Abstract

In our approach to study the behavior of cells and tissues, in our group we integrate physics and mathematical modeling with numerical and computational methods. Our primary tool, hiperlife, is a computational framework that leverages high-performance computing (HPC) to model biological systems focusing on the ability to integrate multiple physics, such as mechanics and biochemical patterning. I will discuss different projects that showcase the ability of hiperlife to deal with complex multiphysics and integrate multiscale behavior. I will also introduce a new integration with Python, simplifying its usage and offering hiperlife’s capabilities (initially programmed in C++) to a broader user base. Finally, I will focus on a specific project where we study the emergence of tissue patterning through the mechanical fracture of the extracellular matrix during cardiac morphogenesis.