AI for Immune Disease Laboratory (AIDL)
Unlocking the Human Immune System Through Genomics
@ GSMSE, KAIST
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Members
Members
Jeong Seok Lee, MD, PhD, Principal Investigator
2020-present, Co-founder, Inocras Inc. (link)
2025-present, Associate Professor, GSMSE, KAIST
2022-2025, Assistant Professor, GSMSE, KAIST
2018-2020, Ph.D. Immunology, Graduate School of Medical Science and Engineering (GSMSE), KAIST
2017-2018, Clinical fellow, Rheumatology, Seoul National Univ. Hospital
2013-2017, Residency, Internal Medicine, Seoul National Univ. Hospital
2011-2015, M.S. Immunology, Seoul National Univ.
2004-2008, M.D. Seoul National Univ.
2000-2004, B.S. Chemistry, KAIST
Woogil Song, PharmD, Graduate Student (2022.3-)
Song W*, Lee EE, Park S, et al. Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis. Nat Commun. 2025. [PMID: 40593526]
Yi K*, Jo S*, and Song W*, et al. Analysis of Single-Cell Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies OX40-Positive and Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Positive Pathogenic Th17 Cells. Arthritis Rheum. 2023. [PMID: 36787119]
Seyoung Jung, Korean MD, Graduate Student (2022.9-)
Kim HD*, Jung S*, et al. Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer. J Immunother Cancer. 2025. [PMID: 40032602]
Chang SH*, Jung S*, Chae JJ*, et al. Therapeutic Single-Cell Landscape: Methotrexate Exacerbates Interstitial Lung Disease by Compromising the Stemness of Alveolar Epithelial Cells under Systemic Inflammation. eBioMedicine. 2024. [PMID: 39303666]
Kim HD*, Jung S*, et al. Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial. Nat Med. 2024. [PMID: 38374347]
Yongjae Lee, MD, MS, Graduate Student (2023.3-)
Jeongho Joo, MD, MS, Graduate Student (2023.3-)
Lee SE*, Joo JH*, Hwang HS*, et al. Spatial transcriptional landscape of human heart failure. Eur Heart J. 2025. [PMID: 40335066]
Jungyu Kim, MD, MS, Graduate Student (2023.3-)
Junghee Kim, BS, Graduate Student (2024.3-)
Sung Woo Chang, BS, Graduate Student (2024.3-)
Geum Jeong Choi, BS, Graduate Student (2025.3-)
Jiseon Kim, Administrative Staff
Research
Research
We pursue data-driven scientific breakthroughs to solve pressing medical challenges
By design: cohort-based immune profiling of human inflammatory diseases
By approach: multimodal, genome-based, and perturbation-oriented studies
Inflammatory arthritis, Lupus, Interstitial lung disease, Emerging and critically ill infectious diseases, Cancer with immune-modulation
Mechanism of pathologic and organ-damaging hyperinflammation
Multi-organ investigation to study myeloid cell and T cell heterogeneity and differentiation
T cell receptor and B cell receptor repertoire diversity and tracking method development
Genomic mosaicism and its pathologic roles
Understanding complex immune networks in acute and chronic inflammation to develop an immune foundation model
Publication
Publication
Selected Publications from AIDL (*1st, #corresponding)
2025
14. Song W*, Lee EE*, Park S*, Choi B, Kim MG, Ban SY, Choi SR, Kim JY, Kim SU, Kim JI, Shin EC, Jung I#, Lee JS#, Lee EY#; Single-Cell Atlas of Immune Diseases Consortium. Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis. Nat Commun. 2025 Jul 1;16(1):5531. doi: 10.1038/s41467-025-60445-6. [PMID: 40593526]
13. Kim S*, Kwak JE*, Koh JY*, Lee JE, Kook HW, Kim M, Chung H, Kim Y, Kim SJ, Kim JS, Cheong JW, Lee MG, Lee H, Park SH, Shin EC, Shin S, Yoon SO, Choi IK#, Lee JS#, Cho H#. NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma. Blood. 2025 Mar 19:blood.2024025875.(accepted) [PMID: 40106762]
12. Kim HD*, Jung S*, Bang YH, Kim J, Kim HJ, Lee HE, Hyung J, Yoo C, Kim WT, Yoon MJ, Lee H, Ryou JH, Jeon H, Yanai H, Lee JS, Lee G#, Ryu MH#. Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer. J Immunother Cancer. 2025 Mar 3;13(3):e010455. [PMID: 40032602]
2024
11. Park K*, Lee JH*, Shin E, Jang HY, Song WJ, Kwon HS, Cho YS, Lee JE, Adcock I, Chung KF, Lee JS#, Won S#, Kim TB#. Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics. Exp Mol Med. 2024 Dec 13; Online ahead of print. [PMID: 39672815]
10. Chang SH*, Jung S*, Chae JJ*, Kim JY, Kim SU, Choi JY, Han HJ, Kim HT, Kim HJ, Kim HJ, Park WY, Sparks JA, Lee EY#, Lee JS#. Therapeutic Single-Cell Landscape: Methotrexate Exacerbates Interstitial Lung Disease by Compromising the Stemness of Alveolar Epithelial Cells under Systemic Inflammation. EBioMedicine. 2024 Sep 19:108:105339. [PMID: 39303666]
9. Choi SJ*, Lee W*, Kim SC, Jo HY, Park HY, Kim HB, Park WY, Park SH#, Ko JH#, Lee JS#. Longitudinal Multiomic Profiling and Corticosteroid Modulation of the Immediate Innate Immune Response to an Adenovirus-vector Vaccine. Vaccine. 2024 Jul 17:S0264-410X(24)00774-6. [PMID: 39025696]
8. Kim HD*, Jung S*, Lim HY, Ryoo BY, Ryu MH, Chuah S, Chon HJ, Kang B, Hong JY, Lee HC, Moon DB, Kim KH, Kim TW, Tal D, Chew V, Lee JS, Finn RS, Koh JY#, Yoo C#. Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial. Nat Med. 2024 Mar;30(3):699-707. [PMID: 38374347]
7. Kang DH*, Kim GHJ*, Park SB, Lee SI, Koh JS, Brown MS, Abtin F, McNitt-Gray MF, Goldin JG#, Lee JS#. Quantitative Computed Tomography Lung COVID Scores with Laboratory Markers: Utilization to Predict Rapid Progression and Monitor Longitudinal Changes in Patients with Coronavirus 2019 (COVID-19) Pneumonia. Biomedicines. 2024 Jan 6;12(1):120. [PMID: 38255225]
2023
6. Kim CG*, Koh JY*, Shin SJ*, Shin JH*, Hong M, Chung HC, Rha SY, Kim HS, Lee CK, Lee JH, Han Y, Kim H, Che X, Yun UJ, Kim H, Kim JH, Lee SY, Park SK, Park S, Kim H, Ahn JY, Jeung HC#, Lee JS#, Nam YD#, Jung M#. Prior antibiotic administration disrupts outcomes of PD-1 blockade in advanced gastric cancer by altering gut microbiome and systemic immune response. Cell Rep Med. Sep 27; 2023 [IF=14.3][PMID: 37890486]
5. Yi K*, Jo S*, Song W*, Lee HI, Kim HJ, Kang JH, Kim SU, Lee SH, Park J, Kim TH, Lee JS#, Lee EY#, Kim TJ#. Analysis of Single-Cell Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies OX40-Positive and Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Positive Pathogenic Th17 Cells. Arthritis Rheum. 2023 Jul;75(7):1176-1186. [IF=15.483][PMID: 36787119]
4. Koh JY*, Ko JH*, Lim SY*, Bae S, Huh K, Cho SY, Kang CI, Chung DR, Chung CR, Kim SH#, Peck KR#, Lee JS#. Triple immune modulator therapy for aberrant hyperinflammatory responses in severe COVID-19. Clin Immunol. 2023 Jun;251:109628. [IF=10.19][PMID: 37119951]
3. Jeong HW*, Lee JS*, JH Ko*, Hong S, Oh ST, Choi SK, Peck KR#, Yang JH#, Chung S#, Kim SH#, Kim YS#, Shin EC#. Corticosteroid reduces pathologic interferon responses by down-regulating STAT1 in patients with high risk COVID-19. Exp Mol Med. 2023 Mar;55(3):653-664. [IF= 12.153][PMID: 36941461]
2. Jung S*, Lee JS#. Single Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases. Mol Cells. 2023 Feb 28;46(2):120-129. [IF=4.250][PMID: 36859476]
2022
1. Jo S*, Lee JS*, Nam B, Lee YL, Kim H, Lee EY, Park YS, Kim TH#. SOX9+ enthesis cells is associated with spinal ankylosis in ankylosing spondylitis. Osteoarthritis Cartilage. 2022 Feb;30(2):280-290. [IF=6.576][PMID: 34826571]
News
News
2025
Jul: Woogil and Jeong Seok published an article "Single-Cell Atlas of Immune Diseases Consortium. Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis" in Nature Communications.
Jun: All lab members gathered at KAIST for the 2025 Summer Workshop, where we spent a day reviewing our research progress over the past 3 months, discussing future plans, and strategizing the lab's overall research portfolio.
Mar: All lab members gathered at KAIST for the 2025 Spring Workshop, where we spent a half day reviewing our research progress over the past 3 months, discussing future plans, and strategizing the lab's overall research portfolio.
Mar: Geum Jeong joined as a graduate student.
Feb: Seyoung has been selected as an outstanding graduate student by the Asan Foundation and will receive a scholarship.
2024
Dec: Jeong Seok was awarded 'Impact Research Award' from KAIST.
Dec: All lab members gathered at KAIST for the 2024 Winter Workshop, where we spent a day reviewing our research progress over the past year, discussing future plans, and strategizing the lab's overall research portfolio.
Oct: Seyoung and Jeong Seok published an article "Therapeutic Single-Cell Landscape: Methotrexate Exacerbates Interstitial Lung Disease by Compromising the Stemness of Alveolar Epithelial Cells under Systemic Inflammation " in EBioMedicine.
Sep: All lab members gathered at KAIST for the 2024 Autumn Workshop, where we spent a half day reviewing our research progress over the past 3 months, discussing future plans, and strategizing the lab's overall research portfolio.
Aug: Jeong Seok was awarded 2024 KHIDI grant (Physician-Scientist Leader Research Fund) for 5 years.
Jul: Jeong Seok published an article "Longitudinal Multiomic Profiling and Corticosteroid Modulation of the Immediate Innate Immune Response to an Adenovirus-vector Vaccine " in Vaccine.
Jun: All lab members gathered at KAIST for the 2024 Summer Workshop, where we spent a half day reviewing our research progress over the past 3 months, discussing future plans, and strategizing the lab's overall research portfolio.
May: Jeong Seok was awarded the 2024 Young Investigator Award from Korean College of Rheumatology. This is an award given annually to one young researcher in rheumatology under the age of 45.
Apr: Seyoung has been selected as an outstanding graduate student by the Ministry of Science and ICT of Korea and will receive a Presidential Science Scholarship.
Apr: Jeong Seok was awarded 2024 NRF grant (Outstanding Junior Research Fund, 우수신진연구) for 4 years.
Apr: Jungyu Kim joined as a 2nd year PhD student.
Mar: All lab members gathered at KAIST for the 2024 Spring Workshop, where we spent a half day reviewing our research progress over the past 3 months, discussing future plans, and strategizing the lab's overall research portfolio.
Mar: Junghee Kim joined as a graduate student.
Feb: Woogil has been selected as an outstanding graduate student by the Asan Foundation and will receive a scholarship.
Feb: Seyoung published an article "Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial" in Nature Medicine.
2023
Dec: Jeong Seok was awarded 'Impact Research Award' from KAIST.
Dec: All lab members gathered at KAIST for the 2023 Winter Workshop, where we spent a day reviewing our research progress over the past year, discussing future plans, and strategizing the lab's overall research portfolio.
Nov: Jeong Seok published an article "Prior antibiotic administration disrupts outcomes of PD-1 blockade in advanced gastric cancer by altering gut microbiome and systemic immune response" in Cell Reports Medicine.
Apr: Jeong Seok published an article "Triple immune modulator therapy for aberrant hyperinflammatory responses in severe COVID-19" in Clinical Immunology.
Mar: Yongjae Lee and Jeongho Joo joined as a graduate student.
Mar: Jeong Seok published an article "Corticosteroid reduces pathologic interferon responses by down-regulating STAT1 in patients with high risk COVID-19" in Experimental & Molecular Medicine.
Feb: Jeong Seok is appointed as Ewon endowed assistant professor at KAIST.
Feb: Woogil & Jeong Seok published an article "Analysis of Single-Cell Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies OX40-Positive and Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Positive Pathogenic Th17 Cells" in Arthritis & Rheumatology.
2022
Dec: Jeong Seok was awarded 'Impact Research Award' from KAIST.
Sep : Seyoung Jung joined as a graduate student.
Aug : We have moved our lab to the third floor of building N28.
Mar: Woogil Song joined as a graduate student.
Mar: Ji Sun Kim joined as an administrative staff.
Mar: Jeong Seok was awarded 2022 NRF grant (Outstanding Junior Research Fund, 우수신진연구) for 2 years.
Feb: We have opened our lab on the third floor of building N26 (Center for High-Performance Integrated Syetems).
Jan: Started AIDL @ KAIST GSMSE
Contact: chemami@kaist.ac.kr
Contact: chemami@kaist.ac.kr
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