Prof. Amal Chandra Mondal
Laboratory of Cellular & Molecular Neurobiology
Room: 211 & 215, School of Life Sciences,
Jawaharlal Nehru University, New Delhi, Delhi- 110067, India.
Email:
Phone: +91-11-26704505 (office)
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RESEARCH AREA
RESEARCH AREA
Our lab investigates the cellular and molecular basis for human neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Depression, Type-II Diabetes, and Neuropathic pain to understand their pathophysiology, molecular mechanisms, and therapeutic strategies. We are especially interested in the identification and therapeutic investigation of novel synthetic and natural therapeutic agents (phytochemicals, polyphenols), small molecule inhibitors against these devastating conditions using cellular and rodent model systems. We venture into understanding how modulating cellular signaling pathways leads to changes in cellular oxidative stress, mitochondrial dysfunction, neuroinflammation, synaptic dysfunction, neuronal death, and eventually degeneration of physiological functions in an attempt to find a solution against these diseases. To achieve this, we employ a multi-disciplinary approach combining 1) advanced imaging in differentiated neuronal models, 2) cell-based assays, 3) rodent behavior assays, 4) biochemical estimations, 5) histopathological studies, 6) molecular studies, and beyond. We are also currently investigating therapeutic potential of iPSC derived neural progenitor cells in 6-OHDA induced rat model of Parkinson’s diseases.
AWARDS/ FELLOWSHIPS/ RECOGNITIONS
1. Elected Fellow, International Union of Physiological Sciences (FIUPS) - 2025
2. Elected Fellow, Royal Society of Biology (FRSB) - 2025
3. Elected Fellow, West Bengal Academy of Science & Technology (FAScT) - 2022
4. Awarded NESA Eminent Scientist of the Year - 2022
5. Awarded Prof. A. K. Mukherjee Memorial Oration from The Physiological Society of India, 2021.
6. Received Dr. A. Namasivayam Award by IABMS-2016
7. Awarded ITG by UGC to attend XXI World Congress of Neurology in Vienna, Austria- 2013.
8. Awarded ITG by UGC to attend XIX World Congress on Parkinson’s disease and related disorders in Shanghai, China- 2011.
9. Awarded Dr. K. Anji Reddy Prize, a certificate & cash award from PSI- PHYSICON-2011
10. Awarded Post Doctoral Research Fellowship, University of Illinois at Chicago (UIC), Chicago, IL, USA.---2003
TEACHING
TEACHING
M.Sc. Courses:
LS-104: Animal Biology
LS 427A-Animal Physiology
LS 431A- Life Sciences Practical-II-Animal Physiology
LS 569-Neural and Behavioural Biology
LS 452A- Research Design, Ethics and Scientific publishing
LS 580 Research Design, Ethics and Scientific Publishing
Ph.D. Courses:
LS 642A- Cellular and Molecular Neurobiology
LAB MEMBERS
LAB MEMBERS
CURRENT MEMBERS
Dr. Mir Hilal Ahmad
Post doctoral fellow
Project title: Exploring the therapeutic potential of neural stems cells in Parkinson’s Disease
Punit Prasanna Kujur
Ph.D. (Pursuing) (2023-)
Thesis title: Studying the potential therapeutic effects of Biochanin A in a rat model of chronic constriction injury (CCI)-induced neuropathic pain
Sehar Siddiqui
Ph.D. (Pursuing)(2024-)
Course work
Surendar E
(Ph.D Pursuing) (2024-)
course work
Sana Naz
(Ph.D Pursuing) (2025-)
course work
Sunidhi Bisht
MSc Dissertation (2024-)
(pursuing)
DISSERTATION
•Ms. Anamika Singh (2017)
•Ms. Rhea Subba (2018)
•Mr. Sandeep (2019)
•Mr. Manuvendra Nandan (2020)
•Ms. Roshni Sherpa (2021)
•Ms. Payyavula Ragini (2022)
•Ms. Priyanka Biswal (2023)
•Ms. Palak Gupta (2024)
•Ms. Rubi (2024)
•Ms. Sunidhi Bisht (Persuing)
INTERNSHIP
•Ms. Aditi Thakur (2017)
•Mr. Divyam Singh (2017)
•Md. Abu Nasar (2018)
•Ms. Anjali (2019)
•Ms. Surbhi Mishra (2020)
•Ms. Surbhi Bihani (2021)
•Mr. Aman (2022)
•Ms. Kirti (2023)
•Mr. Vivekanand Choudhury (2023)
•Ms. Anuskha Garg (2024)
PUBLICATIONS
PUBLICATIONS
1. Sahu MR, Ahmad MH, & Mondal AC* MST1 selective inhibitor Xmu-mp-1 ameliorates neuropathological changes in a rat model of sporadic Alzheimer’s disease by modulating Hippo-Wnt signaling crosstalk. Apoptosis 2024 May 17. doi:10.1007/s10495-024-01975-0. JIF- 7.2 (Link)
2. Sushma, Sahu MR, Murugan NA, & Mondal AC*. Amelioration of Amyloid-β Induced Alzheimer’s Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/ β-Catenin Signaling. Molecular Nutrition & Food Research 2023 Dec 24: e2300245, doi: 10.1002/mnfr.202300245). JIF- 5.20 (Link)
3. Ahmad MH, Rizvi MA, Ali M & Mondal AC*. Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies. Ageing Research Reviews 2 Jan, (85) 2023. doi.org/10.1016/j.arr.2022.101840). JIF- 13.10 (Link)
4. Rani L, Ghosh B, Ahmad MH, & Mondal AC*. Potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and a mouse model of Parkinson’s disease (Molecular Neurobiology 5 May, 2023, doi.org/ 10.1007/s12035-023-03358-z). IF- 5.68 (Link)
5. Ahmad MH, Fatima M, Ali M, Rizvi MA, Mondal AC*. Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson’s disease. Neuropharmacology, 2021, 201, 108831 Oct 13. doi:10.1016/j.neuropharm. 2021.108831. IF-5.27 (Link)
6. Paul A, Kumar S, Kalita S, Kalita S, Sarkar D, Bhunia A, Bandyopadhyay A, Mondal AC*, Mondal B. An explicitly designed paratope of Amyloid-β prevents neuronal apoptosis in vitro and hippocampal damage in rat brain. Chemical Science, 2021, 12 (8):2853-2862. Edge article. IF-9.96 (Link)
7. Srivastav S, Anand BG, Fatima M, Prajapati KP, Yadav SS, Kar K, Mondal AC*. Piperine coated gold nanoparticles alleviate paraquat-induced neurotoxicity in Drosophila melanogaster. ACS Chemical Neuroscience 2020;11(22):3772-3785. IF-5.78 (Link)
8. Kumar S, Srivastav S, Fatima M, Giri RS, Mandal B, Mondal AC*. A Synthetic Pro-Drug Peptide Reverses Amyloid-β-Induced Toxicity in the Rat Model of Alzheimer's Disease. Journal of Alzheimer’s Disease 2019, 69(2):499-512. IF-4.46 (Link)
9. Fatima M, Srivastav S, Ahmad MH, Mondal AC*. Effects of chronic unpredictable mild stress induced prenatal stress on neurodevelopment of neonates: Role of GSK-3β. Scientific Reports 2019 Feb 4, 9 (1):1305 (doi: 10.1038/s41598-018-38085-2). IF-5.13 (Link)
10.Ahmad MH, Fatima M, Hossain M, Mondal AC*. Evaluation of naproxen-induced oxidative stress, hepatotoxicity and in-vivo genotoxicity in male Wistar rats. Journal of Pharmaceutical Analysis, 2018 Dec; 8(6):400-406. IF-8.80 (Link)
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