Research topics
1. Plant Protection: plant stress, pest control
1.1. Mode of action of Bacillus thuringiensis toxins against different pest insects.
1.2. Natural defense mechanisms of plants against attack by pathogens and insects.
1.3. Early detection of stress in plants of agronomic interest, using biotic and abiotic stress biomarkers.
1.4. Impact of the gut microbiome of insects on the adaptation of plants to climate change
2. Characterization of the therapeutic activity of peptides derived from insects
2.1 Antimicrobial activity against human pathogens (Escherichia coli, Staphylococcus aureus and Candida albicans).
2.2. Therapeutic potential as anticancer agents, through combined action with chemotherapeutic drugs for the treatment of triple negative breast cancer (TNTC).
Group Members
Publications
Ochoa-Campuzano C.; Sánchez J.; García-Robles I.; Real MD.; Rausell C. (2012) Identification of a Calmodulin-binding site within the domain I of Bacillus thuringiensis Cry3Aa toxin. Archives of Insect Biochemistry and Physiology , 81(1), pp. 53 - 62 . ISSN: 0739-4462
Inmaculada García-Robles; Jesús Sánchez-Navarro;Marcos de la Peña (2012) Intronic hammerhead ribozymes in mRNA biogenesis.Biological Chemistry , 393(11), pp. 1317 - 1326 . ISSN: 1431-6730
de la Pena, M ; Garcia-Robles, I (2010) Ubiquitous presence of the hammerhead ribozyme motif along the tree of life. RNA-A Publication of the Rna Society , 16(10), pp. 1943 - 1950 . ISSN: 1355-8382
de la Pena, Marcos; Garcia-Robles, Inmaculada (2010) Intronic hammerhead ribozymes are ultraconserved in the human genome.Embo Reports , 11(9), pp. 711 - 716 . ISSN: 1469-221X
García-Robles I.; Ochoa-Campuzano C.; Sánchez J.; Contreras E.; Real MD.; Rausell C. (2012) Functional significance of membrane associated proteolysis in the toxicity of Bacillus thuringiensis Cry3Aa toxin against Colorado potato beetle. Toxicon , 60, pp. 1063 - 1071 . ISSN: 0041-0101
Inmaculada García-Robles; Camila Ochoa-Campuzano; Emma Fernández-Crespo; Gemma Camañes; Amparo C. Martínez-Ramírez; Carmen González-Bosch; Pilar García-Agustín; Carolina Rausell; María Dolores Real (2013) Combining hexanoic acid plant priming with Bacillus thuringiensis insecticidal activity against Colorado Potato Beetle. International Journal Of Molecular Sciences , 14(6), pp. 12138 - 12156 . ISSN: 1422-0067
García-Robles I.; Ochoa-Campuzano C.; Sánchez J.; Contreras E.; Real MD.; Rausell C. (2012) Functional significance of membrane associated proteolysis in the toxicity of Bacillus thuringiensis Cry3Aa toxin against Colorado potato beetle. Toxicon , 60, pp. 1063 - 1071 . ISSN: 0041-0101
Ruiz-Arroyo VM; García-Robles I; Ochoa-Campuzano ; Goig GA; Zaitseva E; Baaken G; Martínez-Ramírez AC; Rausell C; Real MD. (2017) Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata). Insect Molecular Biology , 26(2), pp. 204 - 214 . ISSN: 0962-1075
de la Peña M; García-Robles I; Cervera A (2017) The Hammerhead Ribozyme: A Long History for a Short RNA. Molecules , 22(1) . ISSN: 1420-3049
Ekaterina Zaitseva;Gerhard Baaken; Victor M. Ruiz-Arroyo; Inmaculada García-Robles, Camila Ochoa-Campuzano; Galo A. Goig; Amparo C. Martıínez-Ramıírez; Carolina Rausell;Jan Behrends, Dolores Real (2017) Monitoring of Bacillus Thuringiensis Cry3Aa Toxin Pore Formation using Artificial Bilayer Array with Fused Brush Border Membrane Vesicles from Colorado Potato Beetle Larvae.Biophysical Journal , 112(3), p. 523 . ISSN: 0006-3495
López-Galiano M.J.; Ruiz-Arroyo V.M; Fernández-Crespo E.; Rausell C.; Real M.D.; García-Agustín P.; González-Bosch C.; García-Robles I. (2017) Oxylipin mediated stress response of a miraculin-like protease inhibitor in Hexanoi acid primed eggplant plants infested by Colorado potato beetle. Journal of Plant Physiology , 215, pp. 59 - 64 . ISSN: 0176-1617
López-Galiano M.J.; González-Hernández A.I.; Crespo-Salvador O.; Rausell C.; Real M.D.; Escamilla M.; Camañes G.; García-Agustín P.; González-Bosch C.; García-Robles I. (2018) Epigenetic regulation of the expression of WRKY75 transcription factor in response to biotic and abiotic stresses in Solanaceae plants. Plant Cell Reports , 37(1), pp. 167 - 176 . ISSN: 0721-7714
Sean D. Schoville; Yolanda H. Chen; Martin N. Andersson; Joshua B. Benoit; Anita Bhandari; Julia H. Bowsher; Kristian Brevik; Kaat Cappelle; Mei-Ju M. Chen; Anna K. Childers; Christopher Childers; Olivier Christiaens; Justin Clements; Elise M. Didion; Elena N. Elpidina; Patamarerk Engsontia; Markus Friedrich; Inmaculada García-Robles; Richard A. Gibbs; Chandan Goswami; Alessandro Grapputo; Kristina Gruden; Marcin Grynberg; Bernard Henrissat; Emily C. Jennings; Jeffery W. Jones; Megha Kalsi; Sher A. Khan; Abhishek Kumar; Fei Li; Vincent Lombard; Xingzhou Ma; Alexander Martynov; Nicholas J. Miller; Robert F. Mitchell; Monica Munoz-Torres; Anna Muszewska; Brenda Oppert; Subba Reddy Palli; Kristen A. Panfilio; Yannick Pauchet; Lindsey C. Perkin; Marko Petek; Monica F. Poelchau; Éric Record; Joseph P. Rinehart; Hugh M. Robertson; Andrew J. Rosendale; Victor M. Ruiz-Arroyo; Guy Smagghe; Zsofia Szendrei; Gregg W.C. Thomas; Alex S. Torson; Iris M. Vargas Jentzsch; Matthew T. Weirauch; Ashley D. Yates; George D. Yocum; June-Sun Yoon ; Stephen Richards (2018) A model species for agricultural pest genomics: the genome of the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae). Scientific Reports , 8(1931), pp. 1 - 18 . ISSN: 2045-2322
María José López-Galiano; Vicente Sentandreu; Amparo C. Martínez-Ramírez; Carolina Rausell; M. Dolores Real; Gemma Camañes; Omar Ruiz-Rivero; Oscar Crespo-Salvador; Inmaculada García-Robles (2019) Identification of stress associated microRNAs in Solanum lycopersicum by high-throughput Sequencing. Genes , 10(6), p. 475 . ISSN: 2073-4425
María José López-Galiano; Inmaculada García-Robles; Ana I. González-Hernández; Gemma Camañes; Begonya Vicedo; M. Dolores Real; Carolina Rausell (2019) Expression of miR159 is altered in tomato plants undergoing drought stress. Plants-Basel , 8(7), pp. 201-1 - 201-11 . ISSN: 2223-7747
María José López-Galiano; Inmaculada García-Robles; Víctor Manuel Ruiz-Arroyo;Sara Sanchís Oltra; Marko Petek; Carolina Rausell; M. Dolores Real (2019) Colorado potato beetle chymotrypsin genes are differentially regulated in larval midgut in response to the plant defense inducer hexanoic acid or the Bacillus thuringiensis Cry3Aa toxin. Journal of Invertebrate Pathology , Volume 166(107224) . ISSN: 0022-2011
Inmaculada García-Robles; Jessica De Loma; Miguel Capilla; Isabel Roger; Paz Boix-Montesinos; Pablo Carrión; Marcos Vicente; M. José López-Galiano; M. Dolores Real; Carolina Rausell (2020) Proteomic insights into the immune response of the Colorado potato beetle larvae challenged with Bacillus thuringiensis. Developmental and Comparative Immunology , 104, p. 103525 . ISSN: 0145-305X
Óscar Crespo-Salvador ; Lorena Sánchez-Giménez; Mª José López-Galiano; Emma Fernández-Crespo; Loredana Schalschi; Inmaculada García-Robles; Carolina Rausell; M Dolores Real; Carmen González-Bosch (2020) The Histone Marks Signature in Exonic and Intronic Regions Is Relevant in Early Response of Tomato Genes to Botrytis cinerea and in miRNA Regulation. Plants-Basel , 9(3), p. 300 . ISSN: 2223-7747
Lopez-Galiano, MJ; Garcia-Robles, I; Gonzalez-Hernandez, AI; Camanes, G; Vicedo, B; Real, MD; Rausell, C (2019) Role of miR159 in tomato plants undergoing drought stress. Febs Open Bio, 9, pp. 309 - 310 . ISSN: 2211-5463
Aida Robles-Fort; Inmaculada García-Robles; Wasundara Fernando; David W. Hoskin; Carolina Rausell ; María Dolores Real (2021) Dual Antimicrobial and Antiproliferative Activity of TcPaSK Peptide Derived from a Tribolium castaneum Insect Defensin. Microorganisms, 9(2)(222) . ISSN: 2076-2607
Bassolino, L.; Petroni, K.; Polito, A.; Marinelli, A.; Azzini, E.; Ferrari, M.; Ficco, D.B.M.; Mazzucotelli, E.; Tondelli, A.; Fricano, A.; Paris, R.; García-Robles, I.; Rausell, C.; Real, M.D.; Pozzi, C.M.; Mandolino, G.; Habyarimana, E.; Cattivelli, L. (2022) Does Plant Breeding for Antioxidant-Rich Foods Have an Impact on Human Health?. Antioxidants, 11(794) . ISSN: 2076-3921