wu DR, Lin YJ,
Poon PW, Cheng ML, Wang CH, Chern Y. Dysregulated brain creatine kinase is
associated with hearing impairment in mouse models of Huntington disease. J Clin
Invest. 2011 Apr 1;121(4):1519-23. (Co-first author) (14.15)
100. Huang YC, Wu YR, Tseng MY, Chen YC, SY Hsieh, Chen CM*. Increased
prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of
patients with Huntington’s disease. PLoS ONE. 2011 Jan 31;6(1): e15809. (4.4)
101. Liao MF, Huang CC, Lyu RK, Chen CM, Chang HS, Chu CC, Hsu WC, Wu YR,
Kuo HC, Cheng MY, Hung PC, Chou ML, Lin KL, Hsieh MY, Ro LS. Acute
disseminated encephalomyelitis that meets modified McDonald criteria for
dissemination in space is associated with a high probability of conversion to
multiple sclerosis in Taiwanese patients. Eur J Neurol. 2011 Feb;18(2):252-9.
102. Wu YR, Tan EK, Chen CM, Kumar M, Lee-Chen JG, Chen ST "Genetic analysis
of “leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo
receptor-interacting protein -1 (LINGO1) in two independent Chinese Parkinson’s
Disease populations" Am J Med Genet B Neuropsychiatr Genet. 2011
Jan;156(1):99-103. (PSYCHIATRY: Ranking:35/117= 29.9%;SCI, IF = 3.481)
103. Tan EK, Lu CS, Peng R, Teo YY, Wu-Chou YH, Chen RS, Weng YH, Chen
CM, Fung HC, Tan LC, Zhang ZJ, An XK, Lee-Chen GJ, Lee MC, Fook-Chong
S, Burgunder JM, Wu RM, Wu YR*. Analysis of the UCHL1 genetic variant in
Parkinson's disease among Chinese. Neurobiol Aging. 2010 Dec;31(12):2194-6.
104. Chiang MC, Chen CM, Lee MR, Chen HW, Chen HM, Wu YS, Hung CH, Kang
JJ, Chang CP, Chang C, Wu YR, Tsai YS, Chern Y. Modulation of energy
deficiency in Huntington's disease via activation of the peroxisome
proliferator-activated receptor gamma. Hum Mol Genet. 2010 Oct
15;19(20):4043-58.
105. Lin CH, Chen CM, Hou YT, Wu YR, Hsieh-Li HM, Su MT, Lee-Chen GJ. The
CAG repeat in SCA12 functions as a cis element to up-regulate PPP2R2B
expression. Hum Genet. 2010 Aug;128(2):205-12.
106. Wu YR, Chen CM, Chen YC, Chao CY, Ro LS, Fung HC, Hsiao YC, Hu FJ,
Lee-Chen GJ. Ubiquitin specific proteases USP24 and USP40 and ubiquitin
thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's
disease among Taiwanese. Clin Chim Acta. 2010 Jul 4;411(13-14):955-8.
107. Chen YC, Hu FJ, Chen P, Wu YR, Wu HC, Chen ST, Lee-Chen GJ, Chen CM.
Association of TNF-alpha gene with spontaneous deep intracerebral hemorrhage in
the Taiwan population: a case control study. BMC Neurol. 2010 Jun 10;10:41. doi:
10.1186/1471-2377-10-41.
108. Chang KH; Tsou JC; Chen ST; Ro LS; Lyu RK; Chang HS; Hsu WC; Chen CM;
Wu YR; Chen CJ. Temporal Features of Magnetic Resonance Imaging and
Spectroscopy in Nonketotic Hyperglycemic Chorea-Ballism Patients. Eur J Neurol.
2010 Apr;17(4):589-93. (CLINICAL NEUROLOGY: Ranking: 52/156=
33.3%;SCI, IF = 2.732).
109. Huang YC, Fan JY, Ro LS, Lyu RK, Chang HS, Chen ST, Hsu WC, Chen CM,
Wu YR. Validation of a Chinese version of disease specific quality of life scale
(HFS-36) for hemifacial spasm in Taiwan. Health Qual Life Outcomes. 2009 Dec
24;7:104.
110. Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER,
Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, et al. Multicenter Analysis of
Glucocerebrosidase Mutations in Parkinson Disease. New England Journal of
Medicine. 2009;361:1651-1661.
111. Tan EK, Peng R, Wu YR, Wu RM, Wu-Chou YH, Tan LC, An XK, Chen CM,
Fook-Chong S, Lu CS*. LRRK2 G2385R modulates age at onset: a pooled
analysis. Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):1022-3.
112. Cheng MY, Lyu RK, Chang YJ, Chen CM, Chen ST, Wai YY, Ro LS*.
Concomitant spinal cord and vertebral body infarction is highly associated with
aortic pathology: a clinical and magnetic resonance imaging study. J Neurol. 2009
Sep;256(9):1418-26 (SCI；IF＝2.359；Clinical Neurology 68/156)
113. Chiang MC, Chen HM, Lai HL, Chen HW, Chou SY, Chen CM, Tsai FJ, Chern
Y*. The A2A adenosine receptor rescues the urea cycle deficiency of
Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.
Hum Mol Genet. 2009 Aug 15;18(16):2929-42 (SCI；IF＝7.249; Genetics &
Heredity 13/138=9%).
114. Kuo HC, Chen CM, Lee-Chen G-J, Hu FJ, Chu CC, Liou CW, Huang CC*.
Study of a Taiwanese family with oculopharyngeal muscular dystrophy. J Neurol
Sci. 2009 Mar 15;278(1-2):21-4 (SCI；IF＝2.359；Clinical Neurology 68/156).
115. Wu YR, Chen CM, Chao CY, Lyu RK, Lee-Chen GJ*. Pantothenate
kinase-associated neurodegeneration in two Taiwanese siblings: Identification of a
novel PANK2 gene mutation. Mov Disord. 2009 Feb 17;24(6):940-941 (SCI；IF
＝3.898；Clinical Neurology 21/156).
116. Chen IC, Lin HY, Lee GC, Kao SH, Chen CM, Wu YR, Hsieh-Li HM, Su MT,
Lee-Chen GJ*. Spinocerebellar ataxia type 8 larger triplet expansion alters histone
modification and induces RNA foci. BMC Mol Biol. 2009 Feb 10;10:9. (SCI；IF
＝2.81；Biochemistry & Molecular Biology 125/276).
117. Gutti U, Fung HC, Hruska KS, Lamarca ME, Chen CM, Wu YR, Sidransky E*.
The need for appropriate genotyping strategies for glucocerebrosidase mutations
in cohorts with Parkinson disease. Arch Neurol. 2008 Jun;65(6):850-1 (SCI；IF
＝5.874；Clinical Neurology 10/156).
118. Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI, Mata IF,
Lee-Chen GJ, Chen CM, Tang M, Zhao Y, Hattori N, Farrer MJ, Tan EK, Wu
RM*. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Ann
Neurol. 2008 Jul;64(1):88-92 (SCI；IF＝9.935；Clinical Neurology 2/156).
119. Chen SR, Lin KP, Kuo HC, Chen CM, Hsieh ST, Lee MJ, Yang CC, Liu CS,
Huang CC, Lyu RK, Ro LS*. Comparison of two PCR-based molecular methods
in the diagnosis of CMT 1A and HNPP diseases in Chinese. Clin Neurol
Neurosurg 2008;110:466-471 (SCI；IF＝1.323；Clinical Neurology 115/156).
120. Hsieh MJ, Lyu RK, Chang WN, Chang KH, Chen CM, Chang HS, Wu YR, Chen
ST, Ro LS*. Hypokalemic Thyrotoxic Periodic Paralysis: Clinical Characteristics
and Predictors of Recurrent Paralytic Attacks. European Journal of Neurology
2008 Jun;15(6):559-64 (SCI；IF＝2.732；Clinical Neurology 52/156).
121. Huang YC, Ro LS, Chang HS, Chen CM, Wu YR, Lee JD, Lyu RK*. A clinical
study of hirayama disease in Taiwan. Muscle Nerve. 2008 May;37(5):576-82
(SCI；IF＝2.594；Clinical Neurology 58/156).
122. Huang YC, Wu YR, Tseng MY, Chen YC, Hsieh SY, Chen CM*. Increased
prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of
patients with Huntington’s disease. PLoS ONE. 2011 Jan 31;6(1): e15809.
123. Chen YC, Hu FJ, Chen P, Wu YR, Wu HC, Chen ST, Lee-Chen GJ, Chen CM*.
Association of TNF-α gene with spontaneous deep intracerebral hemorrhage in the
Taiwan population: a case control study. BMC Neurol. 2010 Jun 10;10(1):41.
124. Wu YR, Wu CH, Chao CY, Kuan CC, Zhang WL, Wang CK, Chang CY, Chang
YC, Lee-Chen GJ, Chen CM*. Genetic analysis of Parkin in early onset
Parkinson's disease (PD): Novel intron 9 g > a single nucleotide polymorphism
and risk of Taiwanese PD. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan
5;153B(1):229-34.
125. Chen YC, Lee-Chen GJ, Wu YR, Hu FJ, Wu HC, Kuo HC, Chu CC, Ryu SJ,
Chen ST, Chen CM*. Analyses of interaction effect between apolipoprotein E
polymorphism and alcohol use as well as cholesterol concentrations on
spontaneous deep intracerebral hemorrhage in the Taiwan population. Clin Chim
Acta. 2009 Oct;408(1-2):128-32.
126. Chiang HL, Lyu RK, Tseng MY, Chang KH, Chang HS, Hsu WC, Kuo HC, Chu
CC, Wu YR, Ro LS, Huang CC, Chen CM*. Analyses of transthyretin
concentration in the cerebrospinal fluid of patients with Guillain-Barré syndrome
and other neurological disorders. Clin Chim Acta. 2009 Jul;405(1-2):143-7
(SCI；IF＝2.96；Medical Laboratory Technology 5/26).
127. Wu YR, Chen IC, Soong BW, Kao SH, Lee GC, Huang SY, Fung HC, Lee-Chen
GJ, Chen CM*.SCA8 repeat expansion: large CTA/CTG repeat alleles in
neurological disorders and functional implications. Hum Genet. 2009
May;125(4):437-44 (SCI；IF＝4.042；Genetics & Heredity 30/138).
128. Huang YC, Lyu RK, Tseng MU, Chang HS, Hsu WC, Chu CC, Wu YR, Huang
CC, Chen CM*. Decreased intrathecal synthesis of prostaglandin D synthase in
the cerebrospinal fluid of patients with acute inflammatory demyelinating
polyneuropathy. Journal of Neuroimmunology. 2009 Jan 3;206(1-2):100-5
(SCI；IF＝3.159；Neuroscience 82/219).
129. Hsu WC, Wang HK, Lee LC, Fung HC, Lin JC, Hsu HP, Wu YR, Ro LS, Hu FJ,
Chang YT, Lee-Chen GJ, Chen CM*. Promoter polymorphisms modulating
HSPA5 expression may increase susceptibility to Taiwanese Alzheimer’s disease.
J Neural Transm. 2008 Nov;115(11):1537-43 (SCI；IF＝2.514；Clinical
Neurology 63/156).
130. Chen WL, Lin JW, Huang HJ, Wang SM, Su MT, Lee-Chen GJ, Chen CM*,
Hsieh-Li HM*. SCA8 mRNA expression suggests an antisense regulation of
KLHL1 and correlates to SCA8 pathology. Brain Res. 2008 Oct 3;1233:176-84
(SCI；IF＝2.494；Neuroscience 120/219).
131. Chen CM, Lee LC, Soong BW, Fung HC, Hsu WC, Lin PY, Huang HJ, Chen FL,
Lin CY, Lee-Chen GJ, Wu YR. SCA17 repeat expansion: Mildly expanded
CAG/CAA repeat alleles in neurological disorders and the functional implications.
Clin Chim Acta. 2010 Mar;411(5-6):375-80.
132. Chen CM, Liu JL, Wu YR, Chen YC, Cheng HS, Cheng ML, Chiu D TY*.
Increased oxidative damage in peripheral blood correlates with severity of
Parkinson's disease. Neurobiol Dis. 2009; Mar,33:429–435 (SCI；IF＝4.852；
Neuroscience 38/219).
133. Lee LC, Chen CM, Chen FL, Lin PY, Hsiao YC, Wang PR, Su MT, Hsieh-Li
HM, Hwang JC, Wu CH, Lee GC, Singh S, Lin Y, Hsieh SY, Lee-Chen GJ, Lin
JY*. Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia
type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis.
Clin Chim Acta 2009 Feb;400(1-2):56-62 (Co-first author) (SCI；IF＝2.96；
Medical Laboratory Technology 5/26).
134. Chen CM, Hou YT, Liu JY, Wu YR, Lin CH, Fung HC, Hsu WC, Hsu Y, Lee
SH, Hsieh-Li HM, Su MT, Chen ST, Lane HY, Lee-Chen GJ*. PPP2R2B CAG
repeat length in the Han Chinese in Taiwan: Association analyses in neurological
and psychiatric disorders and potential functional implications. Am J Med Genet
B Neuropsychiatr Genet. 2009 Jan; 150B(1):124-129 (SCI；IF＝3.932；Psychiatry
23/101).
135. Chen CM, Chen YC, Wu YR, Hu FJ, Lyu RK, Chang HS, Ro LS, Hsu WC,
Chen ST, Lee-Chen GJ*. Angiotensin-converting enzyme (ACE) polymorphisms
and risk of spontaneous deep intracranial hemorrhage in Taiwan. Euro J Neurol.
2008 Nov;15(11):1206-11 (SCI；IF＝2.732；Clinical Neurology 52/156).
136. Chen CM, Wu YR, Hu FJ, Chen YC, Chuang TJ, Cheng YF, Lee-Chen GJ*.
HSPA5 promoter polymorphisms and risk of Parkinson’s disease in Taiwan.
Neurosci Lett. 2008;435:219-222 (SCI；IF＝2.200；Neuroscience 139/219).
137. Wu YR, Chen CM, Hwang JC, Chen ST, Feng IH, Hsu HC, Liu CN, Liu YT,
Lai YY, Huang HJ, G. Lee-Chen GJ*. Interleukin-1a polymorphism has influence
on late-onset sporadic Parkinson’s disease in Taiwan. J Neural Transm. 2007
Sep;114(9):1173-7 (SCI；IF＝2.514；Clinical Neurology 63/156).
138. Wu YR, Chen CM, Chao CY, Ro LS, Lyu RK, Chang KH, Lee-Chen GJ*.
Glucocerebrosidase gene mutation is a risk factor for early onset of Parkinson’s
disease among Taiwanese. J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):977-9
(SCI；IF＝4.622；Surgery 5/148).
139. Huang HJ, Liang KC, Chen CP, Chen CM, Hsieh-Li HM*. Intrahippocampal
administration of Abeta (1-40) impairs spatial learning and memory in
hyperglycemic mice. Neurobiol Learn Mem. 2007 May;87(4):483-94 (SCI；IF＝
3.757；Psychology 8/61).
140. Chang KH, Chuang CC, Lyu RK, Chen CM, Ro LS, Chen ST, Wu YR*. Clinical
characteristics of corticobasal syndrome amongst Chinese in Taiwan.
Parkinsonism Relat Disord. 2007 May;13(4):219-23 (SCI；IF＝1.907；Clinical
Neurology 83/156).
141. Ro LS, Chen CM, Chang HS, Lyu RK, Wu YR, Hsu WC, Lee-Chen G-J*.
Contribution of clinical screening to carrier detection in a large Chinese family
with Fabry disease due to a novel alpha-galactosidase A gene deletion. Euro J
Neurol. 2007 May;14(5):493-7 (SCI；IF＝2.732；Clinical Neurology 52/156).
142. Chiang MC, Chen HM, Lee YH, Chang HH, Wu YC, Soong BW, Chen CM,
Wu YR, Liu CS, Niu DM, Wu JY, Chen YT, Chern Y*. Dysregulation of
C/EBP by mutant Huntingtin causes the urea cycle deficiency in Huntington’s
disease. Hum Mol Genet. 2007 Mar 1;16(5):483-98 (SCI；IF＝7.249；Genetics &
Heredity 13/138).
143. Huang YC, Chen CM, La SL, Lee TH, Chen ST, Chin SC, Chen YC*.
Spontaneous intrapetrous internal carotid artery dissection: A case report and
literature review. J Neurol Sci. 2007 Feb;253:90-93 (SCI；IF＝2.359；Clinical
Neurology 68/156).
144. Wang HK, Hsu WC, Fung HC, Lin JC, Hsu HP, Wu YR, Hsu Y, Hu FJ,
Lee-Chen GJ, Chen CM*. Interleukin-1 Alpha and -1 Beta Promoter
Polymorphisms in Taiwanese Patients with Dementia. Dement Geriatr Cogn
Disord. 2007;24(2):104-10 (SCI；IF＝3.142；Clinical Neurology 39/156).
145. Chang KH, Lyu RK, Tseng MU, Ro LS, Wu YR, Chang HS, Hsu WC, Hsieh, SY,
Chen CM*. Elevated haptoglobin level of cerebrospinal fluid in Guillain-Barré
syndrome revealed by proteomics analysis. Proteomics Clinical Application 2007
May 3;1(5):467-475 (SCI；IF＝1.514).
146. Wu YR, Feng IH, Lyu RK, Chang KH, Lin YY, Chan H, Hu FJ, Liu YT, Lai YY,
Huang HJ, Lee-Chen GJ, Chen CM*. Tumor Necrosis Factor- promoter
polymorphism is associated with the risk of Parkinson’s disease. Am J Med Genet
Part B: Neuropsychiatric genetics. 2007 April;144B (3):300-304 (SCI；IF＝
3.932；Psychiatry 23/101).
147. Chen CM, Kuan CC, Lee-Chen GJ, Wu YR*. Mitochondrial DNA
polymorphisms and the risk of Parkinson’s disease in Taiwan. J Neural Transm.
2007 Aug;114(8):1017-21 (SCI；IF＝2.514；Clinical Neurology 63/156).
148. Chen CM*, Wu YR, Cheng ML, Liu JL, Lee YM, Lee PW, Soong BW,
Chiu D TY. Increased oxidative damage and mitochondrial abnormalities in the
peripheral blood of Huntington’s disease patients. Biochem Biophys Res Commun.
2007 Jul 27;359(2):335-40 (SCI；IF＝2.648；Biophysics 28/70).
149. Chen CM, Chen IC, Chang KH, Chen YC, Lyu RK, Liu YT, Hu FJ, Chao CY,
Lee-Chen GJ, Wu YR*. Nuclear Receptor NR4A2 IVS6 +18insG and Brain
Derived Neurotrophic Factor (BDNF) V66M Polymorphisms and Risk of
Taiwanese Parkinson’s Disease. Am J Med Genet B: Neuropsychiatric genetics.
2007 June; 144B(4):458-462 (SCI；IF＝3.932；Psychiatry 23/101).
150. Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR*. A common genetic factor
for Parkinson disease in ethnic Chinese population in Taiwan. BMC Neurology
2006 Dec;6:47 (SCI；IF＝2.784；Clinical Neurology 50/156).
151. Fung HC, Xiromerisiou G, Gibbs JR, Wu YR, Eerola J, Gourbali V, Hellström O,
Chen CM, Duckworth J, Papadimitriou A, Tienari PJ, Hadjigeorgiou GM, Hardy
J, Singleton AB. Association of tau haplotype tagging polymorphisms with
Parkinson’s Disease in diverse ethnic PD cohorts. Neurodegenerative Diseases.
2006 June;3:327-333.
152. J Clarimon, S Scholz, HC Fung, J Hardy, J Eerola, O Hellström, CM Chen, et al.,
Conflicting results regarding the Semaphorin gene (SEMA5A) and the risk for
Parkinson's Disease. Am J Hum Genet 2006;78:1082-4. (Impact Factor: 12.629).
153. Chen YC, Wu YR, Hsu WC, Chen CM et al., Basal Ganglia-Thalamic
Hemorrhage in Young Adults: A Hospital-Based Study. Cerebrovasc Dis
2006;22:33-39. (Impact Factor: 2.319).
154. Ro LS, Lee-Chen GJ, Lin TC, Wu YR, Chen CM, et al. Phenotypic features and
genetic findings in two Chinese families with Miyoshi distal myopathy. Arch
Neurol 2004;61:1594-9. (Impact Factor: 5.20).
155. Chen CJ, Hsu HL, Tseng YC, Lyu RK, Chen CM, et al. in Hirayama flexion
myelopathy: Neutral-position MR imaging findings– Importance of loss of
attachment. Radiology 2004; 231:39-44. (Impact Factor: 5.377).
156. JD Lee, Sien-Tsong Chen, Lok-Ming Tang, Man Chang, CM Chen, Yih-Ru Wu,
Yi-Sheng Liao, Long-Sun Ro. Primer-shift PCR in detection of an age-associated
4977-bp deletion of mitochondrial DNA in human muscle tissues. Acta Neurol
Taiwan 1997;6:145-151.
157. Lee JD, Chen ST, Chen CJ, Chen CM, Ro LS. Idiopathic hypereosinophilic
myositis, peripheral neuropathy, and central nervous system. J Formosan Med
Assoc 1996 Dec; 95(12):933-936 (Impact Factor: 0.453).
158. Tang LM, Chen ST, Hsu WC, Chen CM. Klebsiella meningitis in Taiwan: an
overview. Epidemiol Infect 1997;119(2):135-142 (Impact Factor: 1.636).
159. CK Wang, YR Wu, WL Hwu, CM Chen, et al. DNA haplotype analysis of CAG
repeat in Taiwanese Huntington's disease patients. Eur Neurol 2004;52:96-100.
(Impact Factor: 1.312).
160. SC Wang, GJ Lee-Chen, CK Wang, CM Chen, LM Tang, YR Wu. Markedly
Asymmetrical Parkinsonism as a Leading Feature of Adult-Onset Huntington’s
Disease. Movement disorder 2004;19:854-856 (Impact Factor: 3.323).
161. Wu YR, Lee-Chen GJ, Lang AE, Chen CM et al. Dystonia as a presenting sign
of spinocerebellar ataxia type 1. Movement Disorder 2004;19:586-7. (Impact
Factor: 3.323)
162. Lyu RK, Tang LM, Chen CJ, Chen CM, Chang HS, Wu YR: The use of evoked
potentials for clinical correlation and surgical outcome in cervical spondylotic
myelopathy with intramedullary high signal intensity on MRI. J Neurol Neurosurg
Psychiatry 2004;75:256-261. (Impact Factor: 3.630).
163. Huang CC, Chen RS, Chen CM, et al. MELAS syndrome with mitochondrial
tRNALeu(UUR) gene mutation in a Chinese family. J Neurol Neurosurg
Psychiatry 1994;57:586-589 (Impact Factor: 3.630).
164. Chen CJ, Fang W, Chen CM, et al. Spontaneous spinal epidural hematoma with
repeated remission and relapse. Neuroradiology 1997;39 (10):737-740 (Impact
Factor: 1.515).
165. Kennedy L, Evans E, Chen CM, et al. Dramatic tissue-specific mutation length
increases are an early molecular event in Huntington disease pathogenesis. Hum Mol
Genet 2003;12:3359-3367. (Impact Factor: 8.099)
166. Ro LS, Lai SL, Chen CM, et al. Deleted 4977-bp mitochondrial DNA mutation is
associated with sporadic amyotrophic lateral sclerosis: A hospital-based case-control
study. Muscle Nerve 2003;28:737-743. (Impact Factor: 2.432).
167. Wu YR, Wang CK, Chen CM, Hsu Y, Lin SJ, Lin YY, Fung HC, Chang KH,
Lee-Chen GJ. Analysis of Heat shock protein 70 gene polymorphisms and the risk
of Parkinson's disease. Hum Genetics 2004;114:236-241. (Impact Factor: 4.331).
168. Chang KH, Lyu RK, Chen CM, et al. Clinical Characteristics of Multiple
Sclerosis in Taiwan-A Cross-Sectional Study. Mult Scler. 2006;12:501-6.
(Impact Factor: 2.832).
169. YR Wu, CM Chen, LS Ro, RK Lyu, LM Tang. Sensory neuropathy as the initial
manifestation of multiple system atrophy. Formos Med Assoc 2004;103:727-30.
(Impact Factor: 0.453)
170. Fung HC, Chen CM, Wu YR, et al. Heat Shock Protein 70 and Tumor Necrosis
Factor-αin Taiwanese Patients with Dementia. Dement Geriatr Cogn Disord.
2005;20:1-7. (Impact Factor: 2.511).
171. Fung HC, Chen CM, Hardy J, Singleton AB, Lee-Chen GJ, Wu YR. Analysis of
the PINK1 Gene in a cohort of patients with sporadic early-onset parkinsonism in
Taiwan. Neurosci lett. 2006;394:33-36. (Impact Factor: 2.092).
172. Fung HC, Chen CM, Hardy J, et al. Lack of G2019S LRRK2 mutation in a
cohort of Taiwanese with sporadic Parkinson’s disease. Mov Disord
2006;21:880-881 (Impact Factor: 3.323).
173. Wu YR, Fung HC, Lee-Chen GJ, Gwinn-Hardy K, Ro LS, Chen ST, Hsieh-Li
HM, Lin HY, Lin CY, Li SN, Chen CM*. Analysis of polyglutamine-coding
repeats in the TATA-binding protein in different neurodegenerative diseases. J
Neural Transm 2005;112:539-46. (Impact Factor: 2.544) (Corresponding author).
174. Ro LS, Lee-Chen GJ, Wu YR, Lee M, Hsu PY, Chen CM*. Phenotypic
variability in a Chinese family with rimmed vacuolar distal myopathy. J Neurol
Neurosurg Psychiatry. 2005;76:752-5. (Impact Factor: 3.630) (Corresponding
author).
175. KH Chang, RK Lyu, LS Ro, YR Wu, Chen CM*. Coexistence of Pernicious
Anemia and Myasthenia Gravis ~ A Rare Combination of Autoimmune Diseases
in Taiwan. Formos Med Assoc 2006;105:946-9. (Impact Factor: 0.453)
(Corresponding author).
176. Wang HK, Fung HC, Hsu WC, Wu YR, Lin JC, Ro LS, Chang KH, Hwu FJ, Hsu
Y, Huang SY, Lee-Chen GJ, Chen CM*. Analysis of apolipoprotein E,
angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of
Alzheimer's disease and vascular dementia. J Neural Transm.
2006;113:1499-1509. (Impact Factor: 2.938) (Corresponding author).
177. HC Wu, LS Ro, CJ Chen, ST Chen, TH Lee, YC Chen, Chen CM*. Isolated
ocular motor nerve palsy in dural carotid-cavernous sinus fistula. Euro J Neurol.
2006;13: 1221–1225. (Impact Factor: 2.437). (Corresponding author)
178. Chen CM, Lee-Chen GJ, Wu YR, Lin CY, Chen CJ, Chen IC, Ro LS. Recurrent
cerebral venous thrombosis: An Arg359X mutation in the antithrombin gene in a
Taiwanese family. Thromb Res. 2006;118(2):235-40 (Impact Factor: 2.058)
179. Wang CK*, Chen CM*, Chang CY, Chang KH, Chen IC, Li M L, Lee-ChenG-J,
Wu Y R. -Synuclein promoter RsaI T-to-C polymorphism and the risk of
Parkinson's disease. J Neural Transm. 2006;113:1425-1433. (Impact Factor:
2.938). (Co-first author).
180. Chen CM, Lai SC, Chen IC, Hsu KC, Lyu RK, Ro LS, Chang HS. First report of
two Taiwanese siblings with sialidosis type I: a 10-year follow-up study. J Neurol
Sci. 2006;247:65-69. (Impact Factor: 2.412).
181. Chen CM, Lane HY, Wu YR, et al. Expanded trinucleotide repeats in the
TBP/SCA17 gene mapped to chromosome 6q27 are associated with
schizophrenia. Schizophr Res. 2005;78:131-6 (Impact Factor: 4.264)
182. Lee M, Chang HS, Wu HT, Weng HH, Chen CM*. Intractable epilepsy as the
presentation of vitamin B12 deficiency in the absence of macrocytic anemia.
Epilepsia 2005;46:1147–1148. (Impact Factor: 3.526) (Corresponding author).
183. Wu YR, Lin HY, Chen CM*, et al. Genetic testing in spinocerebellar ataxia in
Taiwan: expansions of trinucleotide repeats in SCA8 and SCA17 are associated
with typical Parkinson's disease. Clin Genet 2004;65:209-214. (Impact Factor:
2.367) (Corresponding author)
184. Corcos DM, Chen CM, Quinn NP, Rothwell JC. Strength in Parkinson’s Disease:
Relationship to rate of force. Generation and clinical status. Ann Neurol
1996;39:79-88 (Impact Factor: 7.571).
185. Wu YR, Chen CM, Ro LS, Chen ST, Tang LM. Vocal cord paralysis as an initial
sign of multiple system atrophy in the central nervous system. J Formosan Med
Assoc 1996;95:804-806 (Impact Factor: 0.533).
186. Liao YS, Chen CM, Wu YR, Chen ST, et al: Fluoxetine-induced Parkinsonism:
A Case Report and Literature Review. Acta Neurol Taiwan 1998; 7:32-37.
187. Chen CJ, Chen CM, Lin TK. Enhanced cervical MRI in identifying intracranial
dural arteriovenous fistulae with spinal perimedullary venous drainage.
Neuroradiology 1998;40:393-397 (Impact Factor:1.515).
188. Chen CJ, Chen CM, Wu CL, et al. Hirayama's diseases: MRI diagnosis. Am J
Neuroradiol 1998;19:365-368 (Impact Factor: 2.406).
189. Chen CM, Huang CC, Lee CC, et al. Hypothalamic amenorrhea in a case of
mitochondrial encephalomyopathy. J Formosan Med Assoc 1992;91:1195-1199
(Impact Factor: 0.453).
190. Chen CM, Huang CC. Gonadal dysfunction in mitochondrial
encephalomyopathies. Eur Neurol 1995;35:281-286 (Impact Factor: 1.031).
191. Chen CM, Chang HS, Lyu RK, Tang LM, Chen ST. Myasthenia gravis and
Charcot-Marie-Tooth disease type 1A: an unusual combination of diseases.
Muscle Nerve 1997;20(11):1457-1459 (Impact Factor: 2.456).
192. Chen CM. Investigating the functional consequences of expanded triplet repeat
sequence in a mouse model of Huntington’s disease (HD), 2002 (PhD thesis).
專利
1. 用於抑制小腦萎縮症之醫藥組成物 中華民國 李桂楨、陳瓊美 I484971 2015/5/21-2033/3/3.
2. 用以評估巴金森病罹患風險之生物標記及方法 中華民國 李桂楨、陳瓊美、吳逸如 I494435 2015/8/1- 2032/6/9 .
3. 醫藥組成物於製備不正常多麩醯胺聚集類疾病之藥物上之用途 中華民國 李桂楨、陳瓊美 I507202 2015/11/11-2032/8/26.
4. 醫藥組成物於製備不正常多麩醯胺聚集類疾病之藥物上之用途 中華民國 李桂楨、陳瓊美 I515003 2016/1/1-2034/1/5.
完整個人履歷(學歷、經歷、殊榮、學會或專業認證…等)
Education:
Sep 1980-June 1987 Taipei Medical College, Taipei, Taiwan, M.D.
Post-Graduate Education:
May 1994-April 1995 Research Fellow, Movement Disorders, Institute of
Neurology, The National Hospital for Neurology and
Neurosurgery, Queen Square, London, U.K.
Oct 1998-Aug 2002 Ph.D. Division of Molecular Genetics, Institute of
Biochemistry and life Sciences, University of Glasgow,
U.K.
Academic appointment:
2010 ~ Present, Professor, Department of Neurology, Chang Gung Memorial Hospital.
2007 ~ 2010, Associated professor, Department of Neurology, Chang Gung Memorial
Hospital.
2009 ~ Present, Associated professor, College of Medicine, Chang-Gung University.
Employment Record:
1992—Present Attending Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
2004—Present Physician Scientist, Chang Gung Memorial Hospital, Taipei,
Taiwan.
1987—1991 Resident Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
1991—1992 Fellowship Physician, Department of Neurology, Chang Gung
Memorial Hospital, Taipei, Taiwan.
Board Certification: September 1990, Specialist in Neurology
Certification No: 0192
Licensures: Chinese License No: 016164, Taiwan
Professional Affiliations:
1. Neurological Society, Taiwan
2. Formosan Medical Association, Taiwan
3. American Academy of Neurology, USA
4. Movement Disorder Society, International.
Research Interests:
1. Clinical neurology and movement Disorders
2. Human genetics in mitochondrial diseases, Parkinson’s diseases, Alzheimer's
disease, spinocerebellar ataxia, cerebrovascular disease, Huntington’s disease and
other movement disorders.
3. Cellular model and functional assay studies in spinocerebellar ataxia, Alzheimer's
disease, Parkinson’s disease and Huntington’s disease.
4. Mouse model studies in spinocerebellar ataxia, and Huntington’s disease.
Honor and Awards:
1. ”Best Attending in Teaching” in Chang Gung Memorial Hospital, May, 1993.
醫院行政經歷:
現任: 長庚醫院神經科學術主席, 2017-2020
曾任:
長庚醫院林口總院門診委員會委員 (2003-2007)
長庚醫院神經科學術委員(2004-2007)
公共行政經歷:
現任: 台灣神經罕見疾病學會常任理事
曾任:
1. 台灣神經學學會幹事(1993-1994)
2. 台灣神經學學會教育委員 (2005-2007)
3. 台灣神經學學會運動障礙學組委員(2005-2007)
4. 94年度神經科專科醫師訓練醫院之評鑑委員
5. 台灣神經學學會基因學組委員 (2005-2007)
6. 台灣神經學學會神經基因學組召集人 (2009-2011)
7. 台灣神經罕見疾病學會監事 (2016-2019)
臨床教學相關經歷:
1. 長庚大學醫學系及中醫學系神經學見習指導老師: 2006-2017
2. 長庚大學醫學系及中醫學系PBL教學教員: 2006-2017
3. 神經學學會神經內科專科醫師考試考官：1996年度, 2002 年度, 2003年度,
2004年度, 2005年度
授課科系與課程科目：
1. 長庚大學醫學系: 神經解剖學 (2003), 神經學 (2002-2009), 臨床診斷學
(2005-2013)
2. 長庚大學中醫學系: 神經學 (2002-2013)
3. 長庚大學復健系物理治療組： 神經學 (2002-2014)
4. 陽明大學神經科學研究所: 神經科學 (2004-2005, 2007)
5. 長庚大學醫學院醫學系二: 醫學研究介紹 (2005)
6. 醫師研究訓練營講師: Modeling Human Diseases in Mice (2007/05/04).
7. 長庚大學生命科學研究所醫學新知導論 (2008-2019).
研究相關經歷:
1. Physician Scientist, Chang Gung Memorial Hospital (2004~ now)
2. Associated Editor for BMC Neurology, 2017-2020
3. Editorial Board, Frontier in Neuroscience, 2019-2020
4. Editorial Board, ISRN Neurology, 2011-2013.
5. Member of reviewer board for Neural Regeneration Research, 2007-2009
6. Member of Editorial Board for Chang Gung Medical Journal, 2010-2013.
7. 長庚大學醫學系醫學生研究事務委員會委員, 2008 - 2013.
8. 國科會專題研究計劃審查初審員 2004-2020年度
9. 長庚醫學研究計劃審查委員2008-2020年度
10. 長庚醫院之生物醫學進修審查委員, 2016-2020年
11. 林口研審會之設備審查小組委員主審, 2017-2020年
12. 學術期刊審核審查員:
Neurobiology of Ageing, 2007
Journal of Neurology, Neurosurgery & Psychiatry, 2007
Cellular and Molecular Neurobiology, 2007
Journal of Neuroscience Research, 2007
Journal of Proteome Research, 2008
Journal of Biomedical Science, 2008, 2017, 2018
American Journal of Medical Genetics, Neuropsychiatric Genetics, 2008
European Journal of Neurology, 2008, 2011
Neurobiology of Disease, 2008, 2009
Lipids, 2009
Acta Neurological Sinica, 2009, 2010
Pharmacogenetics and Genomics, 2010
ISRN Neurology, 2011, 2012, 2013
Pharmacogenetics and Genomics, 2010
Brain Research Bulletin, 2011
Basal Ganglia 2011
PloS ONE 2012-2018
Movement Disorders, 2016
journal Computational Biology and Chemistry, 2016
Journal of the Neurological Sciences, 2016
Journal of Neurogenetics, 2016, 2020
Biomedical Journal, 2016~2019
GENE, 2016
Parkinson Disease, 2016
Experimental and Therapeutic Medicine, 2017
Journal of Biomedical Science, 2017, 2018
Clinica Chimica Acta, 2011-2020
Parkinsonism Relat Disord, 2015-2019
Scientific Report, 2017-2020
Aging, 2019
Cerebellum 2019
Biomaterials, 2016, 2019
The American Journal of Chinese Medicine, 2018
Phytomedicine, 2019, 2020
Frontier in Neurology, 2019, 2020
Frontier in Neuroscience, 2019, 2020
13. Grant application reviewer for Parkinson’s Disease Society, United Kingdom,
2007.
14. 長庚大學醫技系碩士班研究生論文考試考試委員(2006, 2009).
15. 國立台灣師範大學生命科學系博士班研究生之論文口試考試委員
(2005-2019) 國立台灣師範大學生命科學系博士班研究生之論文指導委員
(2006-2019)
16. 台灣大學醫學研究所博士班研究生之論文口試考試委員, 2016
17. 國立南台科技大學教師教授資格審查委員, 2016年
18. 陽明大學教師學術卓越教師審查審委查員, 2017年
19. Prinses Beatrix Spierfonds, Netherland 研究計劃審查評審委員, 2016, 2019年
20. 亞東紀念醫院研究計劃審查委員, 2017