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(ANSA) - Rome, January 4 - A woman has become the firstItalian to have a bionic hand fitted, sources said on Thursday.

The hand, built by Silvestro Micera's team from the ScuolaSuperiore Sant'Anna in Pisa and the Polytechnic of Lausanna, wasfitted in June 2016 at Rome's Policlinico Gemelli Hospital byneurosurgeon Paolo Maria Rossini's team. The results of trials with the hand are set to be publishedin an international scientific journal. The hand perceives contact with objects.

The hand was fitted in the six-month-long experiment toAlmerina Mascarello, who lives in Veneto and had lost her handin an accident.

"The hand is an improved version of the one fitted onto aDanish man in 2014," Micera told ANSA.

Mascarello is also the first woman who has been able to getout and about with her hi-tech hand because now, unlike in 2014,all the necessary electronic equipment has been put into abackpack.

This, Micera explained, "includes the system that registersthe movement of the muscles and translates them into electricalsignals, which are then turned into a set of commands for thebionic hand.

"Another system transforms the information registered by thesensors in the hand in signals to send to nerves and thereforeinto sensorial information".

The woman took along the backpack on a foray in Rome inOctober 2016, under the watchful eyes of the Italian researchteam, Micera said.

The ultimate goal, Micera said, is to make the technologyclinically usable.

The backpack was an intermediate step along the way to thisgoal, he said.

"The next step is to miniaturise the electronics," said thelead researcher. Micera said the objective of his team was to miniaturise theelectronics "within a few years' time".

He said this technology, with special adjustments, could thenbecome a "sort of jack-of-all-trades able to be adapted to manykinds of prostheses, including those of the hands, arms andlegs".

Micera said "we are working towards a completely implantableand long-term electronic system".

Mascarello, 55, from Montecchio Precalcino near Vicenza innorthern Italy, told ANSA Thursday: "I'm looking forward to Maywhen the bionic hand made specially for me will arrive.

"Only then will I be able to say that my life has beencompletely changed".

Mascarello lost her hand in a work accident in July 1993,when it was crushed by a press in the industrial factory she wasworking in.

She met the Gemelli team by chance.

"I was flicking through a magazine on invalidity when Inoticed a page asking people to undergo a test for a prosthesis.

"The Gemelli doctor phoned me a year later and asked me if Iwould like to be a guinea pig for a bionic hand.

"I said I would think about it and I said Yes in May of lastyear.

"I went to Rome for the operation in June".

She described using the hand as something "marvelous andstupendous", recalling that she had been missing a hand for 23years.

"Now I'm eagerly awaiting them to call me and tell me it'sready".

Neurologist Paolo Maria Rossini said the hand had been testedon several people from various countries and that each op hadcost "several thousand euros".

As for the innovative technique used, he said "insertingelectrodes no larger than a human hair enables the motor signalssent by the brain to be transmitted to the robotic hand whichgets the input and responds.

"Hitherto the stimulator, batteries and instrumentationlinked to the hand have been carried by the patient in abackpack.

"The next intervention foresees that the whole system,realised in extremely small dimensions, can be included in thearm". Rossini also said a major goal was to "make this technologycheap to use".

He said "we will start trying to drive costs down as soon asthe next prototypes start coming along".

The bionic hand itself is developed by Italian robotics company Prensilia, and is called Mia Hand. It features unique motor and sensory components that allow the user to carry out around 80 per cent of the activities of daily living.

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The woman, Karin, who is 50 years old and from Sweden, was fitted with the prosthetic limb a couple of years ago after she lost her right hand over 20 years ago in a farming accident. Following her accident, she spent several years suffering with phantom limb pain. She also found conventional artificial limbs uncomfortable and unsuitable for regular daily use.

For the development of Karin's bionic limb, a multidisciplinary team of surgeons and engineers from Australia, Italy, and Sweden worked together. The study was headed by Professor Rickard Brnemark, who is an associate professor at Sweden's Gothenburg University and a research affiliate from the Massachusetts Institute of Technology (MIT). The study efforts began in 2019 and details the first-ever neuromusculoskeletal permanent implant.

Because the nerves successfully work, the research explained that Karin's bionic hand also has a limited sense of touch. Professor Christian Cipriani from Italy's Scuola Superiore Sant'Anna, explains that the procedure is remarkably noteworthy as it serves as a consolidation of robotic and prosthetic technologies that are available and that could gravely impact the lives of people.

This debilitating pain took a turn when the groundbreaking bionic technology was tailored for her. Having undergone the surgical procedure in December 2018, Karin began actively using her new arm by mid-2019, marking four years of functional use.

Despite several promising aspects offered by innovative bionic solutions, there are still several limitations, which must be faced prior to the widespread use of similar devices. The main limitation of the majority of studies presented in this article is that these were mainly time-limited studies; therefore, long-term research regarding the behaviour of electrodes in muscles and nerves must be performed in view of their safety and functionality. In the majority of clinical trials, transcutaneous cables were used. The exit points on the skin for the cables are a matter of concern, both from a mechanical standpoint and in terms of preventing infection. Fully implantable solutions must be developed and tested.

The woman who received the bionic hand, Karin (whose full name is undisclosed), now has a limited sense of touch and can move all five of her bionic fingers individually with a success rate of 95 percent.

Case description: We have reported the first combined application of TMR and an OPI to treat a 24-year-old woman with a bilateral amputation at the shoulder level on the right side and at the very proximal transhumeral level on the left side. TMR was performed bilaterally in a single day, accounting for the peculiar patient's anatomy, as preparatory stage to placement of the OPI, and considering the future availability of implantable electromyographic sensors. The 2 OPI surgeries on the left side were completed after 8.5 months, and prosthetic treatment was completed 17 months after TMR.

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Recently, significant progress in prosthetic technology has culminated in a groundbreaking milestone: the fusion of bionic hands with users' nervous and skeletal systems, demonstrating enduring functionality even after years of daily use. This marks the first successful long-term integration of a bionic hand into a patient with a below-elbow amputation.

According to the Bionics Institute, Karin, a Swedish woman who lost her right hand in a farming accident, was implanted with a novel human-machine interface into her residual bone, nerves, and muscles in December 2018.

Karin's life has been transformed by groundbreaking bionic technology. Over 20 years ago, a farming accident claimed her right arm, leaving her with excruciating phantom limb pain and conventional prostheses that were uncomfortable and unreliable. But now, a bionic hand that is integrated with her residual limb allows her to live a full and active life, free from pain.

With the advanced bionic hand she now possesses, Karin can successfully perform approximately 80 percent of her typical daily activities. This includes tasks such as preparing food, handling various objects, and effortlessly turning doorknobs and screws.

She decided to try the Mia Hand after hearing about it from her doctor. She underwent surgery to implant a human-machine interface (HMI) on her arm, which connects the artificial structure to her skeleton and nerves. She is fondly referred to as the "real bionic woman" by the researchers who developed this technology. be457b7860