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Exercise-induced collapse (EIC) is a nervous system disorder that is inherited in Labrador retrievers, curly coated retrievers, Chesapeake Bay retrievers, German wirehaired pointers, cocker spaniels, Boykin spaniels, Bouvier des Flanders, Old English sheepdogs and Pembroke Welsh corgis.


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Dogs affected by EIC are perfectly normal most of the time and it is impossible for an owner or a veterinarian to determine that there is anything wrong with them. They may, however, experience episodes of collapse when they participate in strenuous activities that they find exciting or stressful, especially in warm weather.

Not all dogs affected by EIC (two copies of the mutation) will have had episodes of collapse. Approximately 85 per cent of affected dogs have collapse observed by the time they are three years of age, but some affected dogs never exercise with the intensity and excitement required to induce an episode of collapse.

The best treatment consists of avoiding known trigger activities and activities that involve intensive exercise in conjunction with extreme excitement especially in hot weather. A few d-EIC affected male dogs have experienced improvement after neutering - with an improved ability to tolerate intensive exercise without collapse. Early in our evaluation of dogs with dEIC, Phenobarbital treatment may have resulted in similar improvement in some dogs. Our impression is that improvement with both of these treatments may have simply been a result of a decrease in the general excitement level of the dog.

Current data from the first 45,000 Labradors tested at the University of MN (as of 10/2017) shows that nearly 40 per cent of all Labradors tested have been carriers (with one copy of the mutation: E/N) and approximately six per cent of dogs have been affected (with two copies: E/E) and susceptible to collapse. Some dogs have been tested because of collapse, but most tests have been performed to determine EIC status for breeding purposes. Interestingly, the prevalence of carriers is not different between field trial /hunt test dogs and show dogs and pet dogs.

Most (>80 per cent) affected Labradors (E/E: two copies of the mutation) experience at least one episode of collapse by the time they are four years of age. Many competitive field trial dogs are unable to continue training and competing at a high level but if trigger activities can be avoided, dogs with EIC live normal lives. A few genetically affected (E/E) dogs rarely or never exhibit collapse, perhaps because they do not engage in the required strenuous activity with extreme excitement that is required to produce collapse. DNA testing is the only way to know for certain whether a dog has EIC.

The research laboratory at the University of Minnesota has tested hundreds of samples from many of the other common retriever breeds including golden retrievers, flat-coated retrievers, Chesapeake Bay retrievers, Nova Scotia duck tolling retrievers and curly coated retrievers. So far, in retrievers, the mutation has only been found in Labradors, curly coated retrievers (40 per cent carriers, 18 per cent affected) and in Chesapeake Bay retrievers (17 per cent carriers, three per cent affected).

The laboratory has also tested normal and collapsing dogs from many other working and sporting breeds. The mutation has been identified in Boykin spaniels (33 per cent carriers, seven per cent affected), old English sheepdogs (30 per cent carriers, three per cent affected), and rarely in German wirehaired pointers, Bouvier des Flanders, Pembroke Welsh corgis and cocker spaniels.

Our research team has been investigating a disorder called border collie collapse that affects border collies, Australian cattle dogs, Australian kelpies, Australian shepherds, Shetland sheepdogs, bearded collies, and collies.

Dogs worsen after exercise

It is common for the symptoms to worsen for three to five minutes even after exercise has been terminated. A few affected dogs have died during exercise or while resting immediately after an episode of exercise-induced collapse. An affected dog's exercise should ALWAYS be stopped immediately at the first hint of incoordination or wobbliness.

Veterinary evaluation

Nervous system, cardiovascular and musculoskeletal examinations are unremarkable at rest in dogs with EIC as is routine blood analysis at rest and even during an episode of collapse. These dogs do not experience heart rhythm abnormalities, low blood sugar, electrolyte disturbances or respiratory difficulty during collapse. Body temperature is remarkably elevated during collapse (average 107.1F [41.7C], many up to 108F [42.2C]), and carbon dioxide levels in their blood are very low due to extreme panting to blow off heat, but the high temperatures and degree of hyperventilation are not different from those measured in normal Labradors without EIC who perform the same exercise.

Ambient temperature

Hot weather does not seem to be necessary to induce collapse, but if the temperature is very warm, collapse is more likely. Affected dogs are less likely to collapse in cold weather or while swimming, but dogs have exhibited collapse while breaking ice retrieving waterfowl in frigid temperatures and dogs have drowned when experiencing EIC-related collapse in the water.

Excitement 

Dogs that exhibit the symptoms of EIC are most likely to have intense, excitable personalities, and it is very apparent that their level of excitement plays a role in inducing the collapse. Dogs with EIC are most likely to collapse when engaging in activities that they find very exciting or stressful. This can include retrieving or chasing live birds, participation in field trials with live birds, training drills with electric collar pressure and quartering for upland game

Type of exercise 

Routine exercise like jogging or hiking is not very likely to induce an episode in dogs with EIC. Activities with continuous intense exercise, particularly if accompanied by a high level of excitement or anxiety most commonly cause collapse. Activities commonly implicated include pheasant hunting, repetitive "happy retrieves", repetition of difficult retrieves especially where the dog is having trouble finding a bird or is receiving or anticipating electric collar correction, and excitedly running alongside an all-terrain vehicle.

Until October 2008, EIC could only be diagnosed by systematically ruling out all other disorders causing exercise intolerance and collapse and by observing characteristic clinical features, history and laboratory test results in affected dogs. Even today, any Labrador retriever with exercise intolerance should always have a complete veterinary evaluation to rule-out

Even though EIC is the most common reason for exercise/excitement induced collapse in Labrador retrievers that seem otherwise normal and healthy between collapse episodes, there are many other reasons for Labrador retrievers to collapse.

If a Labrador has episodes of collapse or exercise intolerance they should be fully evaluated by a veterinarian for a number of treatable metabolic, cardiac and neurologic disorders including low blood sugar, low blood cortisol, electrolyte abnormalities, heart failure, cardiac arrhythmias, pulmonary hypertension, respiratory disorders, cauda equina syndrome, muscle disorders and epilepsy.

Most (>83 per cent) affected Labradors (EE) experience at least one episode of collapse by the time they are 4 years of age. Most competitive dogs are unable to continue training and competing at a high level. If trigger activities can be avoided, dogs with d-EIC live normal lives.

A few EE dogs never exhibit collapse, perhaps because they do not engage in the required strenuous activity with extreme excitement as required to produce collapse. DNA testing is the only way to know for certain whether a dog has dEIC. Dogs that are carriers for the dynamin-1 mutation are clinically normal and have no exercise intolerance.

It is important that owners of dogs with EIC be made aware that the dog's exercise should be stopped at the first hint of incoordination or wobbliness as some affected dogs have died during collapse when their owners allowed or encouraged continuing exercise. Not all of the EIC deaths have occurred in dogs rated as severely affected based on their historical number of episodes of collapse or the amount of activity required to induce previous episodes of collapse.

It appears that one of the most common disorders causing episodes of exercise intolerance or collapse after exercise that can be confused with EIC in Labrador retrievers is an atypical seizure disorder. e24fc04721

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