Neurofarmacología y terapéutica experimental
Dr. Bruno Antonio Marichal Cancino
Trayectoria Académica
Jefe del Departamento de Fisiología y Farmacología (2018-2020).
Profesor investigador titular B, UAA (2017-actual).
Investigador Posdoctoral, UNAM (2014-2016).
Profesor Asociado, UAM-X (2014).
Doctorado en Ciencias, CINVESTAV, I.P.N. (2013).
Maestría en Ciencias, CINVESTAV, I.P.N. (2009).
Biólogo, UAM-X (2007).
Premios y distinciones
Investigador Nacional Nivel 1.
Miembro AMEFAR.
Miembro de "Society for Neuroscience" .
Programa Captación y Retención de Investigadores de Alto Nivel UAA.
En el laboratorio, nos interesa comprender la Farmacología del sistema endocannabinoide.
Estamos interesados principalmente en los procesos de aprendizaje y memoria, control motor, regulación de la ingestión de alimentos y la adicción a sustancias. Estamos convencidos de que la comprensión del sistema endocannabinoide nos permitirá generar nuevas dianas terapéuticas para múltiples patologías humanas (e.g., trastorno obsesivo compulsivo, obesidad, adicciones, etc.).
Proyectos financiados
PRODEP UAA-PTC-200 - "Búsqueda de una profilaxis farmacológica para la obesidad: los receptores putativos a cannabinoides.."
UAA Convocatoria de impacto social.
CONACYT Proyecto postdoctoral 2019.
Miembros del laboratorio
Investigador postdoctoral
Dra. Priscila Vázquez León
SNI nivel 1
Miniproyectos
Jessica Gabriela Romo Padilla (2019).
Mario Alberto López Vázquez (2019).
Miguel Ángel Oropeza García (2019).
Perla Carolina Rodríguez Rojas (2020).
Estudiantes
Pregrado
Sharon Sarahí Vargas Castillo (QFB). Graduada
Isaura Edith Delgado Rodríguez (QFB) Graduada
Perla Carolina Rodríguez Rojas (Biología). Graduada
Arlene Stephanie Carrillo Castorena (Biotecnología). En proceso
Posgrado
Sergio Guzmán (Maestría). Graduado
Emmanuel Bernal Jasso (Maestría). En proceso
Alejandro Barba (Doctorado). En proceso
Verano de la ciencia
Dominic González Durán (2019)
Cristina Jenissia Aguayo Llamas (2019)
Lista de Publicaciones
(2020) NPY-Y1 receptors in dorsal periaqueductal gray modulate anxiety, alcohol intake, and relapse in Wistar rats. Pharmacol Biochem Behav. doi: 10.1016/j.pbb.2020.173071.
(2020) The locus of action of CGRPergic monoclonal antibodies against migraine: peripheral over central mechanisms. CNS Neurol Disord Drug Targets. doi: 10.2174/1871527319666200618144637.
(2020) Advances in Neurobiology and Pharmacology of GPR12. Front Pharmacol. doi: 10.3389/fphar.2020.00628.
(2020) Monoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflows. Curr Neuropharmacol. doi: 10.2174/1570159X18666200503223240.
(2020) Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats. J Vasc Res. 3:1-12. doi: 10.1159/000506158
(2019) Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding. Curr Neuropharmacol. 17(10):947-960. doi: 10.2174/1570159X17666190118143014
(2019) Antimicrobial and antibiofilm activity of biopolymer-Ni, Zn nanoparticle biocomposites synthesized using R. mucilaginosa UANL-001L exopolysaccharide as a capping agent. Int J Nanomedicine 14:2557-2571.
(2019) Functional Characterization of the Prejunctional Receptors Mediating the Inhibition by Ergotamine of the Rat Perivascular Sensory Peptidergic Drive. ACS Chem Neurosci.
(2019) Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55. Front Pharmacol 9:1496.
(2018) Side effects associated with current and prospective antimigraine pharmacotherapies. Expert Opin Drug Metab Toxicol 14(1):25-41.
(2018) beta-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do beta3-Adrenoceptors Play a Role? J Vasc Res 55(3):159-168.
(2018) Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of alpha2-adrenoceptors and 5-HT1 receptors. J Headache Pain 19(1):40.
(2018) Possible role of hippocampal GPR55 in spatial learning and memory in rats. Acta Neurobiol Exp (Wars) 78(1):41-50.
(2017) Olcegepant blocks neurogenic and non-neurogenic CGRPergic vasodepressor responses and facilitates noradrenergic vasopressor responses in pithed rats. Br J Pharmacol 174(13):2001-2014.
(2017) Advances in the Physiology of GPR55 in the Central Nervous System. Curr Neuropharmacol 15(5):771-778.
(2016) Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases. Biomed Res Int 2016:2056786.
(2016) mGluR1/5 activation in the lateral hypothalamus increases food intake via the endocannabinoid system. Neurosci Lett 631:104-8.
(2016) Cardiovascular Alterations during the Interictal Period in Awake and Pithed Amygdala-Kindled Rats. Basic Clin Pharmacol Toxicol 119(2):165-72.
(2016) Further evidence for the role of histamine H3, but not H1, H2 or H4, receptors in immepip-induced inhibition of the rat cardioaccelerator sympathetic outflow. Eur J Pharmacol 773:85-92.
(2016) Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm. Behav Pharmacol 27(4):393-6.
(2015) Pharmacological evidence that histamine H3 receptors inhibit the vasodepressor responses by selective stimulation of the rat perivascular sensory CGRPergic outflow. Eur J Pharmacol 754:25-31.
(2015) Specific role of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol 117(1):31-8.
(2014) Role of pre-junctional CB1, but not CB2 , TRPV1 or GPR55 receptors in anandamide-induced inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats. Basic Clin Pharmacol Toxicol 114(3):240-7.
(2014) The role of pre-junctional D2 -like receptors mediating quinpirole-induced inhibition of the vasodepressor sensory CGRPergic out-flow in pithed rats. Basic Clin Pharmacol Toxicol 114(2):174-80.
(2013) Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats. Eur J Pharmacol 721(1-3):168-77.
(2013) Predominant role of the dopamine D3 receptor subtype for mediating the quinpirole-induced inhibition of the vasopressor sympathetic outflow in pithed rats. Naunyn Schmiedebergs Arch Pharmacol 386(5):393-403.
(2013) The role of dopamine D2, but not D3 or D4, receptor subtypes, in quinpirole-induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats. Br J Pharmacol 170(5):1102-11.
(2012) Pharmacological evidence that spinal alpha(2C)- and, to a lesser extent, alpha(2A)-adrenoceptors inhibit capsaicin-induced vasodilatation in the canine external carotid circulation. Eur J Pharmacol 683(1-3):204-10.
(2012) Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors. Eur J Pharmacol 692(1-3):69-77.
(2011) The dopamine receptors mediating inhibition of the sympathetic vasopressor outflow in pithed rats: pharmacological correlation with the D(2) -like type. Basic Clin Pharmacol Toxicol 109(6):506-12.
colaboradores cercanos
Dr. Carlos Miguel Villalón Herrera (SNI 3) Cinvestav-Sur.
Dr. Abimael González Hernández (SNI 2) INB-UNAM.
Dr. Paulino Barragán Iglesias (SNI 2) UAA.
Dra. Paula Morales Instituto de Química Médica (CSIC), España.
Dra. Raquel Guerrero Alba (SNI 1) UAA.
Dr. José Rubén Morones Ramírez (SNI 2) UANL.
Fecha de actualización: Agosto 2020