Using the Cellular Capsules Technology, we aime to recapitulate the environmental cues received by hepatocytes in vivo, including the physical interactions between PHHs and non-parenchymal cells, the secreted chemical signals, and some mechanical cues. This controlled micro-compartmentalization strategy is expected to ensure the formation of the metabolic zonated-like architecture within 3D hepatic spheroids and lead to relevant drug screening assays (ANR REVIL 2021).

Adapted from S. Ben Moshe et al, Nature Metabolism 2019