Biography.......
After completing my Doctoral research from Cellular and Molecular Neurobiology Unit at Indian Institute of Technology Jodhpur, I worked as an Assistant Professor in Department of Biochemistry, Central University of Rajasthan. Since my undergraduate studies at Hans Raj College at University of Delhi, I was very much fascinated about evolution of life. During my Post-graduate and doctoral research, my interest got more focused on evolution of sequences, structures and functions of cellular proteins. While teaching at CURAJ, I got a wonderful opportunity to join Feinberg School of medicine, Northwestern University in Chicago. Now, I am looking at the structural diversity of amyloidic aggregates under various neurodegenerative disease conditions. I am more interested in looking at the structural heterogeneity among different types of disease-associated protein aggregates in different regions of the brain. I am also working on the quality assurance pathways and their physiological relevance in maintenance of the cellular health. I look at most of the biological problems from an evolutionary prism and believe that these long-standing problems, like cancer and neurodegeneration, may get possible solutions, only when we can understand their evolutionary history.
Dr. Arun Upadhyay
Arun Upadhyay, Ph.D.
Feinberg School of Medicine, Northwestern University
Chicago, Illinois, United States of America
Past Experience:
Assistant Professor
Department of Biochemistry, Central University of Rajasthan, India
Senior Research Fellow
Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, India
Major Research Publications
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Molecular Neurodegeneration, 2023
Arun Upadhyay, Deepak Chhangani, Nalini R Rao, Julia Kofler, Robert Vassar, Diego E Rincon-Limas, Jeffrey N Savas
hhttps://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00654-z
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
JoVE (Journal of Visualized Experiments), 2022
Arun Upadhyay, Robert J Vassar, Jeffrey N Savas
https://www.jove.com/t/63816/biochemical-purification-proteomic-characterization-amyloid-fibril
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
Genes & Diseases, 2022
Uttpal Anand, Abhijit Dey, Arvind Kumar Singh Chandel, Rupa Sanyal, Amarnath Mishra, Devendra Kumar Pandey, Valentina De Falco, Arun Upadhyay, et al.
https://www.sciencedirect.com/science/article/pii/S2352304222000472
Neurodegeneration & imperfect ageing: Technological limitations and challenges?
Mechanisms of Aging and Development, 2021
Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra
https://journals.sagepub.com/doi/abs/10.1177/1073858421989582
Asymptomatic malaria infection prevailing risks for human health and malaria elimination
Infection, Genetics, and Evolution, 2021
David Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey Savas
https://www.sciencedirect.com/science/article/pii/S2589004220306489
Infection, Genetics and Evolution , 2021
Pragya Prasanna, Shweta Rathee, Arun Upadhyay, Sulakshana Sulakshana
https://www.sciencedirect.com/science/article/pii/S0024320521004136Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go
ACS Pharmacology and Translational Science, 2021
Pragya Prasanna, Arun Upadhyay
Infection and Immunity , 2021
Drug Metabolism Reviews, 2021
Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, Rohan Dhiman, Vijay Kumar Prajapati, Krishna Mohan Poluri, Amit Mishra
https://www.tandfonline.com/doi/abs/10.1080/03602532.2021.1903488
https://www.sciencedirect.com/science/article/pii/S2352304220301203
Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death
The International Journal of Biochemistry & Cell Biology 2020
https://www.sciencedirect.com/science/article/pii/S1357272520300145
LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein
Cellular Signalling, 2021
Ribhav Mishra, Vibhuti Joshi, Arun Upadhyay et al. 2021
https://www.sciencedirect.com/science/article/pii/S0898656820303132
LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases
Cellular and Molecular Life Sciences, 2019
Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Rohan Dhiman, Krishna Mohan Poluri, Nihar Ranjan Jana, Amit Mishra
https://link.springer.com/article/10.1007/s00018-019-03055-y
Journal of Neuroimmunology , 2021
https://www.sciencedirect.com/science/article/pii/S0165572821001636
Structure of proteins: Evolution with unsolved mysteries
Progress in Biophysics and Molecular Biology, 2019
How autophagy can restore proteostasis defects in multiple diseases?
Medicinal Research Reviews, 2020
Vibhuti Joshi, Arun Upadhyay, Vijay K. Prajapati, Amit Mishra
Ag (I) and Au (III) Mercaptobenzothiazole complexes induced apoptotic cell death
Scientific Reports, 2019
https://www.nature.com/articles/s41598-018-36801-6
Book: Molecular Diagnostics in Cancer Patients , 2019
https://link.springer.com/chapter/10.1007/978-981-13-5877-7_4
Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation
Journal of Cellular Physiology, 2019
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28695
Terpenoids as promising therapeutic molecules against Alzheimer’s disease: amyloid beta-and acetylcholinesterase-directed pharmacokinetic and molecular docking analyses
Molecular Simulation, 2018
https://www.tandfonline.com/doi/abs/10.1080/08927022.2017.1334880
Amyloids of multiple species: are they helpful in survival?
Biological Reviews, 2018
Arun Upadhyay, Amit Mishra
https://onlinelibrary.wiley.com/doi/abs/10.1111/brv.12399
Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases
Molecular Neurobiology, 2018
A Upadhyay, A Amanullah, D Chhangani, R Mishra, A Prasad, A Mishra
https://link.springer.com/article/10.1007/s12035-016-0377-2
Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
Medicinal Research Reviews, 2018
Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Amit Mishra
https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21502
Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities
Journal of Cellular Physiology, 2018
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.26081
Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins?
Journal of Cellular Physiology, 2018
Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration
Progress in Neurobiology, 2017
Ayeman Amanullah, Arun Upadhyay, Vibhuti Joshi, Ribhav Mishra, Nihar Ranjan Jana, Amit Mishra
https://doi.org/10.1016/j.pneurobio.2017.08.005
https://pubs.acs.org/doi/abs/10.1021/acschembio.7b00699
Frontiers in Cellular Neuroscience, 2017
E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
Frontiers in Molecular Neuroscience, 2017
Arun Upadhyay, Vibhuti Joshi, Ayeman Amanullah, Ribhav Mishra, Naina Arora, Amit Prasad, Amit Mishra
https://www.frontiersin.org/articles/10.3389/fnmol.2017.00151
Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway
Journal of Cellular Biochemistry, 2017
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.25666
Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model
Neurobiology of Disease, 2016
Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms
Molecular Neurobiology, 2016
Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Prasad, Amit Mishra
https://link.springer.com/article/10.1007/s12035-015-9379-8
Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction
Molecular Neurobiology 2016
Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Vibhuti Joshi, Ribhav Mishra, Amit Mishra
https://link.springer.com/article/10.1007/s12035-015-9603-6
Molecular and Cellular Insights: Neuroinflammation and Amyotrophic Lateral Sclerosis
Book: Inflammation: the Common Link in Brain Pathologies, 2016
Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Prasad, Amit Mishra
https://link.springer.com/article/10.1007/s12035-015-9379-8
A decade of boon or burden: what has the CHIP ever done for cellular protein quality control mechanism implicated in neurodegeneration and aging?
Frontiers in Molecular Neuroscience, 2016
Vibhuti Joshi, Ayeman Amanullah, Arun Upadhyay, Ribhav Mishra, Amit Kumar, Amit Mishra
https://www.frontiersin.org/articles/10.3389/fnmol.2016.00093/full
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Ageing Research Reviews, 2015
Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Mishra
https://doi.org/10.1016/j.arr.2015.07.009
Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity
BBA-Molecular Basis of Disease, 2014
https://www.sciencedirect.com/science/article/pii/S092544391400101X
Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins
Scientific Reports, 2014
https://www.nature.com/articles/srep05077
Book: Public Health and Development on India, 2014
Editors: S.B. Nimse & M.K. Agarwal
Northern Book Center New Delhi