Graphical abstract from the paper.
Arrieta M.C. , Arévalo, A., Stiemsma, L., Dimitriu, P., Chico, M.E., Loor, S., Vaca, M., Boutin, R.C., Morien, E., Jin, M., Turvey, S.E. (2017)
Given that asthma is the most prevalent childhood chronic disease and that early-life gut microbial changes (dysbiosis) have been shown to affect asthma development, this paper discusses effects of gut microbial dysbiosis on atopic wheeze in a population living in a distinct developing world environment. The authors show that fungal and bacterial microbiota play a crucial role during the first 100 days of life on the development of atopic wheeze and provide additional support for considering modulation of the gut microbiome as a primary asthma prevention strategy.
This paper has been published in the Journal of Allergy and Clinical Immunlogy.
Fig.1. Summary of findings from epidemiological studies of asthma. Protective (green box) and risk-associated (red box) factors for asthma development are described
van Tilburg Bernardes, E. & Arrieta M.C. (2017)
This review in Archives in Medical Research summarizes up-to-date information on genetic and environmental factors associated with asthma in different human populations, and presents evidence that calls for caution when associating hygiene with the pathogenesis of asthma and other allergic conditions.
Laforest-Lapointe, I. & Arrieta M.C. (2017)
This review in Frontiers in Immunology highlights the recent findings on the interactions between the human gut microbial community and host immune system through the lenses of community ecology theory.
Perez-Muñoz M.E., Arrieta M.C., Ramer-Tait A. & Walter, J. (2017)
This recent review in the Open Access journal Microbiome discusses the importance of methodology when working with the "rare microbiome", especially when studying human organs that are scientifically believed to be sterile.
This work serves as a reminder of the importance of negative controls, test of bacterial viability, and use of appropriate molecular techniques when studying "low biomass" microbial samples.
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Arrieta, M.C., Sadarangani M., Brown, E.M., Russell, S.L., Nimmo, M., Dean, J., Turvey, S.E., Chan, E.S. & Finlay, B. (2016)
This addendum, published in the journal Gut Microbes as a follow-up to Arrieta et al. (2015) in Science Translational Medicine, provide additional data on the use of a humanized gut microbiota mouse model to study the development of asthma in children, highlighting the differences in immune development between germ-free mice colonized with human microbes compared to those colonized with mouse gut microbiota.
Arrieta, M.C., Stiemsa, L.T., Dimitriu, P.A., Thorson, L., Russell, S., Yurist-Doutsch, S., Kuzeljevic, B., Gold, M.J., Britton, H.M., Lefebvre, D.L., Subbarao, P., Mandhane, P., Becker, A., McNagny, K.M., Sears, M.R., Kollmann, T., The CHILD Study Investigators, Mohn, W.W., Turvey, S.E. & Finlay, B.B. (2015)
This article involves the CHILD Study cohort, which highlights research on a prospective longitudinal birth cohort study. This means that CHILD researchers are actively following the Study participants over time as they grow and develop—from mid-pregnancy into childhood and adolescence. CHILD is designed this way so it can collect information at time points that are considered to be especially critical to the health and development of children.
This work is based on the recent findings that changes in the gut microbiota have been implicated in the development of asthma in animal models. However, it has remained unclear whether these findings hold true in humans. This article reports in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life.