Biography....... 

After completing my Doctoral research from Cellular and Molecular Neurobiology Unit at Indian Institute of Technology Jodhpur, I worked as an Assistant Professor in Department of Biochemistry, Central University of Rajasthan. Since my undergraduate studies at Hans Raj College at University of Delhi, I was very much fascinated about evolution of life. During my Post-graduate and doctoral research, my interest got more focused on evolution of sequences, structures and functions of cellular proteins.  While teaching at CURAJ, I got a wonderful opportunity to join Feinberg School of medicine, Northwestern University in Chicago. Now, I am looking at the structural diversity of amyloidic aggregates under various neurodegenerative disease conditions. I am more interested in looking at the structural heterogeneity among different types of disease-associated protein aggregates in different regions of the brain. I am also working on the quality assurance pathways and their physiological relevance in maintenance of the cellular health. I look at most of the biological problems from an evolutionary prism and believe that these long-standing problems, like cancer and neurodegeneration, may get possible solutions, only when we can understand their evolutionary history.  

Dr. Arun  Upadhyay

Arun Upadhyay, Ph.D.

The Ken and Ruth Davee Department of Neurology

Feinberg School of Medicine, Northwestern University

Chicago, Illinois, United States of America

Past Experience:

Assistant Professor 

Department of Biochemistry, Central University of Rajasthan, India

Senior Research Fellow

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, India

Major Research Publications

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Molecular Neurodegeneration, 2023

Arun Upadhyay, Deepak Chhangani, Nalini R Rao, Julia Kofler, Robert Vassar, Diego E Rincon-Limas, Jeffrey N Savas

hhttps://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00654-z

Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain

JoVE (Journal of Visualized Experiments), 2022

Arun Upadhyay, Robert J Vassar, Jeffrey N Savas

https://www.jove.com/t/63816/biochemical-purification-proteomic-characterization-amyloid-fibril

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Genes & Diseases, 2022

Uttpal Anand, Abhijit Dey, Arvind Kumar Singh Chandel, Rupa Sanyal, Amarnath Mishra, Devendra Kumar Pandey, Valentina De Falco, Arun Upadhyay, et al.

https://www.sciencedirect.com/science/article/pii/S2352304222000472

Neurodegeneration & imperfect ageing: Technological limitations and challenges?

Mechanisms of Aging and Development, 2021

Naveen Sundaria, Arun Upadhyay, Amit Prasad, Vijay Kumar Prajapati, Krishna Mohan Poluri, Amit Mishra   https://www.sciencedirect.com/science/article/abs/pii/S0047637421001469

Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra 

https://journals.sagepub.com/doi/abs/10.1177/1073858421989582

Timothy J Hark, Nalini R Rao, Charlotte Castillon, Tamara Basta, Samuel Smukowski, Huan Bao, Arun Upadhyay et al., 2021   https://www.sciencedirect.com/science/article/pii/S2405471220304580
Dhaneswar Prusty, Nidhi Gupta, Arun Upadhyay, Ashraf Dar, Biswajit Naik, Navin Kumar, Vijay Kumar Prajapati  https://www.sciencedirect.com/science/article/pii/S1567134821002847   

David Graykowski, Yi-Zhi Wang, Arun Upadhyay, Jeffrey Savas

https://www.sciencedirect.com/science/article/pii/S2589004220306489

Pragya Prasanna, Rakesh Kumar, Vijay Kumar Singh, Arun Upadhyay   https://www.sciencedirect.com/science/article/abs/pii/S1567134821000356  

Pragya Prasanna, Shweta Rathee, Arun Upadhyay, Sulakshana Sulakshana 

https://www.sciencedirect.com/science/article/pii/S0024320521004136
Pragya Prasanna, Arun Upadhyay   https://journals.asm.org/doi/abs/10.1128/iai.00559-20  

Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, Rohan Dhiman, Vijay Kumar Prajapati, Krishna Mohan Poluri, Amit Mishra

https://www.tandfonline.com/doi/abs/10.1080/03602532.2021.1903488

Arun Upadhyay
https://www.sciencedirect.com/science/article/pii/S2352304220301203

Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death  

The International Journal of Biochemistry & Cell Biology 2020

Ribhav MIshra,  Ayeman Amanullah, Arun Upadhyay, et al
https://www.sciencedirect.com/science/article/pii/S1357272520300145  

Ribhav Mishra, Vibhuti Joshi, Arun Upadhyay et al. 2021

https://www.sciencedirect.com/science/article/pii/S0898656820303132

Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Rohan Dhiman, Krishna Mohan Poluri, Nihar Ranjan Jana, Amit Mishra 

https://link.springer.com/article/10.1007/s00018-019-03055-y 

Shweta Jakhmola, Arun Upadhyay, Khushboo Jain, Amit Mishra, Hem Chandra Jha    
https://www.sciencedirect.com/science/article/pii/S0165572821001636 

Structure of proteins: Evolution with unsolved mysteries   

Progress in Biophysics and Molecular Biology, 2019

How autophagy can restore proteostasis defects in multiple diseases?    

Medicinal Research Reviews, 2020

Vibhuti Joshi, Arun Upadhyay, Vijay K. Prajapati, Amit Mishra

https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21662 

Ag (I) and Au (III) Mercaptobenzothiazole complexes induced apoptotic cell death 

Scientific Reports, 2019

Jositta Sherine, Arun Upadhyay, Amit Mishra, Deepak Kumar, Samanwita Pal, S Harinipriya  
https://www.nature.com/articles/s41598-018-36801-6 

Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors  

Book: Molecular Diagnostics in Cancer Patients , 2019

Vibhuti Joshi, Arun Upadhyay, Ayeman Amanullah, Ribhav Mishra, Amit Mishra   
https://link.springer.com/chapter/10.1007/978-981-13-5877-7_4  

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation 

Journal of Cellular Physiology, 2019

Vibhuti Joshi, Ribhav Mishra, Arun Upadhyay, Ayeman Amanullah, Krishna Mohan Poluri, Sarika Singh, Amit Kumar, Amit Mishra 
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28695 

Terpenoids as promising therapeutic molecules against Alzheimer’s disease: amyloid beta-and acetylcholinesterase-directed pharmacokinetic and molecular docking analyses  

Molecular Simulation, 2018

Manika Awasthi, Arun K Upadhyay, Swati Singh, Veda P Pandey, Upendra N Dwivedi 
https://www.tandfonline.com/doi/abs/10.1080/08927022.2017.1334880  

Amyloids of multiple species: are they helpful in survival? 

Biological Reviews, 2018

Arun Upadhyay, Amit Mishra

https://onlinelibrary.wiley.com/doi/abs/10.1111/brv.12399

Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases

Molecular Neurobiology, 2018

A Upadhyay, A Amanullah, D Chhangani, R Mishra, A Prasad, A Mishra 

https://link.springer.com/article/10.1007/s12035-016-0377-2

Ribhav Mishra, Arun Upadhyay, Vijay Kumar Prajapati, Amit Mishra 

https://onlinelibrary.wiley.com/doi/abs/10.1002/med.21502

Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities 

Journal of Cellular Physiology, 2018

Ayeman Amanullah, Ribhav Mishra, Arun Upadhyay, Pothula P Reddy, Ranabir Das, Amit Mishra  
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.26081 

Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins?

Journal of Cellular Physiology, 2018

Vibhuti Joshi, Arun Upadhyay, Deepak Chhangani, Ayeman Amanullah, Rajesh N Sharan, Amit Mishra https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.26618 

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Progress in Neurobiology, 2017

Ayeman Amanullah, Arun Upadhyay, Vibhuti Joshi, Ribhav Mishra, Nihar Ranjan Jana, Amit Mishra 

https://doi.org/10.1016/j.pneurobio.2017.08.005

Eshan Khan, Arpita Tawani, Subodh Kumar Mishra, Arun Kumar Verma, Arun Upadhyay, Mohit Kumar, Rajat Sandhir, Amit Mishra, Amit Kumar 
https://pubs.acs.org/doi/abs/10.1021/acschembio.7b00699 
Vibhuti Joshi, Arun Upadhyay, Amit Kumar, Amit Mishra https://www.frontiersin.org/articles/10.3389/fncel.2017.00259/full 

Arun Upadhyay, Vibhuti Joshi, Ayeman Amanullah, Ribhav Mishra, Naina Arora, Amit Prasad, Amit Mishra 

https://www.frontiersin.org/articles/10.3389/fnmol.2017.00151

Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway

Journal of Cellular Biochemistry, 2017

Ayeman Amanullah, Arun Upadhyay, Deepak Chhangani, Vibhuti Joshi, Ribhav Mishra, Koji Yamanaka, Amit Mishra 
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.25666

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

Neurobiology of Disease, 2016

Deepak Chhangani, Fumito Endo, Ayeman Amanullah, Arun Upadhyay, Seiji Watanabe, Ribhav Mishra, Koji Yamanaka, Amit Mishra https://doi.org/10.1016/j.nbd.2015.11.017

Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms

Molecular Neurobiology, 2016

Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Prasad, Amit Mishra 

https://link.springer.com/article/10.1007/s12035-015-9379-8

Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Vibhuti Joshi, Ribhav Mishra, Amit Mishra

https://link.springer.com/article/10.1007/s12035-015-9603-6

Molecular and Cellular Insights: Neuroinflammation and Amyotrophic Lateral Sclerosis 

Book: Inflammation: the Common Link in Brain Pathologies, 2016

Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Prasad, Amit Mishra 

https://link.springer.com/article/10.1007/s12035-015-9379-8

A decade of boon or burden: what has the CHIP ever done for cellular protein quality control mechanism implicated in neurodegeneration and aging?  

Frontiers in Molecular Neuroscience, 2016

Vibhuti Joshi, Ayeman Amanullah, Arun Upadhyay, Ribhav Mishra, Amit Kumar, Amit Mishra  

https://www.frontiersin.org/articles/10.3389/fnmol.2016.00093/full 

Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing

Ageing Research Reviews, 2015

Arun Upadhyay, Ayeman Amanullah, Deepak Chhangani, Ribhav Mishra, Amit Mishra

https://doi.org/10.1016/j.arr.2015.07.009


Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity

BBA-Molecular Basis of Disease, 2014

Deepak Chhangani, Nobuyuki Nukina, Masaru Kurosawa, Ayeman Amanullah, Vibhuti Joshi, Arun Upadhyay, Amit Mishra 
https://www.sciencedirect.com/science/article/pii/S092544391400101X

Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins

Scientific Reports, 2014

Deepak Chhangani, Arun Upadhyay, Ayeman Amanullah, Vibhuti Joshi, Amit Mishra 
https://www.nature.com/articles/srep05077
Upendra Nath Dwivedi, Manika Awasthi, Arun K Upadhyay, Swatii Singh, Veda Prakash Pandey 
Editors: S.B. Nimse &  M.K. Agarwal
Northern Book Center New Delhi

We Do Not Remember Days, We Remember Moments ..........................

Jodhpur

Kumbhalgarh

Jaisalmer

Mumbai

Mount Abu

Ranthambore

Delhi

Agra