In our approach to study the behavior of cells and tissues, in our group we integrate physics and mathematical modeling with numerical and computational methods. Our primary tool, hiperlife, is a computational framework that leverages high-performance computing (HPC) to model biological systems focusing on the ability to integrate multiple physics, such as mechanics and biochemical patterning. I will discuss different projects that showcase the ability of hiperlife to deal with complex multiphysics and integrate multiscale behavior. I will also introduce a new integration with Python, simplifying its usage and offering hiperlife’s capabilities (initially programmed in C++) to a broader user base. Finally, I will focus on a specific project where we study the emergence of tissue patterning through the mechanical fracture of the extracellular matrix during cardiac morphogenesis.