Epilepsy is a neurological disorder with abnormal electrical activity in the brain, causing seizures.Almost 3 million people suffer from the epileptic seizures . There are a lot of ways to controlling seizure activity. The ketogenic diet (KD) is a high-fat, low-carbohydrate (4:1) dietary therapy that helps to control seizures in some people with epilepsy. Mostly it used for the refractory epilepsy patients, which are resistant to antiepileptic drugs (AEDs). KD produces ketone bodies (KB's) that is expected to have have anticonvulsant properties, such as beta-hydroxybutyrate (B-HB).My experiment purpose is to determine the duration of seizure activity for the MAD and KD with a period of behavior between each stages of the seizure and to find the diet that is less mortal to the mutant culture.I hypothesize that the higher concentration of Ketone Bodies or B-HB in Ketogenic Diet will cause the smaller duration of seizure but higher mortality rate of the mutant strain than in the Calorie reduced and in Modified Atkins Diet. However, the lower concentration of Ketone Bodies orB-HB in Modified Atkins Diet will cause the higher duration of seizure but lower mortality rate of the mutant strains than in the Ketogenic Diet and in the Calorie reduced. Several methods that I performed: extracting virgin female and male flies with in 7 hours after eclosion ,prepare the KD and MAD solution using the chemical B-BH for the concentration of 2mM for KD and ImM for MAD through dilution. I expose the 5 pair of flies of both strains into prepared dietary categories : Control, KD and MAD with prepared chemical solution, Calorie Reduced Diet 20% .Expose the cultures to seizure simulation on 3 -post eclosion into mechanical stress seizure activity by vortexing at the highest speed for 10 sec. Record the behavior of the flies through taking images with elapsed time of 1 sec with stereo microscope, camera and software until mutant fly recovers from the seizure stage. Incidence of eas flies' seizure activity on the KD was significantly less, (p<0.01)based on ANOVA than that of flies on the MAD diet with a lower concentration of the chemical, suggesting that the observed effects of the KB B-HB on seizure activity even at high concentration controls more the seizure in the organism. Regarding the development, eas mutant in MAD had the highest mortality rate and significantly greater (p<0.01) based on ANOVA than all my diets The KD showed the least mortality rate, compared to all rest of the cultures of mutant. In a Drosophila model of epilepsy, using bang-sensitive eas mutant flies, the results demonstrated that direct application of the KB, B-HB greatly reduces the incidence of seizure activity, as evaluated manual image analysis of behaviors. Ketogenic diet with a calorie reduced food and with a higher concentration of B BH greatly reduces the seizure, and flies experienced significantly low mortal rate for the eas bs mutant, making KD helpful to the organism. The MAD have a significantly high mortality rate and caused some exhibition of seizure activity for the eas bs seizure mutants but much much less than KD. As the result, KD is an effective diet to keep the normal development without significantly harming the organism, while efficiently controlling the seizure activity in bs seizure mutants.