Almeida Lab

Center for Discovery Brain Sciences

University of Edinburgh

Despite the attention devoted to synapses, neurons can also release neurotransmitters away from presynaptic terminals, such as along axonal hotspots. Non-synaptic neurotransmitter release is implicated in the function of many neural circuits, but we have a poor understanding of the underlying molecular mechanisms and of how it impacts the nervous system. The Almeida Lab uses the zebrafish model organism to study...

Axonal mechanisms

How do axons release neurotransmitters? 

Cellular Responses

Which cells respond and how? 

Axon-myelin interactions

How does axonal release regulate myelination?

SNAREopathies

How does non-synaptic transmission contribute to neurological conditions?