Auto-CHO

Auto-CHO is an open source (MIT Licence) and free-to-use software developed by Academia Sinica for providing solutions of hierarchical one-pot glycan synthesis.

Auto-CHO software | Version: 1.0.110 | Last update: Dec. 17, 2018 | User Guide | Source Code

Download software for Windows from [Google Drive]

Download software for macOS from [Google Drive]

Download software for Ubuntu from [Google Drive]

System Requirements

      • Operating System:

        • Microsoft Windows 7 or above (64bit, recommended).

        • macOS 10.13 or above (64bit).

        • Ubuntu 18.04 LTS or above (64bit, Beta version).

      • Java Runtime Environment (JRE): version 8.0 (64bit) or above

        • To click HERE to download the JRE.

        • JRE installation instructions: JRE 8 or JRE 10.

      • Processor: 1GHz or higher.

      • Hard Drive: 5GB or more free space.

      • Memory (RAM): 4GB or more.

      • Minimum screen resolution: 1024x768.

      • Recommended screen resolution: 1920x1080 or higher.

Update Log

      • 12/17/2018 - Text modification.

      • 10/17/2018 - Refinement; Bug fixed.

      • 10/08/2018 - Refinement; Bug fixed.

      • 10/04/2018 - Bug fixed.

      • 9/29/2018 - Ubuntu supported; Feedback function for virtual BBLs built; Bug fixed; User guide updated.

      • 6/21/2018 - Add more than 2,000 virtual building blocks (GlcN and GlcA) into the library.

      • 6/13/2018 - UI bug fixed for macOS.

      • 6/12/2018 - Bug fixed.

      • 6/06/2018 - Bug fixed; Result text improvement.

      • 5/28/2018 - UI improvement.

      • 5/17/2018 - To enhance the filtering function for virtual BBLs.

      • 5/16/2018 - To add a check function for parameter inputs.

      • 5/15/2018 - Bug fixed.

Data

Download the optimized RRV predictor from [Google Drive].

Download the machine learning feature profiles from [Google Drive].

Java code and Related Data for Calculating the Performance of Feature Selection by N-fold Cross-validation

Download the Java code from [Google Drive].

Reference

Cheng-Wei Cheng, Yixuan Zhou, Wen-Harn Pan, Supriya Dey, Chung-Yi Wu, Wen-Lian Hsu, and Chi-Huey Wong, Hierarchical and Programmable One-pot Synthesis of Oligosaccharides, Nature Communications, 2018.

Technical Support

If you have any technical question about the Auto-CHO software, please contact autocho.sinica[at]gmail.com