MEDICAL RESEARCH ON XANTHONES

1. NEURODEGENERATIVE illnesses: therapeutic potential of xanthone derivatives within the scope of neurodegenerative disorders, including Alzheimer's disease, Parkinson’s disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and neuroinflammation. NB: outstanding References at the bottom of the paper https://www.sciencedirect.com/science/article/abs/pii/S1568163725001187

2. Xanthones as promising antiviral agents https://pubmed.ncbi.nlm.nih.gov/39752822/

3. Xanthone GarcinonE anti cancer "significantly abolished,..strongly inhibited tumor growth & reduced tumor weight,..was the most potent dual inhibitor. https://www.sciencedirect.com/science/article/abs/pii/S0944711323004993

4. 2024 Exhibit cytotoxicity against human cancer cell lines including lung adenocarcinoma, cervical carcinoma, prostatic carcinoma, pancreatic carcinoma, hepatocellular carcinoma, bladder urothelial cancer, & triple-negative breast cancer cells https://www.sciencedirect.com/.../pii/S0753332224012502

5. 2024 Anti-glioma properties of β-mangostin ability to foster an immunosuppressive microenvironment that inhibits glioma growth https://www.sciencedirect.com/.../pii/S0753332224009582

6. Regulation of the renal, hepatic, & cardiac enzymes. All current evidence shows that G. mangostana and its components have extremely promising benefits www.ncbi.nlm.nih.gov/pmc/articles/PMC10083825/

7. Increases autophagy..helps cells kill off old damaged parts to clean up our bodies...& decrease the damages caused by high blood sugar. https://pubmed.ncbi.nlm.nih.gov/38164489/

8.  Protect cognition against/improve neuroinflammatiory diseases, Alzheimers etc & to boost brain-derived neurotrophic factor (BDNF) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267462/

9. Biochemical features & therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, & health benefits https://www.sciencedirect.com/science/article/pii/S0753332223004985

10. Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996534/

11. Common oral diseases, including dental caries, periodontal disease, & candidiasis..effective against S. mutans, P. gingivalis, & C. albicans…preventing.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022392

12. Impedes the growth & survival of SiHa CERVICAL CANCER CELLS..a promising strategy for targeted cancer immunotherapy development https://pubmed.ncbi.nlm.nih.gov/35641300/

13. Adjunctive Therapy for Bipolar Disorder & Schizophrenia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424889/

14. Protective effects from irradiation-induced injury. Commercial, or medical radiation injury ..lowers damage, inflammations disturbances & pro-apoptotic alternations induced by IR.’https://pubmed.ncbi.nlm.nih.gov/34220386/

15. High potential as anti-SARS-CoV-2 in the treatment of COVID-19 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343608/ 

16. Therapeutic potential in the treatment of colorectal cancer  https://www.sciencedirect.com/science/article/pii/S0753332223004055

17. NEURO-PROTECTIVE effects on ALZHEIMER: can attenuate oxidative stress & inflammation..& also protect neurons against toxic injury, suggesting that it may exert a protective effect in AD https://pubmed.ncbi.nlm.nih.gov/34998794/

18. Demonstrates that mangostanin is effective in protecting the skin from the action of free radicals, thus PREVENTING SKIN AGING, confirming a potential toward its development in the nutraceutical and cosmeceutical fields https://pubmed.ncbi.nlm.nih.gov/35056141/

19. A novel therapeutic approach to prostrate cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093438/

20. The analgesic properties of α-mangostin..for effective pain management. https://www.sciencedirect.com/science/article/abs/pii/S0944711323001526

21. A summary available of the work that has been done to explore the anticancer & anti tumor activities of α-mangostin, lesser xanthones, and mangosteen extracts in vitro, in vivo, & in humans in various cancers https://pubmed.ncbi.nlm.nih.gov/34896543/

22. Protective effects against (a chemo therapy) doxorubicin-induced cardiotoxicity by antioxidant, anti inflammatory, and antiapoptotic effects that may ameliorate doxorubicin cardiotoxicity in human chemotherapy without reduction in its anticancer effect  https://pubmed.ncbi.nlm.nih.gov/34962009/

23. Mangosteen suppresses colon carcinogenesis (The process by which normal cells are transformed into cancer cells.) https://pubmed.ncbi.nlm.nih.gov/34802869/

24. Mangosteen peel extracts inhibit diabetic glomerulosclerosis condition (neuropathy) & may help increase helpful kidney cells https://www.ncbi.nlm.nih.gov/pubmed/30524699

25. Mangosteen pericarp has antibacterial effects, anti-inflammatory effect against methicillin-resistant Staphylococcus aureus (MRSA)-induced superficial skin infection   https://www.ncbi.nlm.nih.gov/pubmed/30611995

26. Alleviate stress induced liver fibrosis.  https://www.ncbi.nlm.nih.gov/pubmed/30502394

27. Helps collagen induced arthritis https://www.ncbi.nlm.nih.gov/pubmed/30484004

28. Mangosteen is stronger than milk thistle in protecting liver https://www.ncbi.nlm.nih.gov/pubmed/30306536

29. Suppress development of atherosclerosis https://www.ncbi.nlm.nih.gov/pubmed/30959963

30. Preclinical evidence proved helpful with scizophrenia. Controlled trial underway https://www.ncbi.nlm.nih.gov/pubmed/30905130

31. Check out the Table 1 & 2 for remarkable compilation of medical benefits  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368837/

32. Enhance memory and protect neurons effects of γ-mangostin. https://www.ncbi.nlm.nih.gov/pubmed/31019651

33. Mediated autoimmune diseases © 2019 Asia Pacific League of Associations for Rheumatology & protected from kidney damage https://www.ncbi.nlm.nih.gov/m/pubmed/31769201/

34. Reduce body weight, & the liver and kidney problems caused by high fat diet https://www.ncbi.nlm.nih.gov/pubmed/31791316

35. Significant improvement of severe acne, with no severe side effects like the drugs cause. https://www.ncbi.nlm.nih.gov/pubmed/30688020

36. Inhibits prostate cancer. Good for prevention and treatment https://www.ncbi.nlm.nih.gov/pubmed/31782573/

37. Anti tumor for glioblastoma! & squamous cell PLUS, for 1st time, anti nematode (parasites/worms) https://www.ncbi.nlm.nih.gov/pubmed/31542481

38. Protective role could be due to its efficacy to activate the Nrf-2 ! xanthones greatly improve tissue architecture from kidney damage https://www.ncbi.nlm.nih.gov/pubmed/31886417

39. Assists nerve development (protects against neurodegeneration ie: Alzheimer) AND is potent to stop breast cancer cells proliferation https://pubmed.ncbi.nlm.nih.gov/31711765/

40. Inhibits growth of Prostrate Cancer. prevention & treatment  https://pubmed.ncbi.nlm.nih.gov/31782573/

41. Prevent vascular complications caused by high glucose in patients with diabetes. https://pubmed.ncbi.nlm.nih.gov/31792920/

42.  Protective Anti-Inflammatory Activity Against Acute Lung Injury and Its Potential Cytotoxicity to Epithelial Lung and Breast Carcinomas
    https://pubmed.ncbi.nlm.nih.gov/31218570/

43. Promising for the treatment of AD (Alzheimer Disease), PD (Parkinson Disease) and depression https://pubmed.ncbi.nlm.nih.gov/32867357/

44. Considered a potent anticancer agent for treating ORAL cancer & CERVICAL cancer https://pubmed.ncbi.nlm.nih.gov/32986355/

45. Activate Nrf2 pathways and protect intestinal barrier (leaky guy) https://pubmed.ncbi.nlm.nih.gov/33310139/

46. Reduced inflammation of ulcerative colitis https://pubmed.ncbi.nlm.nih.gov/32927006/

2018 Research:: 

1. BREAST CANCER LINES: showed a significant reduction in cell adhesion that did not stimulate cell migration but, on the contrary, blunted cell motility. www.ncbi.nlm.nih.gov/pubmed/29333084

2. BREAST & LUNG CANCER: NEW Xanthones discovered. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma and breast carcinoma cell lines. www.ncbi.nlm.nih.gov/pubmed/29307236

3. OSTEOPOROSIS: fresh juice mixtures (mangosteen) can be used as a remedy for the prevention of postmenopausal osteoporosis  www.ncbi.nlm.nih.gov/pubmed/29387722

4. ARTHRITIS & JOINTS:  superior anti-inflammatory effects..regulation of immune functions was deeply involved in the therapeutic actions of mangosteen on Arthritis, and it was associated to the protection of joints www.ncbi.nlm.nih.gov/pubmed/29367090

5. LIVER DAMAGE from drugs remarkably enhanced  www.ncbi.nlm.nih.gov/pubmed/29790527

6. IMPROVES INSULIN SECRETION (diabetics) protects from apoptotic (cancer) www.ncbi.nlm.nih.gov/pubmed/29772703.

7. DIABETIC CHRONIC INFLAMMATIONS LESSENED in adipose (connective) tissue. Critical to avoid onset of of insulin resistance and type 2 diabetes  www.ncbi.nlm.nih.gov/pubmed/29446826

8. DIABETIC CONTROL of obesity, insulin resistance, and inflammation www.ncbi.nlm.nih.gov/pubmed/29747432

9. Thai Doctors unveil successful use mangosteen product with cancer patients.  https://www.youtube.com/watch?v=W03Hi-ErqhM\

10. Significantly reduced the production of inflammatory factors. a xanthone from mangosteen rind   https://www.ncbi.nlm.nih.gov/pubmed/30132203

11. PROVING αMangosteen inhibits the hallmark mechanisms of inflammation acts well as an anti-inflammatory agent. https://www.ncbi.nlm.nih.gov/pubmed/29953154

12. Primary LIVER CANCER results: mangosteen has been reported for its cell-death induction and its chemosensitizing and anti-metastatic properties in MANY cancer cell types, such as OVARIAN cancer, LUNG cancer, and hepatocellular  carcinoma. https://www.ncbi.nlm.nih.gov/pubmed/30195041

13. Apoptosis & significant anti-metastatic effect in anti-small-cell neuroendocrine carcinomas in a very aggressive form of prostrate cancer https://www.ncbi.nlm.nih.gov/pubmed/30340816

14. Mangosteen extract supplementation is effective in increasing muscle strength, muscle size and, total lean mass, as well as endurance performance. A controlled human trial in resistance trained adult males https://www.ncbi.nlm.nih.gov/pubmed/30348185

15. Alleviated acute lung injury inflammation https://www.ncbi.nlm.nih.gov/pubmed/30405740

16. Treatment for tuberculosis “Xanthones were previously proven to be effective against other bacterial infections such as Staphylococcus , therefore this prompted the team to investigate its potential in tackling multi-drug resistant TB bacteria.”  click here

2017 Research ::

1. Hepatocellular (liver), Breast, Colonrectal Cancer: natural cytotoxic agent against various cancers. click here

2. Anti Bacterial and anti fungal properties:  https://www.ncbi.nlm.nih.gov/pubmed/28208680

3. Anti Malaria. https://www.ncbi.nlm.nih.gov/m/pubmed/28241761/?i=2&from=mangosteen%20xanthones

4. Druggability https://www.ncbi.nlm.nih.gov/m/pubmed/28284429/?i=1&from=mangosteen%20xanthones

5. Late stage APOPTOSIS “It is noteworthy that the new compound can promote cells apoptosis in late stage, having a remarkable inhibition effect..” https://www.ncbi.nlm.nih.gov/pubmed/28441346

6. Prevent Heart hypertension  garcinia mangostana…prevented the development of hypertension and cardiovascular remodeling induced by ..oxidative stress and inflammation”  https://www.ncbi.nlm.nih.gov/pubmed/28455132

7. Bile Duct CANCER cholangiocarcinoma: “α-mangostin from Garcinia mangostana pericarp could inhibit CCA cell proliferation by inducing apoptosis through the mitochondrial pathway; induce G1 cell-cycle arrest; and inhibit metastasis. Moreover, α-mangostin could inhibit CCA growth, i.e. reduce tumor mass (weight and size).”  https://www.ncbi.nlm.nih.gov/pubmed/28441703

8. PERIDONTAL disease…cavities, pockets, bleeding gums etc “significant improvement in the periodontal status with the application of mangostana gel in periodontal pockets” https://www.ncbi.nlm.nih.gov/pubmed/28321995

9. Efflux/detox the body from drug build up including chemo naturally with the mangosteen that is also be cancer preventative and anti tumor https://www.ncbi.nlm.nih.gov/pubmed/28641010

10. COLITIS significantly prevented weight loss, reduced disease activity index scores, and preserved colon length. Findings suggest that MGE alleviates ulcerative colitis https://www.ncbi.nlm.nih.gov/pubmed/28654307

11. Anti-inflammatory results from naturally occurring mangosteen are better than its synthetic counterparts  https://www.ncbi.nlm.nih.gov/pubmed/28715912

12. Lowers Pancreatic CHOLESTEROL Hypercholesterolemia is a major risk factors for the development and progression of atherosclerosis. mangosteen can  prevent and treat cardiovascular diseases associated with hypercholesterolemia  https://www.ncbi.nlm.nih.gov/pubmed/28741279

13. Pancreatic Cancer mangosteen “can induce apoptosis and autophagy in pancreatic cancer cells” https://www.ncbi.nlm.nih.gov/pubmed/28822990

14. Ovarian Cancer Excellent effects in anticancer activities by inducing apoptosis and suppressing migration and invasion  https://www.ncbi.nlm.nih.gov/pubmed/28878295

15. Strong ANTIBACTERIAL properties in newly discovered xanthone click here.

16. Killing and eradicating DRUG RESISTANT staphylococci INFECTIONS click here

17. DIABETIC vascular complications protected click here

18. DEPRESSION behaviors are reversed by acute garcinia mangosteen treatment (mangosteen equals drug performance) click here

19. Delays progression of & has a potential therapeutic effect on OSTEO ARTHRITIS click here

20. A promising strategy against MELANOMA click here. And inhibits SKIN CANCER click here

21. ANTIVIRAL α-mangostin  INHIBITS severe DENV (mosquito borne virus) better than antiviral agent (ribavirin) and anti inflammatory drug (dexamethasone). click here

22. CERVICAL CANCER (2) dietary antioxidant α-mangostin could inhibit the tumor growth of cervical cancer cells. click here

23. KIDNEY CANCER α-mangostin suppresses cell migration and invasion… a promising anti-metastatic click here

24. ANTI INFLAMMATORY β-mangostin demonstrated better anti-inflammatory activity than synthetic drugs ! click here

25. FATTY LIVER and INSULIN RESISTANCE alpha mangostin ameliorates (makes it better) click here

26. HEART significantly increased myocardial relaxation click here

27. alpha-mangostin novel neuroprotective agent through intervention of multiple pathological processes of ALZHEIMERS DISEASE (AD) click here

28. PARKINSONS DISEASE α-mangostin has neuroprotective effects against related neuronal injury. click here

29. educed brain levels of Neuroinflammation in AD (Alzheimer Disease), PD (Parkinson’s Disease) MULTIPLE SCLEROSIS   evaluating alpha mangosteen as an adjuvant treatment in  neurodegenerative diseases. click here

2016 Research::

1. Cervical Cancer:”Mangostin showed the strongest suppression of human cervical cancer”http://www.ncbi.nlm.nih.gov/m/pubmed/26781450/

2. Breast Cancer: (#3 study) “α-mangostin may be used as food supplement ..therapeutic compound for breast cancer.” http://www.ncbi.nlm.nih.gov/m/pubmed/26892433/

3. Tongue Cancer: “α-mangostin induces the apoptosis of …tongue carcinoma cell”http://www.ncbi.nlm.nih.gov/m/pubmed/26951885/

4. Lung Cancer: “a natural xanthone, was isolated from Garcinia mangostana… Apoptosis (kills cancer cells) in Lung Cancer Cells and Decreases Xenograft Tumor Growth”http://www.ncbi.nlm.nih.gov/m/pubmed/26310849/

5. Effective against Macular Degeneration.  “alpha-mangostin could suspend the onset and development of Age-related Macular Degeneration.” http://www.ncbi.nlm.nih.gov/pubmed/26888416

6. Effective against Alzheimers Disease, and for therapy of the Disease. “natural xanthones have multifunctional activities against Alzheimer’s disease (AD) and..for the therapy of AD.”  http://www.ncbi.nlm.nih.gov/pubmed/27038926

7. Effective to promote growth of Stem Cells (help repair brain injury or degenerative central nervous system diseases…develop garcinone D as a lead compound to promote the proliferation of endogenous neural stem cells (NSCs).” http://www.ncbi.nlm.nih.gov/pubmed/27177723

8. Blood sugar control   https://www.ncbi.nlm.nih.gov/m/pubmed/27738860/?i=1&from=mangosteen+xanthones+2016

9. Reduce inflammation  https://www.ncbi.nlm.nih.gov/m/pubmed/26895796/?i=6&from=mangosteen+xanthones+2016

10. Reduce hypoglycemia/Possibly increase insulin https://www.ncbi.nlm.nih.gov/m/pubmed/27208974/?i=3&from=mangosteen+xanthones+2016

2013-2015 Research::

1. Mangosteen antibiotics against Super Bugs http://newshub.nus.edu.sg/headlines/1309/mangosteen_23Sep13.php

2. Auto immune, arthritis help http://www.ncbi.nlm.nih.gov/pubmed/24738849

3. Breast and prostate Cancer 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693070/

4. Colon Cancer http://www.ncbi.nlm.nih.gov/pubmed/23239542

5. Bladder Cancer http://www.ncbi.nlm.nih.gov/pubmed/23682785

6. Leukemia http://www.ncbi.nlm.nih.gov/pubmed/23734655

7. Tongue Cancer http://www.ncbi.nlm.nih.gov/pubmed/24660467

8. Stomach Cancer http://www.ncbi.nlm.nih.gov/pubmed/24976157

9. Inhibits Human Cancer. Anti proliferation http://www.ncbi.nlm.nih.gov/pubmed/23811100

10. Liver Cancer (hepatocellular) Antitumour http://www.ncbi.nlm.nih.gov/pubmed/23927480

11. Skin Cancer http://www.ncbi.nlm.nih.gov/pubmed/22993323

12. Alzheimers and Cognition http://www.ncbi.nlm.nih.gov/pubmed/25525451

13. Anti-Obesity http://www.ncbi.nlm.nih.gov/pubmed/25520256

14. Multiple Pharmalogical Properties http://www.ncbi.nlm.nih.gov/pubmed/25518194

15. Dental Caries Prevention http://www.ncbi.nlm.nih.gov/pubmed/25498719

16. Preventing/treating Acne without toxicity http://www.ncbi.nlm.nih.gov/pubmed/24327275

17. Treatment of inflammatory conditions (Cox-2 inhibition means lowers pain and inflammation)http://www.ncbi.nlm.nih.gov/pubmed/24607509

18. Eradicate liver cancer cells http://www.ncbi.nlm.nih.gov/m/pubmed/25955534/?i=15&from=mangosteen

19. Improvement of skin conditions http://www.ncbi.nlm.nih.gov/m/pubmed/26236097/?i=8&from=mangosteen

20. Lupus http://www.ncbi.nlm.nih.gov/m/pubmed/26330173/?i=5&from=mangosteen

21. Regulating Metabolism. http://www.ncbi.nlm.nih.gov/m/pubmed/26452017/?i=2&from=mangosteen

22. 46% reduction of C Reactive Protein markers (inflammation levels in blood) in the test group drinking a mangosteen based beverage. No side effects! http://www.ncbi.nlm.nih.gov/pubmed/26286710

Daily I use a whole fruit puree of mangosteen, that includes flesh, pericarp & seeds. It tastes great! AND is a registered proprietary formula !! 

Excellent article on mangosteen CLICK HERE

—The ONLY effective mangosteen product worth buying & my personal choice is the original whole fruit formula by Isagenix, Xango. Select your market CLICK HERE  .  Get best results by drinking 3 times daily....one or two ounce shots every serving