The Bolding Lab does basic neuroscience and advanced imaging research (with a strong emphasis on MRI physics). My collaborators and I are applying MRI, materials engineering, and ultrasound in novel ways to to study brain function and neuropathology. In addition to pursuing our own research, our lab facilitates the research of many other investigators by maintaining multiple shared resources.
Lab goals and lines of work are for the next few years are:
- Development of an MRI targeted non-invasive drug delivery system for precision neuromodulation: cFUS
- Developing other techniques for non-invasive neuromodulation including x-ray stimulated optogenetics.
Dr. Bolding is also Director of the CINL and Co-Director of the SAISF. The Bolding Lab facilitates neuroscience research at the University of Alabama at Birmingham through continued growth of key UAB imaging centers including the Civitan International Neuroimaging Lab (CINL), and the 9.4T in UAB's Small Animal Imaging Shared Facility and through the creation of a new shared transcranial ultrasound core facility. We are a member of the Alabama Advanced Imaging Consortium.
Civitan International Neuroimaging Laboratory
The centerpiece of the UAB Civitan International Neuroimaging Laboratory (CINL) is a Siemens 3.0 Tesla Prisma whole body MRI scanner.
- To serve as a state-of-the-art research laboratory that fosters the advancement of functional magnetic resonance imaging and spectroscopy technique development for neurosciences, neuro-developmental and cognitive applications, CNS diagnostics, and Glial biology research.
- Provide clinical functional neuroimaging capabilities to a wide array of researchers in translational neurosciences
- To assist with planning neuroimaging and spectroscopy data analyses and post-processing
Small Animal Imaging Shared Facility
The facility was established to enable UAB researchers to apply non-invasive, molecular imaging technologies in animal models. Imaging is accomplished with a range of imaging modalities, including gamma camera imaging, X-ray CT, microPET/CT, microSPECT/CT, bioluminescence, fluorescence, magnetic resonance (MR) imaging, and ultrasound imaging. It is expected that the successful application of small animal imaging will speed efforts to translate basic research to human clinical trials.
- To provide state-of-the-art molecular imaging for preclinical studies in small animals, and support transition to human imaging studies
- To provide training to Cancer Center members in the applications of molecular imaging in cancer models
- To establish methods for image analyses
- To maintain the instruments and keep them accurately calibrated
- To develop novel imaging technologies and acquire new instruments.
We work collaboratively with many others through the imaging centers that we direct, the Alabama Advanced Imaging Consortium, and the UAB Comprehensive Neuroscience Center. Our lab is a central resource for MRI research and image analysis expertise at UAB.
Our primary collaborators are:
- Yuping Bao, UA, nanoparticles
- Eugenia Kharlampieva, UAB, microcapsules
- Thompson Mefford, Clemson U, MRI contrast agents
- Lei Liu, UAB, vision science
- Claudio Busettini, UAB, vision science
- Mark Adams, AU, embedded systems
- Tom Denney, AU, MRI physics
- Farah Lubin, UAB, epilepsy and memory
- Lynn Dobrunz, UAB, synapses
- Lori McMahon, UAB, many things
- Kristina Visscher, UAB, fMRI
- Dawn DeCarlo, UAB, visual impairments
- Adrienne Lahti, UAB, schizophrenia