We can provide quotes for both clinical laboratory and anatomic pathology testing and diagnostic services. Do you have a tight budget? Let us know. We can help you to get the most from your funding. The staff at UR Medicine Labs looks for opportunities to reduce costs by finding the most economical methods for your study. Download research test price quote form. E-mail completed forms to InternalURMCClinicalTrials@urmc.rochester.edu.

Our project managers will design a plan to meet your specific needs. Set-up includes testing guidelines, custom requisitions, billing procedures, report handling, point-of-care testing considerations, specimen storage, and any special requirements of your study. Have a complex project? Not quite sure how to request what you want? Our new Researcher Biospecimen Planning Tool may help guide you through some of your questions/concerns or you can call UR Medicine Labs to speak with a project manager at (585) 758-0525 to discuss the details of your project. Download our study set-up request form. E-mail completed forms to InternalURMCClinicalTrials@urmc.rochester.edu.

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UR Medicine Labs offers a complete range of histology services including grossing, tissue processing, embedding, unstained and stained slides (H&E and special stains), punch cores, whole mounts, microtube thick sectioning, immunocytochemical staining, immunofluorescent and in situ hybridization, neuromuscular morphometric analysis, and tissue microarray construction. Our project managers can provide pricing information and set up meetings for you with lab personnel to discuss your specific needs. Call (585) 758-0525 to speak to a project manager.

Studies conducted in the Rochester, NY area may arrange for specimen collection at our numerous patient service centers. Our project managers can provide information on pricing, custom requisitions, and specimen delivery. Call UR Medicine Labs at (585) 758-0525 to speak to a project manager.

The Division of Laboratory Animal Medicine provides veterinary consultation and assistance with experimental design, specimen and tissue collection, and submission of animal specimens for diagnostic testing. We can work with them to help you meet your specific testing needs. Call UR Medicine Labs at (585) 758-0525 to speak to a project manager. Please note: UR Central Labs is not an animal testing laboratory. All our assays are validated only for use with human specimens, and we have no reference ranges for species other than humans.

Our forty faculty include pathologists, clinical laboratory scientists; and basic, translational, and clinical researchers in many subspecialty areas. We can put you in touch with someone with expertise regarding choice and utilization of tests for your study. Call UR Medicine Labs at (585) 758-0525 to speak to a project manager.

(RTTNews) - Carisma Therapeutics Inc. (CARM) announced the clearance of Investigational New Drug application by the FDA for CT-0525 in treatment of solid tumors that overexpress human epidermal growth factor receptor 2. Carisma expects to initiate a Phase 1 study in the coming months and to treat the first patient in the first half of 2024.

The Phase 1 study for CT-0525 is designed to assess the safety, tolerability, and the manufacturing feasibility of CT-0525. The study will enroll participants with locally advanced or metastatic solid tumors overexpressing HER2 whose disease has progressed on standard approved therapies. The study will consist of two cohorts.

PHILADELPHIA, Nov. 28, 2023 /PRNewswire/ -- Carisma Therapeutics Inc. (Nasdaq: CARM) ("Carisma" or the "Company"), a clinical stage biopharmaceutical company focused on discovering and developing innovative immunotherapies, today announced the clearance of its Investigational New Drug application (IND) by the U.S. Food and Drug Administration (FDA) for CT-0525, an ex vivo gene-modified autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2). Having received a Study May Proceed notification from the FDA, Carisma expects to initiate a Phase 1 study in the coming months and to treat the first patient in the first half of 2024.

"Clearance of the IND for CT-0525 is a significant milestone in Carisma's mission to develop innovative myeloid cell therapies for metastatic solid tumors," said Steven Kelly, President and Chief Executive Officer of Carisma. "Through this Phase 1 study, we aim to advance our understanding of safety, tolerability, manufacturing feasibility and mechanism of action of CT-0525."

Monocytes are the precursor cells to macrophages, and there are numerous potential benefits to a CAR-Monocyte approach to help overcome certain challenges of treating solid tumors. The CAR-Monocyte manufacturing platform enables the ability to manufacture up to 10 billion cells from a single apheresis and utilizes a rapid, single-day manufacturing process. This manufacturing process holds the potential to significantly reduce the future cost of goods and manufacturing turnaround time associated with this autologous cell therapy. Pre-clinical data presented at The Society for Immunotherapy of Cancer's Annual Meeting in November 2022 demonstrate that CT-0525 therapy reduced tumor growth in multiple pre-clinical solid tumor models.

"CT-0525 is the first CAR-Monocyte to be evaluated in the solid tumor setting. With a CAR-Monocyte's in vivo persistence, ability to differentiate into pro-inflammatory CAR macrophages, and multi-modal anti-tumor mechanism of action, along with its high cell yield, CT-0525 has the potential to improve the treatment paradigm for patients with HER2 overexpressing metastatic solid tumors," said Michael Klichinsky, PharmD, PhD, Co-Founder and Chief Scientific Officer at Carisma. "We look forward to the clinical development of CT-0525."

The Phase 1 study for CT-0525 is designed to assess the safety, tolerability, and the manufacturing feasibility of CT-0525. This study will enroll participants with locally advanced (unresectable) or metastatic solid tumors overexpressing HER2 whose disease has progressed on standard approved therapies. The study will consist of two cohorts: Cohort 1 will receive IV administration of up to 3 billion CAR-positive cells, while Cohort 2 will receive IV administration of CT-0525 of up to 10 billion CAR-positive cells.

CT-0525 is an ex vivo gene-modified autologous chimeric antigen receptor-monocyte (CAR-Monocyte) cellular therapy intended to treat solid tumors that overexpress human epidermal growth factor receptor 2 (HER2). The CAR-Monocyte approach has the potential to address the challenges of treating solid tumors with cell therapies, including tumor infiltration, immunosuppression within the tumor microenvironment, and antigen heterogeneity.

3. The Optics Division provides anti-reflection coating services on these windows. Please refer to our coating services, V-coating, and Broadband anti-reflection coating for the details. Please contact us for a quote.

I starting a rental business, and my website is geared towards giving people quotes for the items that they want. However, the Shopify checkout is still available before the customer receives their quote. I would like checkout to not be available until they have accepted their quote. How do I solve this? I am expecting to change the code in some way.

Hi, @lw0525 

Greetings and thanks for posting!

I understand you are wanting to disable the checkout for your products as they require a certain quote. While disabling the checkout isn't an option, there are workarounds!

For example, there is a great app called Quick Quote which provides exactly what you're looking for. Additionally, another option is to adjust the 'Add to Cart' button to a 'Call for quote' button. There are apps that provide this function such as Request a Quote.

I hope that helps! In the meantime, I'd love to take a look at your store to see what additional feedback I can provide. When you have a moment please provide your URL.

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You can review the price and details of the Samson PN 0520-0525 Diaphragm 350 cm product with Samson, product code PN 0520-0525  below. To get a quotation, fill in the online quotation form.

Our skilled experienced will first measure the area designated for pressure cleaning and confirm the quote initially provided via phone. Following this, the equipment preparation commences. It's necessary to note that our technician will need access to electricity and a running water supply.An external water tap is convenient. As soon as the pressure cleaning machine is ready, the technician initiates the cleaning task. The machine releases a potent water stream, capable of dislodging accumulated dirt, grime, and even specific types of stains from your pavement, patio, and driveway. No harmful substances are required; the high-pressure water does all the work.

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